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1. 发明授权

US09855219B2 Core-shell nanoparticles 有权
公开(公告)号：US09855219B2
公开(公告)日：2018-01-02
申请号：US12438596
申请日：2007-09-05
申请人： Nanning Joerg Arfsten , Steven Armes , Pascal Jozef Paul Buskens , Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven
发明人： Nanning Joerg Arfsten , Steven Armes , Pascal Jozef Paul Buskens , Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven
IPC分类号： G02B1/10 , C08K9/02 , A61K9/50 , C08K3/36 , C08K9/00 , C09D7/12 , G02B1/111 , C08L53/00
CPC分类号： A61K9/5089 , A61K9/501 , C08K3/36 , C08K9/00 , C08K9/02 , C08K9/10 , C08K9/12 , C08K2201/011 , C08K2201/013 , C08L53/00 , C08L2207/53 , C09D7/70 , G02B1/111 , Y10T428/254 , Y10T428/2998
摘要： The present invention relates to a composition suitable for forming an optical coating, the composition comprising core-shell nanoparticles, wherein said nanoparticles comprise: (a) core material comprising polymer; and (b) shell material comprising metal oxide.

2. 发明申请

US20100015433A1 CORE-SHELL NANOPARTICLES 有权
标题翻译：核心纳米粒子
公开(公告)号：US20100015433A1
公开(公告)日：2010-01-21
申请号：US12438596
申请日：2007-09-05
申请人： Nanning Joerg Arfsten , Steven Armes , Pascal Jozef Paul Buskens , Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven
发明人： Nanning Joerg Arfsten , Steven Armes , Pascal Jozef Paul Buskens , Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven
IPC分类号： G02B1/10 , C08K9/02 , C08K3/18 , B32B5/16 , C08K3/36
CPC分类号： A61K9/5089 , A61K9/501 , C08K3/36 , C08K9/00 , C08K9/02 , C08K9/10 , C08K9/12 , C08K2201/011 , C08K2201/013 , C08L53/00 , C08L2207/53 , C09D7/70 , G02B1/111 , Y10T428/254 , Y10T428/2998
摘要： The present invention relates to a composition suitable for forming an optical coating, the composition comprising core-shell nanoparticles, wherein said nanoparticles comprise: (a) core material comprising polymer; and (b) shell material comprising metal oxide.
摘要翻译：本发明涉及一种适用于形成光学涂层的组合物，该组合物包含核 - 壳纳米颗粒，其中所述纳米颗粒包含：（a）包含聚合物的芯材; 和（b）包含金属氧化物的壳材料。

3. 发明申请

US20100009001A1 NOVEL NANOPARTICLES 审中-公开
标题翻译：新型纳米材料
公开(公告)号：US20100009001A1
公开(公告)日：2010-01-14
申请号：US12438591
申请日：2007-09-05
申请人： Steven Armes , Jian-Jun Yuan
发明人： Steven Armes , Jian-Jun Yuan
IPC分类号： A61K9/14 , A61P43/00
CPC分类号： A61K9/5089 , A61K9/501 , C08K3/36 , C08K9/00 , C08K9/02 , C08K9/12 , C08K2201/011 , C08K2201/013 , C08L53/00 , C08L2207/53 , C09D7/70 , G02B1/111 , Y10T428/254 , Y10T428/2998
摘要： The invention provides a composition comprising core-shell nanoparticles, the nanoparticles comprising (a) cationic core material comprising polymer; and (b) a shell material comprising silica. Preferred core materials comprise diblock copolymer micelles comprising one block of dialkylaminoethyl methacrylate units which are partially or fully quaternised and one block of dialkylaminoethyl methacrylate units that remain non-quaternised. The invention also provides a method for the preparation of the said composition, the method involving (a) preparing a cationic core material comprising polymer; and (b) coating the core material with a shell comprising silica by treating the polymer with a silica precursor under ambient conditions. The invention also envisages a composition comprising core-shell nanoparticles which is adapted to facilitate controlled delivery of at least one active agent into a system in response to controlled changes in the pH of the system.
摘要翻译：本发明提供包含核 - 壳纳米颗粒的组合物，所述纳米颗粒包含（a）包含聚合物的阳离子核心材料; 和（b）包含二氧化硅的壳材料。优选的核心材料包括二嵌段共聚物胶束，其包含部分或全部季铵化的一个二烷基氨基乙基甲基丙烯酸酯单元和一个保持非季铵化的一个二烷基氨基乙基甲基丙烯酸酯单元。本发明还提供了一种制备所述组合物的方法，所述方法包括（a）制备包含聚合物的阳离子核心材料; 和（b）在环境条件下用二氧化硅前体处理聚合物，用包含二氧化硅的壳涂覆芯材。本发明还设想包含核 - 壳纳米颗粒的组合物，其适于响应于系统的pH的受控变化而促进至少一种活性剂被控制递送到系统中。

