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1. 发明申请

WO2007134169A2 INDOLE, BENZIMIDAZOLE, AND BENZOLACTAM BORONIC ACID COMPOUNDS, ANALOGS THEREOF AND METHODS OF USE THEREOF 审中-公开
标题翻译：吲哚，苯并咪唑和苯并咪唑硼酸化合物，其模拟物及其使用方法
公开(公告)号：WO2007134169A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/068671
申请日：2007-05-10
申请人： NUADA, LLC , DIDSBURY, John, R. , DYAKONOV, Tatyana , HAYDAR, Simon, N. , JONES, Michael, L. , LI, Francine, F. , MARKWORTH, Christopher, J. , SCICINSKI, Jan, J. , CABANA, Leonard, A. , MATHEW, Jessymol , MIDDLEMISS, David, N. , COLLUPY, Glenn, C. , SCHOENEN, Frank, J. , BURNS, James, F. , VANVLIET, David, N.
发明人： DIDSBURY, John, R. , DYAKONOV, Tatyana , HAYDAR, Simon, N. , JONES, Michael, L. , LI, Francine, F. , MARKWORTH, Christopher, J. , SCICINSKI, Jan, J. , CABANA, Leonard, A. , MATHEW, Jessymol , MIDDLEMISS, David, N. , COLLUPY, Glenn, C. , SCHOENEN, Frank, J. , BURNS, James, F. , VANVLIET, David, N.
IPC分类号： C07D235/06 , C07D235/18 , C07D417/02 , C07F5/02
CPC分类号： C07D417/02 , C07D235/06 , C07D235/18 , C07D241/46 , C07D279/16 , C07F5/025
摘要： Benzimidazole, indole and benzolactam boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.
摘要翻译：还描述了苯并咪唑，吲哚和苯并内酰胺硼酸化合物，其类似物和药物制剂，以及其用于抑制有需要的受试者中的炎性细胞因子如肿瘤坏死因子α（TNF-α）的方法。

2. 发明申请

WO2006050053A2 COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：化合物及其使用方法
公开(公告)号：WO2006050053A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/038853
申请日：2005-10-27
申请人： NUADA, LLC , BURNS, James, F. , CABANA, Leonard, A. , COLLUPY, Glenn, C. , DIDSBURY, John, R. , DYAKONOV, Tatyana , HAYDAR, Simon, N. , JONES, Michael, L. , LI, Francine, F. , MARKWORTH, Christopher, J. , MATHEW, JessyMol , SCHOENEN, Frank, J. , VANVLIET, David, N. , MIDDLEMISS, David, N.
发明人： BURNS, James, F. , CABANA, Leonard, A. , COLLUPY, Glenn, C. , DIDSBURY, John, R. , DYAKONOV, Tatyana , HAYDAR, Simon, N. , JONES, Michael, L. , LI, Francine, F. , MARKWORTH, Christopher, J. , MATHEW, JessyMol , SCHOENEN, Frank, J. , VANVLIET, David, N. , MIDDLEMISS, David, N.
IPC分类号： A61K31/4745
CPC分类号： C07F5/025 , C07D235/18 , C07D417/04
摘要： Imidazole and benzimidazole boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.
摘要翻译：本发明描述了咪唑和苯并咪唑硼酸化合物，其类似物和药物制剂，以及其在有此需要的受试者中用于抑制炎性细胞因子如肿瘤坏死因子α（TNF-α）的方法。

3. 发明申请

WO2006050054A2 COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：化合物及其使用方法
公开(公告)号：WO2006050054A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/038854
申请日：2005-10-27
申请人： NUADA, LLC , DYAKONOV, Tatyana , JONES, Michael, L. , MARKWORTH, Christopher, J. , MATHEW, JessyMol , SCHOENEN, Frank, J. , VANVLIET, David, N. , MIDDLEMISS, David, N.
发明人： DYAKONOV, Tatyana , JONES, Michael, L. , MARKWORTH, Christopher, J. , MATHEW, JessyMol , SCHOENEN, Frank, J. , VANVLIET, David, N. , MIDDLEMISS, David, N.
CPC分类号： C07F5/025
摘要： Benzolactam boronic acid compounds and pharmaceutical formulations are described along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.
摘要翻译：描述了苯并内酰胺硼酸化合物和药物制剂以及其用于在有需要的受试者中抑制炎性细胞因子如肿瘤坏死因子α（TNF-α）的方法。

4. 发明公开

EP1812451A2 COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：化合物及其使用方法
公开(公告)号：EP1812451A2
公开(公告)日：2007-08-01
申请号：EP05813762.1
申请日：2005-10-27
申请人： Nuada, LLC
发明人： BURNS, James, F. , CABANA, Leonard, A. , COLLUPY, Glenn, C. , DIDSBURY, John, R. , DYAKONOV, Tatyana , HAYDAR, Simon, N. , JONES, Michael, L. , LI, Francine, F. , MARKWORTH, Christopher, J. , MATHEW, JessyMol , SCHOENEN, Frank, J. , VANVLIET, David, N. , MIDDLEMISS, David, N.
IPC分类号： C07F5/02
CPC分类号： C07F5/025 , C07D235/18 , C07D417/04
摘要： Imidazole and benzimidazole boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.

