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1. 发明授权

US5200561A Process for producing optically active amines 失效
标题翻译：生产光活性胺的方法
公开(公告)号：US5200561A
公开(公告)日：1993-04-06
申请号：US771569
申请日：1991-10-07
申请人： Naoto Konya , Yukio Yoneyoshi , Yoji Sakito , Shinji Nishii , Gohfu Suzukamo , Hiroko Sakane
发明人： Naoto Konya , Yukio Yoneyoshi , Yoji Sakito , Shinji Nishii , Gohfu Suzukamo , Hiroko Sakane
IPC分类号： C07B53/00 , C07C209/40 , C07C209/52 , C07C211/03 , C07C211/27
CPC分类号： C07C209/40
摘要： Disclosed is a process for producing an optically active amine represented by the formula (IV) ##STR1## wherein R.sub.7 and R.sub.8 each denote an alkyl group, aryl group or aralkyl group, providing that they do not denote the same group at the same time, and * indicates an asymmetric carbon atom, which comprises reacting an asymmetric reducing agent obtained from (1) an optically active amine derivative represented by the formula (I) ##STR2## wherein R.sub.1 denotes an alkyl group, aryl group or aralkyl group; R.sub.2 denotes a hydrogen atom, alkyl group or aralkyl group; R.sub.3 denotes an aryl group or a substituent represented by the formula (II) ##STR3## wherein R.sub.4 and R.sub.5 each denote a hydrogen atom, aryl group or aralkyl group, and * is as defined above, (2) a metal borohydride and (3) sulfuric acid, with either the syn-isomer or the anti-isomer of an oxime derivative represented by the formula (III) or with a mixture rich in either one of the two isomers ##STR4## wherein R.sub.6 denotes an alkyl group, aralkyl group or alkyl-substituted silyl group, and R.sub.7 and R.sub.8 are as defined above.The optically active amine obtained can be used as a resolving agent for preparing medicinal agents, agricultural chemicals, or intermediates thereof.

2. 发明授权

US5801280A Processes for preparing optically active alcohols and optically active amines 失效
公开(公告)号：US5801280A
公开(公告)日：1998-09-01
申请号：US628154
申请日：1996-04-05
申请人： Yukio Yoneyoshi , Naoto Konya , Gohfu Suzukamo , Masashi Kamitamari , Takashi Miyawaki
发明人： Yukio Yoneyoshi , Naoto Konya , Gohfu Suzukamo , Masashi Kamitamari , Takashi Miyawaki
IPC分类号： C07B53/00 , C07B57/00 , C07C29/143 , C07C33/34 , C07C209/40 , C07C213/02
CPC分类号： C07B53/00 , C07B57/00 , C07C209/40 , C07C213/02 , C07C29/143 , C07B2200/07
摘要： A process for preparing an optically active alcohol by reacting a prochiral ketone corresponding to the optically active alcohol and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride; or obtained from the optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine and (2) a metal borohydride; and a process for preparing an optically active amine by reacting an oxime derivative and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride, or obtained from said optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine, and (2) a metal borohydride.

3. 发明授权

US6025531A Processes for preparing optically active alcohols and optically active amines 失效
标题翻译：制备光学活性醇和光学活性胺的方法
公开(公告)号：US6025531A
公开(公告)日：2000-02-15
申请号：US89349
申请日：1998-06-03
申请人： Yukio Yoneyoshi , Naoto Konya , Gohfu Suzukamo
发明人： Yukio Yoneyoshi , Naoto Konya , Gohfu Suzukamo
IPC分类号： C07B53/00 , C07B57/00 , C07C29/143 , C07C33/34 , C07C209/40 , C07C213/02
CPC分类号： C07B53/00 , C07B57/00 , C07C209/40 , C07C213/02 , C07C29/143 , C07B2200/07
摘要： A process for preparing an optically active alcohol by reacting a prochiral ketone corresponding to the optically active alcohol and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride; or obtained from the optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine and (2) a metal borohydride; and a process for preparing an optically active amine by reacting an oxime derivative and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride, or obtained from said optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine, and (2) a metal borohydride.
摘要翻译：通过使对应于光学活性醇的前手性酮与酸与（1）选自以下的混合物的混合物反应制备光学活性醇的方法：i）硼烷化合物，其由光学活性β-氨基醇和硼氢化物; 或由光学活性β-氨基醇，金属硼氢化物和酸获得，和ii）光学活性的恶唑硼烷和（2）金属硼氢化物; 和通过使肟衍生物和酸与（1）选自以下的含硼化合物的混合物制备光学活性胺的方法：i）由光学活性β-氨基醇获得的硼烷化合物和硼氢化物，或从所述光学活性β-氨基醇，金属硼氢化物和酸获得的硼氢化物，和ii）光学活性的恶唑硼烷，和（2）金属硼氢化物。

