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1. 发明授权

US4828990A Method for purifying an interferon 失效
标题翻译：纯化干扰素的方法
公开(公告)号：US4828990A
公开(公告)日：1989-05-09
申请号：US908707
申请日：1986-10-10
申请人： Naoki Higashi , Shunjiro Sugimoto , Masafumi Tsujimoto , Hounai Shirasawa , Tsutomu Okada , Kazumori Yamamoto , Tattanahalli L. Nagabhushan , Paul P. Trotta
发明人： Naoki Higashi , Shunjiro Sugimoto , Masafumi Tsujimoto , Hounai Shirasawa , Tsutomu Okada , Kazumori Yamamoto , Tattanahalli L. Nagabhushan , Paul P. Trotta
IPC分类号： C12N15/09 , A61K38/21 , C07K1/14 , C07K14/52 , C07K14/555 , C07K14/57 , C12P21/00 , C12P21/02 , C12R1/19
CPC分类号： C07K14/57 , Y10S435/811 , Y10S930/142
摘要： A method of purifying a polypeptide having a physiological activity such as one having interferon activities from a culture mixture of a microorganism obtained by a recombinant DNA technique and capable of producing the polypeptide is disclosed. The method comprises subjecting the cultured cells to extraction and purification in the presence of a salt of zinc or copper and polyethyleneimine thereby inhibiting decomposition and denaturation of the polypeptide. The extracted polypeptide can be further purified by column chromatographies using a column containing an anion exchange resin, column containing a cation exchange resin and column containing a gel filtration resin.
摘要翻译： PCT No.PCT / JP85 / 00715 Sec。 371日期1986年10月10日第 102（e）日期1986年10月10日PCT 1985年12月26日PCT PCT。第WO86 / 04067号公报日本1986年7月17日。一种纯化具有生理活性的多肽的方法，例如具有干扰素活性的多肽，其由通过重组DNA技术获得的能够产生该多肽的微生物的培养物混合物中进行。该方法包括在锌或铜盐和聚乙烯亚胺的存在下使培养的细胞进行提取和纯化，从而抑制多肽的分解和变性。提取的多肽可以使用含有阴离子交换树脂的柱，含有阳离子交换树脂的柱和含有凝胶过滤树脂的柱，通过柱色谱进一步纯化。

2. 发明申请

US20090312602A1 PRESSING MEMBER, ENDOSCOPIC TREATMENT SYSTEM, AND ENDOSCOPIC SUTURING DEVICE 有权
标题翻译：压力部件，内窥镜治疗系统和内窥镜治疗装置
公开(公告)号：US20090312602A1
公开(公告)日：2009-12-17
申请号：US11996447
申请日：2006-07-21
申请人： Yuji Sakamoto , Tsutomu Okada , Satoshi Miyamoto
发明人： Yuji Sakamoto , Tsutomu Okada , Satoshi Miyamoto
IPC分类号： A61B1/018 , A61B17/29 , A61B17/04 , A61B1/01
CPC分类号： A61B17/32056 , A61B17/0218 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/062 , A61B17/29 , A61B18/1477 , A61B18/1492 , A61B2017/00269 , A61B2017/00292 , A61B2017/00296 , A61B2017/00557 , A61B2017/0409 , A61B2017/0417 , A61B2017/0451 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2017/2926 , A61B2018/1407 , A61B2018/141 , A61B2018/1425
摘要： An endoscopic treatment system 1 of the present invention includes an overtube 2 that is inserted into the body of a patient. An endoscope 7 and a suturing device 8 are inserted into the overtube 2. The overtube 2 has a long and flexible tube main body 3, and a chamber 4 is provided at the distal end of the tube main body 3. The chamber 4 has a lateral hole 10 formed on the lateral surface thereof. The width of the lateral hole 10 is set such that a lesion can be drawn into the lateral hole 10 while preventing other organs on the periphery of the lesion from being drawn into the lateral hole 10.
摘要翻译：本发明的内窥镜治疗系统1包括插入患者体内的外套管2。内窥镜7和缝合装置8插入到外套管2中。外套管2具有长且柔性的管主体3，并且在管主体3的远端设置有腔室4.腔室4具有形成在其侧表面上的横向孔10。侧孔10的宽度被设定为使病变能够被拉入侧孔10，同时防止病变周围的其他器官被吸入侧孔10。

