专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4423215A Method of preparing sodium salts of imidazoledicarboxylic acid substituted cephalosporin derivatives 失效
标题翻译：制备咪唑二羧酸取代头孢菌素衍生物的钠盐的方法
公开(公告)号：US4423215A
公开(公告)日：1983-12-27
申请号：US353809
申请日：1982-03-02
申请人： Naohiko Yasuda , Hisao Iwagami , Yasuo Irie , Eiji Nakanishi , Hideomi Saito
发明人： Naohiko Yasuda , Hisao Iwagami , Yasuo Irie , Eiji Nakanishi , Hideomi Saito
IPC分类号： C07D501/04 , C07D501/38 , C07D501/46
CPC分类号： C07D501/46
摘要： A method of preparing sodium salts of an imidazoledicarboxylic acid derivative of a substituted cephalosporin represented by the general formula of ##STR1## where X is a radical selected from the group consisting of hydrogen, halogen, hydroxyl, alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkyloxy, mercapto, alkylthio, arylthio, aralkylthio, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, amino, mono- or dialkylamino, mono- or diarylamino, mono- or diaralkylamino, acylamino, sulfonic acid, nitro or heterocyclic group;and where R is a radical selected from hydrogen, an organic radical such as alkyl, aryl or aralkyl or a heterocyclic group, said organic radical and heterocyclic group being optionally substituted;said method comprising reacting a compound represented by the following formula: ##STR2## with 4-pyridineethanesulfonic acid in an aqueous solution of sodium iodide and subsequently recovering the salt.The compounds are useful in the treatment of bacterial infections, particularly Pseudomonas aeruginosa, in man and other animals.
摘要翻译：一种制备由通式（I）＆lt; IMAGE＆gt;表示的取代头孢菌素的咪唑二羧酸衍生物的钠盐的方法，其中X是选自氢，卤素，羟基，烷基，芳基芳烷氧基，烷氧基，芳氧基，芳烷硫基，芳烷硫基，烷基磺酰基，芳基磺酰基，芳烷基磺酰基，烷基亚磺酰基，芳基亚磺酰基，芳烷基亚磺酰基，氨基，一烷基氨基或二芳基氨基，单或二芳基氨基，，硝基或杂环基; 并且其中R是选自氢，有机基团如烷基，芳基或芳烷基或杂环基的基团，所述有机基团和杂环基团任选被取代; 所述方法包括将由下式表示的化合物与4-吡啶乙磺酸在碘化钠水溶液中反应，随后回收盐。这些化合物可用于治疗人和其他动物中细菌感染，特别是铜绿假单胞菌（Pseudomonas aeruginosa）。

2. 发明授权

US4465631A 5-Substituted-3-isoxazolecarboxylic acid derivatives 失效
标题翻译： 5-取代的3-异恶唑羧酸衍生物
公开(公告)号：US4465631A
公开(公告)日：1984-08-14
申请号：US482544
申请日：1983-04-06
申请人： Naohiko Yasuda , Hisao Iwagami , Eiji Nakanishi , Yukio Sasaki , Shigeru Yamanaka
发明人： Naohiko Yasuda , Hisao Iwagami , Eiji Nakanishi , Yukio Sasaki , Shigeru Yamanaka
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D499/00 , C07D499/64 , C07D499/68 , C07D499/70 , C07D501/20 , C07D501/22 , C07D501/44
CPC分类号： C07D499/00
摘要： A 5-substituted-3-isoxazolecarboxylic acid derivative of the general formula: ##STR1## wherein X stands for a phenyl group, thienyl group, furyl group or pyridyl group, each of which optionally may carry at least one substituent group; R stands for a phenyl group or hydroxyphenyl group; and A stands for a group of the formula: ##STR2## wherein Y stands for ##STR3## in which the carbon atom with which the carboxyl group combines with the nitrogen atom in A, M stands for a hydrogen atom or a substituent group, and Z stands for a hydrogen atom, hydroxy group, acyloxy group, carbamoyloxy group, aromatic heterocycle thio group or aromatic nitrogen-containing heterocycle quaternary ammonium group, is disclosed along with methods for producing these compounds.
摘要翻译：其中X代表苯基，噻吩基，呋喃基或吡啶基，其中每一个可以任选地带有至少一个取代基;一个5-取代的3-异恶唑羧酸衍生物，其通式如下： R代表苯基或羟基苯基; A代表下式的基团：其中Y代表其中羧基与A中的氮原子结合的碳原子，M代表氢原子或取代基的，以及 Z表示氢原子，羟基，酰氧基，氨基甲酰氧基，芳香族杂环硫基或芳香族含氮杂环季铵基，同时也包括这些化合物的制造方法。

