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1. 发明申请

WO2018189020A2 METHODS FOR IDENTIFYING PRE-DISPOSITION TO COGNITIVE DECLINE AND AGENTS FOR REDUCING OR PREVENTING COGNITIVE DECLINE, OR IMPROVING COGNITIVE ABILITY 审中-公开
公开(公告)号：WO2018189020A2
公开(公告)日：2018-10-18
申请号：PCT/EP2018/058701
申请日：2018-04-05
申请人： NESTEC S.A.
发明人： BOWMAN, Gene , HUDRY-LABBE, Julie , SCHMITT, Jeroen Antonius Johannes , BOSCHAT, Corina , RIEKER, Claus
IPC分类号： A61K31/202 , A61P25/28 , A61K31/14 , A61K31/4415 , A61K31/51 , A61K31/592 , A61K31/593
CPC分类号： A61K31/198 , A61K31/14 , A61K31/202 , A61K31/4415 , A61K31/51 , A61K31/592 , A61K31/593 , A61K31/714 , A61P25/28 , A61K2300/00
摘要： A method for identifying pre-disposition to cognitive decline in a subject, the method comprising determining levels of: (a) omega-3 fatty acids, and vitamin D or a metabolite thereof; (b) omega-3 fatty acids, and homocysteine; (c) vitamin D or a metabolite thereof, and homocysteine; or (d) omega-3 fatty acids, vitamin D or a metabolite thereof, and homocysteine, independently in one or more samples obtained from the subject.

2. 发明申请

WO2018060396A1 OMEGA 3 FATTY ACIDS AND CHOLINE AS NEUROPROTECTANT IN PATIENTS WITH NO DEMENTIA 审中-公开
标题翻译： OMEGA 3脂肪酸和胆碱作为神经保护剂在无痴呆病人中的应用
公开(公告)号：WO2018060396A1
公开(公告)日：2018-04-05
申请号：PCT/EP2017/074731
申请日：2017-09-29
申请人： NESTEC S.A.
发明人： RIEKER, Claus , HUDRY-LABBE, Julie , SCHMITT, Jeroen Antonius Johannes , BOSCHAT, Corina , SILBER, Yvonne Beata
IPC分类号： A61K31/202 , A61P25/28 , A61K31/14
摘要： A method of attenuating, treating or preventing cognitive aging in an individual who does not have dementia includes administering to the individual a therapeutically effective amount of a composition containing an omega-3 fatty acid and choline. The method can achieve a benefit that is one or more of decreasing brain atrophy, increasing or maintaining number of synapses, increasing amyloid-β phagocytosis, or decreasing or maintaining neuroinflammation in the non-demented individual. The method can prevent dementia in an individual at risk thereof, for example an elderly human. The composition can be administered to the individual in a daily dose that provides 5.5 mg/day to 5,500 mg/day of the choline, for example 85 mg/day to 3,500 mg/day of the choline.
摘要翻译：减轻，治疗或预防没有痴呆的个体的认知衰老的方法包括向个体施用治疗有效量的含有ω-3脂肪酸和胆碱的组合物。该方法可以实现减少脑萎缩，增加或维持突触数量，增加淀粉样蛋白-β吞噬作用，或减少或维持非痴呆个体的神经炎症中的一种或多种益处。该方法可以预防有风险的个体，例如老年人的痴呆。该组合物可以以提供5.5mg /天至5,500mg /天的胆碱，例如85mg /天至3,500mg /天的胆碱的日剂量给予个体。

