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1. 发明申请

WO2005003778A2 A METHOD FOR IDENTIFYING A SYNTHETIC MOLECULE HAVING AFFINITY TOWARDS A TARGET 审中-公开
标题翻译：识别具有目标的亲和力的合成分子的方法
公开(公告)号：WO2005003778A2
公开(公告)日：2005-01-13
申请号：PCT/DK2004/000466
申请日：2004-06-30
申请人： NUEVOLUTION A/S , FRESKGÅRD, Per-Ola , LUNDORF, Mikkel, Dybro , JAKOBSEN, Søren, Nyboe
发明人： FRESKGÅRD, Per-Ola , LUNDORF, Mikkel, Dybro , JAKOBSEN, Søren, Nyboe
IPC分类号： G01N33/68
CPC分类号： C40B30/04 , C12N15/1068
摘要： The present invention relates to a method for identifying a synthetic molecule having affinity towards a target. The method includes the steps of providing a library of bifunctional complexes, wherein each complex of the library comprises a synthetic molecule attached to an identifier, which codes for said molecule; subjecting, under binding conditions, the library of bifunctional complexes to a target; removing the non-binding members of the library; separating the identifiers of complexes comprising synthetic molecules having affinity towards the target, and decoding the identifiers to establish the identity of the molecule.
摘要翻译：本发明涉及鉴定对靶具有亲和性的合成分子的方法。该方法包括提供双功能复合物文库的步骤，其中文库的每个复合物包含连接到编码所述分子的标识符的合成分子; 在结合条件下将双功能复合物文库进行靶化; 删除图书馆的非约束成员; 将包含对靶标具有亲和力的合成分子的复合物的标识符分离，并且解码标识符以建立分子的身份。

2. 发明申请

WO2004039825A2 ENZYMATIC ENCODING 审中-公开
标题翻译： ENZYMATIC编码
公开(公告)号：WO2004039825A2
公开(公告)日：2004-05-13
申请号：PCT/DK2003/000739
申请日：2003-10-30
申请人： NUEVOLUTION A/S , FRESKGÅRD, Per-Ola , FRANCH, Thomas , GOULIAEV, Alex, Haahr , LUNDORF, Mikkel, Dybro , FELDING, Jakob , OLSEN, Eva, Kampmann , HOLTMANN, Anette , JAKOBSEN, Søren, Nyboe , SAMS, Christian , GLAD, Sanne, Schrøder , JENSEN, Kim, Birkebæk , PEDERSEN, Henrik
发明人： FRESKGÅRD, Per-Ola , FRANCH, Thomas , GOULIAEV, Alex, Haahr , LUNDORF, Mikkel, Dybro , FELDING, Jakob , OLSEN, Eva, Kampmann , HOLTMANN, Anette , JAKOBSEN, Søren, Nyboe , SAMS, Christian , GLAD, Sanne, Schrøder , JENSEN, Kim, Birkebæk , PEDERSEN, Henrik
IPC分类号： C07H21/00
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.
摘要翻译：公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个并且使用一种或多种酶提供标识启动位点处的反应物的各个标签。

