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1. 发明授权

US08759400B2 Histone deacetylase inhibitors for enhancing activity of antifungal agents 失效
标题翻译：组蛋白脱乙酰酶抑制剂，用于增强抗真菌剂的活性
公开(公告)号：US08759400B2
公开(公告)日：2014-06-24
申请号：US11641615
申请日：2006-12-19
申请人： Nafsika Georgopapadakou , Wenqi Hu , Nadia Campeol , Jean Bedard , Robert Deziel , Alain Ajamian
发明人： Nafsika Georgopapadakou , Wenqi Hu , Nadia Campeol , Jean Bedard , Robert Deziel , Alain Ajamian
IPC分类号： A01N37/18 , A61K31/165 , A61K31/16 , A61K31/497 , A01N43/40 , A61K31/44 , A01N43/64 , A61K31/41 , A01N43/52 , A61K31/415
CPC分类号： C07C259/06 , A01N43/653 , A01N43/84 , A61K31/165 , A61K31/166 , A61K31/19 , A61K31/35 , A61K31/351 , A61K31/404 , A61K31/4196 , A61K31/496 , A61K31/506 , A61K45/06 , A01N37/28 , A01N43/16 , A01N43/38 , A01N61/00 , A01N2300/00 , A61K2300/00
摘要： The present invention relates to compositions and methods to selectively treat fungal infection. More particularly, this invention relates to compositions and methods for selectively enhancing fungal sensitivity to antifungal compounds.
摘要翻译：本发明涉及选择性处理真菌感染的组合物和方法。更具体地说，本发明涉及用于选择性提高对真菌化合物的真菌敏感性的组合物和方法。

2. 发明申请

US20070197550A1 Histone deacetylase inhibitors for enhancing activity of antifungal agents 失效
标题翻译：组蛋白脱乙酰酶抑制剂，用于增强抗真菌剂的活性
公开(公告)号：US20070197550A1
公开(公告)日：2007-08-23
申请号：US11641615
申请日：2006-12-19
申请人： Nafsika Georgopapadakou , Wenqi Hu , Nadia Campeol , Jean Bedard , Robert Deziel , Alain Ajamian
发明人： Nafsika Georgopapadakou , Wenqi Hu , Nadia Campeol , Jean Bedard , Robert Deziel , Alain Ajamian
IPC分类号： A61K31/496 , A61K31/404 , A61K31/35 , A61K31/19 , C07C259/04
CPC分类号： C07C259/06 , A01N43/653 , A01N43/84 , A61K31/165 , A61K31/166 , A61K31/19 , A61K31/35 , A61K31/351 , A61K31/404 , A61K31/4196 , A61K31/496 , A61K31/506 , A61K45/06 , A01N37/28 , A01N43/16 , A01N43/38 , A01N61/00 , A01N2300/00 , A61K2300/00
摘要： The present invention relates to compositions and methods to selectively treat fungal infection. More particularly, this invention relates to compositions and methods for selectively enhancing fungal sensitivity to antifungal compounds.
摘要翻译：本发明涉及选择性处理真菌感染的组合物和方法。更具体地说，本发明涉及用于选择性提高对真菌化合物的真菌敏感性的组合物和方法。

4. 发明授权

US07985769B2 Compounds and methods for the treatment or prevention of Flavivirus infections 失效
标题翻译：用于治疗或预防黄病毒感染的化合物和方法
公开(公告)号：US07985769B2
公开(公告)日：2011-07-26
申请号：US11042442
申请日：2005-01-26
申请人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Kumar Das , Nghe Nguyen Ba , Oswy Z. Pereira , Thumkunta Jagadeeswar Reddy , Mohammad Arshad Siddiqui , Wuyi Wang , Constanin Yannopoulos
发明人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Kumar Das , Nghe Nguyen Ba , Oswy Z. Pereira , Thumkunta Jagadeeswar Reddy , Mohammad Arshad Siddiqui , Wuyi Wang , Constanin Yannopoulos
IPC分类号： A61K31/35 , C07D333/38 , C07D333/36
CPC分类号： C07D409/04 , A61K31/20 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/426 , A61K45/06 , C07D333/38 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/14 , C07D471/10 , C07D495/04
摘要： The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.
摘要翻译：本发明提供由式I表示的新化合物：或其药学上可接受的盐，用于治疗黄病毒科病毒感染。

