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1. 发明申请

US20100056496A1 MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：肌肉受体拮抗剂
公开(公告)号：US20100056496A1
公开(公告)日：2010-03-04
申请号：US12439771
申请日：2007-09-04
申请人： Naresh Kumar , Kirandeep Kaur , Yogesh D. Shejul , Abhijit Ray , Suman Gupta , Shivani Malhotra , Rajkumar Shirumalla
发明人： Naresh Kumar , Kirandeep Kaur , Yogesh D. Shejul , Abhijit Ray , Suman Gupta , Shivani Malhotra , Rajkumar Shirumalla
IPC分类号： A61K31/55 , C07D223/14 , A61P1/00 , A61P11/00 , A61P3/00
CPC分类号： C07D221/24 , C07D209/12 , C07D209/14
摘要： The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The present invention also relates to processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors. Formula (I) or a pharmaceutically accepted salt, pharmaceutically acceptable solvate, enantiomers, diastereomer, polymorph or N-oxide thereof, wherein X is.
摘要翻译：本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。本发明还涉及制备本文所述化合物的方法，其药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。式（I）或其药学上可接受的盐，药学上可接受的溶剂合物，对映异构体，非对映体，多晶型物或N-氧化物，其中X为。

2. 发明申请

US20100144801A1 MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：肌肉受体拮抗剂
公开(公告)号：US20100144801A1
公开(公告)日：2010-06-10
申请号：US12443838
申请日：2007-10-02
申请人： Naresh Kumar , Jaskiran Kaur , Abhijit Ray , Suman Gupta , Shivani Malhotra , Rajkumar Shirumalla
发明人： Naresh Kumar , Jaskiran Kaur , Abhijit Ray , Suman Gupta , Shivani Malhotra , Rajkumar Shirumalla
IPC分类号： A61K31/44 , C07D213/55 , C07D233/54 , A61K31/4164 , A61P11/00 , A61P13/00 , A61P1/00 , A61P3/00
CPC分类号： C07D233/64 , C07D211/70 , C07D213/30
摘要： The present invention generally relates to muscarinic receptor antagonists of formula I, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. Formula (I) wherein Het: is heterocyclyl or heteroaryl X: O, S or NR1 and the other substituents are defined as in the claims.
摘要翻译：本发明一般涉及式I的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。式（I）其中Het：是杂环基或杂芳基X：O，S或NR1，其它取代基如权利要求中所定义。

3. 发明申请

US20090221664A1 PHARMACEUTICAL COMPOSITIONS OF MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：药物受体拮抗剂的药物组合物
公开(公告)号：US20090221664A1
公开(公告)日：2009-09-03
申请号：US12090805
申请日：2006-10-19
申请人： Abhijit Ray , Sunanda G. Dastidar , Rajkumar Shirumalla , Shivani Malhotra
发明人： Abhijit Ray , Sunanda G. Dastidar , Rajkumar Shirumalla , Shivani Malhotra
IPC分类号： A61K31/403
CPC分类号： A61K31/401
摘要： Provided herein are pharmaceutical compositions comprising one or more muscarinic receptor antagonists (“MRA”), and at least one additional active ingredients selected from one or more β2-agonists, p38 MAP kinase inhibitors, PDE-IV inhibitors, corticosteroids or a mixture thereof and optionally one or more pharmaceutically acceptable carriers, excipients or diluents. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.
摘要翻译：本文提供包含一种或多种毒蕈碱受体拮抗剂（“MRA”）和至少一种选自一种或多种β-激动剂，p38MAP激酶抑制剂，PDE-IV抑制剂，皮质类固醇或其混合物的另外的活性成分的药物组合物，任选的一种或多种药学上可接受的载体，赋形剂或稀释剂。此外，提供了治疗自身免疫性，炎性或过敏性疾病或病症的方法。

