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1. 发明授权

US5432200A Method for increasing urinary excretion of electrolytes 失效
标题翻译：增加电解质排泄尿的方法
公开(公告)号：US5432200A
公开(公告)日：1995-07-11
申请号：US46013
申请日：1993-04-12
申请人： Neill B. Walsdorf , George Alexandrides , Charles Y. C. Pak
发明人： Neill B. Walsdorf , George Alexandrides , Charles Y. C. Pak
IPC分类号： A23L1/304 , A61K31/19 , C07C59/265
CPC分类号： A61K31/19 , A23L33/16 , C07C59/265
摘要： A method for supplementing dietary potassium, magnesium and citrate is disclosed that comprises orally administering an effective amount of potassium magnesium citrate in a single salt. Methods for decreasing urinary calcium and oxalate by the administration of potassium magnesium citrate in a single salt are also disclosed.
摘要翻译：公开了一种补充膳食钾，镁和柠檬酸盐的方法，其包括在单一盐中口服施用有效量的柠檬酸钾钾。还公开了通过在单一盐中施用柠檬酸钾钾来降低尿钙和草酸盐的方法。

2. 发明授权

US5219889A Dietary supplementation with potassium magnesium citrate 失效
标题翻译：膳食补充柠檬酸钾镁
公开(公告)号：US5219889A
公开(公告)日：1993-06-15
申请号：US803689
申请日：1991-12-03
申请人： Neill B. Walsdorf , George Alexandrides , Charles Y. C. Pak
发明人： Neill B. Walsdorf , George Alexandrides , Charles Y. C. Pak
IPC分类号： A23L1/304 , A61K31/19 , C07C59/265
CPC分类号： A61K31/19 , A23L33/16 , C07C59/265
摘要： A method for supplementing dietary potassium, magnesium and citrate is disclosed that comprises orally administering an effective amount of potassium magnesium citrate in a single salt. Methods for decreasing urinary calcium and oxalate by the administration of potassium magnesium citrate in a single salt are also disclosed.
摘要翻译：公开了一种补充膳食钾，镁和柠檬酸盐的方法，其包括在单一盐中口服施用有效量的柠檬酸钾钾。还公开了通过在单一盐中施用柠檬酸钾钾来降低尿钙和草酸盐的方法。

3. 发明授权

US5075499A Calcium supplementation by dicalcium citrate-lactate 失效
标题翻译：钙柠檬酸钙补充钙
公开(公告)号：US5075499A
公开(公告)日：1991-12-24
申请号：US275046
申请日：1988-11-21
申请人： Neill B. Walsdorf , George Alexandrides , Charles Y. C. Pak
发明人： Neill B. Walsdorf , George Alexandrides , Charles Y. C. Pak
IPC分类号： A61K31/19 , C07C59/08 , C07C59/265
CPC分类号： A61K31/19 , C07C59/08 , C07C59/265
摘要： One aspect of the present invention includes the novel compound having the formula:Ca.sub.2 (OOC--CH.sub.2 --COHCOO-CH.sub.2 COO)(CH.sub.3 CHOH-COO)In another aspect of the present invention, a method is provided for the treatment of a calcium related pathology. The inventive method includes the steps of providing a pharmaceutically acceptable composition, including as the active principle the compound dicalcium citrate-lactate, and administering to an individual in need thereof a therapeutically effective amount of said pharmaceutically acceptable composition.In yet another aspect of the present invention, a process is provided for producing the compound dicalcium citrate-lactate. The inventive process comprising the steps of: (a) admixing stoichiometric quantities of citric acid and a calcium compound selected from the group consisting of calcium carbonate, calcium oxide and calcium hydroxide; (b) initiating a reaction by admixing stoichiometric quantities of lactic acid and water with said citric acid and calcium compound of step (a); (c) mixing the reactance of step (b) to produce a dense, hydrated mixture comprising calcium ions, citrate ions and lactate ions in a ratio of about 2:1:1; and (d) dehyrating the dense, hydrated mixture of step (c).
摘要翻译：本发明的一个方面包括具有下式的新化合物：Ca2（OOC-CH2-COHCOO-CH2COO）（CH3CHOH-COO）在本发明的另一方面，提供了一种治疗钙相关病理学的方法。本发明的方法包括提供药学上可接受的组合物的步骤，其包括作为活性成分的柠檬酸二钙 - 乳酸盐化合物，以及向有需要的个体施用治疗有效量的所述药学上可接受的组合物。在本发明的另一方面，提供了一种制备柠檬酸二钙柠檬酸酯化合物的方法。本发明的方法包括以下步骤：（a）混合化学计量的柠檬酸和选自碳酸钙，氧化钙和氢氧化钙的钙化合物; （b）通过将化学计量的乳酸和水与步骤（a）的所述柠檬酸和钙化合物混合来引发反应; （c）将步骤（b）的电抗混合以产生约2:1:1比例的钙离子，柠檬酸根离子和乳酸盐离子的致密的水合混合物; 和（d）使步骤（c）的致密，水合的混合物脱氢。