4. 发明申请

US20150174250A1 Composition And Method 审中-公开
标题翻译：组合和方法
公开(公告)号：US20150174250A1
公开(公告)日：2015-06-25
申请号：US14129098
申请日：2012-06-29
申请人： Lee Griffiths , Malcolm Tom McKechnie , Steven Armes , Adam Blanazs
发明人： Lee Griffiths , Malcolm Tom McKechnie , Steven Armes , Adam Blanazs
IPC分类号： A61K47/32 , C11D3/37 , C11D17/00
CPC分类号： A61K47/32 , A61K9/1273 , B01J13/14 , C11D3/3707 , C11D3/3765 , C11D3/3773 , C11D17/0017 , C11D17/0039
摘要： The present invention is directed to a method of delivering an active agent to a locus using a polymersome containing composition. The composition comprises a plurality of polymersome vesicles and a liquid matrix. The polymersome vesicles are formed in a process which comprises a cross-linking step.
摘要翻译：本发明涉及使用含聚合物的组合物将活性剂递送至场所的方法。该组合物包含多个聚合物囊泡和液体基质。在包含交联步骤的方法中形成聚合物囊泡。

5. 发明授权

US08580311B2 Nanoparticles 有权
公开(公告)号：US08580311B2
公开(公告)日：2013-11-12
申请号：US13363114
申请日：2012-01-31
申请人： Steven Armes , Jian-Jun Yuan
发明人： Steven Armes , Jian-Jun Yuan
IPC分类号： A61K9/14 , A61K9/51 , B23B5/16
CPC分类号： A61K9/5089 , A61K9/501 , C08K3/36 , C08K9/00 , C08K9/02 , C08K9/10 , C08K9/12 , C08K2201/011 , C08K2201/013 , C08L53/00 , C08L2207/53 , C09D7/70 , G02B1/111 , Y10T428/254 , Y10T428/2998
摘要： Methods for the preparation of polymer-templated core-shell nanoparticles include the steps of (a) preparing a cationic polymeric core material comprising polymeric micelles, and (b) coating the core material with a silica-comprising shell by depositing the shell onto the polymeric micelles from at least one silica precursor to form the core-shell nanoparticles. Compositions which include the core-shell nanoparticles are adapted to facilitate controlled delivery of at least one active agent into a system in response to controlled changes in the pH of the system.

