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1. 发明申请

WO2014147127A1 POLYPEPTIDES WITH LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有脂酶活性的多肽和编码其的多核苷酸
公开(公告)号：WO2014147127A1
公开(公告)日：2014-09-25
申请号：PCT/EP2014/055509
申请日：2014-03-19
申请人： NOVOZYMES A/S
发明人： MORANT, Marc Dominique , REISER, Anna Verena , HANSEN, Carsten Hoerslev , BORCH, Kim , BAUNSGAARD, Lone , BHATIA, Vikram Kjoeller
IPC分类号： C11D3/386 , C12N9/20
CPC分类号： C11D3/38627 , C11D3/38681 , C12N9/20 , C12P13/008
摘要： The present invention relates to isolated polypeptides with lipase activity, selected from the group consisting of:(a)a polypeptide having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 4;(b)a polypeptide encoded by a polynucleotide that hybridizes under low stringency conditions, medium stringency conditions, medium-high stringency conditions, high stringency conditions, or very high stringency conditions with (i) SEQ ID NO: 3or the full-length complement of (i);(c)a polypeptide encoded by a polynucleotide having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 3;(d)a polypeptide which is a variant of SEQ ID NO: 4 comprising a substitution, deletion, and/or insertion at one or more (e.g. several) positions; and(e)a polypeptide which is a fragment of any of the polypeptides of (a), (b), (c) or (d).The invention also relates to polynucleotides encoding the polypeptides; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the polypeptides.
摘要翻译：本发明涉及具有脂肪酶活性的分离的多肽，其选自：（a）多肽，其具有至少75％，至少80％，至少85％，至少90％，至少91％，在与SEQ ID NO：4的至少92％，至少93％，至少94％，至少95％，至少96％，至少97％，至少98％，至少99％或100％的序列同一性 ;（b）由多核苷酸编码的多肽，其在低严格条件，中等严格条件，中等严格条件，高严格条件或非常高严格条件下与（i）SEQ ID NO：3或全长补体（c）由多核苷酸编码的多肽，所述多核苷酸具有至少75％，至少80％，至少85％，至少90％，至少91％，至少92％，至少93％与SEQ ID NO：3的至少94％，至少95％，至少96％，至少97％，至少98％，至少99％或100％的序列同一性;（d） SEQ ID NO：4的变体包含取代，和/或插入在一个或多个（例如，几个）职位; （e）多肽，其是（a），（b），（c）或（d）的多肽的片段。本发明还涉及编码多肽的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 和使用多肽的方法。

2. 发明申请

WO2018113745A1 POLYPEPTIDES HAVING LYSOZYME ACTIVITY, POLYNUCLEOTIDES ENCODING SAME AND USES AND COMPOSITIONS THEREOF 审中-公开
公开(公告)号：WO2018113745A1
公开(公告)日：2018-06-28
申请号：PCT/CN2017/117765
申请日：2017-12-21
申请人： NOVOZYMES A/S , LI, Ming
发明人： LI, Ming , KLAUSEN, Mikkel , SCHNORR, Kirk Matthew , NYMAND-GRARUP, Soren , OLSEN, Peter Bjarke , COHN, Marianne Thorup , OLINSKI, Robert Piotr , MORANT, Marc Dominique , LIU, Ye , SKOV, Lars Kobberoee , SKOVLUND, Dominique Aubert , HAN, Bucong
IPC分类号： A61K38/47 , C12N9/24 , C12N9/36 , C12N15/56 , C11D3/386
摘要： Provided are animal feed or animal feed additives comprising one or more polypeptides having lysozyme activity. Provived are polypeptides having lysozyme activity, polynucleotides encoding the polypeptides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

