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1. 发明专利

JP2013257332A Method for mass spectrometry 有权
标题翻译：大量光谱法
公开(公告)号：JP2013257332A
公开(公告)日：2013-12-26
申请号：JP2013145875
申请日：2013-07-11
申请人： National Sun Yat-Sen Univ , 国立中山大学National Sun Yat−Sen University
发明人： SHIEA JENTAIE , YUAN CHENG-HUI
IPC分类号： G01N27/62 , H01J49/10
CPC分类号： H01J49/145 , H01J49/0431 , H01J49/0463 , H01J49/165
摘要： PROBLEM TO BE SOLVED: To provide a method for mass spectrometry capable of conducting direct analysis of mass spectrometry on a liquid sample under atmospheric pressure by using a laser desorption device and a mass spectrometry assembly.SOLUTION: A method for mass spectrometry comprises the step of irradiating a liquid sample with a laser beam such that, upon irradiation, laser energy is passed on to at least one of analytes contained in the solution of the liquid sample via a matrix so that the at least one of the analytes contained in the liquid sample is desorbed to fly along a flying path which intersects the traveling path of multiply-charged liquid drops of an electrospray medium so as to enable the at least one of the analytes to be occluded in the multiply-charged liquid drops, and such that as a result of dwindling in size of the multiply-charged liquid drops when approaching a receiving unit from a nozzle of an electrospray unit along the traveling path, charges of the liquid drops will pass on to the at least one of the analytes occluded therein to form a corresponding one of the ionized analytes. In the method for mass spectrometry, the material serving as the matrix is selected from a group of materials that are non-transmissible by laser.
摘要翻译：要解决的问题：提供一种能够通过使用激光解吸装置和质谱装置在大气压下对液体样品进行质谱分析的质谱法的方法。解决方案：质谱法包括以下步骤：用激光束照射液体样品，使得在照射时，激光能量通过基质通过液体样品溶液中的至少一种分析物，使得液体样品中所含的至少一种分析物被解吸，沿着与电喷雾介质的多次充液液滴的行进路径相交的飞行路径飞行，以使得至少一种分析物能够被吸入多次充液的液滴中，并且使得作为当从电喷雾单元的喷嘴沿着行进路径接近接收单元时，多次充液的液滴的尺寸减小的结果，液体的电荷滴剂将传递到其中封闭的至少一种分析物以形成相应的一种电离分析物。在质谱法中，用作基质的材料选自不能通过激光传播的一组材料。