4. 发明授权

US4814177A Ultradense and more soluble and bioavailable preparations of calcium citrate 失效
标题翻译：柠檬酸柠檬酸钙的超级和更可溶性和生物可利用的制剂
公开(公告)号：US4814177A
公开(公告)日：1989-03-21
申请号：US896651
申请日：1986-08-13
申请人： Neill B. Walsdorf , George Alexandrides , Charles Y. C. Pak
发明人： Neill B. Walsdorf , George Alexandrides , Charles Y. C. Pak
IPC分类号： A23L1/304 , A61K9/46 , A61K31/19 , A61K9/20 , A61K33/00 , A61K33/06
CPC分类号： A61K31/19 , A23L33/16 , A61K9/0007 , Y10S514/891
摘要： A calcium citrate composition having a bulk density greater than about 1.1 g/cc. Citric acid and a calcium compound are mixed to produce a mixture having a calcium compound/citric acid molar ratio of about 1.5. A hydrated mixture percent is produced by agitatively adding water to the mixture, although when desired the calcium compound, citric acid and water mayBACKGROUND OF THE INVENTIONA portion of the development of the present invention was supported by Grant No. P01-AM 20543 from the United States Government, National Institutes of Health.
摘要翻译：体积密度大于约1.1g / cc的柠檬酸钙组合物。将柠檬酸和钙化合物混合以产生钙化合物/柠檬酸摩尔比为约1.5的混合物。通过向混合物中搅拌加水来产生水合的混合物百分数，尽管如果需要，钙化合物，柠檬酸和水可以在一个步骤中混合。将水合混合物混合以促进柠檬酸与钙化合物的反应，并形成主要由直径在约1/64英寸至约1/16英寸之间的颗粒组成的颗粒状物质。然后将造粒物质干燥至约10重量％至约13重量％之间的水分含量，以产生堆积密度大于约1.1g / cc的柠檬酸钙组合物。对于柠檬酸钙片剂，该柠檬酸钙组合物通过将一种或多种压片粘合剂接合而形成压片组合物。然后将压片组合物通过多工位压片机进料以形成高密度柠檬酸钙片剂。高密度柠檬酸钙片剂大于约15重量％的钙，钙/柠檬酸盐摩尔比为约1.5。这种片剂特征性地具有大于约1.5g / cc的密度，并且为了美学或其它目的可以用包含物质如糖，聚乙烯吡咯烷酮，碳酸钙和二氧化钛的混合物包衣。

5. 发明授权

US06287607B1 Potassium calcium citrate compositions and methods therefor 有权
公开(公告)号：US06287607B1
公开(公告)日：2001-09-11
申请号：US09356649
申请日：1999-07-19
申请人： Charles Y. C. Pak , George Alexandrides , Neill B. Walsdorf
发明人： Charles Y. C. Pak , George Alexandrides , Neill B. Walsdorf
IPC分类号： A61K3306
摘要： A composition useful as a dietary supplement for providing potassium, calcium, and citrate is presented, as well as processes for producing the composition, and methods for using the composition as a dietary supplement. Administration of the composition counters bone loss associated with aging or menopause by providing bioavailable calcium and, simultaneously, delivering alkali load. In addition, administration of the composition produces a substantial increase in urinary citrate, which counters kidney-stone formation.

