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1. 发明申请

US20090049180A1 GATEWAY APPARATUS 审中-公开
标题翻译：网关设备
公开(公告)号：US20090049180A1
公开(公告)日：2009-02-19
申请号：US12184352
申请日：2008-08-01
申请人： Nami EI , Hirofumi Masukawa , Hitoshi Yoshida , Kazuma Yumoto
发明人： Nami EI , Hirofumi Masukawa , Hitoshi Yoshida , Kazuma Yumoto
IPC分类号： G06F15/16
CPC分类号： H04L67/14 , H04L67/02 , H04L67/28
摘要： Even when all of usable sessions are in use, a communication can be established for a new session and the interrupted session is automatically restored. Information on degrees of importance of communication sessions and information of restoration requirement are set in advance and stored in a session importance table in association with identifier (URI) of communication initiating terminals and identifier of destinations of communication. When a connection request for a session having a high degree of importance such as an emergency session is received, the session having the lowest degree of importance is selected and interrupted. Information of the interrupted session such as the communication initiator identifier and the communication destination identifier is stored in a session restoration table. The session is automatically restored as soon as a session resource becomes unoccupied according to the communication initiator identifier and the communication destination identifier stored in the session restoration table.
摘要翻译：即使所有可用会话都在使用中，可以为新会话建立通信，并且中断的会话被自动恢复。与通信发起终端的标识符（URI）和通信目的地的标识符相关联地，预先设置关于通信会话的重要性和恢复要求的信息的信息，并存储在会话重要性表中。当接收到诸如紧急会话之类的具有高度重要性的会话的连接请求时，选择和中断具有最低重要度的会话。诸如通信发起者标识符和通信目的地标识符的中断会话的信息被存储在会话恢复表中。一旦会话资源根据通信发起者标识符和存储在会话恢复表中的通信目的地标识符未被占用，会话被自动恢复。

2. 发明授权

US08027246B2 Network system and node apparatus 失效
标题翻译：网络系统和节点设备
公开(公告)号：US08027246B2
公开(公告)日：2011-09-27
申请号：US12071266
申请日：2008-02-19
申请人： Kazuma Yumoto , Hirofumi Masukawa , Hitoshi Yoshida , Kazuhiro Kusama , Takuro Mori
发明人： Kazuma Yumoto , Hirofumi Masukawa , Hitoshi Yoshida , Kazuhiro Kusama , Takuro Mori
IPC分类号： H04J3/14
CPC分类号： H04L43/0811 , H04L45/22 , H04L45/245 , H04L45/28 , H04L69/40 , Y02D50/30
摘要： A failure detection protocol is applied so that failure detection requests for the same aggregated link can be processed even when the failure detection requests differ among routing protocols. The failure detection protocol is executed for each of the physical links that form an aggregated link, and a notification is sent to a higher-level application (for example, a routing protocol), which is a requesting source of a communication line failure monitoring request, with a discrimination between a case in which the communication of the aggregated link in its entirety fails and a case in which some physical links of the aggregated link fail.
摘要翻译：应用故障检测协议，即使当路由协议中的故障检测请求不同时，也可以处理相同聚合链路的故障检测请求。为形成聚合链路的每个物理链路执行故障检测协议，并将通知发送到作为通信线路故障监视请求的请求源的更高级应用（例如，路由协议）在整体聚合链路的通信失败的情况与聚合链路的一些物理链路失败的情况之间的区分。