3. 发明申请

WO2005026387A1 A METHOD FOR OBTAINING STRUCTURAL INFORMATION CONCERNING AN ENCODED MOLECULE AND METHOD FOR SELECTING COMPOUNDS 审中-公开
标题翻译：获得关于编码分子的结构信息的方法和选择化合物的方法
公开(公告)号：WO2005026387A1
公开(公告)日：2005-03-24
申请号：PCT/DK2004/000630
申请日：2004-09-17
申请人： NUEVOLUTION A/S , THISTED, Thomas , LUNDORF, Mikkel, Dybro , RASMUSSEN, Torben, Ravn , FRESKGÅRD, Per-Ola
发明人： THISTED, Thomas , LUNDORF, Mikkel, Dybro , RASMUSSEN, Torben, Ravn , FRESKGÅRD, Per-Ola
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12N15/1068 , C12Q1/6811 , C12Q2531/113 , C12Q2565/501
摘要： In one aspect, the present invention relates to a method for obtaining structural information about an encoded molecule. The encoded molecule may be produced by a reaction of a plurality of chemical entities and may be capable of being connected to an identifier oligonucleotide containing codons informative of the identity of the chemical entities which have participated in the formation of the encoded molecule. In a certain embodiment, primers are designed complementary to the codons appearing on the identifier oligonucleotide, and the presence, absence or relative abundance of a codon is evaluated by mixing a primer with the identifier oligonucleotide in the presence of a polymerase and substrate (deoxy)ribonucleotide triphosphates measuring the extension reaction. In another aspect, the invention provides a method for selecting compounds which binds to a target. More specifically, the invention relates to a method in which a target associated with an oligonucleotide initially is mixed with a library of complexes, each complex comprising a display molecule and an oligonucleotide identifying said display molecule. Next, due an increased proximity, the target oligonucleotide is coupled to the identifier oligonucleotide of complexes having a display molecule with affinity towards the target. In a final stage the coupled nucleotides are analysed to deduce at least the identity of the display molecule.
摘要翻译：一方面，本发明涉及获得关于编码分子的结构信息的方法。编码的分子可以通过多个化学实体的反应产生，并且可以能够连接到含有密码子的标识符寡核苷酸，该密码子包括参与编码分子形成的化学实体的身份。在一些实施方案中，设计引物与出现在标识寡核苷酸上的密码子互补，并且通过在聚合酶和底物（脱氧））存在下将引物与标识寡核苷酸混合来评估密码子的存在，不存在或相对丰度，核糖核酸三磷酸测量延伸反应。另一方面，本发明提供了选择与靶标结合的化合物的方法。更具体地，本发明涉及一种方法，其中与寡核苷酸相关的靶标最初与复合物文库混合，每个复合物包含显示分子和识别所述显示分子的寡核苷酸。接下来，由于接近度增加，靶寡核苷酸与具有与靶具有亲和性的显示分子的复合物的标识符寡核苷酸偶联。在最后阶段，分析耦合的核苷酸以至少推断显示分子的身份。

4. 发明申请

WO2003078627A3 A BUILDING BLOCK CAPABLE OF FUNCTIONAL ENTITY TRANSFER TO NUCLEOPHIL 审中-公开
公开(公告)号：WO2003078627A3
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000177
申请日：2003-03-14
申请人： NUEVOLUTION A/S , GOULIAEV, Alex, Haahr , PEDERSEN, Henrik , THISTED, Thomas , LUNDORF, Mikkel, Dybro , SAMS, Christian , FRANCH, Thomas , HUSEMOEN, Gitte, Nystrup , HO, Justin
发明人： GOULIAEV, Alex, Haahr , PEDERSEN, Henrik , THISTED, Thomas , LUNDORF, Mikkel, Dybro , SAMS, Christian , FRANCH, Thomas , HUSEMOEN, Gitte, Nystrup , HO, Justin
IPC分类号： C07H21/00
摘要： A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is diclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.

