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1. 发明公开

EP2475656A1 2, 3, 6 -TRIAMINO SUBSTITUTED PYRIDINES AS KV7 (KCNQ) CHANNEL MODULATORS 审中-公开
标题翻译：作为KV7（KCNQ）通道调节剂的2,3,6-三取代氨基取代的吡啶
公开(公告)号：EP2475656A1
公开(公告)日：2012-07-18
申请号：EP10748096.4
申请日：2010-09-02
申请人： NeuroSearch A/S
发明人： BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
IPC分类号： C07D405/14 , C07D413/14
CPC分类号： C07D413/14 , C07D405/14
摘要： The present application relates to novel substituted aminopyridine derivatives, to their use in therapy, to pharmaceutical compositions comprising the derivatives, to the use of said derivatives in the manufacture of a medicament, and to therapeutic methods comprising the administration of the derivatives. The present derivatives are useful for treating a disorder responsive to activation of K
V 7 channels. Due to the distribution of K
V 7 channels within the organism, K
V 7 channel modulators are considered potentially useful for the treatment or alleviation of conditions as diverse as CNS disorders, psychiatric disorders, CNS damage caused by trauma, stroke or neurodegenerative illness or diseases, a variety of neuronal hyperexcitability disorders and conditions, epilepsy, pain, neuropathic pain, migraine, tension type headache, learning and cognitive disorders, motion and motor disorders, multiple sclerosis, cardiac disorders, heart failure, cardio-myopathia, inflammatory diseases, ophthalmic conditions, deafness, progressive hearing loss, tinnitus, obstructive or inflammatory airway diseases, for inducing or maintaining bladder control including the treatment or prevention of urinary incontinence.
摘要翻译：本申请涉及新的取代的氨基吡啶衍生物，其在治疗中的用途，包含所述衍生物的药物组合物，所述衍生物在制备药物中的用途，以及包括所述衍生物的施用的治疗方法。本发明衍生物可用于治疗对K V7通道活化有反应的病症。由于生物体内K V7通道的分布，K V7通道调节剂被认为可能用于治疗或缓解各种病症，如中枢神经系统疾病，精神疾病，由创伤，中风或神经退行性疾病或疾病引起的CNS损伤，癫痫症，疼痛，神经性疼痛，偏头痛，紧张型头痛，学习和认知障碍，运动和运动障碍，多发性硬化症，心脏病，心力衰竭，心 - 肌病，炎性疾病，眼科病症，耳聋，进行性听力丧失，耳鸣，阻塞性或炎性气道疾病，用于诱导或维持膀胱控制，包括治疗或预防尿失禁。

2. 发明申请

WO2011026891A1 SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：取代的吡啶衍生物及其医学用途
公开(公告)号：WO2011026891A1
公开(公告)日：2011-03-10
申请号：PCT/EP2010/062860
申请日：2010-09-02
申请人： NEUROSEARCH A/S , BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
发明人： BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
IPC分类号： C07D405/12 , A61K31/443 , A61P13/10 , A61P25/04 , A61P25/08 , A61P25/18
CPC分类号： C07D405/12
摘要： The present application relates to novel substituted pyridine derivatives, to their use in therapy, to pharmaceutical compositions comprising the derivatives, to the use of said derivatives in the manufacture of a medicament, and to therapeutic methods comprising the administration of the derivatives. The present derivatives are useful for treating a disorder responsive to activation of K v 7 channels. Formula (I).
摘要翻译：本申请涉及新型取代的吡啶衍生物，其在治疗中的用途，包含该衍生物的药物组合物，所述衍生物在制备药物中的用途，以及包括施用衍生物的治疗方法。本发明的衍生物可用于治疗对Kv7通道的激活作出反应的病症。式（I）。

3. 发明申请

WO2010097379A1 SUBSTITUTED PYRIMIDIN DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：取代的吡咯嗪衍生物及其医学用途
公开(公告)号：WO2010097379A1
公开(公告)日：2010-09-02
申请号：PCT/EP2010/052257
申请日：2010-02-23
申请人： NEUROSEARCH A/S , JESSEN, Carsten , BROWN, William, Dalby , STRØBÆK, Dorte
发明人： JESSEN, Carsten , BROWN, William, Dalby , STRØBÆK, Dorte
IPC分类号： C07D405/12 , A61P25/00 , A61K31/506
CPC分类号： C07D405/12
摘要： The present application discloses novel substituted tetrahydro-pyran-4-ylmethyl-pyrimidin derivatives and their use as modulators of the voltage gated K V 7 (KCNQ) potassium ion channels. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.
摘要翻译：本申请公开了新型取代的四氢 - 吡喃-4-基甲基嘧啶衍生物及其作为电压门控KV7（KCNQ）钾离子通道的调节剂的用途。在其它方面，本申请公开了这些化合物在治疗方法中的用途以及包含这些化合物的药物组合物。

4. 发明公开

EP2408747A1 SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：取代的吡啶及其医药用途
公开(公告)号：EP2408747A1
公开(公告)日：2012-01-25
申请号：EP10708196.0
申请日：2010-03-11
申请人： NeuroSearch A/S
发明人： JESSEN, Carsten , BROWN, William, Dalby , STRØBÆK, Dorte
IPC分类号： C07D213/74 , A61K31/444 , A61P25/00
CPC分类号： C07D213/74
摘要： The present application discloses novel substituted pyridinyl-methylamine derivatives and their use as modulators of the voltage gated K
v 7 (KCNQ) potassium ion channels. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.

