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1. 发明授权

US5955477A Methods for treating gastrointestinal motility dysfunction using optically pure (--) cisapride 失效
标题翻译：使用光学纯（ - ）西沙必利治疗胃肠蠕动功能障碍的方法
公开(公告)号：US5955477A
公开(公告)日：1999-09-21
申请号：US752984
申请日：1996-11-21
申请人： Nancy M. Gray , James W. Young
发明人： Nancy M. Gray , James W. Young
IPC分类号： C07D211/62 , A61K31/445 , A61K31/4468 , A61P1/00 , A61P1/08 , A61P1/10 , A61P1/14
CPC分类号： A61K31/445 , A61K31/4468
摘要： The optically pure (-) isomer of cisapride is useful for the treatment of dyspepsia and such other conditions as may be related to the activity of (-) cisapride as a prokinetic agent, such as gastroparesis, constipation, post-operative ileus, and intestinal pseudo-obstruction, without the concomitant liability of adverse effects associated with the racemic mixture of cisapride. The (-) isomer of cisapride also exhibits longer duration of action than does racemic cisapride and is useful for treatment of disorders of the central nervous system.
摘要翻译：西沙必利的光学纯（ - ）异构体可用于治疗消化不良和其他可能与（ - ）西沙必利作为促动力剂如胃轻瘫，便秘，手术后肠梗阻和肠道活动有关的其他病症假性梗阻，没有与西沙必利的外消旋混合物有关的副作用的伴随的责任。西沙必利的（ - ）异构体也表现出比外消旋西沙必利更长的作用时间，并且可用于治疗中枢神经系统疾病。

2. 发明授权

US5629329A Methods for treating disorders associated with the central nervous system using opticallly pure (+) cisapride 失效
标题翻译：使用光学纯（+）西沙必利治疗与中枢神经系统相关疾病的方法
公开(公告)号：US5629329A
公开(公告)日：1997-05-13
申请号：US690242
申请日：1996-07-19
申请人： Nancy M. Gray , James W. Young
发明人： Nancy M. Gray , James W. Young
IPC分类号： C07D211/62 , A61K31/445 , A61K31/4468 , A61P1/00 , A61P1/08 , A61P1/10 , A61P1/14 , A61K31/395 , C07D409/06
CPC分类号： A61K31/445 , A61K31/4468
摘要： Methods are disclosed utilizing the optically pure (+) isomer of cisapride. This compound is a potent drug for the treatment of gastro-esophageal reflux disease while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of cisapride. This compound is also useful in treating or preventing emesis while substantially reducing adverse effects associated with racemic cisapride. The optically pure (+) isomer of cisapride is also useful for the treatment of dyspepsia and such other conditions as may be related to the activity of (+) cisapride as a prokinetic agent, such as gastroparesis, constipation, post-operative ileus, and intestinal pseudo-obstruction, without the concomitant liability of adverse effects associated with the racemic mixture of cisapride. The (+) isomer of cisapride also exhibits longer duration of action than does racemic cisapride and is useful for treatment of disorders of the central nervous system.
摘要翻译：公开利用西沙必利的光学纯（+）异构体的方法。该化合物是用于治疗胃食管反流疾病的有效药物，同时显着减少与西沙必利的外消旋混合物相关的副作用的伴随的责任。该化合物也可用于治疗或预防呕吐，同时显着降低与西西沙必利素有关的不良反应。西沙必利的光学纯的（+）异构体也可用于治疗消化不良和其它可能与（+）西沙必利作为促动力剂的活性相关的其它病症，例如胃轻瘫，便秘，手术后肠梗阻和肠假性梗阻，没有与西沙必利的外消旋混合物相关的副作用的伴随的责任。西沙必利的（+）异构体也表现出比外消旋西沙必利更长的作用时间，并且可用于治疗中枢神经系统疾病。

3. 发明授权

US6066654A Methods for treating disorders associated with the central nervous system using optically pure (-) cisapride 失效
标题翻译：使用光学纯（ - ）西沙必利治疗与中枢神经系统相关疾病的方法
公开(公告)号：US6066654A
公开(公告)日：2000-05-23
申请号：US329328
申请日：1999-06-10
申请人： Nancy M. Gray , James W. Young
发明人： Nancy M. Gray , James W. Young
IPC分类号： C07D211/62 , A61K31/445 , A61K31/4468 , A61P1/00 , A61P1/08 , A61P1/10 , A61P1/14
CPC分类号： A61K31/445 , A61K31/4468
摘要： Methods are disclosed utilizing the optically pure (-) isomer of cisapride. The (-) isomer of cisapride also exhibits longer duration of action than does racemic cisapride and is useful for treatment of disorders of the central nervous system.
摘要翻译：公开利用西沙必利的光学纯（ - ）异构体的方法。西沙必利的（ - ）异构体也表现出比外消旋西沙必利更长的作用时间，并且可用于治疗中枢神经系统疾病。