3. 发明申请

US20080253295A1 Network system and node apparatus 失效
标题翻译：网络系统和节点设备
公开(公告)号：US20080253295A1
公开(公告)日：2008-10-16
申请号：US12071266
申请日：2008-02-19
申请人： Kazuma Yumoto , Hirofumi Masukawa , Hitoshi Yoshida , Kazuhiro Kusama , Takuro Mori
发明人： Kazuma Yumoto , Hirofumi Masukawa , Hitoshi Yoshida , Kazuhiro Kusama , Takuro Mori
IPC分类号： G01R31/08
CPC分类号： H04L43/0811 , H04L45/22 , H04L45/245 , H04L45/28 , H04L69/40 , Y02D50/30
摘要： A failure detection protocol is applied so that failure detection requests for the same aggregated link can be processed even when the failure detection requests differ among routing protocols. The failure detection protocol is executed for each of the physical links that form an aggregated link, and a notification is sent to a higher-level application (for example, a routing protocol), which is a requesting source of a communication line failure monitoring request, with a discrimination between a case in which the communication of the aggregated link in its entirety fails and a case in which some physical links of the aggregated link fail.
摘要翻译：应用故障检测协议，即使当路由协议中的故障检测请求不同时，也可以处理相同聚合链路的故障检测请求。为形成聚合链路的每个物理链路执行故障检测协议，并将通知发送到作为通信线路故障监视请求的请求源的更高级应用（例如，路由协议）在整体聚合链路的通信失败的情况与聚合链路的一些物理链路失败的情况之间的区分。

4. 发明申请

US20080225731A1 NETWORK SYSTEM, NODE DEVICE AND MANAGEMENT SERVER 失效
标题翻译：网络系统，节点设备和管理服务器
公开(公告)号：US20080225731A1
公开(公告)日：2008-09-18
申请号：US11964210
申请日：2007-12-26
申请人： Takuro Mori , Kazuma Yumoto , Hitoshi Yoshida
发明人： Takuro Mori , Kazuma Yumoto , Hitoshi Yoshida
IPC分类号： G06F11/00
CPC分类号： H04L47/10 , H04L47/11 , H04L47/283
摘要： Erroneous detection of a failure in spite of the absence of failure on the route on account of a communication delay is to be prevented. A node device detects a failure on the route to a remote node device is detected by a failure to receive a packet from the remote node device after the elapse of a determined detection time. The node device sets “remote system transmission interval x detection multiplier” to be a first detecting time on the basis of a packet transmission interval determined by negotiation with the remote node device. It also sets the sum of “remote system actual transmission interval x detection multiplier” and “tolerable delay time” to be a second detecting time. The first detecting time and the second detecting time are compared, and what is longer is determined as the detecting time to be applied to actual operation.
摘要翻译：考虑到由于通信延迟而导致路由不存在故障，故障的错误检测是可以防止的。在经过确定的检测时间之后，通过从远程节点设备接收到分组的故障来检测节点设备检测到到远程节点设备的路由的故障。基于通过与远程节点设备协商确定的分组传输间隔，节点设备将“远程系统传输间隔x检测乘数”设置为第一检测时间。它还将“远程系统实际传输间隔x检测乘数”和“容忍延迟时间”的和设置为第二检测时间。比较第一检测时间和第二检测时间，将更长的时间确定为要应用于实际操作的检测时间。

5. 发明授权

US07801051B2 Network system, node device and management server 失效
标题翻译：网络系统，节点设备和管理服务器
公开(公告)号：US07801051B2
公开(公告)日：2010-09-21
申请号：US11964210
申请日：2007-12-26
申请人： Takuro Mori , Kazuma Yumoto , Hitoshi Yoshida
发明人： Takuro Mori , Kazuma Yumoto , Hitoshi Yoshida
IPC分类号： H04J3/14 , G06F11/00
CPC分类号： H04L47/10 , H04L47/11 , H04L47/283
摘要： Erroneous detection of a failure in spite of the absence of failure on the route on account of a communication delay is to be prevented. A node device detects a failure on the route to a remote node device is detected by a failure to receive a packet from the remote node device after the elapse of a determined detection time. The node device sets “remote system transmission interval×detection multiplier” to be a first detecting time on the basis of a packet transmission interval determined by negotiation with the remote node device. It also sets the sum of “remote system actual transmission interval ×detection multiplier” and “tolerable delay time” to be a second detecting time. The first detecting time and the second detecting time are compared, and what is longer is determined as the detecting time to be applied to actual operation.
摘要翻译：考虑到由于通信延迟而导致路由不存在故障，故障的错误检测是可以防止的。在经过确定的检测时间之后，通过从远程节点设备接收到分组的故障来检测节点设备检测到到远程节点设备的路由的故障。节点设备基于通过与远程节点设备协商确定的分组传输间隔将“远程系统传输间隔×检测乘数”设置为第一检测时间。它还将“远程系统实际发送间隔×检测乘数”和“可容忍延迟时间”的和设置为第二检测时间。比较第一检测时间和第二检测时间，将更长的时间确定为要应用于实际操作的检测时间。