5. 发明公开

EP2231611A1 NOVEL 2-PYRROLIDINYL-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS 审中-公开
标题翻译： NEW -2-吡咯烷基-3-氨基-6-氨基 - 吡啶衍生物可用作钾通道活化剂
公开(公告)号：EP2231611A1
公开(公告)日：2010-09-29
申请号：EP08860335.2
申请日：2008-12-10
申请人： NeuroSearch A/S
发明人： BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
IPC分类号： C07D213/75 , C07D405/12 , A61K31/44 , A61P29/00
CPC分类号： C07D213/75 , C07D405/12
摘要： This invention relates to novel 2-pyrrolidinyl-3-amido-6-amino-pyhdine derivatives having medical utility, to use of the 2-pyrrolidinyl-3-amido-6-amino- pyridine derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2-pyrrolidinyl-3-amido-6-amino- pyridine derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of Kv7 channels.

6. 发明公开

EP1940829A2 IMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX 审中-公开
标题翻译：咪唑衍生物及其调制GABAA受体复合物
公开(公告)号：EP1940829A2
公开(公告)日：2008-07-09
申请号：EP06807181.0
申请日：2006-10-12
申请人： NeuroSearch A/S
发明人： BROWN, William, Dalby , LARSEN, Janus, S. , TEUBER, Lene , BROWN, David, Tristam , AHRING, Philip, K. , MIRZA, Naheed , NIELSEN, Elsebet, Østergaard
IPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , A61K31/4178 , A61P25/00
CPC分类号： C07D413/04 , C07D233/88 , C07D403/04 , C07D405/04 , C07D413/14 , C07D417/04
摘要： This invention relates to novel imidazole derivatives of the general formula (I): pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.

7. 发明公开

EP2231610A1 NOVEL 2-DIMETHYLAMINO-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS 审中-公开
标题翻译： NEW 2-二甲基氨基-3-氨基-6-氨基 - 吡啶衍生物可用作钾通道活化剂
公开(公告)号：EP2231610A1
公开(公告)日：2010-09-29
申请号：EP08859320.7
申请日：2008-12-10
申请人： NeuroSearch A/S
发明人： BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
IPC分类号： C07D213/75 , A61K31/44 , A61P29/00
CPC分类号： C07D213/75
摘要： This invention relates to novel 2-dimethylamino-3-amido-6-amino-pyhdine derivatives having medical utility, to use of the 2-dimethylamino-3-amido-6-amino- pyridine derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2-dimethylamino-3-amido-6-amino- pyridine derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of Kv7 channels.

8. 发明公开

EP2152272A2 NOVEL 2,3-DIAMINO-QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：新的2,3-二氨基喹唑啉酮衍生物及其医药用途
公开(公告)号：EP2152272A2
公开(公告)日：2010-02-17
申请号：EP08759923.9
申请日：2008-05-22
申请人： NeuroSearch A/S
发明人： JESSEN, Carsten , BROWN, William, Dalby , DEMNITZ, Joachim , STRØBÆK, Dorte , KORSGAARD, Mads, Gersdorff , CHRISTOPHERSEN, Palle
IPC分类号： A61K31/498 , C07D239/95 , C07D403/04 , C07D405/12 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/24 , A61P13/00
CPC分类号： C07D239/95 , C07D403/04 , C07D405/12
摘要： This invention relates to novel 2,3-diamino-quinazolinone derivatives having medical utility, to use of the 2,3-diamino-quinazolinone derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2,3- diamino-quinazolinone derivatives of the invention, and to methods of treating a disord disease or a condition of a subject, which disorder, disease or condition is responsiv to activation of KV7 channels. A 2,3-diamino-quinazolinone derivative of Formula (I) a stereoisomer or a mixture of its stereoisomers, or a pharmaceutically-acceptable addition salt thereof, or an N-oxide thereof.

9. 发明公开

EP1996560A1 QUINAZOLINONES AND THEIR USE AS POTASSIUM CHANNELS ACTIVATORS 审中-公开
标题翻译：喹唑啉酮和ANWENDNUG作为钾通道激动剂
公开(公告)号：EP1996560A1
公开(公告)日：2008-12-03
申请号：EP07726760.7
申请日：2007-03-09
申请人： NeuroSearch A/S
发明人： BROWN, William, Dalby , JESSEN, Carsten , DEMNITZ, Joachim , DYHRING, Tino , STRØBÆK, Dorte
IPC分类号： C07D239/92 , A61K31/517 , A61P25/00
CPC分类号： C07D239/92
摘要： This invention relates to novel quinazolinone derivatives of formula (I) having medical utility, to use of the quinazolinone derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the quinazolinone derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of Kv7 channels.

10. 发明公开

EP1940822A1 IMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA-A RECEPTOR COMPLEX 审中-公开
标题翻译：咪唑衍生物及其调制GABAA受体复合物
公开(公告)号：EP1940822A1
公开(公告)日：2008-07-09
申请号：EP06807182.8
申请日：2006-10-12
申请人： NeuroSearch A/S
发明人： BROWN, William, Dalby , LARSEN, Janus, S. , TEUBER, Lene , BROWN, David, Tristam , AHRING, Philip, K. , MIRZA, Naheed , NIELSEN, Elsebet, Østergaard
IPC分类号： C07D401/12 , C07D401/10 , C07D403/12 , C07D403/10 , C07D233/90 , A61K31/4178 , A61K31/4439 , A61K31/506 , A61P25/00
CPC分类号： C07D233/90 , C07D401/10 , C07D401/12 , C07D403/12
摘要： This invention relates to novel imidazole derivatives of formula (I), pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.

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