6. 发明授权

US4904478A Slow-release sodium fluoride tablet and method for treatment of osteoporosis 失效
标题翻译：缓释氟化钠片及治疗骨质疏松症的方法
公开(公告)号：US4904478A
公开(公告)日：1990-02-27
申请号：US112202
申请日：1987-10-22
申请人： Neill B. Walsdorf , Charles Y. C. Pak
发明人： Neill B. Walsdorf , Charles Y. C. Pak
IPC分类号： A61K9/20 , A61K33/16
CPC分类号： A61K33/16 , A61K9/2013
摘要： A novel slow-release sodium fluoride preparation and its use. Such slow-release sodium preparation comprises carnauba wax and talc and may be used to provide a safe but effective level of fluoride in serum, optimal for the treatment of osteoporosis. Gastrointestinal side effects are minimized by limiting the amount of fluoride released in the stomach and rheumatic complications are reduced by avoiding toxic levels of fluoride is serum. The amount of fluoride absorbed is nevertheless sufficient to stimulate bone formation and prevent fractures. Thus, the maintenance of serum fluoride as encompassed in this invention, allows for a safe and effective treatment of osteoporosis.
摘要翻译：一种新型缓释氟化钠制剂及其用途。这种缓释钠制剂包含巴西棕榈蜡和滑石，并且可用于提供血清中安全但有效的氟化物水平，对于治疗骨质疏松症是最佳的。通过限制在胃中释放的氟化物的量来减少胃肠道副作用，并通过避免氟化物是血清的毒性水平来降低风湿并发症。然而，吸收的氟化物的量足以刺激骨形成并防止骨折。因此，维持本发明所包含的血清氟化物，可以安全有效地治疗骨质疏松症。

7. 发明授权

US4851221A Liquid calcium supplementation from readily soluble mixtures of calcium compound and citric acid 失效
标题翻译：从钙化合物和柠檬酸的易溶混合物中补充液体钙
公开(公告)号：US4851221A
公开(公告)日：1989-07-25
申请号：US935666
申请日：1986-11-26
申请人： Charles Y. C. Pak , Neill B. Walsdorf
发明人： Charles Y. C. Pak , Neill B. Walsdorf
IPC分类号： A23L2/52 , A23L1/304 , A23L2/38 , A23L2/68 , A61K31/00 , A61K31/19 , A61K33/06 , A61P3/00 , A61P3/02 , A61P3/14 , A61P43/00
CPC分类号： A23L2/68 , A23L2/38 , A23L33/16 , A61K31/19 , A61K33/06 , Y10S514/891
摘要： The present invention comprises a composition of matter consisting essentially of citric acid and one or more calcium compounds selected from the group consisting of calcium hydroxide, calcium carbonate and calcium oxide. The composition of matter is preferably a substantially dry mixture which may be used, for example, as a powder for making an "instant" beverage of potable liquid. A preferred calcium compound/citric acid molar ratio in the composition of matter of the present invention is between about 0.6 and about 1.5.In a most preferred embodiment, the composition of matter of the present invention consists essentially of calcium hydroxide and citric acid having a calcium compound/citric acid or calcium hydroxide/citric acid molar ratio of about 1.25.The composition of matter of the present invention has a utility demostrated by dissolution in water to form a liquid dietary calcium supplement comprising soluble calcium citrate. This composition of matter may comprise one or more of a flavorant, lubricant, sweetener or colorant usable to maintain a powdery texture or to enhance the flavor of a beverage prepared therefrom.
摘要翻译：本发明包括基本上由柠檬酸和一种或多种选自氢氧化钙，碳酸钙和氧化钙的钙化合物组成的物质组合物。物质的组成优选为基本上干燥的混合物，其可以用作例如用于制造饮用液体的“即时”饮料的粉末。本发明物质组合物中优选的钙化合物/柠檬酸摩尔比为约0.6至约1.5。在最优选的实施方案中，本发明的物质组成基本上由具有约1.25的钙化合物/柠檬酸或氢氧化钙/柠檬酸摩尔比的氢氧化钙和柠檬酸组成。本发明的物质组成具有通过在水中溶解形成含有可溶性柠檬酸钙的液体膳食钙补充剂的功效。该物质组合物可以包含一种或多种调味剂，润滑剂，甜味剂或着色剂，其可用于保持粉末质地或增强由其制备的饮料的风味。

