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1. 发明申请

WO2005103082A3 GROUP 1 MITE POLYPEPTIDE VARIANTS 审中-公开
公开(公告)号：WO2005103082A3
公开(公告)日：2006-02-16
申请号：PCT/DK2005000277
申请日：2005-04-21
申请人： NOVOZYMES AS , BATORI VINCENT , ROGGEN ERWIN LUDO , ERNST STEFFEN , LYNGSTRAND STINA THULESEN
发明人： BATORI VINCENT , ROGGEN ERWIN LUDO , ERNST STEFFEN , LYNGSTRAND STINA THULESEN
IPC分类号： C07K14/435 , A61K39/00 , A61K39/35 , C12N15/12
CPC分类号： C07K14/43531 , A61K39/00 , A61K2039/57
摘要： This invention concerns variants of a group 1 mite polypeptide, wherein the mature polypeptide of the variants comprise one or more mutations in the positions or corresponding to positions consisting of P11, I14, D15, L16, M19-P24, Q28, F37, S38, T43, A46-A49, Q53-L57, V63, A66-H69, H72, D74-R77, I80, Y82, Q84, H85, S92, I113, S114, P121, V124, K126, R128-A130, A132-S136, A139, L147, A149-H152, T157, Q160, N163, H170, A171, S178, V183, D184, R189, D193, F204, A206, N207, P217, L222 of SEQ ID NO: 1 or alternatively 11, 14, 15, 16, 19-24, 28, 37, 38, 43, 46-49, 53-57, 63, 66-69, 72, 74-77, 80, 82, 84, 85, 92, 113, 114, 121, 124, 126, 128-130, 132-136, 139, 147, 149-152, 157, 160, 163, 170, 178, 183, 189, 193, 204, 206, 207, 217, 222 of the mature Der p 1 polypeptide.
摘要翻译：本发明涉及组1螨多肽的变体，其中变体的成熟多肽包含位置或对应于由P11，I14，D15，L16，M19-P24，Q28，F37，S38， T43，A46-A49，Q53-L57，V63，A66-H69，H72，D74-R77，I80，Y82，Q84，H85，S92，I113，S114，P121，V124，K126，R128-A130，A132-S136， SEQ ID NO：1的A139，L147，A149-H152，T157，Q160，N163，H170，A171，S178，V183，D184，R189，D193，F204，A206，N207，P217，L222或者11,14,15 ，16,19-24,28,37,38,43,46-49,53-57,63,66-69,72,74-77,80,82,84,85,92,113,114,121 ，成熟Der的第124,126,128-130,132-136,139,147,149-152,157,160,163,170,178,183,189,193,204,206,207,217,222。 p 1多肽。

2. 发明申请

WO2005095592A3 SUBTILASE VARIANTS HAVING ALTERED IMMUNOGENICITY 审中-公开
标题翻译：具有改变的免疫原性的变体
公开(公告)号：WO2005095592A3
公开(公告)日：2006-12-14
申请号：PCT/DK2005000225
申请日：2005-04-01
申请人： NOVOZYMES AS , MINNING STEFAN , DRABORG HENRIETTE , ROGGEN ERWING LUDO , SONI NANNA KRISTENSEN , BERG NINNA WILLESTOFTE , LYNGSTRAND STINA THULESEN
发明人： MINNING STEFAN , DRABORG HENRIETTE , ROGGEN ERWING LUDO , SONI NANNA KRISTENSEN , BERG NINNA WILLESTOFTE , LYNGSTRAND STINA THULESEN
IPC分类号： C12N9/54 , A61K8/66 , A61K38/48 , A61Q19/00 , C11D3/386 , C12N9/00 , C12N9/56
CPC分类号： C12Y304/21062 , A61K8/66 , A61K38/00 , A61Q19/00 , C11D3/386 , C12N9/54
摘要： The present invention relates to subtilase subtilases with an altered immunogenicity, particu-larly subtilases with a reduced allergenicity. Furthermore, the invention relates to expression of said subtilase variants and subtilases and to their use, such as in detergents and oral care products.
摘要翻译：本发明涉及具有改变的免疫原性的特异性减毒酶，具有降低的过敏原性的特异性降解酶。此外，本发明涉及所述脱羧酶变体和枯草芽孢杆菌的表达及其用途，例如洗涤剂和口腔护理产品。