3. 发明申请

WO2015004102A1 POLYPEPTIDES WITH LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有脂酶活性的多肽和编码其的多核苷酸
公开(公告)号：WO2015004102A1
公开(公告)日：2015-01-15
申请号：PCT/EP2014/064540
申请日：2014-07-08
申请人： NOVOZYMES A/S
发明人： MORANT, Marc Dominique , REISER, Anna Verena , HANSEN, Carsten Hoerslev , BORCH, Kim , BAUNSGAARD, Lone , BHATIA, Vikram Kjoeller
IPC分类号： C12N9/20
CPC分类号： C12N9/20 , C11D3/38627 , C11D3/38681 , C12Y301/01 , C12Y301/01003 , D06L4/40
摘要： The present invention relates to isolated polypeptides with lipase activity, selected from the group consisting of: (a)a polypeptide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 2; (b) a polypeptide encoded by a polynucleotide that hybridizes under low stringency conditions, medium stringency conditions, medium-high stringency conditions, high stringency conditions, or very high stringency conditions with (i) SEQ ID NO: 1or the full-length complement of (i); (c)a polypeptide encoded by a polynucleotide having at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 1; (d) a polypeptide which is a variant of SEQ ID NO: 2 comprising a substitution, deletion, and/or insertion at one or more (e.g. several) positions; and(e)a polypeptide which is a fragment of any of the polypeptides of (a), (b), (c) or (d).The invention also relates to polynucleotides encoding the polypeptides; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the polypeptides.
摘要翻译：本发明涉及具有脂肪酶活性的分离的多肽，其选自：（a）多肽，其具有至少80％，至少85％，至少90％，至少91％，至少92％，在与SEQ ID NO：2的至少93％，至少94％，至少95％，至少96％，至少97％，至少98％，至少99％或100％的序列同一性; （b）由多核苷酸编码的多肽，其在低严格条件，中等严格条件，中等严格条件，高严格条件或非常高严格条件下与（i）SEQ ID NO：1或全长互补的（一世）; （c）由多核苷酸编码的多肽，所述多肽具有至少80％，至少85％，至少90％，至少91％，至少92％，至少93％，至少94％，至少95％与SEQ ID NO：1的至少96％，至少97％，至少98％，至少99％或100％的序列同一性; （d）在一个或多个（例如多个）位置上包含取代，缺失和/或插入的SEQ ID NO：2的变体的多肽; （e）多肽，其是（a），（b），（c）或（d）的多肽的片段。本发明还涉及编码多肽的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 和使用多肽的方法。

4. 发明公开

EP4015524A1 POLYPEPTIDES HAVING TREHALASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 无效
公开(公告)号：EP4015524A1
公开(公告)日：2022-06-22
申请号：EP21212235.2
申请日：2018-06-26
申请人： Novozymes A/S
发明人： KANG, Zhengfang , MORANT, Marc Dominique , MATSUI, Tomoko , SCHNORR, Kirk Matthew , FUKUYAMA, Shiro , TSUTSUMI, Noriko
IPC分类号： C07K14/39 , C12P19/14 , C12N9/24 , C07K14/37 , C12P7/10 , C12P7/06
摘要： The present invention relates to polypeptides having trehalase activity, particularly derived from Talaromyces. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides for the production of ethanol.

5. 发明公开

EP3861111A1 POLYPEPTIDES HAVING NUCLEASE ACTIVITY 审中-公开
公开(公告)号：EP3861111A1
公开(公告)日：2021-08-11
申请号：EP19869453.1
申请日：2019-10-03
申请人： Novozymes A/S
发明人： SALOMON, Jesper , GORI, Klaus , GJERMANSEN, Morten , MORANT, Marc Dominique , STRINGER, Mary Ann , SUN, Tianqi
IPC分类号： C12N9/22 , C11D3/386 , C11D3/48 , C12N15/12 , C12N15/63

6. 发明公开

EP3645555A1 POLYPEPTIDES HAVING TREHALASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 有权
公开(公告)号：EP3645555A1
公开(公告)日：2020-05-06
申请号：EP18743163.0
申请日：2018-06-26
申请人： Novozymes A/S
发明人： KANG, Zhengfang , MORANT, Marc Dominique , MATSUI, Tomoko , SCHNORR, Kirk Matthew , FUKUYAMA, Shiro , TSUTSUMI, Noriko
IPC分类号： C07K14/39 , C12P19/14 , C12N9/24 , C07K14/37 , C12P7/10

7. 发明授权

EP2976416B1 POLYPEPTIDES WITH LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 有权
公开(公告)号：EP2976416B1
公开(公告)日：2018-05-16
申请号：EP14710916.9
申请日：2014-03-19
申请人： Novozymes A/S
发明人： MORANT, Marc Dominique , REISER, Anna Verena , HANSEN, Carsten Hoerslev , BORCH, Kim , BAUNSGAARD, Lone , BHATIA, Vikram Kjoeller
IPC分类号： C11D3/386 , C12N9/20
CPC分类号： C11D3/38627 , C11D3/38681 , C12N9/20 , C12P13/008
摘要： The present invention relates to isolated polypeptides with lipase activity, selected from the group consisting of: (a) a polypeptide having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 4; (b) a polypeptide encoded by a polynucleotide that hybridizes under low stringency conditions, medium stringency conditions, medium-high stringency conditions, high stringency conditions, or very high stringency conditions with (i) SEQ ID NO: 3 or the full-length complement of (i); (c) a polypeptide encoded by a polynucleotide having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO: 3; (d) a polypeptide which is a variant of SEQ ID NO: 4 comprising a substitution, deletion, and/or insertion at one or more (e.g. several) positions; and (e) a polypeptide which is a fragment of any of the polypeptides of (a), (b), (c) or (d). The invention also relates to polynucleotides encoding the polypeptides; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the polypeptides.

