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    • 4. 发明申请
    • Systems and methods for cutting materials
    • 切割材料的系统和方法
    • US20120132313A1
    • 2012-05-31
    • US11895557
    • 2007-08-24
    • Anubha BhatlaAlessio SalernoNabil SimaanY. Lawrence YaoGerhard Randers-PehrsonGuy Y. GartyAparajita DuttaDavid J. Brenner
    • Anubha BhatlaAlessio SalernoNabil SimaanY. Lawrence YaoGerhard Randers-PehrsonGuy Y. GartyAparajita DuttaDavid J. Brenner
    • B65B3/26
    • C40B30/10C40B60/12
    • Systems and methods for cutting materials are disclosed herein In some embodiments, methods of at least partially severing a capillary vessel can include: focusing a laser on a predetermined point on the capillary vessel, said capillary vessel containing a biological sample; and cutting the capillary vessel using a laser at the predetermined point. In some embodiments, the methods further can include capturing an image of the capillary vessel and analyzing the image to determine the predetermined point. In some embodiments, a beam of the laser can be moved using one or more galvanometric mirrors. In some embodiments, the methods further can include cutting a plurality of capillary vessels using the laser. In some embodiments, the methods can include utilizing a plurality of lasers, and/or further can include rotating the capillary vessel while the laser can be cutting the capillary vessel. In some embodiments, cutting the capillary vessel can include cutting only a portion of the capillary vessel.
    • 用于切割材料的系统和方法在一些实施例中,至少部分地切断毛细管的方法可以包括:将激光聚焦在毛细血管上的预定点上,所述毛细血管容纳生物样品; 以及在预定点处使用激光切割毛细血管。 在一些实施例中,所述方法还可包括捕获毛细管血管的图像并分析图像以确定预定点。 在一些实施例中,可以使用一个或多个电流计反射镜移动激光束。 在一些实施例中,所述方法还可包括使用所述激光切割多个毛细血管。 在一些实施例中,该方法可以包括利用多个激光器,和/或还可以包括旋转毛细血管,同时激光器可以切割毛细血管。 在一些实施例中,切割毛细血管可包括仅切割毛细血管的一部分。
    • 5. 发明申请
    • ELECTRODE ARRAYS AND SYSTEMS FOR INSERTING SAME
    • 电极阵列及其插入系统
    • US20120109274A1
    • 2012-05-03
    • US13347041
    • 2012-01-10
    • Nabil SimaanSpiros Manolidis
    • Nabil SimaanSpiros Manolidis
    • A61F11/04A61N1/05
    • A61N1/0541B33Y80/00
    • Electrode arrays and systems for inserting same are disclosed. In some embodiments, electrode arrays are provided, the electrode arrays comprising: a passive-bending portion; an active-bending portion coupled to the passive bending portion; a plurality of electrodes located in at least one of the passive-bending portion and the active bending portion; and an actuator that causes the active-bending portion to deflect from the passive-bending portion. In some embodiments, systems for inserting an electrode array in the body are provided, the systems comprising: an insertion module for controllably inserting the electrode array in the body and sensing forces applied to the electrode array; a monitor for providing information to a user; and a controller coupled to the insertion module and the monitor, wherein the controller causes the insertion module to control an amount of force that is applied to the electrode array.
    • 公开了用于插入其的电极阵列和系统。 在一些实施例中,提供电极阵列,电极阵列包括:被动弯曲部分; 耦合到被动弯曲部分的主动弯曲部分; 多个电极,位于被动弯曲部和主动弯曲部中的至少一个中; 以及使主动弯曲部从被动弯曲部偏转的致动器。 在一些实施例中,提供了用于在电极体内插入电极阵列的系统,所述系统包括:插入模块,用于将电极阵列可控地插入到体内并感测施加到电极阵列的力; 用于向用户提供信息的监视器; 以及耦合到所述插入模块和所述监视器的控制器,其中所述控制器使所述插入模块控制施加到所述电极阵列的力的量。
    • 10. 发明授权
    • Systems and methods for high-throughput radiation biodosimetry
    • 用于高通量辐射生物测定法的系统和方法
    • US07822249B2
    • 2010-10-26
    • US11895417
    • 2007-08-24
    • Guy GartyDavid J. BrennerGerhard Randers-PehrsonY. Lawrence YaoNabil SimaanAlessio SalernoAnubha BhatlaJian ZhangOleksandra V. LyulkoAparajita Dutta
    • Guy GartyDavid J. BrennerGerhard Randers-PehrsonY. Lawrence YaoNabil SimaanAlessio SalernoAnubha BhatlaJian ZhangOleksandra V. LyulkoAparajita Dutta
    • G06K9/00
    • C40B30/10C40B60/12
    • Systems and methods for high-throughput radiation biodosimetry are disclosed herein. In some embodiments, a high-throughput methods of analyzing a population for radiation exposure can include, in various possible sequences: marking a first capillary designed to retain a first sample from the population with a first identifier; transporting a plurality of samples to a biodosimetry system; inputting the samples into the biodosimetry system; centrifuging the plurality of samples including the first sample wherein each sample can be retained in a capillary and the first sample can be retained in the first capillary; transferring the plurality of capillaries including the first capillary from the centrifuge to a cutting device using a robotic device; cutting the first capillary; reading the first identifier; transferring at least one portion of the first sample from the first capillary to a well in an array, wherein the array can include one or more filters in a multi-well plate; correlating the first identifier to a location of the array that includes the at least one portion of the first sample; one or more cycles of biological processing, which can include addition of a reagent and/or incubation of a selected temperature such as, for example, 37° C., 4° C., room temperature, and the like; sealing the array; positioning the array adjacent to an imaging element; focusing the imaging element; capturing an image of the first sample in the array; and analyzing the image to determine whether the first sample indicates a level of radiation exposure exceeding a predetermined threshold.
    • 本文公开了用于高通量辐射生物测定法的系统和方法。 在一些实施例中,用于分析用于辐射暴露的群体的高通量方法可以以各种可能的顺序包括:标记设计成用第一标识符从群体保留第一样本的第一毛细管; 将多个样品运送到生物测定系统; 将样品输入生物测定系统; 将包括第一样品的多个样品离心,其中每个样品可以保留在毛细管中,并且第一样品可以保留在第一毛细管中; 使用机器人装置将包括第一毛细管的多个毛细管从离心机转移到切割装置; 切割第一根毛细管; 阅读第一个标识符; 将所述第一样品的至少一部分从所述第一毛细管转移到阵列中的阱,其中所述阵列可以包括多孔板中的一个或多个过滤器; 将所述第一标识符与包括所述第一样本的所述至少一部分的所述阵列的位置相关联; 一个或多个生物处理循环,其可以包括添加试剂和/或选择温度的温育,例如37℃,4℃,室温等; 密封阵列; 将阵列定位成与成像元件相邻; 聚焦成像元件; 捕获阵列中第一个样本的图像; 并分析图像以确定第一样本是否指示超过预定阈值的辐射暴露水平。