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1. 发明授权

US4687831A Antithrombogenic synthetic elastomer and process of preparation thereof 失效
标题翻译：抗血栓性合成弹性体及其制备方法
公开(公告)号：US4687831A
公开(公告)日：1987-08-18
申请号：US852656
申请日：1986-04-16
申请人： Naoya Ogata , Kohei Sanui , Nobuhiko Yui , Kazuhiko Nojima , Kazunori Kataoka , Teruo Okano , Yasuhisa Sakurai
发明人： Naoya Ogata , Kohei Sanui , Nobuhiko Yui , Kazuhiko Nojima , Kazunori Kataoka , Teruo Okano , Yasuhisa Sakurai
IPC分类号： C08G18/00 , A61L27/00 , A61L27/18 , A61L33/06 , C08G18/10 , C08G18/32 , C08G18/65 , C08G18/66 , C08G18/76
CPC分类号： C08G18/7671 , A61L27/18 , A61L33/068 , C08G18/10
摘要： Antithrombogenic synthetic elastomer having repeat units comprising portion I which is a soft segment unit containing a polyether and portion II which is a hard segment unit: ##STR1## R is a straight-chain or branched-chain alkylene group containing 2 to 4 carbon atoms, R' is amide a urethane, an urea, n ranges up to 180, m is an integer of 1 to 20, l is an integer of 1 to 10, said polymer having a microdomain structure composed of soft and hard segments, the domains of which have an average size of 10 to 20 nm, and a molecular weight of about 80,000 to about 500,000.The polymer shows little adhesion of blood platelets thereto, little deformation of adhering blood platelets and an excellent antithrombogenic property. This polymer has excellent mechanical properties as an elastomer. This polymer is useful for artificial organs such as blood vessels, kidneys, hearts, and for functional biomaterials and devices such as absorbents for biological components, carriers for sustained release preparations, adhesive materials for living tissue, injectors, blood bags and catheters.
摘要翻译：具有重复单元的抗血栓形成合成弹性体，其包含作为包含聚醚的软链段单元的部分I和作为硬链段单元的部分II。R是直链或支链亚烷基含有2至4个碳原子的基团，R'是酰胺氨基甲酸酯，脲，n范围高达180，m是1至20的整数，l是1至10的整数，所述聚合物具有由以下组成的微区结构：软和硬链段，其结构域的平均尺寸为10至20nm，分子量为约80,000至约500,000。聚合物对血小板附着力小，血小板附着变形小，抗血栓性优异。该聚合物作为弹性体具有优异的机械性能。该聚合物可用于人造器官如血管，肾脏，心脏，以及用于生物组分的吸收剂，持续释放制剂的载体，活组织的粘合剂材料，注射器，血袋和导管等功能生物材料和装置。

2. 发明授权

US4873292A Antithrombogenic synthetic polymer and process for its preparation 失效
标题翻译：抗血栓形成合成聚合物及其制备方法
公开(公告)号：US4873292A
公开(公告)日：1989-10-10
申请号：US154003
申请日：1988-02-09
申请人： Naoya Ogata , Kohei Sanui , Nobuhiko Yui , Kazunori Kataoka , Teruo Okano , Yasuhisa Sakurai
发明人： Naoya Ogata , Kohei Sanui , Nobuhiko Yui , Kazunori Kataoka , Teruo Okano , Yasuhisa Sakurai
IPC分类号： A61L33/06 , C08G69/44
CPC分类号： C08G69/44 , A61L33/068
摘要： An antithrombogenic synthetic polymer has repeat structural units represented by the following structural formula consisting of portions I and II: ##STR1## a microdomain structure composed of crystalline phases and amorphous phases, each phase having an average size of 5 to 10 nm, and a molecular weight in the range of about 10,000 to about 300,000. The polymer exhibits little adhesion of blood platelets thereto, an excellent antithrombogenic property and a sufficient mechanical strength.
摘要翻译：抗血栓形成合成聚合物具有由以下结构式表示的重复结构单元，其由I和II部分组成：由结晶相和非晶相组成的微区结构，每个相的平均尺寸为5〜10nm，分子重量在约10,000至约300,000的范围内。该聚合物对其血小板粘附力很小，具有优异的抗血栓形成性能和足够的机械强度。

3. 发明申请

US20100161021A1 MYOCARDIAL PAD 审中-公开
公开(公告)号：US20100161021A1
公开(公告)日：2010-06-24
申请号：US12663204
申请日：2007-06-07
申请人： Kenji Iino , Go Watanabe , Nobuhiko Yui , Tooru Ooya , Ryoji Kawabata
发明人： Kenji Iino , Go Watanabe , Nobuhiko Yui , Tooru Ooya , Ryoji Kawabata
IPC分类号： A61N1/05
CPC分类号： A61N1/0587
摘要： This invention relates to a myocardial pad used in cardioversion, pacing, or the like and to a myocardial lead and a therapeutic apparatus for cardiac disease comprising the same. The myocardial pad of this invention is bondable to epicardia and has conductivity, biocompatibility, and biodegradability. Using this pad, the myocardial lead can be immobilized onto the atrium without suture. Thus, bleeding from the atrium, which is a lethal complication, caused by lead removal can be prevented.
摘要翻译：本发明涉及用于心脏复律，起搏等的心肌垫，以及涉及包含该心肌的心脏病的心肌梗塞和治疗装置。本发明的心肌垫可与心外膜粘合并具有导电性，生物相容性和生物降解性。使用该垫，心肌引线可以固定在心房而不缝合。因此，可以防止由去除铅引起的致死并发症的心房出血。

