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1. 发明公开

EP0815091A1 POLYAZACYCLOALKANE COMPOUNDS 失效
标题翻译：聚氮杂环烷烃化合物
公开(公告)号：EP0815091A1
公开(公告)日：1998-01-07
申请号：EP96904204.0
申请日：1996-03-01
申请人： NYCOMED IMAGING AS , COCKBAIN, Julian Roderick Michaelson
发明人： SCHULTZE, Lisa , BULLS, Alan, Ray
IPC分类号： C07D257
CPC分类号： C07D257/02
摘要： The present invention relates to tribenzylcyclen compounds of formula (I) (where R is hydrogen, or a C1-12 alkyl group optionally substituted by hydroxy, alkoxy or aryl groups or R is an amphiphilic aralkyl group comprising a N, S, O or P interrupted C2-25alkylene chain, e.g. a polyalkylene oxide chain or R provides a bridge to a second tribenzylcyclen group, but with the proviso that R is other than benzyl; X is CHR1, or where R is hydrogen two X groups may each represent CO groups; and R1 is hydrogen, a C1-6alkyl group optionally substituted by hydroxy, alkoxy or carboxy groups or an aralkyl group having 1 to 6 carbons in the alkyl moiety and optionally substituted in the aryl moiety by alkyl, alkoxy, hydroxy or isothiocyanate groups). These compounds are useful in the preparation of DO3A, N-substituted-1,4,7,10-tetraazacyclododecane-N',N',N'''-triacetic acids, and the phosphonic acid analogs.
摘要翻译：本发明涉及式（I）的三苄基环化合物（其中R为氢或任选被羟基，烷氧基或芳基取代的C 1-12烷基或R 2为包含N，S，O或P的两亲性芳烷基中断的C2-25亚烷基链，例如聚亚烷基氧链或R提供桥接到第二个三苄基环庚基，但条件是R不是苄基; X是CHR1，或其中R是氢，两个X基团可各自代表CO基团 ;并且R 1为氢，任选被羟基，烷氧基或羧基取代的C 1-6烷基或在烷基部分具有1-6个碳原子并且在芳基部分任选被烷基，烷氧基，羟基或异硫氰酸酯基团取代的芳烷基）。这些化合物可用于制备DO3A，N-取代-1,4,7,10-四氮杂环十二烷-N'，N'，N“' - 三乙酸和膦酸类似物。

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