4. 发明授权

US5331000A Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen 失效
标题翻译：解热止痛方法和含有光学纯的R（ - ）酮洛芬的组合物
公开(公告)号：US5331000A
公开(公告)日：1994-07-19
申请号：US24728
申请日：1993-03-01
申请人： James W. Young , Nancy M. Gray , William J. Wechter
发明人： James W. Young , Nancy M. Gray , William J. Wechter
IPC分类号： A61K31/192 , A61K31/19 , A61P25/04 , A61P29/00
CPC分类号： A61K31/19
摘要： Methods and compositions are disclosed utilizing optically pure R(-) ketoprofen for the treatment of pain including, but not limited to, pain associated with toothaches, headaches, sprains, joint pain and post-surgical pain, for example dental pain and ophthalmic pain, while substantially reducing adverse effects including, but not limited to, gastrointestinal, renal and hepatic toxicities, and leukopenia, which are associated with the administration of racemic ketoprofen. Optically pure R(-) ketoprofen is also useful in treating pyrexia while substantially reducing the adverse effects associated with the administration of racemic ketoprofen.
摘要翻译：公开了使用光学纯的R（ - ）酮洛芬用于治疗疼痛的方法和组合物，包括但不限于与牙痛，头痛，扭伤，关节疼痛和手术后疼痛相关的疼痛，例如牙痛和眼痛，同时显着降低与外消旋酮洛芬的施用相关的不良反应，包括但不限于胃肠道，肾脏和肝脏毒性以及白细胞减少。光学纯的R（ - ）酮洛芬也可用于治疗发热，同时显着减少与外消旋酮洛芬的给药相关的不良反应。

5. 发明授权

US5955478A Methods for treating gastrointestinal motility dysfunction using optically pure (+) cisapride 失效
标题翻译：使用光学纯（+）西沙必利治疗胃肠蠕动功能障碍的方法
公开(公告)号：US5955478A
公开(公告)日：1999-09-21
申请号：US754657
申请日：1996-11-21
申请人： Nancy M. Gray , James W. Young
发明人： Nancy M. Gray , James W. Young
IPC分类号： C07D211/62 , A61K31/445 , A61K31/4468 , A61P1/00 , A61P1/08 , A61P1/10 , A61P1/14
CPC分类号： A61K31/445 , A61K31/4468
摘要： Methods are disclosed utilizing the optically pure (+) isomer of cisapride. The optically pure (+) isomer of cisapride is useful for the treatment of dyspepsia and such other conditions as may be related to the activity of (+) cisapride as a prokinetic agent, such as gastroparesis, constipation, post-operative operative ileus, and intestinal pseudo-obstruction, without the concomitant liability of adverse effects associated with the racemic mixture of cisapride. The (+) isomer of cisapride also exhibits longer duration of action than does racemic cisapride and is useful for treatment of disorders of the central nervous system.
摘要翻译：公开利用西沙必利的光学纯（+）异构体的方法。西沙必利的光学纯（+）异构体可用于治疗消化不良和其他可能与（+）西沙必利作为促动力剂的活性相关的其它病症，如胃轻瘫，便秘，手术后肠梗阻和肠假性梗阻，没有与西沙必利的外消旋混合物相关的副作用的伴随的责任。西沙必利的（+）异构体也表现出比外消旋西沙必利更长的作用时间，并且可用于治疗中枢神经系统疾病。

6. 发明授权

US5629328A Methods for treating gastro-esophageal reflux disease and other disorders associated with the digestive tract using optically pure (+) cisapride 失效
标题翻译：使用光学纯（+）西沙必利治疗胃食管反流病和与消化道相关的其他疾病的方法
公开(公告)号：US5629328A
公开(公告)日：1997-05-13
申请号：US135769
申请日：1993-10-12
申请人： Nancy M. Gray , James W. Young
发明人： Nancy M. Gray , James W. Young
IPC分类号： C07D211/62 , A61K31/445 , A61K31/4468 , A61P1/00 , A61P1/08 , A61P1/10 , A61P1/14
CPC分类号： A61K31/445 , A61K31/4468
摘要： Methods are disclosed utilizing the optically pure (+) isomer of cisapride. This compound is useful in treating emesis while substantially reducing adverse effects associated with racemic cisapride.
摘要翻译：公开利用西沙必利的光学纯（+）异构体的方法。该化合物可用于治疗呕吐，同时显着降低与西西沙必利素有关的不良反应。