3. 发明授权

US07588580B2 Mucosa excision device using endoscope 有权
标题翻译：粘膜切除装置使用内窥镜
公开(公告)号：US07588580B2
公开(公告)日：2009-09-15
申请号：US10724812
申请日：2003-12-01
申请人： Tsutomu Okada
发明人： Tsutomu Okada
IPC分类号： A61B17/26 , A61B1/04 , A61B1/00
CPC分类号： A61B1/00147 , A61B1/00087 , A61B1/00089 , A61B1/00101 , A61B18/14 , A61B18/149 , A61B2017/00269 , A61B2017/00296 , A61B2018/00982 , A61B2018/1407 , A61B2018/1495
摘要： In a mucosa excising device using an endoscope according to the present invention, engagement pieces are provided in the vicinity of a claw portion formed at an end edge of a cap, the engagement pieces press the snare wire arranged along the claw portion, both the claw portion and the engagement pieces hold the snare wire, and the snare wire of a high-frequency snare is prevented from accidentally coming off at the time of insertion into a body cavity or during a treatment in the body cavity when conducting endoscopic mucosal resection.
摘要翻译：在根据本发明的使用内窥镜的粘膜切除装置中，在形成在帽的端部边缘的爪部附近设置有接合片，所述接合片按压沿爪部布置的圈套，并且接合片保持圈套线，并且当进行内窥镜粘膜切除时，防止在插入体腔时或者在体腔内的治疗期间高频圈套的圈套被意外脱落。

4. 发明授权

US07520882B2 Apparatus for ligating living tissues 有权
公开(公告)号：US07520882B2
公开(公告)日：2009-04-21
申请号：US11231106
申请日：2005-09-20
申请人： Junichi Muramatsu , Tsutomu Okada
发明人： Junichi Muramatsu , Tsutomu Okada
IPC分类号： A61B17/10 , A61B17/08
CPC分类号： A61B17/128 , A61B17/00234 , A61B17/0643 , A61B17/122 , A61B17/1227 , A61B17/1285
摘要： A apparatus for ligating living tissues comprises an introducing tube capable of being inserted into a living body cavity, at least two or more manipulating wires movably inserted into the introducing tube, and at least two or more clips having a proximal end portion, a pinch section being formed at a distal end of an arm section extending from the proximal end. This clipping apparatus is characterized in that a plurality of clips are arranged in series in the introducing tube so as to engage the clip and the manipulating wire with each other, respectively.

5. 发明申请

US20080015410A1 ENDOSCOPE TREATMENT TOOL INSERTION-EXTRACTION SYSTEM 有权
标题翻译：内窥镜治疗工具插入提取系统
公开(公告)号：US20080015410A1
公开(公告)日：2008-01-17
申请号：US11777782
申请日：2007-07-13
申请人： Tsutomu Okada
发明人： Tsutomu Okada
IPC分类号： A61B1/00
CPC分类号： A61B17/29 , A61B1/00133 , A61B1/018 , A61B10/06 , A61B2017/00398 , A61B2017/22075 , A61B2017/2905
摘要： This endoscope treatment tool insertion-extraction system is provided with: a first treatment tool and a second treatment tool which are insertable into and retractable from a forceps channel of an endoscope; a first insertion-extraction mechanism which feeds the first treatment tool into the forceps channel or removes the first treatment tool from the forceps channel; a second insertion-extraction mechanism which feeds the second treatment tool into the forceps channel or removes the second treatment tool from the forceps channel; one driving section which drives the first insertion-extraction mechanism and the second insertion-extraction; and a selection section which selectively engage the driving section with one of the first insertion-extraction mechanism and the second insertion-extraction mechanism.
摘要翻译：该内窥镜治疗工具插入取出系统设置有：第一处理工具和第二处理工具，其能够插入到内窥镜的镊子通道内并从其缩回; 第一插入提取机构，其将所述第一治疗工具进入所述钳子通道或从所述钳子通道移除所述第一治疗工具; 第二插入提取机构，其将所述第二处理工具进给到所述钳子通道中或者从所述钳子通道移除所述第二处理工具; 一个驱动部分，其驱动第一插入提取机构和第二插入提取; 以及选择部，其选择性地将驱动部与第一插入取出机构和第二插入取出机构中的一个接合。