5. 发明申请

WO2003078626A2 A BUILDING BLOCK CAPABLE OF TRANSFERRING A FUNCTIONAL ENTITY 审中-公开
标题翻译：传输功能实体的建筑块
公开(公告)号：WO2003078626A2
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000174
申请日：2003-03-14
申请人： NUEVOLUTION A/S , GOULIAEV, Alex, Haahr , HO, Justin , FELDING, Jakob , SAMS, Christian , PEDERSEN, Henrik , JENSEN, Kim, Birkebæk , HANSEN, Anders, Holm , LUNDORF, Mikkel, Dybro , HUSEMOEN, Gitte, Nystrup , FRANCH, Thomas , THISTED, Thomas
发明人： GOULIAEV, Alex, Haahr , HO, Justin , FELDING, Jakob , SAMS, Christian , PEDERSEN, Henrik , JENSEN, Kim, Birkebæk , HANSEN, Anders, Holm , LUNDORF, Mikkel, Dybro , HUSEMOEN, Gitte, Nystrup , FRANCH, Thomas , THISTED, Thomas
IPC分类号： C12N15/10
CPC分类号： C07D405/04 , C07B2200/11 , C07F9/65586 , C07F9/65616 , C07H21/00 , C07H21/02 , C07H23/00 , C12N15/1068 , C12P19/34 , C40B40/00
摘要： A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is disclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.
摘要翻译：具有转移遗传信息的双重功能的构建块，例如，通过识别编码元件并将功能实体传送到接收者反应组。构建块可以设计成具有可调节的可转移性，同时考虑到构件的部件。构建单元可以用于生成单个复合体或不同复合物的文库，其中复合物包含与编码元件连接的编码分子。复合物库可用于寻求药物活性化合物。

6. 发明申请

WO2003078446A3 A BUILDING BLOCK FORMING A C-C OR A C-HETERO ATOM BOND UPONREACTION 审中-公开
公开(公告)号：WO2003078446A3
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000176
申请日：2003-03-14
申请人： NUEVOLUTION A/S , GOULIÆV, Alex, Haahr , PEDERSEN, Henrik , JENSEN, Kim, Birkebærd , LUNDORF, Mikkel, Dybro , SAMS, Christian , FELDING, Jakob , GODSKESEN, Michael, Anders
发明人： GOULIÆV, Alex, Haahr , PEDERSEN, Henrik , JENSEN, Kim, Birkebærd , LUNDORF, Mikkel, Dybro , SAMS, Christian , FELDING, Jakob , GODSKESEN, Michael, Anders
IPC分类号： C07H21/00
摘要： A building block having the dual capabilities of transferring genetic information and functional entity precursor to a recipient reactive group is disclosed. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.

7. 发明申请

WO2003078626A3 A BUILDING BLOCK CAPABLE OF TRANSFERRING A FUNCTIONAL ENTITY 审中-公开
公开(公告)号：WO2003078626A3
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000174
申请日：2003-03-14
申请人： NUEVOLUTION A/S , GOULIAEV, Alex, Haahr , HO, Justin , FELDING, Jakob , SAMS, Christian , PEDERSEN, Henrik , JENSEN, Kim, Birkebæk , HANSEN, Anders, Holm , LUNDORF, Mikkel, Dybro , HUSEMOEN, Gitte, Nystrup , FRANCH, Thomas , THISTED, Thomas
发明人： GOULIAEV, Alex, Haahr , HO, Justin , FELDING, Jakob , SAMS, Christian , PEDERSEN, Henrik , JENSEN, Kim, Birkebæk , HANSEN, Anders, Holm , LUNDORF, Mikkel, Dybro , HUSEMOEN, Gitte, Nystrup , FRANCH, Thomas , THISTED, Thomas
IPC分类号： C07H21/00
摘要： A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is disclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.

8. 发明申请

WO2005078122A2 METHOD FOR ENRICHMENT INVOLVING ELIMINATION BY MISMATCH HYBRIDISATION 审中-公开
标题翻译：利用MISMATCH杂交法消除消除的方法
公开(公告)号：WO2005078122A2
公开(公告)日：2005-08-25
申请号：PCT/DK2005/000106
申请日：2005-02-17
申请人： NUEVOLUTION A/S , FRESKAARD, Per-Ola , LUNDORF, Mikkel, Dybro , FRANCH, Thomas
发明人： FRESKAARD, Per-Ola , LUNDORF, Mikkel, Dybro , FRANCH, Thomas
IPC分类号： C12Q1/68
CPC分类号： C12N15/1068 , Y10T436/143333
摘要： The present invention relates to a method for selecting a molecule from a library of such molecules associated with identifier oligonucleotides, said molecule having affinity towards a target. The method involves contacting library with a target to allow for an interaction between the molecules and the target and partitioning a fraction enriched in identifier oligonucleotides of molecules interacting with the target. After an optional nucleic acid amplification of the partitioned fraction, the fraction is subjected to conditions at which hetero-duplexes and homo-duplexes are formed. The homo-duplexes are subsequently recovered and decoded to identify the identity of the molecule interacting with the target.
摘要翻译：本发明涉及用于从与标识符寡核苷酸相关的此类分子的文库中选择分子的方法，所述分子对靶标具有亲和性。该方法涉及使文库与靶标接触以允许分子与靶标之间的相互作用并分配富集与靶标相互作用的分子的标识符寡核苷酸的部分。在分配部分的任选核酸扩增之后，将部分置于形成杂双链体和同型双链体的条件下。随后回收并解码同双螺旋以鉴定与靶相互作用的分子的身份。