5. 发明授权

US08329924B2 Compounds and methods for the treatment or prevention of Flavivirus infections 失效
标题翻译：用于治疗或预防黄病毒感染的化合物和方法
公开(公告)号：US08329924B2
公开(公告)日：2012-12-11
申请号：US13081780
申请日：2011-04-07
申请人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Kumar Das , Nghe Nguyen-Ba , Oswy Z. Pereira , Thumkunta Jagadeeswar Reddy , Mohammad Arshad Siddiqui , Wuyi Wang , Constantin G. Yannopoulos
发明人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Kumar Das , Nghe Nguyen-Ba , Oswy Z. Pereira , Thumkunta Jagadeeswar Reddy , Mohammad Arshad Siddiqui , Wuyi Wang , Constantin G. Yannopoulos
IPC分类号： C07D409/00 , C07D333/42
CPC分类号： C07D333/40 , A61K31/381 , A61K45/06 , C07D333/38 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/14 , C07D471/10 , C07D495/04
摘要： The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.
摘要翻译：本发明提供由式I表示的新化合物：或其药学上可接受的盐，用于治疗黄病毒科病毒感染。

6. 发明申请

US20110200553A1 COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS 失效
标题翻译：用于治疗或预防FLAVIVIRUSUS感染的化合物和方法
公开(公告)号：US20110200553A1
公开(公告)日：2011-08-18
申请号：US13081780
申请日：2011-04-07
申请人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Kumar Das , Nghe Nguyen Ba , Oswy Z. Pereira , Thumkunta Jagadeeswar Reddy , Mohammed Arshad Siddiqui , Wuyi Wang , Constanin G. Yannopoulos
发明人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Kumar Das , Nghe Nguyen Ba , Oswy Z. Pereira , Thumkunta Jagadeeswar Reddy , Mohammed Arshad Siddiqui , Wuyi Wang , Constanin G. Yannopoulos
IPC分类号： A61K31/381 , C07D333/36 , C07D409/12 , A61K31/4535 , A61K31/438 , A61K31/496 , A61K31/55 , A61K38/21 , A61K31/7056 , A61K38/20 , A61K38/13 , A61P31/12
CPC分类号： C07D333/40 , A61K31/381 , A61K45/06 , C07D333/38 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/14 , C07D471/10 , C07D495/04
摘要： The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.
摘要翻译：本发明提供由式I表示的新化合物：或其药学上可接受的盐，用于治疗黄病毒科病毒感染。

7. 发明申请

US20130123242A1 COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS 审中-公开
标题翻译：用于治疗或预防FLAVIVIRUSUS感染的化合物和方法
公开(公告)号：US20130123242A1
公开(公告)日：2013-05-16
申请号：US13661508
申请日：2012-10-26
申请人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Kumar Das , Nghe Nguyen-Ba , Oswy Z. Pereira , Thumkunta Jagadeeswar Reddy , Mohammad Arshad Siddiqui , Wuyi Wang , Constantin G. Yannopoulos
发明人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Kumar Das , Nghe Nguyen-Ba , Oswy Z. Pereira , Thumkunta Jagadeeswar Reddy , Mohammad Arshad Siddiqui , Wuyi Wang , Constantin G. Yannopoulos
IPC分类号： C07D333/40 , C07D409/14 , C07D417/12 , C07D409/04 , C07D409/10 , C07D417/04 , C07D409/12 , C07D471/10
CPC分类号： C07D333/40 , A61K31/381 , A61K45/06 , C07D333/38 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/14 , C07D471/10 , C07D495/04
摘要： The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.
摘要翻译：本发明提供由式I表示的新化合物：或其药学上可接受的盐，用于治疗黄病毒科病毒感染。