4. 发明申请

US20100004215A1 COMPOSITIONS OF PHOSPHODIESTERASE TYPE IV INHIBITORS 审中-公开
标题翻译：磷酸二酯酶IV型抑制剂的组合物
公开(公告)号：US20100004215A1
公开(公告)日：2010-01-07
申请号：US12109752
申请日：2008-04-25
申请人： Abhijit Ray , Sunanda G. Dastidar , Rajkumar Shirumalla , Suman Gupta
发明人： Abhijit Ray , Sunanda G. Dastidar , Rajkumar Shirumalla , Suman Gupta
IPC分类号： A61K31/56 , A61K31/407 , A61K31/519 , A61K31/46
CPC分类号： A61K45/06 , A61K31/407 , A61K31/46 , A61K31/519 , A61K31/56 , A61K2300/00
摘要： Provided herein are pharmaceutical compositions comprising one or more phosphodiesterase inhibitors of type IV (“PDE-IV”), and at least one other active ingredient such as muscarinic receptor antagonists (MRA), β2-agonists, p38 MAP Kinase inhibitors, or corticosteroids and optionally one or more pharmaceutically acceptable excipients. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.
摘要翻译：本文提供包含一种或多种IV型磷酸二酯酶抑制剂（“PDE-IV”）和至少一种其它活性成分如毒蕈碱受体拮抗剂（MRA），β2-激动剂，p38 MAP激酶抑制剂或皮质类固醇的药物组合物，以及任选地一种或多种药学上可接受的赋形剂。此外，提供了治疗自身免疫性，炎性或过敏性疾病或病症的方法。

5. 发明申请

US20090054382A1 COMPOSITIONS OF PHOSPHODIESTERASE TYPE IV INHIBITORS 审中-公开
标题翻译：磷酸二酯酶IV型抑制剂的组合物
公开(公告)号：US20090054382A1
公开(公告)日：2009-02-26
申请号：US12090798
申请日：2006-10-19
申请人： Abhijit Ray , Sunanda G. Dastidar , Rajkumar Shirumalla , Suman Gupta
发明人： Abhijit Ray , Sunanda G. Dastidar , Rajkumar Shirumalla , Suman Gupta
IPC分类号： A61K31/573 , A61K31/407 , A61K31/424
CPC分类号： A61K31/41
摘要： Provided herein are pharmaceutical compositions comprising one or more phosphodiesterase inhibitors of type IV (“PDE-IV”), and at least one other active ingredients selected from muscarinic receptor antagonists (MRA), β2-agonists, p38 MAP Kinase inhibitors, and corticosteroids and optionally one or more pharmaceutically acceptable excipients and/or other therapeutic agents. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.
摘要翻译：本文提供了包含一种或多种IV型磷酸二酯酶抑制剂（“PDE-IV”）和至少一种选自毒蕈碱受体拮抗剂（MRA），β2-激动剂，p38 MAP激酶抑制剂和皮质类固醇的其它活性成分的药物组合物，以及任选地一种或多种药学上可接受的赋形剂和/或其它治疗剂。此外，提供了治疗自身免疫性，炎性或过敏性疾病或病症的方法。

6. 发明申请

US20100113371A9 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds 审中-公开
标题翻译：戊糖单糖衍生物作为抗炎化合物
公开(公告)号：US20100113371A9
公开(公告)日：2010-05-06
申请号：US11722573
申请日：2005-12-22
申请人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Muthukaman Nagarajan , Rajkumar Shirumalla , Gurpreet Kaur Aulakh , Abhijit Ray
发明人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Muthukaman Nagarajan , Rajkumar Shirumalla , Gurpreet Kaur Aulakh , Abhijit Ray
IPC分类号： A61K31/7008 , C07H15/04 , A61P29/00 , C07H15/12
CPC分类号： C07H3/02 , C07H15/02 , C07H15/18 , C07H15/26
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本发明的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥或银屑病。本发明还涉及含有这些单糖衍生物的药物组合物，以及治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥和其它炎症和/或自身免疫的方法疾病