8. 发明授权

US4726952A Slow-release sodium fluoride tablet, method of making, and method of treatment of osteoporosis 失效
标题翻译：缓释氟化钠片，制法及治疗骨质疏松症的方法
公开(公告)号：US4726952A
公开(公告)日：1988-02-23
申请号：US842304
申请日：1986-03-21
申请人： Neill B. Walsdorf , Charles Y. C. Pak
发明人： Neill B. Walsdorf , Charles Y. C. Pak
IPC分类号： A61K33/00 , A61K9/20 , A61K9/22 , A61K33/16 , A61K9/26
CPC分类号： A61K9/2013 , A61K33/16
摘要： A novel use for a slow-release sodium fluoride preparation. Such slow-release sodium preparation is shown to provide a safe but effective level of fluoride in serum, optimal for the treatment of osteoporosis. It minimizes gastrointestinal side effects by limiting the amount of fluoride released in the stomach and it reduces rheumatic complications by avoiding toxic levels of fluoride in serum. The amount of fluoride absorbed is nevertheless sufficient to stimulate bone formation and prevent fractures. Thus, the maintenance of serum fluoride as encompassed in this invention, allows for a safe and effective treatment of osteoporosis.
摘要翻译：缓释氟化钠制剂的新用途。这种缓释钠制剂显示提供了血清中安全但有效的氟化物水平，是治疗骨质疏松症最佳的。它通过限制胃中释放的氟化物的量来最大限度地减少胃肠道副作用，并通过避免血清中的氟化物含量降低风湿并发症。然而，吸收的氟化物的量足以刺激骨形成并防止骨折。因此，维持本发明所包含的血清氟化物，可以安全有效地治疗骨质疏松症。

9. 发明授权

US06818228B1 Dietary supplements containing ultradense calcium citrate and carbonyl iron 失效
标题翻译：含有超级柠檬酸钙和羰基铁的膳食补充剂
公开(公告)号：US06818228B1
公开(公告)日：2004-11-16
申请号：US08667503
申请日：1996-06-21
申请人： Neill B. Walsdorf , Cindy L. Wabner , George Alexandrides
发明人： Neill B. Walsdorf , Cindy L. Wabner , George Alexandrides
IPC分类号： A61K920
CPC分类号： A61K33/26 , Y10S514/904 , Y10S514/905 , A61K31/19 , A61K2300/00
摘要： A vitamin and mineral supplement containing ULTRADENSE™ calcium citrate and carbonyl iron for use in humans. Calcium in the form of citrate enhances absorption of iron, zinc, and magnesium. ULTRADENSE™ calcium citrate provides more bioavailable calcium than usual preparations of calcium citrate. Carbonyl iron provides iron in a form that significantly reduces the risk to children of accidental iron poisoning from formulations that provide iron in salt form. The supplement may further contain a number of vitamins and minerals in a tablet that is elegantly small, weighing about 1.5-1.6 g. The small size allows ease of swallowing and encourages patient acceptability. Methods of making such a supplement and methods of treating maladies in need of vitamin and mineral supplementation are provided.
摘要翻译：含有ULTRADENSE TM柠檬酸钙和羰基铁的维生素和矿物质补充剂用于人类。柠檬酸钙的形式增加了铁，锌，镁的吸收。 ULTRADENSE TM柠檬酸钙比通常的柠檬酸钙制剂提供更多的生物可利用的钙。羰基铁提供铁，其形式可以显着降低由提供盐形式的铁制剂引起的意外铁中毒儿童的风险。该补充剂可以进一步含有一些优雅地小于约1.5-1.6g的维生素和矿物质。小尺寸允许容易吞咽，并鼓励病人的可接受性。提供了制备这种补充剂的方法和治疗需要维生素和矿物质补充剂的疾病的方法。

10. 发明授权

US4985593A Magnesium potassium citrate 失效
标题翻译：柠檬酸钾钾
公开(公告)号：US4985593A
公开(公告)日：1991-01-15
申请号：US140818
申请日：1988-01-05
申请人： Neill B. Walsdorf , George Alexandrides
发明人： Neill B. Walsdorf , George Alexandrides
IPC分类号： A23L1/304 , C07C59/265
CPC分类号： C07C59/265 , A23L33/16
摘要： A dual mineral salt consisting essentially of magnesium, potassium and citrate. A method for manufacturing the subject salt in a form having a bulk density ranging from about 1.0 g/cc to about 1.3 g/cc is also disclosed, and the use of the subject salt as a dietary supplement are also disclosed.

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