3. 发明申请

WO2017037105A1 METHODS AND COMPOSITIONS USING BIFIDOBACTERIUM LONGUM TO OPTIMIZE BREASTFEEDING 审中-公开
标题翻译：使用双歧杆菌的方法和组合物优化乳化
公开(公告)号：WO2017037105A1
公开(公告)日：2017-03-09
申请号：PCT/EP2016/070496
申请日：2016-08-31
申请人： NESTEC S.A.
发明人： ROCHAT, Florence , BERGONZELLI DEGONDA, Gabriela , HAUSER, Jonas , SCHMITT, Jeroen Antonius Johannes , ALVES NUNES, Tiago , MARQUARDT, Valerie
IPC分类号： A61K35/745 , A61P25/24
CPC分类号： A61K35/745
摘要： B. longum ATCC BAA-999, or a composition comprising B. longum ATCC BAA-999, for use in an individual to; support breastfeeding initiation and/or to optimise breastfeeding duration and/or to optimize the quality and/or quantity ofbreast milk and/or to prevent or treat peripartum emotional distress and/or to regulate amygdala activity and/or to regulate the release of CRH, and to prevent or treat the negative effects of peripartum emotional distress in the offspring of individuals.
摘要翻译： B. longum ATCC BAA-999，或包含长双歧杆菌ATCC BAA-999的组合物，用于个体; 支持母乳喂养开始和/或优化母乳喂养持续时间和/或优化乳汁的质量和/或数量和/或预防或治疗围产期情绪困扰和/或调节杏仁核的活动和/或调节CRH的释放，并预防或治疗围产期情绪困扰对个体后代的负面影响。

4. 发明申请

WO2013164402A1 METHODS OF IMPROVING MENTAL OR HEALTH CONDITIONS 审中-公开
标题翻译：改善心理或健康条件的方法
公开(公告)号：WO2013164402A1
公开(公告)日：2013-11-07
申请号：PCT/EP2013/059141
申请日：2013-05-02
申请人： NESTEC S.A.
发明人： SILBER, Yvonne Beata , SCHMITT, Jeroen Antonius Johannes
IPC分类号： A23F5/02 , A61K31/216 , A61K36/185
CPC分类号： A61K36/74 , A23F5/20 , A23L33/105 , A23V2002/00 , A23V2200/00 , A61K31/216 , A23V2200/322 , A23V2250/2108
摘要： Methods of improving mental or health conditions of an individual are provided. In a general embodiment, the method provides administering to an individual in need of an improved mental or health condition a decaffeinated coffee product. The methods can be, for example, for improved alertness in the individual, improved attention, improved reaction time, reduction in the individual's jitteriness, tension, tiredness, mental fatigue and/or headache.
摘要翻译：提供改善个人精神或健康状况的方法。在一般实施方案中，该方法提供对需要改善的精神或健康状况的个体给予脱咖啡因咖啡产品。方法可以是例如改善个体的警觉性，改善的注意力，改善的反应时间，减少个体的抖动，紧张，疲劳，精神疲劳和/或头痛。

5. 发明申请

WO2010052324A1 SIALIC ACID PRODUCING BACTERIA 审中-公开
标题翻译：酸碱生产细菌
公开(公告)号：WO2010052324A1
公开(公告)日：2010-05-14
申请号：PCT/EP2009/064842
申请日：2009-11-09
申请人： NESTEC S.A. , COLAROW, Ladislas N.A. , JANKOVIC, Ivana , SPRENGER, Norbert , SCHMITT, Jeroen Antonius Johannes , DEBECHE, Takoua
发明人： COLAROW, Ladislas N.A. , JANKOVIC, Ivana , SPRENGER, Norbert , SCHMITT, Jeroen Antonius Johannes , DEBECHE, Takoua
IPC分类号： A23L1/29 , A23L1/30
CPC分类号： A61K35/74 , A23L33/135 , A23L33/40 , A61K31/7008
摘要： The present invention generally relates to the field of sialic acids, in particular to the field of sialic acid enriched food products and their uses. One embodiment of the present invention relates to a food product enriched with food-grade sialic acid producing bacteria and/or a fraction thereof containing sialic acid.
摘要翻译：本发明一般涉及唾液酸领域，特别是唾液酸富集食品领域及其用途。本发明的一个实施方案涉及富含食品级唾液酸生产菌和/或其含有唾液酸的级分的食品。