2. 发明专利

JP2009042206A Mass spectrometric imaging method and mass spectrometer system 审中-公开
标题翻译：大量光谱成像方法和质谱仪系统
公开(公告)号：JP2009042206A
公开(公告)日：2009-02-26
申请号：JP2007253799
申请日：2007-09-28
申请人： National Sun Yat-Sen Univ , 国立中山大学National Sun Yat−Sen University
发明人： SHIEA JENTAIE
IPC分类号： G01N27/62 , H01J49/16
摘要： PROBLEM TO BE SOLVED: To provide a mass spectrometric imaging method which enables speedy and accurate acquisition of imaging profiles of a sample, having a self-sustained shape under atmospheric pressure. SOLUTION: The mass spectrometric imaging method includes the steps of sequentially forcing generated charged liquid drops to move toward the receiving unit of a mass spectrometer along the traveling path, scanning a sample with a laser beam which has irradiated energy sufficient to cause analytes contained in the sample to be desorbed to be made to undergo flight along a plurality of flight paths, respectively, and positioning the laser beam to render the plurality of flight paths intersecting the traveling path so as to permit a plurality of the analytes, respectively along the plurality of flight paths to be confined in a plurality of the charged liquid drops, respectively, to thereby form a plurality of corresponding ionized analytes. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种质谱成像方法，其能够快速且准确地获取在大气压下具有自持形状的样品的成像轮廓。解决方案：质谱成像方法包括以下步骤：顺序地迫使产生的带电液滴沿着行进路径向质谱仪的接收单元移动，用具有足够辐射能量的激光束扫描样品以产生分析物包含在待解吸的样品中以分别沿着多个飞行路径飞行，并且定位激光束以使多个飞行路线与行进路径相交，以允许分别沿着多个飞行路径多个飞行路径被分别限制在多个带电液滴中，从而形成多个相应的电离分析物。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2008147165A Laser desorption device, mass spectrometer assembly, and environmental liquid mass spectrometry method 审中-公开
标题翻译：激光解吸装置，质谱仪组件和环境液体质谱法
公开(公告)号：JP2008147165A
公开(公告)日：2008-06-26
申请号：JP2007253798
申请日：2007-09-28
申请人： National Sun Yat-Sen Univ , 国立中山大学National Sun Yat−Sen University
发明人： SHIEA JENTAIE , YUAN CHENG-HUI
IPC分类号： H01J49/16 , G01N27/62 , H01J49/26
CPC分类号： H01J49/145 , H01J49/0431 , H01J49/0463 , H01J49/165
摘要： PROBLEM TO BE SOLVED: To provide a laser desorption device, a mass spectrometer assembly and a mass spectrometry method in which a mass spectrometry of a liquid test piece can be carried out directly under an atmospheric pressure. SOLUTION: The electro-spray assisted laser desorption device for irradiating laser to a testpiece is provided with an electro-spray unit with a nozzle, a voltage supplying part which is arranged between the nozzle and a receiving unit and in which solvent drops for the electro-spray formed by the nozzle are charged and a potential difference is created forcibly toward the receiving unit from the nozzle alongside a transfer passage. Desorption of an analyzing object contained in the testpiece is conducted when laser is irradiated and it flies alongside a flying passage which crosses the transfer passage and is confined in the polyvalent charged drops and is transferred alongside the transfer passage and a size of the drop becomes smaller gradually, and an electric charge of the drop is transferred to least one of the analyzing objects confined in the drop and an ionized analyzing object is formed. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种激光解吸装置，质谱仪组合和质谱法，其中液体试样的质谱可以在大气压下直接进行。解决方案：用于向激光束照射激光的电喷激光辅助激光解吸装置设置有具有喷嘴的电喷单元，设置在喷嘴和接收单元之间的电压供给部，其中溶剂滴对于由喷嘴形成的电喷雾进行充电，并且从传送通道旁边的喷嘴强制地向接收单元产生电位差。包含在试件中的分析对象的解吸是在激光照射时进行的，并且与穿过传送通道的飞行通道一起飞行并被限制在多价带电的液滴中并且沿传送通道传送并且液滴的尺寸变小并且将液滴的电荷转移到限制在液滴中的分析对象中的至少一个，并且形成电离分析对象。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2011191302A Cycling electrospray ionization device 有权
标题翻译：循环电极离子化装置
公开(公告)号：JP2011191302A
公开(公告)日：2011-09-29
申请号：JP2011053452
申请日：2011-03-10
申请人： National Sun Yat-Sen Univ , ナショナルスンイーシエンユニバーシティNational Sun Yat−Sen University
发明人： SHIEA JENTAIE
IPC分类号： G01N27/62 , B05B5/04 , B05B5/08 , B05D1/04
CPC分类号： H01J49/165
摘要： PROBLEM TO BE SOLVED: To provide a circulation type electrospray ionization device for solving the problem of relatively-low intensity and stability of signal responsive to analyte obtained by a mass analyzer, after only a portion of ionized analyte reaches the mass analyzer, because the associated position of a nozzle used in spraying electrospray solution is fixed, in conventional types. SOLUTION: The circulation type electrospray ionization device 5 includes a drive mechanism 51 and a nozzle 52. When droplets of electrospray medium are formed sequentially, and potential difference is impressed between the nozzle 52 and a receiving unit 6, in order to provide the droplets with plural electric charges for ionizing the analyte to produce ionized analyte, the nozzle 52 forms a transfer path between a mass spectrometer 2 and the receiving unit 6 so that the electrically-charged droplets are forced to be transferred toward the receiving unit 6, along the transfer path. The nozzle axis is driven by the drive mechanism 51 that should be moved forward a circulation route A centered about a cyclic axis RC. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了提供一种循环型电喷雾离子化装置，用于解决响应于由质量分析器获得的分析物的信号的相对低的强度和稳定性的问题，在仅一部分电离分析物到达质量分析器之后，因为在喷雾电喷雾溶液中使用的喷嘴的相关位置是固定的。解决方案：循环型电喷雾离子化装置5包括驱动机构51和喷嘴52.当顺序地形成电喷雾介质的液滴，并且在喷嘴52和接收单元6之间施加电位差时，为了提供具有用于电离分析物以产生离子化分析物的多个电荷的液滴，喷嘴52在质谱仪2和接收单元6之间形成传送路径，使得带电液滴被迫朝向接收单元6传送，沿着传输路径。喷嘴轴线由驱动机构51驱动，驱动机构51应该以围绕循环轴线RC为中心的循环路径A向前移动。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2014212109A マルチモードイオン化装置有权
标题翻译：多模式离子化装置
公开(公告)号：JP2014212109A
公开(公告)日：2014-11-13
申请号：JP2014077526
申请日：2014-04-04
申请人：國立中山大學 , National Sun Yat-Sen Univ
发明人： SHIEA JENTAIE
IPC分类号： H01J49/10 , G01N27/62
CPC分类号： H01J49/107 , H01J49/165 , H01J49/168
摘要：【課題】被検体を同時にかつ同じ場所でイオン化するための2つのイオン化ユニットを含み、それによって、極性および非極性の被検体が、より効率的かつ効果的にイオン化できる装置を提供する。【解決手段】エレクトロスプレーユニット31は、進行経路Xに沿って進行するエレクトロスプレープルームを形成するように構成される。電荷発生ユニット4は、液状エレクトロスプレー媒質が、質量分析計2の受けユニット21に向かって進むために、エレクトロスプレープルームとしてエレクトロスプレーユニットを離れることが可能となるように構成される。プラズマ供給ユニット32は、プラズマプルームを発生させ、かつ合流ゾーンX1でプルーム結合体が得られるように、進行経路の直線的に伸びる端部ゾーンX2に沿って受けユニットまで進行できるように方向付けられる。【選択図】図2
摘要翻译：要解决的问题：提供一种包括两个离子化单元的装置，用于在同一地点同时电离对象，从而能够有效和有效地电离极性和非极性的对象。解决方案：电喷单元31被配置为形成电喷雾羽流沿着进行路线X前进。电荷产生单元4被配置为使得液体电喷雾介质可以作为电喷雾羽流从电喷雾单元分离，以朝向质谱仪2的接收单元21前进。等离子体供应单元32产生等离子体羽流，并且被定向为使得等离子体羽流沿着沿着线性地延伸到接收单元的进行路线的端部区域X2前进，并且在汇合区域X1中获得羽流共轭。

