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1. 发明申请

US20120094999A1 EGFR INHIBITORS AND METHODS OF TREATING DISORDERS 有权
标题翻译： EGFR抑制剂和治疗疾病的方法
公开(公告)号：US20120094999A1
公开(公告)日：2012-04-19
申请号：US13319079
申请日：2010-05-05
申请人： Nathanael S. Gray , Pasi Janne , Michael J. Eck , Wenjun Zhou
发明人： Nathanael S. Gray , Pasi Janne , Michael J. Eck , Wenjun Zhou
IPC分类号： A61K31/52 , C07D403/12 , A61K31/506 , C07D487/04 , A61K31/519 , C07D401/12 , A61K31/53 , C07D471/04 , C07D239/48 , C07D413/12 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61P35/00 , C07D401/14 , C07D403/14 , C07D473/16
CPC分类号： C07D473/16 , C07D403/14
摘要： The present invention relates to novel pyrimidine, pyrrolo-pyrimidine, pyrrolo-pyridine, pyridine, purine and triazine compounds which are able to modulate epidermal growth factor receptor (EGFR), including Her-kinases, and the use of such compounds in the treatment of various diseases, disorders or conditions.
摘要翻译：本发明涉及能够调节表皮生长因子受体（EGFR）的新型嘧啶，吡咯并 - 吡啶，吡啶，嘌呤和三嗪化合物，包括Her-激酶，以及这些化合物在治疗中的用途各种疾病，病症或病症。

2. 发明授权

US09908884B2 EGFR inhibitors and methods of treating disorders 有权
公开(公告)号：US09908884B2
公开(公告)日：2018-03-06
申请号：US13319079
申请日：2010-05-05
申请人： Nathanael S. Gray , Pasi Janne , Michael J. Eck , Wenjun Zhou
发明人： Nathanael S. Gray , Pasi Janne , Michael J. Eck , Wenjun Zhou
IPC分类号： C07D403/12 , C07D473/16 , C07D403/14
CPC分类号： C07D473/16 , C07D403/14
摘要： The present invention relates to novel pyrimidine, pyrrolo-pyrimidine, pyrrolo-pyridine, pyridine, purine and triazine compounds which are able to modulate epidermal growth factor receptor (EGFR), including Her-kinases, and the use of such compounds in the treatment of various diseases, disorders or conditions.

3. 发明申请

US20110207736A1 COMPOUNDS THAT MODULATE EGFR ACTIVITY AND METHODS FOR TREATING OR PREVENTING CONDITIONS THEREWITH 审中-公开
标题翻译：调节EGFR活性的化合物及其治疗或预防条件的方法
公开(公告)号：US20110207736A1
公开(公告)日：2011-08-25
申请号：US12976980
申请日：2010-12-22
申请人： Nathanael S. GRAY , Wenjun Zhou
发明人： Nathanael S. GRAY , Wenjun Zhou
IPC分类号： A61K31/53 , C07D487/04 , A61K31/519 , A61P35/00 , C12N9/99
CPC分类号： C07D495/04 , C07D239/95 , C07D285/135 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D471/04 , C07D473/18 , C07D487/04
摘要： Provided are compounds and methods for treating or preventing kinase-mediated disorders therewith.
摘要翻译：提供用于治疗或预防激酶介导的疾病的化合物和方法。

4. 发明申请

US20130137709A1 Compounds that modulate EGFR activity and methods for treating or preventing conditions therewith 审中-公开
标题翻译：调节EGFR活性的化合物和用于治疗或预防病症的方法
公开(公告)号：US20130137709A1
公开(公告)日：2013-05-30
申请号：US13695765
申请日：2011-05-05
申请人： Nathanael S. Gray , Wenjun Zhou
发明人： Nathanael S. Gray , Wenjun Zhou
IPC分类号： A61K31/5377 , C07D239/48 , C07D487/04 , A61K31/519
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D487/04
摘要： Provided are compounds and methods for treating or preventing kinase-mediated disorders therewith.
摘要翻译：提供用于治疗或预防激酶介导的疾病的化合物和方法。

5. 发明申请

US20130325866A1 Community Profiling for Social Media 有权
公开(公告)号：US20130325866A1
公开(公告)日：2013-12-05
申请号：US13485510
申请日：2012-05-31
申请人： Hongxia Jin , Yan Liu , Wenjun Zhou
发明人： Hongxia Jin , Yan Liu , Wenjun Zhou
IPC分类号： G06F17/30
CPC分类号： G06Q50/01
摘要： Embodiments of the invention relate to modeling communities associated with groups of data items. Tools are provided to iteratively assign data items to communities and to update topic and participant distribution in the assigned communities. As the distributions are updated, the characteristics of the communities are updated. Each activity area is defined from the perspective of a single user. Participants in a community are connected to a user, but not necessarily to each other. The combination of formations of communities and the statistical aspect of evaluating characteristics of the communities provides a multi-facetted organization of connections between data items and associated participants.