3. 发明申请

WO2004096844A3 GROUP 1 MITE POLYPEPTIDE VARIANTS 审中-公开
公开(公告)号：WO2004096844A3
公开(公告)日：2004-12-16
申请号：PCT/DK2004000280
申请日：2004-04-23
申请人： NOVOZYMES AS
发明人： SONI NANNA KRISTENSEN , FRIIS ESBEN PETER , ROGGEN ERWIN LUDO , LYNGSTRAND STINA THULESEN
IPC分类号： A61K38/11 , A61K39/00 , C07K14/435 , C12N15/12 , A61K38/17 , A61K39/35
CPC分类号： C07K14/43531 , A61K38/00 , A61K39/00
摘要： This invention concerns variants of group 1 mite polypeptides, wherein the mature polypeptide of the variant comprise one or more mutations in the positions or corresponding to the positions consisting of A10, A12, E13, G29, G30, G32, A46, Y47, S54, L55, D64, A66, S67, G73, T75, I80, Q84, N86, G87, S92, Y93, Y96, A98, R99, E100, Q101, R104, R105, P106, Q109, R110, F111, G112, I113, A132, I144, K145, D146, D148, R151, I158, I159, Q160, R161, D162, N163, G164, Y165, Q166, N179, A180, G182, V183, D184, A205, I208 of SEQ ID NO: 1 or 10, 12, 13, 29, 30, 32, 46, 47, 54, 55, 64, 66, 67, 73, 75, I80, 84, 86, 87, 92, Y93, 96, 98, 99, 100, 101, 104, 105, 106, 109, 110, 111, 112, 113, 132, 144, 145, 146, 148, 151, 158, 159, 160, 161, 162, 163, 164, 165, 166, 179, 180, 182, 183, 184, 205, 208 of the mature Der p 1 polypeptide.
摘要翻译：本发明涉及组1螨多肽的变体，其中变体的成熟多肽包含一个或多个在A10，A12，E13，G29，G30，G32，A46，Y47，S54， L55，D64，A66，S67，G73，T75，I80，Q84，N86，G87，S92，Y93，Y96，A98，R99，E100，Q101，R104，R105，P106，Q109，R110，F111，G112，或SEQ ID NO：1的A132，I144，K145，D146，D148，R151，I158，I159，Q160，R161，D162，N163，G164，Y165，Q166，N179，A180，G182，V183，D184，A205， 10，12，13，29，30，32，46，47，54，55，64，66，67，73，75，I80，84，86，87，92，Y93,96,98,99,100， 101,104,105,106,109,110,111,112,113,132,144,145,146,148,151,158,159,160,161,162,163,164,165,166,179， 180,182,183,184,205,208的成熟Der p 1多肽。

4. 发明专利

CA2523402A1 GROUP 1 MITE POLYPEPTIDE VARIANTS 未知
公开(公告)号：CA2523402A1
公开(公告)日：2004-11-11
申请号：CA2523402
申请日：2004-04-23
申请人： NOVOZYMES AS
发明人： LYNGSTRAND STINA THULESEN , SONI NANNA KRISTENSEN , ROGGEN ERWIN LUDO , FRIIS ESBEN PETER
IPC分类号： C12N15/12 , A61K38/095 , A61K38/17 , A61K39/00 , A61K39/35 , A61P37/08 , C07K14/435 , C07K17/08 , C12P21/02
摘要： This invention concerns variants of group 1 mite polypeptides, wherein the mature polypeptide of the variant comprise one or more mutations in the positions or corresponding to the positions consisting of A10, A12, E13, G29 , G30, G32, A46, Y47, S54, L55, D64, A66, S67, G73, T75, I80, Q84, N86, G87, S92, Y93, Y96, A98, R99, E100, Q101, R104, R105, P106, Q109, R110, F111, G11 2, I113, A132, I144, K145, D146, D148, R151, I158, I159, Q160, R161, D162, N163 , G164, Y165, Q166, N179, A180, G182, V183, D184, A205, I208 of SEQ ID NO: 1 o r 10, 12, 13, 29, 30, 32, 46, 47, 54, 55, 64, 66, 67, 73, 75, I80, 84, 86, 87, 92, Y93, 96, 98, 99, 100, 101, 104, 105, 106, 109, 110, 111, 112, 113, 132, 144, 145, 146, 148, 151, 158, 159, 160, 161, 162, 163, 164, 165, 166, 179, 180, 182, 183, 184, 205, 208 of the mature Der p 1 polypeptide.

