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1. 发明申请

US20070135431A1 INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：用于治疗疾病的组织脱乙酰酶的抑制剂
公开(公告)号：US20070135431A1
公开(公告)日：2007-06-14
申请号：US11608726
申请日：2006-12-08
申请人： Nicholas Smith , Celine Bonnefous , Joseph Payne , Timothy Hoffman , Paul Wash , Christian Hassig , Shawn Scranton
发明人： Nicholas Smith , Celine Bonnefous , Joseph Payne , Timothy Hoffman , Paul Wash , Christian Hassig , Shawn Scranton
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4439 , C07D413/14 , C07D401/14
CPC分类号： C07D401/12 , C07C327/30 , C07D211/46 , C07D213/30 , C07D213/38 , C07D213/76 , C07D295/096 , C07D295/26 , C07D413/12
摘要： Disclosed herein are carbonyl compounds of having the structural formula: or a salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译：本文公开了具有以下结构式的羰基化合物：或其盐，酯或前药。公开了用于治疗疾病状态的方法和组合物，包括但不限于癌症，自身免疫疾病，组织损伤，中枢神经系统疾病，神经变性使用本发明的化合物，疾病，纤维化，骨病，聚谷氨酰胺重复病症，贫血，地热病，炎性病症，心血管病症和血管发生在发病机理中发挥作用的病症。此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

2. 发明申请

US20070027184A1 Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease 审中-公开
标题翻译：多环磺酰胺化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病
公开(公告)号：US20070027184A1
公开(公告)日：2007-02-01
申请号：US11496784
申请日：2006-07-27
申请人： James Malecha , Stewart Noble , Brandon Wiley , Timothy Hoffman , Celine Bonnefous , Michael Sertic , Paul Wash , Nicholas Smith , Christian Hassig , Shawn Scranton , Joseph Payne , Jeffery Hager
发明人： James Malecha , Stewart Noble , Brandon Wiley , Timothy Hoffman , Celine Bonnefous , Michael Sertic , Paul Wash , Nicholas Smith , Christian Hassig , Shawn Scranton , Joseph Payne , Jeffery Hager
IPC分类号： A61K31/47 , C07D215/12 , C07D319/14 , A61K31/36
CPC分类号： C07D405/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12
摘要： Disclosed herein are sulfonamide compounds of Formula VII as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译：本文公开的是本文所述的式VII的磺酰胺化合物。公开了用于治疗疾病状态的方法和组合，包括但不限于癌症，自身免疫性疾病，组织损伤，中枢神经系统疾病，神经变性疾病，纤维化，骨病，聚谷氨酰胺 - 重复病症，贫血，地中海贫血，炎性病症，心血管疾病以及使用本发明化合物的血管发生在发病机理中起作用的病症。此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

3. 发明申请

US20080194681A1 Novel Inhibitors of Histone Deacetylase for the Treatment of Disease 审中-公开
标题翻译：组蛋白脱乙酰酶治疗疾病的新型抑制剂
公开(公告)号：US20080194681A1
公开(公告)日：2008-08-14
申请号：US11792624
申请日：2005-12-09
申请人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman , Celine Bonnefous , NIcholas Smith
发明人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman , Celine Bonnefous , NIcholas Smith
IPC分类号： A61K31/265 , C07C327/32 , A61P9/00 , A61P7/06 , A61P35/00 , A61P35/04
CPC分类号： C07D213/74 , C07C327/22 , C07C327/28 , C07C327/30 , C07C327/32 , C07D213/32 , C07D213/70 , C07D215/36 , C07D215/38 , C07D231/38 , C07D241/44 , C07D295/192 , C07D295/26 , C07D319/18
摘要： Disclosed herein are carbonyl compounds of Formula: (I) as described herein. Compounds as modulators of his-tone deacetylase (HDAC), pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译：本文公开的是如本文所述的式（I）的羰基化合物。公开了作为其脱色酶脱乙酰酶（HDAC）调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。