4. 发明授权

US5144039A Process for producing optically active alcohol 失效
标题翻译：生产光学活性醇的方法
公开(公告)号：US5144039A
公开(公告)日：1992-09-01
申请号：US471966
申请日：1990-01-29
申请人： Yukio Yoneyoshi , Gohfu Suzukamo , Naoto Konya , Takaharu Ikeda
发明人： Yukio Yoneyoshi , Gohfu Suzukamo , Naoto Konya , Takaharu Ikeda
IPC分类号： C07C29/143 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07C29/143 , C07D233/56 , C07D249/08 , C07B2200/07
摘要： The process for producing an optically active alcohol of the present invention comprises allowing(A) an optically active amino alcohol represented by the general formula (I) ##STR1## (R.sup.1 is an aryl group, R.sup.2 is a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group, and the carbon atoms having a mark * are each an asymmetric carbon atom) and an acid, or a salt of the optically active amino alcohol (I) and an acid,(B) a metal borohydride, and(C) at least one member selected from the group consisting of water, sulfides, cyclic ethers, ethers of mono alcohol to react witha prochiral ketone represented by the general formula (II) ##STR2## [R.sup.4 and R.sup.5 are different and each a lower alkyl group, an aryl group, an aralkyl group or a 2-substituted-1-triazoleethylene group represented by the general formula (III) ##STR3## (R.sup.6 is a halogen- or haloalkyl-substituted or unsubstituted phenyl group or a cycloalkyl group)].According to the present invention, the optically active alcohol (IV) can be obtained with good efficiency and a high optical purity. Therefore, the present process is advantageous in industrial application, in particular.

5. 发明授权

US06660888B2 Process for producing retinol and intermediate compounds for producing the same 失效
标题翻译：制备视黄醇和中间体化合物的方法
公开(公告)号：US06660888B2
公开(公告)日：2003-12-09
申请号：US09978691
申请日：2001-10-18
申请人： Toshiya Takahashi , Shinzo Seko , Kazutaka Kimura , Noriyuki Doi , Naoto Konya
发明人： Toshiya Takahashi , Shinzo Seko , Kazutaka Kimura , Noriyuki Doi , Naoto Konya
IPC分类号： C07C31500
CPC分类号： C07C403/08 , C07B2200/09 , C07C403/12 , C07C403/22 , C07C2601/16 , Y02P20/55
摘要： There are disclosed a disulfone compound of formula (1): wherein Ar denotes an aryl group that may have a substituent, R1 denotes a hydrogen atom or a protective group of a hydroxyl group and the wavy line means that the disulfone compound is an E or Z geometrical isomer or a mixture thereof, a method for producing the same, intermediate compounds therefore and a process for producing retinol through the disulfone compound.
摘要翻译：公开了式（1）的二砜化合物：其中Ar表示可以具有取代基的芳基，R 1表示氢原子或羟基保护基，波浪线表示二砜化合物为E或 Z几何异构体或其混合物，其制备方法，中间体化合物和通过二砜化合物生产视黄醇的方法。

6. 发明授权

US06288283B1 Process for producing retinal and intermediates for producing the same 失效
标题翻译：用于生产视网膜和中间体的方法
公开(公告)号：US06288283B1
公开(公告)日：2001-09-11
申请号：US09584354
申请日：2000-06-01
申请人： Shinzo Seko , Naoto Konya , Toshiya Takahashi
发明人： Shinzo Seko , Naoto Konya , Toshiya Takahashi
IPC分类号： C07C4711
CPC分类号： C07C403/14 , C07B2200/09 , C07C403/10 , C07C403/22 , C07C2601/16
摘要： There are disclosed: a hydroxyaldehyde derivative of formula (1): wherein the wavy line depicted by indicates a single bond and the compound having a double bond to which said single bond is attached represents E or Z isomer or a mixture thereof, a methoxy alcohol derivative of formula (2): wherein the wavy line depicted by indicates a single bond and the compound having a double bond to which said single bond is attached represents E or Z isomer or a mixture thereof, processes for producing the same, and a process for producing a retinal using the same.
摘要翻译：公开了式（1）的羟基醛衍生物：其中由所示的波浪线表示单键，并且具有所述单键的双键的化合物表示E或Z异构体或其混合物，式（2）的甲氧基醇衍生物：其中由