5. 发明专利

DE602005025202D1 SUBTILASEVARIANTEN MIT VERÄNDERTER IMMUNOGENITÄT 未知
公开(公告)号：DE602005025202D1
公开(公告)日：2011-01-20
申请号：DE602005025202
申请日：2005-04-01
申请人： NOVOZYMES AS
发明人： MINNING STEFAN , DRABORG HENRIETTE , ROGGEN ERWING LUDO , SONI NANNA KRISTENSEN , BERG NINNA WILLESTOFTE , LYNGSTRAND STINA THULESEN
IPC分类号： C12N9/00 , A61K8/66 , A61K38/48 , A61Q19/00 , C11D3/386 , C12N9/54 , C12N9/56

6. 发明专利

AT491025T 未知
公开(公告)号：AT491025T
公开(公告)日：2010-12-15
申请号：AT05728219
申请日：2005-04-01
申请人： NOVOZYMES AS
发明人： MINNING STEFAN , DRABORG HENRIETTE , ROGGEN ERWING , SONI NANNA KRISTENSEN , BERG NINNA WILLESTOFTE , LYNGSTRAND STINA THULESEN
IPC分类号： C12N9/54 , A61K8/66 , A61K38/48 , A61Q19/00 , C11D3/386 , C12N9/00 , C12N9/56
摘要： The present invention relates to subtilase subtilases with an altered immunogenicity, particularly subtilases with a reduced allergenicity. Furthermore, the invention relates to expression of said subtilase variants and subtilases and to their use, such as in detergents and oral care products.

7. 发明专利

AU2004233940A1 Group 1 mite polypeptide variants 未知
公开(公告)号：AU2004233940A1
公开(公告)日：2004-11-11
申请号：AU2004233940
申请日：2004-04-23
申请人： NOVOZYMES AS
发明人： FRIIS ESBEN PETER , LYNGSTRAND STINA THULESEN , ROGGEN ERWIN LUDO , SONI NANNA KRISTENSEN
IPC分类号： A61K38/095 , A61K39/00 , C07K14/435 , C12N15/12 , A61K39/35 , A61K38/17
摘要： This invention concerns variants of group 1 mite polypeptides, wherein the mature polypeptide of the variant comprise one or more mutations in the positions or corresponding to the positions consisting of A10, A12, E13, G29, G30, G32, A46, Y47, S54, L55, D64, A66, S67, G73, T75, I80, Q84, N86, G87, S92, Y93, Y96, A98, R99, E100, Q101, R104, R105, P106, Q109, R110, F111, G112, I113, A132, I144, K145, D146, D148, R151, I158, I159, Q160, R161, D162, N163, G164, Y165, Q166, N179, A180, G182, V183, D184, A205, I208 of SEQ ID NO: 1 or 10, 12, 13, 29, 30, 32, 46, 47, 54, 55, 64, 66, 67, 73, 75, I80, 84, 86, 87, 92, Y93, 96, 98, 99, 100, 101, 104, 105, 106, 109, 110, 111, 112, 113, 132, 144, 145, 146, 148, 151, 158, 159, 160, 161, 162, 163, 164, 165, 166, 179, 180, 182, 183, 184, 205, 208 of the mature Der p 1 polypeptide.

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