3. 发明授权

US4297279A Imidazoledicarboxylic acid derivative 失效
标题翻译：咪唑二羧酸衍生物
公开(公告)号：US4297279A
公开(公告)日：1981-10-27
申请号：US134681
申请日：1980-03-27
申请人： Naohiko Yasuda , Eiji Nakanishi
发明人： Naohiko Yasuda , Eiji Nakanishi
IPC分类号： A61K31/495 , A61P31/04 , C07D233/90 , C07D487/14 , C07D499/00 , C07D499/44 , C07D499/68 , C07D501/20 , C07D501/46 , C07D499/04 , C07D487/04 , C07D501/02
CPC分类号： C07D487/14 , C07D233/90 , C07D499/00
摘要： A reactive derivative of imidazolecarboxylic acid having the formula: ##STR1## is useful in preparing imidazoledicarboxylic acid derivatives of alpha-aminopenicillins and cephalosporins.
摘要翻译：具有下式的咪唑羧酸的反应性衍生物可用于制备α-氨基青霉素和头孢菌素的咪唑二羧酸衍生物。

4. 发明授权

US07427818B2 Relaxor ferroelectric solid-solution single crystal, device, and method of using device 失效
标题翻译：放电铁电固溶单晶，器件及其使用方法
公开(公告)号：US07427818B2
公开(公告)日：2008-09-23
申请号：US10587543
申请日：2005-01-28
申请人： Naohiko Yasuda , Hidehiro Ohwa , Makoto Iwata
发明人： Naohiko Yasuda , Hidehiro Ohwa , Makoto Iwata
IPC分类号： H01L41/08
CPC分类号： C30B29/32 , G02F1/0027 , H01L41/18
摘要： A relaxor ferroelectric solid solution single crystal is capable of making transitions, at temperatures below the Curie temperature, between a first state which has a high permittivity and blocks optical transmission and a second state which has a low permittivity and allows optical transmission. The relaxor ferroelectric solid solution single crystal undergoes a transition to the second state if an electric field above a threshold is applied thereto in the first state. The relaxor ferroelectric solid solution single crystal undergoes a transition to the first state if heated to or above the Curie temperature in the second state.
摘要翻译：弛豫铁电固溶体单晶能够在低于居里温度的温度下在具有高介电常数的第一状态和阻挡光透射之间进行转变，并且能够实现具有低介电常数并允许光透射的第二状态。如果在第一状态下施加高于阈值的电场，则弛豫铁电固溶体单晶经历向第二状态的转变。如果在第二状态下加热到或高于居里温度，则弛豫铁电固溶体单晶经历转变到第一状态。

5. 发明授权

US4786737A Aromatic sulfonic acid salts of a proline derivative 失效
标题翻译：脯氨酸衍生物的芳香磺酸盐
公开(公告)号：US4786737A
公开(公告)日：1988-11-22
申请号：US093240
申请日：1987-09-04
申请人： Yasuo Irie , Fusayoshi Kakizaki , Chieko Ishijima , Michito Sumikawa , Naohiko Yasuda
发明人： Yasuo Irie , Fusayoshi Kakizaki , Chieko Ishijima , Michito Sumikawa , Naohiko Yasuda
IPC分类号： C07K5/06 , C07K5/068 , C07D207/09
CPC分类号： C07K5/06086
摘要： A compound which is: ##STR1## wherein R may be 1 to 5 H, Cl, Br, F, C.sub.1 -C.sub.4 straight chain or branched alkyl, OH, or CF.sub.3.
摘要翻译：一种化合物，其为：其中R可以为1至5个H，Cl，Br，F，C 1 -C 4直链或支链烷基，OH或CF 3。

6. 发明授权

US3984417A Method of producing active amino acid esters 失效
标题翻译：生产活性氨基酸酯的方法
公开(公告)号：US3984417A
公开(公告)日：1976-10-05
申请号：US530495
申请日：1974-12-09
申请人： Naohiko Yasuda , Yasuo Ariyoshi , Koji Toi
发明人： Naohiko Yasuda , Yasuo Ariyoshi , Koji Toi
IPC分类号： A61K38/00 , C07D215/26 , C07K1/06 , C07K1/08 , C07K1/10 , C07D215/24 , C07C101/19 , C07C103/52
CPC分类号： C07C251/00 , C07K1/064 , C07K1/084 , C07K1/10 , A61K38/00
摘要： Amino acids having masked amino groups react with amino acids having masked carboxyl groups to form peptide derivatives in good yields if the reaction medium contains an isonitrile. Isonitriles also are effective in causing condensation of amino acids having masked amino groups with compounds having active hydroxyl groups to the corresponding amino acid esters. The yields of the first-mentioned reaction are enhanced if the reaction mixture additionally contains one of the compounds having active hydroxyl groups. Both the peptide derivatives and the amino acid esters of the compounds having active hydroxyl groups are useful for peptide synthesis.
摘要翻译：如果反应介质含有异腈，具有掩蔽的氨基的氨基酸与具有掩蔽的羧基的氨基酸反应以以良好的产率形成肽衍生物。异腈还有效地使具有掩蔽氨基的氨基酸与具有活性羟基的化合物缩合成相应的氨基酸酯。如果反应混合物另外含有具有活性羟基的化合物之一，则提高反应的产率。肽衍生物和具有活性羟基的化合物的氨基酸酯都可用于肽合成。