8. 发明授权

US5199359A Steerable rail-bogie 失效
标题翻译：导轨转向架
公开(公告)号：US5199359A
公开(公告)日：1993-04-06
申请号：US885785
申请日：1992-05-20
申请人： Jean Bedard , Jacques Viens
发明人： Jean Bedard , Jacques Viens
IPC分类号： B61F5/44
CPC分类号： B61F5/44
摘要： A twin-axle rail-bogie which incorporates a steering mechanism for positively steering one or both of the axles of the rail-bogie in proportion to the rotation of the frame of a structure supported by this rail-bogie. Steering is achieved by slidably mounting one of the axle end supporting assemblies onto the chassis of the bogie so that this assembly is longitudinally slidable and thus causes the one axle having one of its ends connected thereto to pivot forwards or rearwards out of its normal transverse position relative to the transversally opposite supporting assembly which holds the other end of the one axle and then acts as a pivot. An operating arm attached to the frame near the one supporting assembly is used for moving via a linking mechanism the one supporting assembly in such a direction as to cause the one axle held by this supporting assembly to pivot in the same direction but at an angle smaller than and proportional to the frame with respect to the chassis of the bogie.
摘要翻译：一种双轴轨道转向架，其包括转向机构，用于与由该轨道转向架支撑的结构的框架的旋转成比例地积极地转向轨道转向架的一个或两个轴。通过将轴端支撑组件中的一个可滑动地安装到转向架的底架上来实现转向，使得该组件可纵向滑动，并且因此使得其一端连接到其上的一个轴线向前或向后枢转到其正常的横向位置相对于横向相对的支撑组件，其保持一个轴的另一端，然后用作枢轴。附接到框架靠近一个支撑组件的操作臂用于通过连接机构移动一个支撑组件，使得该支撑组件保持的一个轴沿相同方向枢转，但是以相对较小的角度与框架相对于转向架的底盘成比例。

9. 发明申请

US20060142347A1 Compounds and methods for the treatment or prevention of Flavivirus infections 失效
标题翻译：用于治疗或预防黄病毒感染的化合物和方法
公开(公告)号：US20060142347A1
公开(公告)日：2006-06-29
申请号：US11042442
申请日：2005-01-26
申请人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Das , Nghe Nguyen Ba , Oswy Pereira , Thumkunta Reddy , Mohammad Siddiqui , Wuyi Wang , Constanin Yannopoulos
发明人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Das , Nghe Nguyen Ba , Oswy Pereira , Thumkunta Reddy , Mohammad Siddiqui , Wuyi Wang , Constanin Yannopoulos
IPC分类号： A61K31/4436 , A61K31/42 , A61K31/381 , C07D409/02 , C07D413/02
CPC分类号： C07D409/04 , A61K31/20 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/426 , A61K45/06 , C07D333/38 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/14 , C07D471/10 , C07D495/04
摘要： The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.
摘要翻译：本发明提供由式I表示的新化合物：或其药学上可接受的盐，用于治疗黄病毒科病毒感染。

10. 发明授权

US06881741B2 Compounds and methods for the treatment or prevention of Flavivirus infections 失效
标题翻译：用于治疗或预防黄病毒感染的化合物和方法
公开(公告)号：US06881741B2
公开(公告)日：2005-04-19
申请号：US10166031
申请日：2002-06-11
申请人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Kumar Das , Nghe Nguyen Ba , Oswy Z. Pereira , Thumkunta Jagadeeswar Reddy , Mohammad Arshad Siddiqui , Wuyi Wang , Constanin Yannopoulos
发明人： Laval Chan Chun Kong , Jean Bedard , Sanjoy Kumar Das , Nghe Nguyen Ba , Oswy Z. Pereira , Thumkunta Jagadeeswar Reddy , Mohammad Arshad Siddiqui , Wuyi Wang , Constanin Yannopoulos
IPC分类号： C07D333/40 , A61K31/20 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/42 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/4436 , A61K31/4535 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/55 , A61K45/00 , A61K45/06 , A61P1/16 , A61P31/12 , C07D333/38 , C07D333/62 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/14 , C07D471/10 , C07D495/04 , C07F7/10 , A61K31/44 , A61K31/38 , C07D211/70 , C07D333/36 , C07D401/00
CPC分类号： C07D409/04 , A61K31/20 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/426 , A61K45/06 , C07D333/38 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/14 , C07D471/10 , C07D495/04
摘要： The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.
摘要翻译：本发明提供由式I表示的新化合物：或其药学上可接受的盐，用于治疗黄病毒科病毒感染。

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