6. 发明申请

US20070263701A1 Code Nco and Gps Receiver 失效
标题翻译：代码Nco和Gps接收器
公开(公告)号：US20070263701A1
公开(公告)日：2007-11-15
申请号：US11663147
申请日：2005-04-07
申请人： Dun Wang , Tsutomu Okada
发明人： Dun Wang , Tsutomu Okada
IPC分类号： H04B1/00
CPC分类号： G01S19/24 , G01S19/29 , G01S19/37 , H04B1/7075 , Y10S331/03
摘要： A code NCO is provided which correctly outputs a predetermined code enable signal by executing a simple control, depending on a frequency of a clock signal, with an optimal circuit scale. A multiplexer 1 receives integers of N and M which are relatively prime, and outputs either of them to an adder 2, depending on an output signal of a comparator 6. The adder 2 adds an integer latched by the register 5 and an integer output by the multiplexer 1, and outputs the result via a multiplexer 4 to the register 5. The register 5 latches and outputs the received integer to the comparator 6 with a frequency fs of a sampling clock signal SCLK. In accordance with a threshold set based on the integers of N and M and the number L of bits of the adder 2 or the register 5, the comparator 6 outputs a signal having the High state only when the output integer of the register 5 satisfies the threshold condition. The code NCO outputs this signal as a code enable signal having a frequency fo.
摘要翻译：提供了代码NCO，其通过以最佳电路规模执行根据时钟信号的频率的简单控制来正确地输出预定的代码使能信号。多路复用器1接收相对于素数的N和M的整数，并根据比较器6的输出信号将它们任一个输出到加法器2。加法器2将由寄存器5锁存的整数和由多路复用器1输出的整数相加，并将结果通过多路复用器4输出到寄存器5。寄存器5以采样时钟信号SCLK的频率f s锁存并将接收到的整数输出到比较器6。根据基于N和M的整数的阈值和加法器2或寄存器5的位数L，比较器6仅在寄存器5的输出整数满足阈值条件。代码NCO将该信号输出为具有频率f 0 o 0的代码使能信号。

7. 发明申请

US20070088199A1 Endoscope 有权
标题翻译：内窥镜
公开(公告)号：US20070088199A1
公开(公告)日：2007-04-19
申请号：US11582170
申请日：2006-10-17
申请人： Jin Ito , Tsutomu Okada , Yasuhito Kura
发明人： Jin Ito , Tsutomu Okada , Yasuhito Kura
IPC分类号： A61B1/12 , A61B1/00
CPC分类号： A61B1/015 , A61B1/00137
摘要： The rear end side of treatment equipment-side duct which enables treatment equipment provided within an insertion unit to be inserted, and which also serves as a suction duct, is disposed generally in parallel with the tip side of a suction-side duct extending forward from a universal cable side so as to be an opening end, and both opening ends are detachably attached with a filter unit in which a forceps plug portion serving as a suction duct opening, and a filter portion for retrieving (storing) tissue by suction are provided, and a suction switchover valve for performing a suction switchover operation is provided at the backward side thereof, thereby enabling retrieval of tissue without influence of the periphery of the suction switchover valve. Thus, defects due to a long duct can be eliminated, and tissue can be retrieved without influence of the periphery of the suction switchover valve.
摘要翻译：处理设备侧管道的后端侧使得设置在插入单元内并且也用作吸入管道的处理设备的处理设备侧管道的大致平行于从吸入侧管道的前侧延伸通用电缆侧为开口端，并且两个开口端均可拆卸地安装有过滤器单元，在该过滤器单元中设置有用作抽吸管道开口的钳子塞部分和用于通过抽吸来回收（存储）组织的过滤器部分并且在其后侧设置有用于进行抽吸切换操作的吸入切换阀，从而能够在不影响吸入切换阀的周围的情况下进行组织的取出。因此，可以消除由于长管道引起的缺陷，并且可以在不影响抽吸切换阀的周边的情况下取回组织。