4. 发明授权

US06673919B2 Chemically modified hyaluronic acid or salts thereof, and a process for producing thereof 有权
标题翻译：化学修饰的透明质酸或其盐及其制备方法
公开(公告)号：US06673919B2
公开(公告)日：2004-01-06
申请号：US10107195
申请日：2002-03-28
申请人： Nobuhiko Yui , Tooru Ooya , Ikuo Sato
发明人： Nobuhiko Yui , Tooru Ooya , Ikuo Sato
IPC分类号： C08B3700
CPC分类号： C08B37/0072
摘要： This invention relates to a chemically modified hyaluronic acid and salts thereof, which are obtained by O-acylating, alkoxylating or crosslinking a complex consisting of hyaluronic acid or a salt thereof and a cationic compound in a nonaqueous solvent, and a process for the production thereof. The nonaqueous solvent used in the invention is preferably one or more solvents selected from the group consisting of chloroform, toluene, methylene chloride and heptane.
摘要翻译：本发明涉及通过在非水溶剂中由透明质酸或其盐和阳离子化合物组成的络合物O-酰化，烷氧基化或交联而获得的化学修饰的透明质酸及其盐及其制备方法。本发明中使用的非水溶剂优选为选自氯仿，甲苯，二氯甲烷和庚烷中的一种或多种溶剂。

5. 发明授权

US6037387A Blood-compatible material of a supramolecular structure 失效
标题翻译：超分子结构的血液相容性材料
公开(公告)号：US6037387A
公开(公告)日：2000-03-14
申请号：US69143
申请日：1998-04-29
申请人： Nobuhiko Yui , Minoru Terano , Hideharu Mori
发明人： Nobuhiko Yui , Minoru Terano , Hideharu Mori
IPC分类号： C08B37/16 , A61L33/00 , A61L33/06 , C08G83/00 , C08J5/18 , C08L5/16 , C08L23/02 , C08L23/26 , C08L71/00 , C08L71/02 , C08L77/00 , C08L77/12 , A01N1/00 , A61K31/765 , A61K47/36
CPC分类号： C08G83/007 , A61L33/068 , C08J5/18 , C08L71/02 , C08L77/00 , C08L77/12 , C08J2377/00 , C08J2377/12
摘要： A platelet metabolism suppressing blood compatible material has a supramolecular structure containing a plurality of cyclic compounds and a hydrophilic straight-chain polymer threading into cavities of the cyclic compounds. Both terminals of the polymer are respectively capped with biodegradable groups having bulks sufficient to prevent the dethreading of the cyclic compounds.
摘要翻译：血小板代谢抑制血液相容材料具有超分子结构，其包含多个环状化合物和亲水性直链聚合物穿入环状化合物的空腔。聚合物的两个末端分别被封闭了具有足以防止环状化合物的脱离的体积的可生物降解的基团。

6. 发明申请

US20080038821A1 Cell-Releasing Agent and Method of Releasing Cell Sheet 失效
标题翻译：细胞释放剂和释放细胞片的方法
公开(公告)号：US20080038821A1
公开(公告)日：2008-02-14
申请号：US11663744
申请日：2005-09-09
申请人： Wanpen Tachaboonyakiat , Masakazu Kato , Tooru Ooya , Nobuhiko Yui
发明人： Wanpen Tachaboonyakiat , Masakazu Kato , Tooru Ooya , Nobuhiko Yui
IPC分类号： C12N5/02 , C07C229/02
CPC分类号： C12N1/02 , C08B37/0012 , C08B37/0015 , C12M33/00
摘要： A cell-sheet releasing agent of the present invention contains an aminated polyrotaxane. The polyrotaxane constituting the skeleton of the cell-releasing agent of the present invention has a structure in which cavities of a plurality of cyclic molecules are threaded onto a linear molecule and both terminals of the linear molecule have a bulky cap bonded thereto so that the cyclic molecules are not dethreaded from the linear molecule. Furthermore, the aminated polyrotaxane contained in the cell-releasing agent of the present invention is a compound in which at least some of hydroxy groups in the cyclodextrin structure contained in the polyrotaxane are each substituted with a substituent having an amino group. According to this cell-sheet releasing agent, cultured cells anchored to the surface of a container can be released without damaging the cells and without controlling the temperature.
摘要翻译：本发明的细胞片脱模剂含有胺化聚轮烷。构成本发明的细胞释放剂的骨架的聚轮烷具有将多个环状分子的空穴螺纹连接到直链状分子上的结构，并且直链状分子的两端具有与其结合的蓬松的盖，使得循环分子不会从线性分子中解离出来。此外，本发明的细胞释放剂中所含的胺化聚轮烷是其中包含在聚轮烷中的环糊精结构中的至少一些羟基各自被具有氨基的取代基取代的化合物。根据该细胞片脱模剂，能够释放固定于容器表面的培养细胞，而不会损害细胞而不控制温度。