6. 发明授权

US08124406B2 Method for modifying chromosomes 有权
标题翻译：染色体修饰方法
公开(公告)号：US08124406B2
公开(公告)日：2012-02-28
申请号：US12979823
申请日：2010-12-28
申请人： Kazuma Tomizuka , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida , Yoshimi Kuroiwa
发明人： Kazuma Tomizuka , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida , Yoshimi Kuroiwa
IPC分类号： C12N5/00 , C12N5/02 , C12N15/01 , C12N15/64 , C07H21/04
CPC分类号： A01K67/0275 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C12N15/85 , C12N15/8509 , C12N15/873 , C12N15/90 , C12N15/907 , C12N2800/30
摘要： The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof.
摘要翻译：本发明涉及一种生产修饰的外源染色体或其片段的方法，其包括以下步骤：（a）制备包含外来染色体或其片段的微细胞并通过与所述微细胞融合将所述外源染色体或片段转移到具有高同源重组效率的细胞中; （b）在具有高同源重组效率的所述细胞中，通过同源重组将靶向载体插入所述外源染色体或其片段的所需位点和/或染色体的所需位点，衍生自具有高同源重组效率的所述细胞，从而标记所述期望的位点; 和（c）在具有高同源重组效率的所述细胞中，导致在所述外源染色体或其片段的标记位点发生缺失和/或易位。

7. 发明授权

US08110671B2 Isolated human chromosome 14 fragment encoding immunoglobulin genes 有权
标题翻译：分离的人染色体14片段编码免疫球蛋白基因
公开(公告)号：US08110671B2
公开(公告)日：2012-02-07
申请号：US11797904
申请日：2007-05-08
申请人： Kazuma Tomizuka , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida
发明人： Kazuma Tomizuka , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida
IPC分类号： C07H21/04
CPC分类号： A01K67/0275 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C07K16/00 , C07K16/18 , C07K2317/21 , C12N15/8509 , C12N15/90 , C12N2517/02 , C12N2800/30
摘要： The specification relates to a method for producing a chimeric non-human animal, which comprises preparing a microcell containing a foreign chromosome(s) or a fragment(s) thereof and transferring the foreign chromosome(s) or fragment(s) thereof into a pluripotent cell by fusion with the microcell; a chimeric non-human animal which can be produced by the above method and its progeny; tissues and cells derived therefrom; and a method for using the same. Further, a pluripotent cell containing a foreign chromosome(s) or a fragment(s) thereof, a method for producing the same, and a method for using the same are also provided. Moreover, a pluripotent cell in which at least two endogenous genes are disrupted, and a method for producing the same by homologous recombination are provided.
摘要翻译：本说明书涉及嵌合非人动物的制造方法，其包括制备含有外来染色体或其片段的微细胞，并将其外来的染色体或片段转移到多细胞与微细胞融合; 可以通过上述方法及其后代产生的嵌合非人动物; 从其衍生的组织和细胞; 及其使用方法。此外，还提供了含有外来染色体或其片段的多能细胞，其制备方法及其使用方法。此外，提供其中至少两个内源基因被破坏的多能细胞，以及通过同源重组产生其的方法。