7. 发明申请

US20070152182A1 Relaxor ferroelectric solid-solution single crystal, device, and method of using device 失效
标题翻译：放电铁电固溶单晶，器件及其使用方法
公开(公告)号：US20070152182A1
公开(公告)日：2007-07-05
申请号：US10587543
申请日：2005-01-28
申请人： Naohiko Yasuda , Hidehiro Ohwa , Makotgo Iwata
发明人： Naohiko Yasuda , Hidehiro Ohwa , Makotgo Iwata
IPC分类号： C04B35/00
CPC分类号： C30B29/32 , G02F1/0027 , H01L41/18
摘要： A relaxor ferroelectric solid solution single crystal is capable of making transitions, at temperatures below the Curie temperature, between a first state which has a high permittivity and blocks optical transmission and a second state which has a low permittivity and allows optical transmission. The relaxor ferroelectric solid solution single crystal undergoes a transition to the second state if an electric field above a threshold is applied thereto in the first state. The relaxor ferroelectric solid solution single crystal undergoes a transition to the first state if heated to or above the Curie temperature in the second state.
摘要翻译：弛豫铁电固溶体单晶能够在低于居里温度的温度下在具有高介电常数的第一状态和阻挡光透射之间进行转变，并且能够实现具有低介电常数并允许光透射的第二状态。如果在第一状态下施加高于阈值的电场，则弛豫铁电固溶体单晶经历向第二状态的转变。如果在第二状态下加热到或高于居里温度，则弛豫铁电固溶体单晶经历转变到第一状态。

8. 发明授权

US06306647B1 Process for producing and purifying 2′,3′-dideoxynucleosides, and process for producing 2′,3′-dideoxy-2′,3′-didehydronucleosides 失效
标题翻译： 2'，3'-二脱氧核苷的生产和纯化方法，以及产生2'，3'-二脱氧-2'，3'-二脱氢核苷的方法
公开(公告)号：US06306647B1
公开(公告)日：2001-10-23
申请号：US08161071
申请日：1993-12-03
申请人： Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda
发明人： Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda
IPC分类号： C12N1500
CPC分类号： C12P19/02 , C12P19/38
摘要： A process for converting uridines to 2′,3′-dideoxy-2′,3′-didehydrouridines by reacting acetic anhydride with a 2′,3′-0-alkoxymethylideneuridine intermediate.
摘要翻译：通过使乙酸酐与2'，3'-O-烷氧基亚甲基奎宁中间体反应，将尿苷转化为2'，3'-二脱氧-2'，3'-二脱氢嘌呤的方法。

9. 发明授权

US4537719A 4-Methylsulfonyl-azetidinone derivatives 失效
标题翻译： 4-甲基磺酰基 - 氮杂环丁酮衍生物
公开(公告)号：US4537719A
公开(公告)日：1985-08-27
申请号：US431557
申请日：1982-09-30
申请人： Toshihisa Kato , Hisao Iwagami , Naohiko Yasuda
发明人： Toshihisa Kato , Hisao Iwagami , Naohiko Yasuda
IPC分类号： C07D205/08 , A61K31/395 , A61K31/397 , A61P31/04 , C07D205/09 , C07D205/095 , C07D403/12 , A61K31/495
CPC分类号： C07D403/12 , C07D205/09 , C07D205/095
摘要： The present invention relates to novel azetidinone derivatives of the general formula: ##STR1## where n is 0 or 2,X is hydrogen, halogen, amino, alkylamino, benzylamino or acylamino, andY is ##STR2## R is lower alkyl, 2,2,2-trichloroethyl, or aralkyl; and M is hydrogen or alkali metal having .beta.-lactamase inhibiting activity.The derivatives of the present invention can be administered together with antibiotics having a .beta.-lactam ring as antibacterial agents against .beta.-lactamase producing bacteria.A method for synthesizing said azetidinone derivatives is also disclosed.
摘要翻译：本发明涉及以下通式的新的氮杂环丁酮衍生物：其中n为0或2，X为氢，卤素，氨基，烷基氨基，苄基氨基或酰基氨基，Y为低级烷基， 2,2-三氯乙基或芳烷基; M是具有β-内酰胺酶抑制活性的氢或碱金属。本发明的衍生物可以与具有β-内酰胺环的抗生素一起作为产生β-内酰胺酶的细菌的抗菌剂一起施用。还公开了合成所述氮杂环丁酮衍生物的方法。

10. 发明授权

US4962193A Process for purifying 2',3'-dideoxynucleosides 失效
标题翻译：纯化2'，3'-二脱氧核苷的方法
公开(公告)号：US4962193A
公开(公告)日：1990-10-09
申请号：US291155
申请日：1988-12-28
申请人： Kenzo Yokozeki , Hideyuki Shirae , Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda , Masaru Otani , Toshiya Tanabe
发明人： Kenzo Yokozeki , Hideyuki Shirae , Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda , Masaru Otani , Toshiya Tanabe
IPC分类号： C12P19/02 , C12P19/38
CPC分类号： C12P19/02 , C12P19/38 , Y10S435/822
摘要： A biological process for producing a 2',3'-dideoxynucleoside from 2',3'-dideoxyuridine is disclosed. the 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式