8. 发明申请

WO2019005755A1 POLYPEPTIDES HAVING TREHALASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
公开(公告)号：WO2019005755A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/039443
申请日：2018-06-26
申请人： NOVOZYMES A/S , KANG, Zhengfang
发明人： KANG, Zhengfang , MORANT, Marc Dominique , MATSUI, Tomoko , SCHNORR, Kirk Matthew , FUKUYAMA, Shiro , TSUTSUMI, Noriko
IPC分类号： C07K14/39 , C12P19/14 , C12N9/24 , C07K14/37 , C12P7/10
摘要： The present invention relates to polypeptides having trehalase activity, particularly derived from Talaromyces. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides for the production of ethanol.

9. 发明申请

WO2015091746A1 COMPOSITIONS AND PROCESSES FOR TREATMENT WITH LIPASES 审中-公开
标题翻译：用于治疗的组合物和方法
公开(公告)号：WO2015091746A1
公开(公告)日：2015-06-25
申请号：PCT/EP2014/078389
申请日：2014-12-18
申请人： NOVOZYMES A/S
发明人： MORANT, Marc Dominique , REISER, Anna Verena , HANSEN, Carsten Hoerslev , BORCH, Kim , BAUNSGAARD, Lone , BHATIA, Vikram Kjoeller
IPC分类号： C11D3/386
CPC分类号： C11D3/38627
摘要： The present invention relates to a composition comprising: (a) at least one surfactant, at least one surfactant system, at least one soap, or any mixtures thereof; and (b) a polypeptide having lipase activity selected from the group consisting of: (I) a polypeptide having at least 80% sequence identity to the mature polypeptide of SEQ ID NO: 2; (II) a polypeptide encoded by a polynucleotide that hybridizes under low stringency conditions with (i) the mature polypeptide coding sequence of SEQ ID NO: 1, or (ii) the full-length complement of (i); (III) a polypeptide encoded by a polynucleotide having at least 80% sequence identity to the mature polypeptide coding sequence of SEQ ID NO: 1; (IV) a variant of the mature polypeptide of SEQ ID NO: 2 comprising a substitution, deletion, and/or insertion at one or more positions; and (V) a fragment of the polypeptide of (I), (II), (III), or (IV); wherein said composition is a cleaning and/or treatment composition. The invention furthermore relates to methods of producing and using the composition.
摘要翻译：本发明涉及一种组合物，其包含：（a）至少一种表面活性剂，至少一种表面活性剂体系，至少一种皂或其任何混合物; 和（b）具有选自以下的脂肪酶活性的多肽：（I）与SEQ ID NO：2的成熟多肽具有至少80％序列同一性的多肽; （II）由寡核苷酸编码的多肽，其在低严格条件下与（i）SEQ ID NO：1的成熟多肽编码序列杂交，或（ii）全长互补序列（i）; （III）由与SEQ ID NO：1的成熟多肽编码序列具有至少80％序列同一性的多核苷酸编码的多肽; （IV）SEQ ID NO：2的成熟多肽的变体，其在一个或多个位置包含取代，缺失和/或插入; 和（V）（I），（II），（III）或（IV）的多肽的片段; 其中所述组合物是清洁和/或治疗组合物。本发明还涉及生产和使用该组合物的方法。

10. 发明申请

WO2014015256A2 ENZYMATIC OXIDATION OF 5-HYDROXYMETHYLFURFURAL AND DERIVATIVES THEREOF 审中-公开
标题翻译： 5-羟甲基糠醛及其衍生物的酶促氧化
公开(公告)号：WO2014015256A2
公开(公告)日：2014-01-23
申请号：PCT/US2013/051272
申请日：2013-07-19
申请人： NOVOZYMES A/S , KALUM, Lisbeth , MORANT, Marc Dominique , LUND, Henrik , JENSEN, Jacob , LAPAINAITE, Ingrida , SOERENSEN, Niels Henrik , PEDERSEN, Sven , ØSTERGAARD, Lars Henrik , XU, Feng
发明人： KALUM, Lisbeth , MORANT, Marc Dominique , LUND, Henrik , JENSEN, Jacob , LAPAINAITE, Ingrida , SOERENSEN, Niels Henrik , PEDERSEN, Sven , ØSTERGAARD, Lars Henrik , XU, Feng
IPC分类号： C12P17/04
CPC分类号： C12P17/04 , C12N9/0006 , C12N9/0065 , C12Y101/03009 , C12Y111/02
摘要： Provided herein are enzymatic methods for oxidation of 5-hydroxymethylfurfural (HMF) and HMF derivatives.
摘要翻译：本文提供了用于氧化5-羟甲基糠醛（HMF）和HMF衍生物的酶促方法。

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