8. 发明授权

US07476536B2 Artificial human chromosome containing human antibody a light chain gene 有权
标题翻译：含有人抗体的人造人染色体为轻链基因
公开(公告)号：US07476536B2
公开(公告)日：2009-01-13
申请号：US10477471
申请日：2002-05-10
申请人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
发明人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
IPC分类号： C12N15/63 , C12N21/02 , C12N15/00
CPC分类号： A01K67/0278 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/052 , A01K2217/054 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A01K2267/0381 , A61K48/00 , A61K2039/505 , C07K16/00 , C07K16/243 , C07K2317/21 , C12N15/8509 , C12N15/87 , C12N15/90 , C12N2800/30
摘要： The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the non-human animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
摘要翻译：本发明涉及一种以高效率遗传传播到下一代的人类人造染色体及其使用方法。更具体地，本发明涉及：人类人造染色体，其中含有源自人染色体22的抗体λ轻链基因的约3.5Mb至约1Mb区域与染色体片段结合，所述染色体片段可通过生殖系的非人类动物，所述染色体片段衍生自另一个人染色体; 携带人类人造染色体的非人类动物及其后代; 一种生产非人动物的方法; 使用非人动物或其后代生产人抗体的方法; 和携带人类人造染色体的人抗体生产小鼠。

9. 发明申请

US20090007282A1 METHOD FOR MODIFYING CHROMOSOMES 有权
标题翻译：修饰色素的方法
公开(公告)号：US20090007282A1
公开(公告)日：2009-01-01
申请号：US12116294
申请日：2008-05-07
申请人： Kazuma TOMIZUKA , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida , Yoshimi Kuroiwa
发明人： Kazuma TOMIZUKA , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida , Yoshimi Kuroiwa
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C12N15/85 , C12N15/8509 , C12N15/873 , C12N15/90 , C12N15/907 , C12N2800/30
摘要： The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof.
摘要翻译：本发明涉及一种生产修饰的外源染色体或其片段的方法，其包括以下步骤：（a）制备包含外来染色体或其片段的微细胞并通过与所述微细胞融合将所述外源染色体或片段转移到具有高同源重组效率的细胞中; （b）在具有高同源重组效率的所述细胞中，通过同源重组将靶向载体插入所述外源染色体或其片段的所需位点和/或染色体的所需位点，衍生自具有高同源重组效率的所述细胞，从而标记所述期望的位点; 和（c）在具有高同源重组效率的所述细胞中，导致在所述外源染色体或其片段的标记位点发生缺失和/或易位。

10. 发明申请

US20080317743A1 Human Artificial Chromosome Containing Human Antibody Lambda Light Chain Gene And Non-Human Animal Containing The Human Artificial Chromosome Capable Of Genetic Transmission 有权
标题翻译：含人源性人类染色体的人类抗体λ轻链基因和含有能够进行遗传传播的人类人造染色体的非人动物
公开(公告)号：US20080317743A1
公开(公告)日：2008-12-25
申请号：US12140009
申请日：2008-06-16
申请人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
发明人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
IPC分类号： A61K39/395 , A01K67/027 , C12P21/08
CPC分类号： A01K67/0278 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/052 , A01K2217/054 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A01K2267/0381 , A61K48/00 , A61K2039/505 , C07K16/00 , C07K16/243 , C07K2317/21 , C12N15/8509 , C12N15/87 , C12N15/90 , C12N2800/30
摘要： The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
摘要翻译：本发明涉及一种以高效率遗传传播到下一代的人类人造染色体及其使用方法。更具体地，本发明涉及：人类人造染色体，其中含有源自人染色体22的抗体λ轻链基因的约3.5Mb至约1Mb区域与染色体片段结合，所述染色体片段可通过生殖系的非人类动物，所述染色体片段衍生自另一个人染色体; 携带人类人造染色体的非人类动物及其后代; 一种生产非人动物的方法; 使用非人动物或其后代生产人抗体的方法; 和携带人类人造染色体的人抗体生产小鼠。

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