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    • 3. 发明申请
    • USE OF POLYPEPTIDES HAVING ANTIMICROBIAL ACTIVITY
    • 使用具有抗微生物活性的多肽
    • WO2007107573A1
    • 2007-09-27
    • PCT/EP2007/052652
    • 2007-03-20
    • NOVOZYMES A/SNOVOZYMES, INC.GORMSEN, ErikYAVER, Debbie
    • GORMSEN, ErikYAVER, Debbie
    • A61K38/16C07K14/32A61L2/00A61P31/00
    • A61K38/164A01N37/46A01N63/02A61L2/16C11D3/3719C11D3/38C11D3/48
    • The present invention relates to the use of polypeptides related to a Bacillus licheniformis polypeptide (amino acids 1-85 of SEQ ID NO: 2) as antimicrobial agents, for example in pharmaceutical applications, including veterinary applications, as well as for preservation, cleaning and disinfection of various surfaces, objects and substances. The polypeptides may in particular be used to treat textiles or laundry, e.g., in detergents, for reducing microbes on textile or laundry, and/or for odor reduction. The invention also relates to use of Bacillus strains producing these polypeptides as antimicrobial agents. Examples of microorganism inhibited by Lento are Gram positive bacterial strains, such as Bacillus cereus, and various species of Corynebacterium, Enterococcus, Micrococcus, Streptococcus, and Staphylococcus.
    • 本发明涉及与地衣芽孢杆菌多肽(SEQ ID NO:2的氨基酸1-85)相关的多肽作为抗微生物剂的用途,例如在药物应用中,包括兽医应用,以及用于保存,清洁和 消毒各种表面,物体和物质。 多肽可特别用于处理纺织品或衣物,例如在洗涤剂中,用于还原织物或衣物上的微生物和/或降低气味。 本发明还涉及产生这些多肽的芽孢杆菌菌株作为抗微生物剂的用途。 由Lento抑制的微生物的实例是革兰氏阳性细菌菌株,如蜡状芽孢杆菌,以及各种棒状杆菌,肠球菌,微球菌,链球菌和葡萄球菌。