8. 发明申请

US20060224162A1 Endoscopic treatment system 有权
标题翻译：内镜治疗系统
公开(公告)号：US20060224162A1
公开(公告)日：2006-10-05
申请号：US11446999
申请日：2006-06-05
申请人： Keita Suzuki , Keiichi Arai , Hiroyoshi Watanabe , Tsutomu Okada
发明人： Keita Suzuki , Keiichi Arai , Hiroyoshi Watanabe , Tsutomu Okada
IPC分类号： A61D1/12
CPC分类号： A61B17/29 , A61B1/00133 , A61B2017/00398
摘要： This endoscopic treatment system is provided with an insertion-retraction and rotating device for a treatment tool, which performs an insertion-retraction operation along a direction of an axis of a treatment tool and a rotating operation around the axis, of the treatment tool inserted in a channel of an endoscope.
摘要翻译：该内窥镜治疗系统设置有用于治疗工具的插入回缩和旋转装置，该治疗工具沿着治疗工具的轴线的方向和围绕轴线的旋转操作执行插入式治疗工具的插入回缩操作内窥镜的通道。

9. 发明授权

US07008420B2 High frequency surgical instrument 有权
标题翻译：高频手术器械
公开(公告)号：US07008420B2
公开(公告)日：2006-03-07
申请号：US10730818
申请日：2003-12-09
申请人： Tsutomu Okada
发明人： Tsutomu Okada
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B2018/00178 , A61B2018/00988 , A61B2018/1407
摘要： The high frequency surgical instrument includes the electrical connection portion configured to detachably connect the connection cord designed for an external high frequency power source, to the slider, and the instrument has such a structure in which the contact pin configured to lead the connection cord backward in substantially parallel with the advancing and retreating direction of the slider is provided in substantially parallel with the advancing and retreating direction of the slider while the connection cord is connected to the electric connection portion.
摘要翻译：高频外科器械包括被配置为将设计用于外部高频电源的连接线可拆卸地连接到滑块的电连接部，并且该仪器具有这样的结构，其中接触针被配置为将连接线向后引导基本上平行于滑块的前进和后退方向设置成与滑块的前进和后退方向基本平行，同时连接线连接到电连接部分。

10. 发明授权

US4768505A Calculus crushing apparatus 失效
标题翻译：微积体破碎装置
公开(公告)号：US4768505A
公开(公告)日：1988-09-06
申请号：US42476
申请日：1987-04-24
申请人： Tsutomu Okada , Mikio Utsugi
发明人： Tsutomu Okada , Mikio Utsugi
IPC分类号： A61B17/22 , A61B17/28
CPC分类号： A61B17/221 , A61B2017/2212 , A61B2017/2923
摘要： A calculus crushing apparatus includes a flexible sheath for insertion into a body cavity and an operation wire slidably inserted in the sheath. A basket for holding a calculus is fixed to the distal end of the operation wire. The basket is formed of a plurality of elastic wires. A connecting rod is connected to the proximal end of the operation wire. By moving the connecting rod by an operation mechanism, the operation wire slides in the sheath, so that the basket is projected from or retracted in the sheath. The connecting rod has a disconnecting portion which is weaker than the elastic wires and operation wire against tension.
摘要翻译：微积石破碎装置包括用于插入体腔的柔性护套和可滑动地插入护套中的操作线。用于保持微积分的篮子固定到操作线的远端。篮子由多根弹性线形成。连接杆连接到操作线的近端。通过操作机构移动连接杆，操作线在护套中滑动，使得筐从鞘中突出或缩回。连杆具有比弹性线弱的操作线和张力的断开部分。

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