6. 发明申请

US20060069203A1 Block copolymers 有权
标题翻译：嵌段共聚物
公开(公告)号：US20060069203A1
公开(公告)日：2006-03-30
申请号：US10544113
申请日：2004-02-05
申请人： Andrew Lewis , Steven Armes , Yinghua Ma
发明人： Andrew Lewis , Steven Armes , Yinghua Ma
IPC分类号： C08L31/00
CPC分类号： C08F293/005 , A61K9/1075 , C08L53/00 , C08L2666/02
摘要： Block copolymers comprise a core block formed of hydrophilic monomers and have pendant zwitterionic groups, and at least two terminal blocks, comprising stimulus-responsive groups. The core block has a degree of polymerisation of at least 100, whilst the terminal blocks have an average degree of polymerisation of at least 20. A solution of polymer in a liquid may be caused to change its characteristics, for instance rheology, upon being subjected to a stimulus such as a change in temperature or pH. Examples comprise core blocks formed of 2-methacryloyloxyethyl-2′-trimethylammonium ethylphosphate inner salt (MPC) and terminal blocks formed of 2-(diisopropylamino)ethyl methacrylate. Upon changing the pH from around 2 to around 8, an aqueous solution of the block copolymer gels, the solution becoming mobile again upon lowering the pH. The effect is due to deprotonation of a quaternary ammonium pendant ion to form a non-ionised group and subsequent protonation to form an ionised group. This changes the hydrophilicity of the terminal blocks and allowing formation of a network of micellar structures when the pendant groups are not ionised and relatively hydrophobic and associated in micelles.
摘要翻译：嵌段共聚物包含由亲水性单体形成的核心嵌段并具有侧基两性离子基团，和包含刺激反应性基团的至少两个末端嵌段。核心嵌段具有至少100的聚合度，而端嵌段的平均聚合度至少为20.聚合物在液体中的溶液可以在经受流动时改变其特性，例如流变性到诸如温度或pH变化的刺激。实例包括由2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸内酯盐（MPC）形成的核心嵌段和由甲基丙烯酸2-（二异丙基氨基）乙酯形成的端基。当将pH从约2改变到约8时，嵌段共聚物的水溶液凝胶化，溶液在降低pH后再次变得流动。该效应是由于季铵离子离子的去质子化而形成非电离基团，随后质子化形成电离基团。当侧基不被离子化并且相对疏水并且在胶束中缔合时，这改变了端基的亲水性并允许形成胶束结构网络。

7. 发明申请

US20060222670A1 Nanocomposite microgel particles and uses thereof 审中-公开
标题翻译：纳米复合微凝胶颗粒及其用途
公开(公告)号：US20060222670A1
公开(公告)日：2006-10-05
申请号：US11096124
申请日：2005-03-31
申请人： Steven Armes , Syuji Fujii
发明人： Steven Armes , Syuji Fujii
IPC分类号： A61K8/81
CPC分类号： A61K8/042 , A61K8/02 , A61K8/25 , A61K8/817 , A61K2800/413 , A61Q19/00 , B82Y5/00
摘要： The use of a nanocomposite microgel as a stimulus responsive particulate emulsifier, wherein the microgel particles comprise an inorganic particulate component and a cross-linked responsive polymer matrix.
摘要翻译：使用纳米复合微凝胶作为刺激反应性颗粒乳化剂，其中微凝胶颗粒包含无机颗粒组分和交联的响应性聚合物基质。