7. 发明申请

US20070287673A1 MONOSACCHARIDE DERIVATIVES 失效
标题翻译：单糖衍生物
公开(公告)号：US20070287673A1
公开(公告)日：2007-12-13
申请号：US11755164
申请日：2007-05-30
申请人： Ashwani Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Rajkumar Shirumalla
发明人： Ashwani Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Rajkumar Shirumalla
IPC分类号： A61K31/7008
CPC分类号： C07H13/12 , C07H9/04
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

8. 发明申请

US20080300196A1 MONOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：单糖衍生物
公开(公告)号：US20080300196A1
公开(公告)日：2008-12-04
申请号：US11866542
申请日：2007-10-03
申请人： Ashwani Kumar Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Rajkumar Shirumalla , Abhijit Ray
发明人： Ashwani Kumar Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Rajkumar Shirumalla , Abhijit Ray
IPC分类号： A61K31/7052 , C07H17/02 , A61K31/70 , A61P9/00 , A61P37/00 , A61P35/00 , A61P29/00 , C07H15/00
CPC分类号： C07H3/02 , C07H9/04 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory, cancer, cardiovascular and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, cancer, cardiovascular diseases, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症，癌症，心血管和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒或过敏性鼻炎。包含本文公开的化合物的药理学组合物和治疗诸如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化症，癌症，心血管疾病，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒症或使用该化合物的过敏性鼻炎和其它炎症和/或自身免疫性疾病。

9. 发明授权

US07790689B2 Monosaccharide derivatives 失效
标题翻译：单糖衍生物
公开(公告)号：US07790689B2
公开(公告)日：2010-09-07
申请号：US11755164
申请日：2007-05-30
申请人： Ashwani Kumar Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Rajkumar Shirumalla
发明人： Ashwani Kumar Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Rajkumar Shirumalla
IPC分类号： A61K31/7008 , A61K31/7012 , A61K31/34 , C07H5/04 , C07H5/06 , C07D323/02 , C07D317/00
CPC分类号： C07H13/12 , C07H9/04
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

10. 发明申请

US20100120902A1 STANDARIZED BIOACTIVE HERBAL EXTRACTS 审中-公开
标题翻译：标准生物活性草药提取物
公开(公告)号：US20100120902A1
公开(公告)日：2010-05-13
申请号：US12532815
申请日：2008-03-24
申请人： Chandra Kant Katiyar , Anil Kanaujia , Rajeev Duggar , Satyapal Singh Yadav , Navin Sharma , Abhijit Ray , Rajkumar Shirumalla , Malini Bajpai , Gyanesh Shukla , Baddireddi Subhadra Lakshmi , Kontham Sanathkumar Vinaykumar
发明人： Chandra Kant Katiyar , Anil Kanaujia , Rajeev Duggar , Satyapal Singh Yadav , Navin Sharma , Abhijit Ray , Rajkumar Shirumalla , Malini Bajpai , Gyanesh Shukla , Baddireddi Subhadra Lakshmi , Kontham Sanathkumar Vinaykumar
IPC分类号： A61K31/352 , A61P29/00 , A61P19/02 , A61P19/00
CPC分类号： A61K36/185
摘要： The present invention relates to standardized extracts of Boerhaavia diffusa, wherein the extracts have anti inflammatory and analgesic activities. The present invention also includes bioassay guided fractionation of Boerhaavia diffusa leading to the identification of bioactive markers; processes for the isolation of the bioactive markers; processes for the preparation of the extracts enriched with bioactive markers from Boerhaavia diffusa; pharmaceutical compositions comprising bioactive markers, or standardized extracts of Boerhaavia diffusa and methods of standardization of the extracts.
摘要翻译：本发明涉及双歧杆菌的标准化提取物，其中提取物具有抗炎和止痛活性。本发明还包括生物测定引导分离的Boerhaavia diffusa，导致鉴定生物活性标记; 分离生物活性标记物的方法; 用于制备富含Boerhaavia diffusa的生物活性标记物的提取物的方法; 包含生物活性标记物或Boerhaavia diffusa的标准化提取物的药物组合物和提取物的标准化方法。

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