5. 发明申请

WO2010039184A3 POROUS BIOABSORBABLE IMPLANT 审中-公开
公开(公告)号：WO2010039184A3
公开(公告)日：2010-04-08
申请号：PCT/US2009/005268
申请日：2009-09-22
申请人： SENORX, INC. , GOVIL, Amit , JONES, Michael, L. , LUBOCK, Paul
发明人： GOVIL, Amit , JONES, Michael, L. , LUBOCK, Paul
IPC分类号： A61L27/20 , A61L27/50 , A61L27/56 , A61L27/58
摘要： The bioabsorbable implant described has a porous body formed of bioabsorbable materials that have an in vivo life span of at least 2 weeks, preferably at least three weeks and not greater than 20 weeks, preferably no greater than ten weeks. The implant has a scaffolding structure which facilitates tissue in-growth and ultimately tissue replacement of the scaffolding structure. The implant has a radiopaque imaging agent at least at the exterior margins and an orientation plurality of radiopaque elements in the interior of implant. The implant preferably has three radiopaque elements within the interior that form a plane within the implant interior.

6. 发明申请

WO2009134314A1 ASSEMBLY WITH HEMOSTATIC AND RADIOGRAPHICALLY DETECTABLE PELLETS 审中-公开
标题翻译：装配有HEMOSTATIC和RADIOGRAPHICALLY DETECTABLE PELLETS
公开(公告)号：WO2009134314A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/002297
申请日：2009-04-14
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L.
发明人： LUBOCK, Paul , JONES, Michael, L.
IPC分类号： A61B19/00
CPC分类号： A61M37/0069 , A61B90/39 , A61B2017/00004 , A61B2017/00831 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3962 , A61B2090/3987
摘要： The remotely imageable pellet system (10) described has a plurality of pellets (18) disposed within a delivery tube or cannula (11) that are formed at least in part of a polysaccharide such as starch and at least one radiographically detectable bioabsorbable pellet (18) which preferably has a radiopaque element. The radiographically detectable bioabsorbable pellet has at least one and preferably two pellets proximal and distal thereto which are formed of polysaccharide.
摘要翻译：所描述的可远程成像的颗粒系统（10）具有设置在输送管或插管（11）内的多个颗粒（18），其形成为至少部分多糖如淀粉和至少一个可放射线检测的生物可吸收颗粒（18）），其优选地具有不透射线的元件。可放射线检测的生物可吸收颗粒具有由多糖形成的至少一个且优选两个近端和远端的颗粒。

7. 发明申请

WO2008008089A2 ASYMMETRICAL IRRADIATION OF A BODY CAVITY 审中-公开
标题翻译：非对称辐照人体腔
公开(公告)号：WO2008008089A2
公开(公告)日：2008-01-17
申请号：PCT/US2006/044067
申请日：2006-11-13
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L. , LOUW, Frank, R.
发明人： LUBOCK, Paul , JONES, Michael, L. , LOUW, Frank, R.
IPC分类号： A61N5/10 , A61M36/04
CPC分类号： A61N5/1014 , A61N5/1002 , A61N5/1015 , A61N2005/1003 , A61N2005/1004 , A61N2005/1005 , A61N2005/1018 , A61N2005/1024
摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.
摘要翻译：本公开描述了用于在体腔或部位处的不对称辐射的装置和方法，例如在移除组织之后，活检或癌症。一个装置包括从纵轴偏离或偏离的腔，以增加由体腔周围的第一组织部分从辐射源接收的辐射强度，并减少或最小化由第二组织部分接收的辐射（例如健康组织）围绕着体腔。

8. 发明申请

WO2010017418A1 PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE 审中-公开
标题翻译： D-氨基酸氧化酶的融合杂环抑制剂的制备
公开(公告)号：WO2010017418A1
公开(公告)日：2010-02-11
申请号：PCT/US2009/053049
申请日：2009-08-06
申请人： SEPRACOR INC. , HEFFERNAN, Michele, L.R. , DENNIS, Richard , DORSEY, James, M. , FOGLESONG, Robert, J. , JONES, Michael, L. , OGBU, Cyprian, O. , SOUKRI, Mustapha , SPEAR, Kerry, L. , WILKINSON, H., Scott , ORSINI, Michael Anthony
发明人： HEFFERNAN, Michele, L.R. , DENNIS, Richard , DORSEY, James, M. , FOGLESONG, Robert, J. , JONES, Michael, L. , OGBU, Cyprian, O. , SOUKRI, Mustapha , SPEAR, Kerry, L. , WILKINSON, H., Scott , ORSINI, Michael Anthony
IPC分类号： C07D491/04 , A61K31/407 , A61P25/00
CPC分类号： C07D491/04
摘要： The invention relates to prodrugs of fused heterocyclic inhibitors of D-amino oxidase (DAAO) and methods of treating diseases and conditions, wherein modulation of D- amino acid oxidase activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject is effective.
摘要翻译：本发明涉及D-氨基氧化酶（DAAO）的稠合杂环抑制剂的前药和治疗疾病和病症的方法，其中调节D-氨基酸氧化酶活性，D-丝氨酸水平，D-丝氨酸氧化产物和NMDA受体活性哺乳动物受试者的神经系统是有效的。

