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    • 2. 发明授权
    • Triazole derivative
    • 三唑衍生物
    • US08022091B2
    • 2011-09-20
    • US12278054
    • 2007-02-05
    • Naoya OnoTetsuo TakayamaFumiyasu ShiozawaHironori KatakaiTetsuya YabuuchiTomomi OtaMakoto YagiMasakazu Sato
    • Naoya OnoTetsuo TakayamaFumiyasu ShiozawaHironori KatakaiTetsuya YabuuchiTomomi OtaMakoto YagiMasakazu Sato
    • A01N43/64A61K31/41C07D249/12
    • C07D249/08
    • An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P1), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which compound is represented by the formula below (where A represents an oxygen atom, a sulfur atom, a group represented by Formula —SO—, a group represented by Formula —SO2—, or the like, R1 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, or the like, R1A represents a hydrogen atom or the like, R2 represents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, or the like, R3 represents an aryl group, R4 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms and optionally substituted with a carboxyl group, and R5 represents an alkyl group having 1-10 carbon atoms, a cycloalkyl group having 3-8 carbon atoms, an aryl group which is optionally substituted, or the like).
    • 本发明的目的是提供具有抑制S1P与其受体Edg-1(S1P1)结合的作用的化合物,可用作药物化合物。 化合物或其药学上可接受的盐,其化合物由下式表示(其中A表示氧原子,硫原子,由式-SO-表示的基团,由式-SO2-表示的基团等) R1表示氢原子,具有1-6个碳原子的烷基等,R1A表示氢原子等,R2表示具有1-6个碳原子的烷基,具有3-6个碳原子的环烷基 原子等,R 3表示芳基,R 4表示氢原子或具有1-6个碳原子并且任选被羧基取代的烷基,R 5表示具有1-10个碳原子的烷基,环烷基 具有3-8个碳原子的基团,任选取代的芳基等)。