6. 发明专利

ES2710004T3 Seguimiento en tiempo real de la síntesis de péptidos en fase sólida por espectrometría de masas 未知
公开(公告)号：ES2710004T3
公开(公告)日：2019-04-22
申请号：ES11835703
申请日：2011-10-28
申请人： SCINOPHARM TAIWAN LTD , NATIONAL SUN YAT SEN UNIV
发明人： CHANG LI-CHIAO , SHIEA JENTAIE , CHO YI-TZU
IPC分类号： G01N33/483 , G01N27/62 , H01J49/26
摘要： Un método para llevar un seguimiento en tiempo real de la síntesis de péptidos en fase sólida (SPPS) utilizando un espectrómetro de masas, comprendiendo dicho método las etapas de: a) proporcionar una muestra sintetizada unida a un soporte de síntesis en fase sólida con un engarce de tritilo en un recipiente, o desde él, en donde tiene lugar la síntesis química; b) proporcionar una placa que está en contacto con la muestra sintetizada, en donde la placa se selecciona del grupo que consiste en una placa de acero y una placa de politereftalato de etileno negro; c) someter la muestra sintetizada, en la placa, a un disolvente orgánico; d) utilizar una fuente de luz para romper el engarce de tritilo entre la muestra y el soporte y transportar las moléculas de analito a un penacho de ionización de electroespray; y e) analizar el espectro de iones precursor de las moléculas de analito para determinar el peso molecular de los productos de síntesis.

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