7. 发明授权

US5618828A Methods for treating gastro-esophageal reflux disease and emesis with optically pure (-) cisapride 失效
标题翻译：用光学纯（ - ）西沙必利治疗胃食管反流病和呕吐的方法
公开(公告)号：US5618828A
公开(公告)日：1997-04-08
申请号：US135776
申请日：1993-10-12
申请人： Nancy M. Gray , James W. Young
发明人： Nancy M. Gray , James W. Young
IPC分类号： C07D211/62 , A61K31/445 , A61K31/4468 , A61P1/00 , A61P1/08 , A61P1/10 , A61P1/14
CPC分类号： A61K31/445 , A61K31/4468
摘要： Methods are disclosed utilizing the optically pure (-) isomer of cisapride. This compound is a potent drug for the treatment of gastro-esophageal reflux disease while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of cisapride. This compound is also useful in treating or preventing emesis while substantially reducing adverse effects associated with racemic cisapride.
摘要翻译：公开利用西沙必利的光学纯（ - ）异构体的方法。该化合物是用于治疗胃食管反流疾病的有效药物，同时显着减少与西沙必利的外消旋混合物相关的副作用的伴随的责任。该化合物也可用于治疗或预防呕吐，同时显着降低与西西沙必利素有关的不良反应。

8. 发明授权

US6069154A Methods for treating gastro-esophageal reflux disease using optically pure (+) cisapride 失效
标题翻译：使用光学纯（+）西沙必利治疗胃食管反流病的方法
公开(公告)号：US6069154A
公开(公告)日：2000-05-30
申请号：US336602
申请日：1999-06-21
申请人： Nancy M. Gray , James W. Young
发明人： Nancy M. Gray , James W. Young
IPC分类号： C07D211/62 , A61K31/445 , A61K31/4468 , A61P1/00 , A61P1/08 , A61P1/10 , A61P1/14
CPC分类号： A61K31/445 , A61K31/4468
摘要： Methods are disclosed utilizing the optically pure (+) isomer of cisapride. This compound is a potent drug for the treatment of gastro-esophageal reflux disease while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of cisapride.
摘要翻译：公开利用西沙必利的光学纯（+）异构体的方法。该化合物是用于治疗胃食管反流疾病的有效药物，同时显着减少与西沙必利的外消旋混合物相关的副作用的伴随的责任。

9. 发明授权

US5561151A Antipyretic and analgesic methods of using optically pure R-etodolac 失效
标题翻译：使用光学纯的R-乙哚乙酸的解热镇痛方法
公开(公告)号：US5561151A
公开(公告)日：1996-10-01
申请号：US368735
申请日：1995-01-04
申请人： James W. Young , Nancy M. Gray , William J. Wechter
发明人： James W. Young , Nancy M. Gray , William J. Wechter
IPC分类号： C07D491/052 , A61K31/40 , A61P25/04
CPC分类号： A61K31/40
摘要： Methods are disclosed utilizing optically pure R(-) etodolac for the treatment of pain, including but not limited to pain associated with toothaches, headaches, sprains, joint pain and surgical pain, for example dental pain and ophthalmic pain, while substantially reducing adverse effects which are associated with the administration of the racemic mixture of etodolac. The optically pure R(-) etodolac is also useful in treating pyrexia while substantially reducing the adverse effects associated with the administration of the racemic mixture of etodolac.
摘要翻译：公开了利用光学纯的R（ - ）依托度酸治疗疼痛的方法，包括但不限于与牙痛，头痛，扭伤，关节疼痛和手术疼痛相关的疼痛，例如牙痛和眼痛，同时显着降低不良反应其与依托度酸的外消旋混合物的施用相关联。光学纯的R（ - ）依托度酸也可用于治疗发热，同时显着减少与依托度酸的外消旋混合物的施用相关的不利影响。

10. 发明授权

US5492933A Methods and compositions for treating urinary incontinence and other disorders using optically pure R-terodiline and hydroxylated derivatives thereof 失效
标题翻译：使用光学纯的罗非二胺及其羟基化衍生物治疗尿失禁和其他疾病的方法和组合物
公开(公告)号：US5492933A
公开(公告)日：1996-02-20
申请号：US134271
申请日：1993-10-08
申请人： Nancy M. Gray , James W. Young
发明人： Nancy M. Gray , James W. Young
IPC分类号： A61K31/135
CPC分类号： A61K31/135
摘要： Methods and compositions are disclosed utilizing the optically pure R-isomers of terodiline or of the hydroxylated derivatives of terodiline, These compounds are potent drugs for the treatment of urinary incontinence, obstructive pulmonary disease and such other conditions as are related to the compounds' activity as anticholinergic agents.
摘要翻译：公开的方法和组合物利用了具有光学纯的异噻唑啉的R-异构体或三苯胺的羟基化衍生物。这些化合物是用于治疗尿失禁，阻塞性肺疾病和与化合物活性相关的其它病症的有效药物抗胆碱剂。

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