8. 发明申请

US20050220880A1 Drug carriers comprising amphiphilic block copolymers 审中-公开
标题翻译：包含两亲性嵌段共聚物的药物载体
公开(公告)号：US20050220880A1
公开(公告)日：2005-10-06
申请号：US10506805
申请日：2003-03-07
申请人： Andrew Lewis , Steven Armes , Andrew Lloyd , Jonathan Salvage
发明人： Andrew Lewis , Steven Armes , Andrew Lloyd , Jonathan Salvage
IPC分类号： A61K9/107 , A61K9/51 , C08F4/40 , C08F293/00 , C08L53/00 , A61K9/14
CPC分类号： C08L53/00 , A61K9/1075 , C08F293/005 , C08L2666/02
摘要： An aqueous composition comprises an amphiphilic block copolymer, having a hydrophilic block comprising pendant zwitterionic groups and a hydrophobic block, and a biologically active compound associated with the polymer. The polymer is preferably in the form of micelles, and preferably the biological active is a hydrophobic drug, for instance having a calculated or experimentally determined logP of at least 1.0, where P is the octanol:water partition coefficient. The hydrophilic block is preferably formed from acrylic monomer including phosphoryicholine groups. The hydrophobic group is suitably formed from monomer which has groups which can be ionised at useful pH's, especially tertiary amine groups. Micelles may be formed by dissolving the block copolymer in aqueous solvent at a pH at which the amine groups are protonated then raising the pH to a value at which the amine groups are substantially deprotonated, whereupon micelles spontaneously form. The preformed micelles are then contacted with active, under conditions such that solubilisation of the active occurs. The active may be a water-insoluble drug, for instance for tumour treatment.
摘要翻译：水性组合物包含具有包含侧基两性离子基团和疏水嵌段的亲水嵌段的两亲性嵌段共聚物和与聚合物缔合的生物活性化合物。聚合物优选为胶束形式，优选地，生物活性剂是疏水性药物，例如具有至少1.0的计算或实验测定的logP，其中P是辛醇：水分配系数。亲水性嵌段优选由包括磷酰胆碱基团的丙烯酸单体形成。疏水基团适当地由具有可以在有用pH，特别是叔胺基团离子化的基团的单体形成。胶束可以通过将嵌段共聚物溶解在水性溶剂中，在胺基质子化的pH下将pH升高至胺基基本上去质子化的值，由此胶束自发形成。然后在预先形成的胶束与活性物质接触的条件下，使活性物发生溶解。活性物质可以是水不溶性药物，例如用于肿瘤治疗。

9. 发明申请

US20050163743A1 Composition of polymers 有权
标题翻译：聚合物的组成
公开(公告)号：US20050163743A1
公开(公告)日：2005-07-28
申请号：US10506814
申请日：2002-03-07
申请人： Andrew Lewis , Steven Armes
发明人： Andrew Lewis , Steven Armes
IPC分类号： A61K47/48 , A61K48/00 , A61K31/785 , C12N15/88
CPC分类号： A61K47/6935 , A61K47/60 , A61K47/6907
摘要： Compositions are described comprising a of a block copolymer having an overall ionic charge and in which one of the blocks has pendant zwitterionic groups and a biologically active compound having a charge opposite that of the polymer. The polymer is preferably a linear diablock copolymer, preferably having a low polydispersity, such as a (tertiary amine group containing monomer) block-(zwitterionic monomer) copolymer. Suitable cationic monomers are dialkyl aminoalkyl(alk)acrylates and -acrylamides and suitable zwitterionic monomers are phosphorylcholine group containing acrylate monomers such as 2-methacyloyloxyetyl-21-trimethyl ammonium ethyl phosphate liner salt. The biologically active compound is generally polyionic and is for instance a nucleic acid, such as DNA, especially plasmid DNA.
摘要翻译：描述了包含具有总离子电荷的嵌段共聚物的组合物，其中一个嵌段具有侧基两性离子基团和具有与聚合物相反的电荷的生物活性化合物。聚合物优选为线性二嵌段共聚物，优选具有低多分散性，例如（含叔胺基的单体）嵌段 - （两性离子单体）共聚物。合适的阳离子单体是二烷基氨基烷基（alk）丙烯酸酯和 - 丙烯酰胺，合适的两性离子单体是含有丙烯酸酯单体如2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸内酯的磷酸胆碱基团。生物活性化合物通常是聚离子的，并且是例如核酸，例如DNA，特别是质粒DNA。

10. 发明申请

US20050159556A1 Zwitterionic polymers 有权
公开(公告)号：US20050159556A1
公开(公告)日：2005-07-21
申请号：US11025968
申请日：2005-01-03
申请人： Andrew Lewis , Sean Willis , Steven Armes , Emma Lobb , Yinghua Ma
发明人： Andrew Lewis , Sean Willis , Steven Armes , Emma Lobb , Yinghua Ma
IPC分类号： A61K9/10 , A61K47/32 , C08F4/40 , C08F20/22 , C08F246/00 , C08F293/00
CPC分类号： C08F4/40 , C08F246/00 , C08F293/005 , C08F2438/01
摘要： Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2′-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.

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