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1. 发明申请

WO1996037461A1 IODINATION PROCESS 审中-公开
公开(公告)号：WO1996037461A1
公开(公告)日：1996-11-28
申请号：PCT/GB1996001219
申请日：1996-05-21
申请人： NYCOMED IMAGING A.S , COCKBAIN, Julian , WISTRAND, Lars-Göran , GOLMAN, Klaes , RADNER, Finn
发明人： NYCOMED IMAGING A.S , COCKBAIN, Julian
IPC分类号： C07C231/12
CPC分类号： C07C237/46 , C07C231/12
摘要： The invention provides a process for the preparation of a 2,4,6-triiodinated or 2,4,6,2',4',6'-hexaiodinated 3,5-disubstituted-aniline or 3,3'-disubstituted-5,5'-linked bisaniline, which process comprises electrochemically iodinating a 3,5-disubstituted-aniline or a 3,3'-disubstituted-5,5'-linked bisaniline in an acidic solvent which comprises water and optionally at least one water-miscible organic solvent.
摘要翻译：本发明提供了制备2,4,6-三碘代或2,4,6,2'，4'，6'-六碘化3,5-二取代苯胺或3,3'-二取代-5 5'-连接的双苯胺，该方法包括在酸性溶剂中电化学碘化3,5-二取代苯胺或3,3'-二取代-5,5'-连接的双苯胺，所述酸性溶剂包含水和任选的至少一种水 - 可混溶有机溶剂。

2. 发明申请

WO1996028433A1 POLYAZACYCLOALKANE COMPOUNDS 审中-公开
标题翻译：聚环氧烷化合物
公开(公告)号：WO1996028433A1
公开(公告)日：1996-09-19
申请号：PCT/GB1996000464
申请日：1996-03-01
申请人： NYCOMED IMAGING A.S , COCKBAIN, Julian , SCHULTZE, Lisa , BULLS, Alan, Ray
发明人： NYCOMED IMAGING A.S , COCKBAIN, Julian
IPC分类号： C07D257/02
CPC分类号： C07D257/02
摘要： The present invention relates to tribenzylcyclen compounds of formula (I) (where R is hydrogen, or a C1-12 alkyl group optionally substituted by hydroxy, alkoxy or aryl groups or R is an amphiphilic aralkyl group comprising a N, S, O or P interrupted C2-25alkylene chain, e.g. a polyalkylene oxide chain or R provides a bridge to a second tribenzylcyclen group, but with the proviso that R is other than benzyl; X is CHR1, or where R is hydrogen two X groups may each represent CO groups; and R1 is hydrogen, a C1-6alkyl group optionally substituted by hydroxy, alkoxy or carboxy groups or an aralkyl group having 1 to 6 carbons in the alkyl moiety and optionally substituted in the aryl moiety by alkyl, alkoxy, hydroxy or isothiocyanate groups). These compounds are useful in the preparation of DO3A, N-substituted-1,4,7,10-tetraazacyclododecane-N',N",N'''-triacetic acids, and the phosphonic acid analogs.
摘要翻译：本发明涉及式（I）的三苄基环化合物（其中R是氢或任选被羟基，烷氧基或芳基取代的C 1-12烷基或R是包含N，S，O或P的两亲性芳烷基间断的C2-25亚烷基链，例如聚环氧烷链或R提供到第二三苄基环系基团的桥，但条件是R不是苄基; X是CHR 1，或其中R是氢，两个X基团可以各自代表CO基团 ; R 1为氢，任选被羟基，烷氧基或羧基取代的C 1-6烷基或烷基部分中具有1至6个碳的芳烷基，并且任选地在芳基部分被烷基，烷氧基，羟基或异硫氰酸酯基取代）。这些化合物可用于制备DO3A，N-取代-1,4,7,10-四氮杂环十二烷-N'，N“，N” - 三乙酸和膦酸类似物。

3. 发明申请

WO1995026754A1 SEGMENTED CHELATING POLYMERS AS IMAGING AND THERAPEUTIC AGENTS 审中-公开
公开(公告)号：WO1995026754A1
公开(公告)日：1995-10-12
申请号：PCT/GB1995000742
申请日：1995-03-31
申请人： NYCOMED IMAGING A.S , COCKBAIN, Julian, Roderick, Michaelson , BUTTERFIELD, Dennis, Earl , FUJII, Dennis, Kiyoshi , LADD, David, Lee , SNOW, Robert, Allan , TAN, Julia, Shieh , TONER, John, Luke
发明人： NYCOMED IMAGING A.S , COCKBAIN, Julian, Roderick, Michaelson
IPC分类号： A61K49/00
CPC分类号： C08G65/329 , Y10S530/815 , Y10S530/816
摘要： A segmented polymer suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating agent residue linked via an amide linkage to a poly(alkylene oxide) moiety, said polymer having a molecular weight of at least 4,500.
摘要翻译：适用于诊断成像的分段聚合物或作为细胞杀伤剂的分段聚合物，其包含通过酰胺键与聚（环氧烷）部分连接的螯合剂残基，所述聚合物的分子量至少为4500。

4. 发明申请

WO1994021301A1 IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS 审中-公开
标题翻译：改进或与对比剂相关
公开(公告)号：WO1994021301A1
公开(公告)日：1994-09-29
申请号：PCT/GB1994000521
申请日：1994-03-16
申请人： HOLMES, Michael, John , NYCOMED IMAGING A.S , BERG, Arne , DUGSTAD, Harald , FOSS, Per, Antonius , KLAVENESS, Jo , OSTENSEN, Jonny , RONGVED, Pål , STRANDE, Per
发明人： HOLMES, Michael, John , NYCOMED IMAGING A.S
IPC分类号： A61K49/00
CPC分类号： A61K49/226 , A61K49/223
摘要： Oil-in-water emulsions in which the oil phase comprises condensed or dissolved oil-soluble gas/fluid or gas precursor are useful as ultrasound contrast agents. Such products contain insignificant amounts of free gas bubbles or microbubbles in their stored form and exhibit good storage stability, but may be designed to promote rapid microbubble generation immediately before or upon administration.
摘要翻译：其中油相包含冷凝或溶解的油溶性气体/流体或气体前体的水包油乳剂可用作超声造影剂。这样的产品在其储存形式中含有不显着量的游离气泡或微泡，并表现出良好的储存稳定性，但可以设计用于在施用之前或之后促进快速产生微泡。

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