6. 发明申请

WO2018189020A3 OMEGA-3 FATTY ACID, HOMOCYSTEIN AND VITAMIN D LEVELS TO IDENTIFY AND ATTENUATE COGNITIVE AGING IN INDIVIDUALS 审中-公开
公开(公告)号：WO2018189020A3
公开(公告)日：2018-10-18
申请号：PCT/EP2018/058701
申请日：2018-04-05
申请人： NESTEC S.A.
发明人： BOWMAN, Gene , HUDRY-LABBE, Julie , SCHMITT, Jeroen Antonius Johannes , BOSCHAT, Corina , RIEKER, Claus
IPC分类号： A61K31/202 , A61P25/28 , A61K31/14 , A61K31/4415 , A61K31/51 , A61K31/592 , A61K31/593
摘要： A method for identifying pre-disposition to cognitive decline in a subject, the method comprising determining levels of: (a) omega-3 fatty acids, and vitamin D or a metabolite thereof; (b) omega-3 fatty acids, and homocysteine; (c) vitamin D or a metabolite thereof, and homocysteine; or (d) omega-3 fatty acids, vitamin D or a metabolite thereof, and homocysteine, independently in one or more samples obtained from the subject.

7. 发明申请

WO2018060395A1 OMEGA 3 FATTY ACIDS, NO RELEASING COMPOUND AND VITAMIN B12 AS NEUROPROTECTANT IN PATIENTS WITH NO DEMENTIA 审中-公开
标题翻译： OMEGA 3脂肪酸，不释放化合物和维生素B12作为神经保护剂在无痴呆病人中的应用
公开(公告)号：WO2018060395A1
公开(公告)日：2018-04-05
申请号：PCT/EP2017/074729
申请日：2017-09-29
申请人： NESTEC S.A.
发明人： SILBER, Yvonne Beata , SCHMITT, Jeroen Antonius Johannes , BOSCHAT, Corina , HUDRY-LABBE, Julie , RIEKER, Claus
IPC分类号： A61K31/198 , A61K31/202 , A61K31/714 , A61P25/28
摘要： A method of attenuating, treating or preventing cognitive aging in an individual who does not have dementia includes administering to the individual a therapeutically effective amount of a composition containing an omega-3 fatty acid, a nitric oxide releasing compound, and Vitamin B12. The composition is administered in a daily dose that provides 50 to 500 times the recommended daily requirement (RDA) of Vitamin B12 per day, for example about 200 times the RDA of Vitamin B12 per day. Optionally Vitamin B6 and/or Vitamin B9 can be included in the composition. The method can achieve a benefit that is one or more of decreasing brain atrophy, increasing or maintaining number of synapses, increasing amyloid-β phagocytosis, or decreasing or maintaining neuroinflammation in the non-demented individual. The method can prevent dementia in an individual at risk thereof, for example an elderly human.
摘要翻译：减轻，治疗或预防没有痴呆的个体的认知衰老的方法包括给予个体治疗有效量的含有ω-3脂肪酸，释放一氧化氮的组合物化合物和维生素B12。组合物以每日剂量施用，其提供维生素B12每日推荐每日需要量（RDA）的50至500倍，例如每天维生素B12的RDA约200倍。任选地，组合物中可包含维生素B6和/或维生素B9。该方法可以实现减少脑萎缩，增加或维持突触数量，增加淀粉样蛋白-β吞噬作用，或减少或维持非痴呆个体的神经炎症中的一种或多种益处。该方法可以预防有风险的个体，例如老年人的痴呆症。