7. 发明授权

US06784321B2 Process for producing retinol and intermediate compounds for producing the same 失效
标题翻译：制备视黄醇和中间体化合物的方法
公开(公告)号：US06784321B2
公开(公告)日：2004-08-31
申请号：US10687880
申请日：2003-10-20
申请人： Toshiya Takahashi , Shinzo Seko , Kazutaka Kimura , Noriyuki Doi , Naoto Konya
发明人： Toshiya Takahashi , Shinzo Seko , Kazutaka Kimura , Noriyuki Doi , Naoto Konya
IPC分类号： C07C31700
CPC分类号： C07C403/08 , C07B2200/09 , C07C403/12 , C07C403/22 , C07C2601/16 , Y02P20/55
摘要： There are disclosed a disulfone compound of formula (1): wherein Ar denotes an aryl group that may have a substituent, R1 denotes a hydrogen atom or a protective group of a hydroxyl group and the wavy line means that the disulfone compound is an E or Z geometrical isomer or a mixture thereof, a method for producing the same, intermediate compounds therefore and a process for producing retinol through the disulfone compound.
摘要翻译：公开了式（1）的二砜化合物：其中Ar表示可以具有取代基的芳基，R 1表示氢原子或羟基保护基，波浪线表示二砜化合物为E或 Z几何异构体或其混合物，其制备方法，中间体化合物和通过二砜化合物生产视黄醇的方法。

8. 发明授权

US06444857B1 Process for producing vitamin A aldehyde and intermediate for producing the same 失效
标题翻译：生产维生素A醛的方法及其制备方法
公开(公告)号：US06444857B1
公开(公告)日：2002-09-03
申请号：US09684922
申请日：2000-10-10
申请人： Shinzo Seko , Naoto Konya , Toshiya Takahashi
发明人： Shinzo Seko , Naoto Konya , Toshiya Takahashi
IPC分类号： C07C4500
CPC分类号： C07C403/14 , C07B2200/09 , C07C403/22 , C07C2601/16
摘要： There are disclosed an alcohol derivative of formula (1): wherein Ar is an optionally substituted aryl group and R is a straight or branched C1-C3 lower alkyl group, and the wavy line depicted by indicates a single bond and stereochemistry relating to a double bond bound therewith is E or Z or a mixture thereof, and a process for producing the same and a process for producing Vitamin A aldehyde using the same.
摘要翻译：公开了式（1）的醇衍生物：其中Ar是任选取代的芳基，R是直链或支链C 1 -C 3低级烷基，并且所描绘的波浪线表示单键和与双键相关的立体化学与其结合的是E或Z或其混合物，及其制备方法和使用其制备维生素A醛的方法。

9. 发明授权

US06355841B1 Process for producing &bgr;-carotene 失效
标题翻译：生产β-胡萝卜素的方法
公开(公告)号：US06355841B1
公开(公告)日：2002-03-12
申请号：US09685030
申请日：2000-10-10
申请人： Naoto Konya , Shinzo Seko
发明人： Naoto Konya , Shinzo Seko
IPC分类号： C07C31500
CPC分类号： C07C403/24 , C07F9/5435 , Y02P20/55
摘要： There are disclosed a process for producing a sulfon derivative of formula (1): wherein Ar represents an aryl group which may be substituted, R represents a lower alkyl group and the wavy line depicted by indicates a single bond and stereochemistry relating to a double bond bound therewith is E or Z or a mixture thereof, which process is characterized by reacting an aldehyde derivative of formula (2): with phosphonium salt of formula (3): in the presence of a base; a sulfone derivative of formula (1) and a process for producing a &bgr;-carotene using sulfone derivative of formula (1).
摘要翻译：公开了式（1）的磺酸衍生物的制备方法：其中Ar表示可被取代的芳基，R表示低级烷基，所示的波浪线表示单键，并且与双键结合相关的立体化学其为E或Z或其混合物，该方法的特征在于使式（2）的醛衍生物与式（3）的鏻盐在碱的存在下反应：式（1）的砜衍生物和使用式（1）的砜衍生物生产β-胡萝卜素的方法。

10. 发明授权

US06331652B1 Process for producing lycopene and intermediate thereof 失效
标题翻译：番茄红素及其中间体的制备方法
公开(公告)号：US06331652B1
公开(公告)日：2001-12-18
申请号：US09624860
申请日：2000-07-24
申请人： Naoto Konya , Shinzo Seko
发明人： Naoto Konya , Shinzo Seko
IPC分类号： C07F954
CPC分类号： C07F9/5428 , C07C1/322 , C07C315/04 , C07C317/18 , C07C317/24 , Y02P20/55 , C07C11/21
摘要： There are disclosed a sulfonaldehyde derivative of formula (2): a phosphonium salt of formula (3): processes for producing the same and a sulfone derivative of formula (4): a process for producing the same and a process for producing lycopene therefrom.
摘要翻译：公开了式（2）的磺醛衍生物：式（3）的鏻盐：其制备方法和式（4）的砜衍生物：其制备方法和由其制备番茄红素的方法。

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