9. 发明申请

WO2009105177A1 POLYSACCHARIDE MARKERS 审中-公开
标题翻译：多糖标记
公开(公告)号：WO2009105177A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/000945
申请日：2009-02-13
申请人： SENORX, INC. , JONES, Michael, L. , LUBOCK, Paul
发明人： JONES, Michael, L. , LUBOCK, Paul
IPC分类号： A61B19/00
CPC分类号： A61B19/54 , A61B90/39 , A61B2017/00004 , A61B2017/00831 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3962 , A61B2090/3987 , A61K9/0024
摘要： The marker member delivery system described has a plurality of marker members disposed within a delivery tube or cannula which contain a suitable polysaccharide such as starch (e.g. corn starch or potato starch) and a binder such as methylcellulose. These marker members are preferably press-formed from powders. The system has preferably has at least one other marker member formed of bioabsorbable material with a radiopaque element attached to or incorporated therein. The marker with a radiopaque marker element is preferably disposed within the delivery tube between two marker members formed of polysaccharide and is preferably formed of a bioabsorbable material other than a polysaccharide.
摘要翻译：所述的标记物传送系统具有多个标记物，其设置在输送管或套管内，其包含合适的多糖如淀粉（例如玉米淀粉或马铃薯淀粉）和粘合剂如甲基纤维素。这些标记物优选由粉末压制成型。该系统优选地具有由生物可吸收材料形成的至少一个其它标记构件，其中附着或结合在其中的不透射线元件。具有不透射线标记元件的标记物优选设置在由多糖形成的两个标记物之间的输送管内，并且优选由除多糖之外的生物可吸收材料形成。

10. 发明申请

WO2007097956A2 TEMPORARY CATHETER FOR BIOPSY SITE TISSUE FIXATION 审中-公开
标题翻译：用于生物场地组织固定的临时导管
公开(公告)号：WO2007097956A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/003877
申请日：2007-02-14
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L.
发明人： LUBOCK, Paul , JONES, Michael, L.
IPC分类号： A61M25/10 , A61B17/00 , A61B17/22 , A61N5/10
CPC分类号： A61M29/02 , A61B10/0041 , A61B17/0218 , A61B90/02 , A61B2017/00557 , A61B2017/00796 , A61B2090/3908 , A61M25/10 , A61M29/00 , A61M2025/1095 , A61N5/1015
摘要： Devices and methods are provided for temporarily maintaining access to a body cavity in a targeted tissue region within a patient's body. One embodiment of the catheter device includes an elongated shaft having a proximal shaft section which is flexible enough to be folded or coiled into a configuration for deployment within the patient. An alternate embodiment includes a catheter device having one or more detachable proximal shaft sections and having at least one one-way valve to restrict fluid flow of inflation fluid to flow to the balloon. After deployment of the catheter device completely within the patient, the opening through which the catheter device is deployed is closed, e.g. by sutures, adhesives and the like to minimize infection at the site. Within a few days or weeks after the tissue has been evaluated for cancer, the temporary catheter device may be removed from the patient. If cancer or pre-cancer cells are found in the specimen removed from the cavity, then a radiation balloon catheter or other irradiation device can be inserted into the patient to irradiate tissue surrounding the biopsy cavity to ensure that cancer cells within the tissue surrounding the cavity are killed.
摘要翻译：提供了用于暂时维持对患者体内的目标组织区域中的体腔的访问的装置和方法。导管装置的一个实施例包括细长轴，其具有近侧轴部，该近端轴部足够柔性以折叠或卷绕成用于部署在患者体内的构造。替代实施例包括具有一个或多个可分离近侧轴部分并且具有至少一个单向阀以限制充气流体流入气囊的流体流动的导管装置。在将导管装置完全展开在患者体内之后，将导管装置展开的开口关闭，例如，通过缝线，粘合剂等来最小化现场的感染。在组织已经被评估癌症后的几天或几周内，临时导管装置可以从患者身上移除。如果在从腔中取出的样品中发现癌症或癌前细胞，则可以将放射气球导管或其它照射装置插入患者体内以照射活检腔周围的组织，以确保围绕腔的组织内的癌细胞被杀

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