7. 发明授权

US07041310B2 Pharmaceutical preparation for the treatment of gynecological diseases 有权
公开(公告)号：US07041310B2
公开(公告)日：2006-05-09
申请号：US10108298
申请日：2002-03-28
申请人： Nobuhiko Yui , Kouichi Murakami , Tooru Ooya , Ikuo Sato
发明人： Nobuhiko Yui , Kouichi Murakami , Tooru Ooya , Ikuo Sato
IPC分类号： A61F6/06 , A61F6/14 , A61F13/02
CPC分类号： A61K9/0036 , A61K9/0039 , A61K47/36
摘要： This invention provides to a novel pharmaceutical preparation for the treatment of gynecological diseases. The pharmaceutical preparation according to the invention comprises a therapeutic drug for the intrauterine, intravaginal or intrapelvic administration, or for the administration into the ovarian endometrioma, and a biodegradable polymer comprising a chemically modified hyaluronic acid or a salt thereof prepared by O-acylating, alkoxylating or crosslinking a complex of hyaluronic acid or a salt thereof and a cationic compound in a nonaqueous solvent. The preparation of the invention is preferably administered intrauterine, intravaginal, intrapelvic, and intratumor cavity.

8. 发明授权

US07829337B2 Cell-releasing agent and method of releasing cell sheet 失效
标题翻译：细胞释放剂和释放细胞片的方法
公开(公告)号：US07829337B2
公开(公告)日：2010-11-09
申请号：US11663744
申请日：2005-09-09
申请人： Wanpen Tachaboonyakiat , Masakazu Kato , Tooru Ooya , Nobuhiko Yui
发明人： Wanpen Tachaboonyakiat , Masakazu Kato , Tooru Ooya , Nobuhiko Yui
IPC分类号： C12N5/00 , C12N5/02 , C07C229/00 , C08B30/18
CPC分类号： C12N1/02 , C08B37/0012 , C08B37/0015 , C12M33/00
摘要： A cell-sheet releasing agent of the present invention contains an aminated polyrotaxane. The polyrotaxane constituting the skeleton of the cell-releasing agent of the present invention has a structure in which cavities of a plurality of cyclic molecules are threaded onto a linear molecule and both terminals of the linear molecule have a bulky cap bonded thereto so that the cyclic molecules are not dethreaded from the linear molecule. Furthermore, the aminated polyrotaxane contained in the cell-releasing agent of the present invention is a compound in which at least some of hydroxy groups in the cyclodextrin structure contained in the polyrotaxane are each substituted with a substituent having an amino group. According to this cell-sheet releasing agent, cultured cells anchored to the surface of a container can be released without damaging the cells and without controlling the temperature.
摘要翻译：本发明的细胞片脱模剂含有胺化聚轮烷。构成本发明的细胞释放剂的骨架的聚轮烷具有将多个环状分子的空穴螺纹连接到直链状分子上的结构，并且直链状分子的两端具有与其结合的蓬松的盖，使得循环分子不会从线性分子中解离出来。此外，本发明的细胞释放剂中所含的胺化聚轮烷是其中包含在聚轮烷中的环糊精结构中的至少一些羟基各自被具有氨基的取代基取代的化合物。根据该细胞片脱模剂，能够释放固定于容器表面的培养细胞，而不会损害细胞而不控制温度。

9. 发明申请

US20050003013A1 Drug 审中-公开
标题翻译：药物
公开(公告)号：US20050003013A1
公开(公告)日：2005-01-06
申请号：US10829243
申请日：2004-04-22
申请人： Nobuhiko Yui , Koichi Murakami , Tooru Ooya , Ikuo Sato , Tuyoshi Nakama , Ryouji Kawabata
发明人： Nobuhiko Yui , Koichi Murakami , Tooru Ooya , Ikuo Sato , Tuyoshi Nakama , Ryouji Kawabata
IPC分类号： A61K9/02 , A61K9/00 , A61K31/58 , A61K47/34 , A61K47/36 , A61P15/00 , A61K9/14
CPC分类号： A61K31/58 , A61K9/0034 , A61K47/36
摘要： A drug is provided comprising of a degradable gel with a saturated moisture content not exceeding 98 wt. % and a functional material, and which permits control of the rate of release of the functional material and performs controlled-release of the functional material over a prolonged period of time, and wherein the gel itself decomposes and dissipates upon completion of release of the functional material.
摘要翻译：提供药物，其包含不超过98重量％的饱和水分含量的可降解凝胶。％和功能材料，并且其允许控制功能材料的释放速率并且在更长的时间段内执行功能材料的控制释放，并且其中凝胶本身在功能释放完成时分解和消散材料。

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