8. 发明申请

WO2017037091A1 METHODS AND COMPOSITIONS USING BIFIDOBACTERIUM LONGUM TO MODULATE EMOTIONAL REACTIVITY AND TREAT OR PREVENT SUB-CLINICAL MOOD DISTURBANCES 审中-公开
标题翻译：使用双歧杆菌的方法和组合物来调节情感反应活性和治疗或预防亚临床感染的干扰
公开(公告)号：WO2017037091A1
公开(公告)日：2017-03-09
申请号：PCT/EP2016/070465
申请日：2016-08-31
申请人： NESTEC S.A.
发明人： BERGONZELLI DEGONDA, Gabriela , ALVES NUNES, Tiago , MARQUARDT, Valerie , SCHMITT, Jeroen Antonius Johannes
IPC分类号： A61K35/745 , A61P25/24
CPC分类号： A61K35/745
摘要： Compositions and methods use Bifidobacterium longum NCC3001 (ATCC BAA-999) to stabilize or improve mood, modulate excessive emotional distress, reduce anxiety, and/or reduce stress. In an embodiment, the composition can be administered daily for at least three weeks.
摘要翻译：组合物和方法使用长双歧杆菌NCC3001（ATCC BAA-999）稳定或改善情绪，调节过度的情绪困扰，减轻焦虑和/或减轻压力。在一个实施方案中，组合物可以每天施用至少三周。

9. 发明公开

EP3388061A1 OMEGA 3 FATTY ACIDS, NO RELEASING COMPOUND, VITAMIN B12 AND CHOLINE AS NEUROPROTECTANT IN PATIENTS WITH NO DEMENTIA 审中-公开
公开(公告)号：EP3388061A1
公开(公告)日：2018-10-17
申请号：EP17193916.8
申请日：2017-09-29
申请人： Nestec S.A.
发明人： RIEKER, Claus , HUDRY-LABBE, Julie , SCHMITT, Jeroen Antonius Johannes , BOSCHAT, Corina
IPC分类号： A61K31/198 , A61K31/202 , A61K31/714 , A61P25/28 , A61K31/14
CPC分类号： A61K31/202 , A61K31/14 , A61K31/198 , A61K31/714 , A61K2300/00
摘要： A method of attenuating, treating or preventing cognitive aging in an individual who does not have dementia includes administering to the individual a therapeutically effective amount of a composition containing an omega-3 fatty acid, a nitric oxide releasing compound, Vitamin B12 and choline. The composition is administered in a daily dose that provides 0.1 to 50 times the recommended daily requirement (RDA) of Vitamin B12 per day, more preferably 0.1 to 40 times the recommended daily requirement (RDA) of Vitamin B12 per day and 0.01 to 10.0 times the recommended daily requirement (RDA) of choline. Optionally Vitamin B6 and/or Vitamin B9 can be included in the composition. The method can achieve a benefit that is one or more of decreasing brain atrophy, increasing or maintaining number of synapses, increasing amyloid-β phagocytosis, or decreasing or maintaining neuroinflammation in the non-demented individual. The method can prevent dementia in an individual at risk thereof, for example an elderly human.

10. 发明公开

EP3344269A1 METHODS AND COMPOSITIONS USING BIFIDOBACTERIUM LONGUM TO OPTIMIZE BREASTFEEDING 审中-公开
公开(公告)号：EP3344269A1
公开(公告)日：2018-07-11
申请号：EP16759752.5
申请日：2016-08-31
申请人： Nestec S.A.
发明人： ROCHAT, Florence , BERGONZELLI DEGONDA, Gabriela , HAUSER, Jonas , SCHMITT, Jeroen Antonius Johannes , ALVES NUNES, Tiago , MARQUARDT, Valerie
IPC分类号： A61K35/745 , A61P25/24
CPC分类号： A61K35/745
摘要： B. longum ATCC BAA-999, or a composition comprising B. longum ATCC BAA-999, for use in an individual to; support breastfeeding initiation and/or to optimise breastfeeding duration and/or to optimize the quality and/or quantity ofbreast milk and/or to prevent or treat peripartum emotional distress and/or to regulate amygdala activity and/or to regulate the release of CRH, and to prevent or treat the negative effects of peripartum emotional distress in the offspring of individuals.

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