9. 发明申请

WO2003078627A2 A BUILDING BLOCK CAPABLE OF FUNCTIONAL ENTITY TRANSFER TO NUCLEOPHIL 审中-公开
标题翻译：能够将功能实体转移至核苷酸的构建区块
公开(公告)号：WO2003078627A2
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000177
申请日：2003-03-14
申请人： NUEVOLUTION A/S , GOULIAEV, Alex, Haahr , PEDERSEN, Henrik , THISTED, Thomas , LUNDORF, Mikkel, Dybro , SAMS, Christian , FRANCH, Thomas , HUSEMOEN, Gitte, Nystrup , HO, Justin
发明人： GOULIAEV, Alex, Haahr , PEDERSEN, Henrik , THISTED, Thomas , LUNDORF, Mikkel, Dybro , SAMS, Christian , FRANCH, Thomas , HUSEMOEN, Gitte, Nystrup , HO, Justin
IPC分类号： C12N15/10
CPC分类号： C07D405/04 , C07B2200/11 , C07F9/65586 , C07F9/65616 , C07H21/00 , C07H21/02 , C07H23/00 , C12N15/1068 , C12P19/34 , C40B40/00
摘要： A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is diclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.
摘要翻译：具有通过识别编码元件并将功能实体转移到受体反应性基团来转移遗传信息的双重能力的结构单元被揭示。考虑到构件的组件，可以将构件设计为具有可调整的可转移性。构建模块可用于产生不同复合物的单个复合物或多个文库，其中复合物包含与编码元件连接的编码分子。复合物库可用于寻找药物活性化合物。

10. 发明申请

WO2003078446A2 A BUILDING BLOCK FORMING A C-C OR A C-HETERO ATOM BOND UPONREACTION 审中-公开
标题翻译：形成C-C或C-HETERO原子键的构建块
公开(公告)号：WO2003078446A2
公开(公告)日：2003-09-25
申请号：PCT/DK2003/000176
申请日：2003-03-14
申请人： NUEVOLUTION A/S , GOULIÆV, Alex, Haahr , PEDERSEN, Henrik , JENSEN, Kim, Birkebærd , LUNDORF, Mikkel, Dybro , SAMS, Christian , FELDING, Jakob , GODSKESEN, Michael, Anders
发明人： GOULIÆV, Alex, Haahr , PEDERSEN, Henrik , JENSEN, Kim, Birkebærd , LUNDORF, Mikkel, Dybro , SAMS, Christian , FELDING, Jakob , GODSKESEN, Michael, Anders
IPC分类号： C07H21/00
CPC分类号： C07D405/04 , C07H21/00 , C12N15/1034 , C12N15/1068 , C40B40/00
摘要： A building block having the dual capabilities of transferring genetic information and functional entity precursor to a recipient reactive group is disclosed. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.
摘要翻译：公开了具有将遗传信息和功能实体前体转移至受体反应性基团的双重能力的构件。构建模块可用于产生不同复合物的单个复合物或多个文库，其中复合物包含与编码元件连接的编码分子。复合物库可用于寻找药物活性化合物。

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