4. 发明申请

US20060030554A1 Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease 失效
标题翻译：新型磺酰胺作为组蛋白脱乙酰酶的抑制剂用于治疗疾病
公开(公告)号：US20060030554A1
公开(公告)日：2006-02-09
申请号：US11150783
申请日：2005-06-09
申请人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman
发明人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman
IPC分类号： A61K31/675 , A61K31/55 , A61K31/21 , C07C237/30
CPC分类号： C07C323/49 , C07C323/67 , C07C327/30 , C07D277/16 , C07D277/36 , C07D295/112 , C07D319/18 , C07D417/12
摘要： Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译：本文公开了具有以下结构式的羰基化合物：或其药学上可接受的盐，酰胺，酯或前药。公开了用于治疗疾病状态的方法和组合物，包括但不限于癌症，自身免疫性疾病，组织损伤，中枢神经使用本发明的化合物，系统疾病，神经变性疾病，纤维化，骨病，聚谷氨酰胺 - 重复病症，贫血，地热病，炎性病症，心血管病症和血管发生在发病机理中起作用的病症。此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

5. 发明申请

US20060030543A1 Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease 失效
标题翻译：多环磺酰胺化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病
公开(公告)号：US20060030543A1
公开(公告)日：2006-02-09
申请号：US11150500
申请日：2005-06-09
申请人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman
发明人： James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman
IPC分类号： A61K31/675 , A61K31/55 , A61K31/519 , A61K31/4745 , A61K31/4743 , A61K31/47 , A61K31/404
CPC分类号： C07D221/04 , C07C323/49 , C07C327/30 , C07D209/08 , C07D209/16 , C07D215/36 , C07D217/06 , C07D241/42 , C07D307/82 , C07D317/62 , C07D319/18 , C07D333/54 , C07D333/62 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07F9/1653
摘要： Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
摘要翻译：本文公开的是本文所述的式I的羰基化合物。公开了用于治疗疾病状态的方法和组合，包括但不限于癌症，自身免疫性疾病，组织损伤，中枢神经系统疾病，神经变性疾病，纤维化，骨病，聚谷氨酰胺 - 重复病症，贫血，地中海贫血，炎性病症，心血管疾病以及使用本发明化合物的血管发生在发病机理中起作用的病症。此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

6. 发明申请

US20070065362A1 Gastrin receptor-avid peptide conjugates 审中-公开
标题翻译：胃泌素受体 - 狂犬病肽缀合物
公开(公告)号：US20070065362A1
公开(公告)日：2007-03-22
申请号：US11592864
申请日：2006-11-03
申请人： Timothy Hoffman , Wynn Volkert , Ning Li , Gary Sieckman , Chrys-Ann Higginbotham
发明人： Timothy Hoffman , Wynn Volkert , Ning Li , Gary Sieckman , Chrys-Ann Higginbotham
IPC分类号： A61K51/00 , C07K14/575
CPC分类号： A61K51/088 , A61K38/00 , C07F5/003 , C07F15/008 , C07K7/086 , C07K14/57572
摘要： A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.
摘要翻译：用作治疗或诊断性放射性药物的化合物包括能够使与能够结合胃泌素释放肽受体的部分连接的医学上有用的金属络合的基团。用于治疗患有肿瘤疾病的受试者的方法包括向受试者施用有效量的具有与螯合基螯合的金属的放射性药物，所述螯合基团连接到能够结合肿瘤细胞上表达的胃泌素释放肽受体的部分，随后内化的细胞。形成治疗或诊断化合物的方法包括使金属合成酶与能够结合胃泌素释放肽受体的部分共价连接的螯合基团反应。

