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1. 发明申请

US20050054019A1 Antibodies to c-Met 有权
标题翻译： c-Met的抗体
公开(公告)号：US20050054019A1
公开(公告)日：2005-03-10
申请号：US10910901
申请日：2004-08-03
申请人： Neil Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry Green , Xiao-Chi Jia
发明人： Neil Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry Green , Xiao-Chi Jia
IPC分类号： A61K39/395 , A61P17/00 , A61P35/00 , C07K16/28 , C07K16/30 , C07K16/44 , C12N15/13 , G01N33/574
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K16/3076 , C07K2317/21 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合c-Met，优选人c-Met的人抗体及其抗原结合部分的抗体，其功能是抑制c-Met。本发明还涉及人抗c-Met抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗c-Met抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗c-Met抗体的方法，包含这些抗体的组合物和使用该抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗c-Met抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物或植物。

2. 发明授权

US08163280B2 Antibodies to c-Met 有权
标题翻译： c-Met的抗体
公开(公告)号：US08163280B2
公开(公告)日：2012-04-24
申请号：US12321963
申请日：2009-01-26
申请人： Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
发明人： Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K16/3076 , C07K2317/21 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合c-Met，优选人c-Met的人抗体及其抗原结合部分的抗体，其功能是抑制c-Met。本发明还涉及人抗c-Met抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗c-Met抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗c-Met抗体的方法，包含这些抗体的组合物和使用该抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗c-Met抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物或植物。

3. 发明申请

US20100040629A1 Antibodies to c-Met 有权
标题翻译： c-Met的抗体
公开(公告)号：US20100040629A1
公开(公告)日：2010-02-18
申请号：US12321963
申请日：2009-01-26
申请人： Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
发明人： Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K16/3076 , C07K2317/21 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合c-Met，优选人c-Met的人抗体及其抗原结合部分的抗体，其功能是抑制c-Met。本发明还涉及人抗c-Met抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗c-Met抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗c-Met抗体的方法，包含这些抗体的组合物和使用该抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗c-Met抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物或植物。

4. 发明授权

US08562985B2 Antibodies to c-Met 有权
公开(公告)号：US08562985B2
公开(公告)日：2013-10-22
申请号：US13454356
申请日：2012-04-24
申请人： Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
发明人： Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K16/3076 , C07K2317/21 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

5. 发明申请

US20120321614A1 ANTIBODIES TO C-MET 有权
标题翻译： C-MET的抗体
公开(公告)号：US20120321614A1
公开(公告)日：2012-12-20
申请号：US13454356
申请日：2012-04-24
申请人： Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
发明人： Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
IPC分类号： C07K16/40 , A61P35/00 , A61P17/02 , C12N15/13 , C07K1/14 , A61K48/00 , C12N15/63 , C12P21/08 , A01K67/027 , A01H5/00 , C12N5/20 , C12N5/10 , C12N1/21 , C12N1/19 , C12N5/071 , C12N5/0786 , A61K39/395
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K16/3076 , C07K2317/21 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合c-Met，优选人c-Met的人抗体及其抗原结合部分的抗体，其功能是抑制c-Met。本发明还涉及人抗c-Met抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗c-Met抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗c-Met抗体的方法，包含这些抗体的组合物和使用该抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗c-Met抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物或植物。

6. 发明授权

US07498420B2 Antibodies to c-Met 有权
标题翻译： c-Met的抗体
公开(公告)号：US07498420B2
公开(公告)日：2009-03-03
申请号：US10910901
申请日：2004-08-03
申请人： Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
发明人： Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
IPC分类号： C07K16/00
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K16/3076 , C07K2317/21 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合c-Met，优选人c-Met的人抗体及其抗原结合部分的抗体，其功能是抑制c-Met。本发明还涉及人抗c-Met抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗c-Met抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗c-Met抗体的方法，包含这些抗体的组合物和使用该抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗c-Met抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物或植物。

7. 发明申请

US20060116383A1 Integrin antagonists useful as anticancer agents 失效
标题翻译：可用作抗癌剂的整联蛋白拮抗剂
公开(公告)号：US20060116383A1
公开(公告)日：2006-06-01
申请号：US11270088
申请日：2005-11-09
申请人： Jason Bloxham , Gary Borzillo , Eric Collington , Shazia Sadiq , Colin Sambrook Smith , Chris Waller , Graham Wynne
发明人： Jason Bloxham , Gary Borzillo , Eric Collington , Shazia Sadiq , Colin Sambrook Smith , Chris Waller , Graham Wynne
IPC分类号： A61K31/496 , A61K31/4439 , A61K31/4184 , C07D403/02 , A61K31/433 , C07D417/02
CPC分类号： C07D235/06 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The invention relates to compounds of the Formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X2, X4, X5 and X1 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of Formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of Formula 1.
摘要翻译：本发明涉及式1的化合物及其药学上可接受的盐和溶剂化物，其中A，X 2，X 4，X 5，和X 1'如本文所定义。本发明还涉及通过施用式1的化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。

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