6. 发明申请

US20130184287A1 INDAZOLE COMPOUNDS AND THEIR USES 有权
标题翻译： INDAZOLE化合物及其用途
公开(公告)号：US20130184287A1
公开(公告)日：2013-07-18
申请号：US13583974
申请日：2011-02-18
申请人： Nathanael Gray , Wenjun Zhou , Xianming Deng
发明人： Nathanael Gray , Wenjun Zhou , Xianming Deng
IPC分类号： A61K31/496 , A61K31/4184 , A61K45/06 , C07D231/56
CPC分类号： A61K31/496 , A61K31/4184 , A61K45/06 , C07D231/56 , C07D401/10 , C07D403/12
摘要： The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.
摘要翻译：本申请涉及治疗性有机化合物，包含有效量的治疗性有机化合物的组合物; 以及治疗和预防疾病的方法，包括向有需要的受试者施用和有效量的治疗性有机化合物。

7. 发明授权

US10132716B2 Method for measuring mode field diameter of single-mode fibre using optical integration technique employing gradually variable aperture 有权
公开(公告)号：US10132716B2
公开(公告)日：2018-11-20
申请号：US15996513
申请日：2018-06-03
申请人： Jin Zhou , Wenjun Zhou
发明人： Jin Zhou , Wenjun Zhou
IPC分类号： G01M11/00 , G02B5/00 , G01J1/04
摘要： The present invention discloses a method for measuring a mode field diameter (MFD) of a single-mode fiber using an optical integration technique employing a gradually variable aperture. The method transforms, according to Petermann II definition, an integral operation in a formula of an MFD of a single-mode fiber into elementary arithmetic operations to be performed on a mean square value of the numerical aperture of the fiber. By using an optical integrator having a gradually variable aperture, the mean square value of the numerical aperture of the single-mode fiber can be precisely measured by one of the following three methods: translation, rotation and beam splitting, thus accordingly solving the MFD of the test fiber. The aforementioned measurement an MFD of a single-mode fiber is characterized by precision, high speed and convenience, and can be widely applied in various applications, such as measurement standards, automated test equipment, and engineering instruments.

8. 发明授权

US08738628B2 Community profiling for social media 有权
公开(公告)号：US08738628B2
公开(公告)日：2014-05-27
申请号：US13485510
申请日：2012-05-31
申请人： Hongxia Jin , Yan Liu , Wenjun Zhou
发明人： Hongxia Jin , Yan Liu , Wenjun Zhou
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06Q50/01
摘要： Embodiments of the invention relate to modeling communities associated with groups of data items. Tools are provided to iteratively assign data items to communities and to update topic and participant distribution in the assigned communities. As the distributions are updated, the characteristics of the communities are updated. Each activity area is defined from the perspective of a single user. Participants in a community are connected to a user, but not necessarily to each other. The combination of formations of communities and the statistical aspect of evaluating characteristics of the communities provides a multi-facetted organization of connections between data items and associated participants.

9. 发明申请

US20130325953A1 Community Profiling for Social Media 有权
标题翻译：社交媒体社区分析
公开(公告)号：US20130325953A1
公开(公告)日：2013-12-05
申请号：US13597315
申请日：2012-08-29
申请人： Hongxia Jin , Yan Liu , Wenjun Zhou
发明人： Hongxia Jin , Yan Liu , Wenjun Zhou
IPC分类号： G06F15/16
CPC分类号： G06Q50/01
摘要： Embodiments of the invention relate to modeling communities associated with groups of data items. Tools are provided to iteratively assign data items to communities and to update topic and participant distribution in the assigned communities. As the distributions are updated, the characteristics of the communities are updated. Each activity area is defined from the perspective of a single user. Participants in a community are connected to a user, but not necessarily to each other. The combination of formations of communities and the statistical aspect of evaluating characteristics of the communities provides a multi-facetted organization of connections between data items and associated participants.
摘要翻译：本发明的实施例涉及对与数据项组相关联的社区的建模。提供工具以迭代地向社区分配数据项，并更新所分配社区中的主题和参与者分布。随着发行版本的更新，社区的特征将被更新。从单个用户的角度定义每个活动区域。社区中的参与者连接到用户，但不一定相互联系。社区组合和评估社区特征的统计方面的组合提供了数据项目和相关参与者之间的多方面的连接组织。

10. 发明授权

US08987275B2 Indazole compounds and their uses 有权
标题翻译：吲唑化合物及其用途
公开(公告)号：US08987275B2
公开(公告)日：2015-03-24
申请号：US13583974
申请日：2011-02-18
申请人： Nathanael Gray , Wenjun Zhou , Xianming Deng
发明人： Nathanael Gray , Wenjun Zhou , Xianming Deng
IPC分类号： A61K31/497 , A01N43/54 , A61K31/506 , A01N43/56 , A61K31/415 , C07D231/56 , A61K31/496 , C07D401/10 , C07D403/12 , A61K31/4184 , A61K45/06
CPC分类号： A61K31/496 , A61K31/4184 , A61K45/06 , C07D231/56 , C07D401/10 , C07D403/12
摘要： The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.
摘要翻译：本申请涉及治疗性有机化合物，包含有效量的治疗性有机化合物的组合物; 以及治疗和预防疾病的方法，包括向有需要的受试者施用和有效量的治疗性有机化合物。

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