7. 发明授权

US06989158B1 Gold-containing chemotherapeutic agents 失效
标题翻译：含金化学治疗剂
公开(公告)号：US06989158B1
公开(公告)日：2006-01-24
申请号：US10019192
申请日：2000-06-23
申请人： Kattesh V. Katti , Wynn A. Volkert , Timothy Hoffman
发明人： Kattesh V. Katti , Wynn A. Volkert , Timothy Hoffman
IPC分类号： A61K31/28 , A61K33/24
CPC分类号： A61K31/28
摘要： There is provided a complex for use as a therapeutic pharmaceutical, the complex has a ligand containing at least one hydroxyalkyl phosphine donor group bound to a gold atom to form a stable gold-ligand complex. Also provided is a method of treating cancer by administering an effective amount of a complex having a ligand of at least one hydroxyalkyl phosphine group bound to a gold atom to form a stable gold-ligand complex. Also provided is a method of preventing the metastasis of cancer and arresting cell growth by administering an effective amount of a complex having a ligand of at least one hydroxyalkyl phosphine group bound to a gold atom to form a stable gold-ligand complex.
摘要翻译：提供了用作治疗药物的复合物，该配合物具有含有至少一个与金原子结合的羟烷基膦供体基团以形成稳定的金 - 配体络合物的配体。还提供了通过施用有效量的具有与金原子结合的至少一个羟基烷基膦基团的配体的络合物以形成稳定的金 - 配体络合物来治疗癌症的方法。还提供了通过施用有效量的具有与金原子结合的至少一个羟烷基膦基配体的配合物以形成稳定的金 - 配体络合物的方法来防止癌症转移和阻止细胞生长的方法。

8. 发明申请

US20060067886A1 Gastrin receptor-avid peptide conjugates 审中-公开
公开(公告)号：US20060067886A1
公开(公告)日：2006-03-30
申请号：US11267001
申请日：2005-11-04
申请人： Timothy Hoffman , Wynn Volkert , Gary Sieckman , Charles Smith , Hariprasad Gali
发明人： Timothy Hoffman , Wynn Volkert , Gary Sieckman , Charles Smith , Hariprasad Gali
IPC分类号： A61K51/00 , C07K14/595
CPC分类号： A61K51/088
摘要： A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.

9. 发明授权

US09944649B2 Compounds and compositions as toll-like receptor 7 agonists 有权
公开(公告)号：US09944649B2
公开(公告)日：2018-04-17
申请号：US15307510
申请日：2015-04-29
申请人： Alex Cortez , Timothy Hoffman , Yongkai Li , Tom Yao-Hsiang Wu , Xiaoyue Zhang
发明人： Alex Cortez , Timothy Hoffman , Yongkai Li , Tom Yao-Hsiang Wu , Xiaoyue Zhang
IPC分类号： C07D487/04 , A61K31/519 , A61P31/18 , A61P31/20 , A61P35/00 , A61P29/00 , A61P19/10 , A61P37/00
CPC分类号： C07D487/04
摘要： The invention provides a compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.

10. 发明申请

US20060038379A1 TRAVEL TRAILER HAVING IMPROVED TURNING RADIUS 有权
标题翻译：具有改进的驾驶RADIUS的旅行车
公开(公告)号：US20060038379A1
公开(公告)日：2006-02-23
申请号：US11091070
申请日：2005-03-28
申请人： Brian Brady , John Rhymer , Douglas Lantz , Timothy Hoffman , Scott Tuttle
发明人： Brian Brady , John Rhymer , Douglas Lantz , Timothy Hoffman , Scott Tuttle
IPC分类号： B62D25/02 , B62D53/06 , B60J5/00
CPC分类号： B62D63/06 , B60P3/32 , B60P3/36 , B62D21/20 , B62D33/04 , B62D53/061
摘要： Abstract of the DisclosureA travel trailer configured to be coupled to and towed by a vehicle is provided. The travel trailer has a compartment that is attached to a chassis which includes a front end and a rear end. A plurality of wheels are attached to the chassis adjacent the rear end, and a hitch assembly is attached to the chassis adjacent the front end. The compartment at the front end of the chassis forms first and second corners. A recess, directed inwardly toward the interior of the compartment, is located at each corner of the compartment. Cavities formed by each recess may receive a portion of the vehicle while the vehicle is engaged in a turn.
摘要翻译：公开摘要提供了一种被配置为联接到车辆并被拖曳的旅行拖车。旅行拖车具有附接到包括前端和后端的底盘的隔室。多个车轮相邻于后端附接到底盘，并且牵引组件附接到靠近前端的底盘。底盘前端的隔间形成第一和第二个角。向内指向隔室内部的凹槽位于隔室的每个角落处。每个凹部形成的腔可以在车辆转弯的同时接收车辆的一部分。

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