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1. 发明申请

WO1996013303A1 VASCULAR SYSTEM TREATING METHOD AND APPARATUS 审中-公开
标题翻译：血管系统治疗方法和装置
公开(公告)号：WO1996013303A1
公开(公告)日：1996-05-09
申请号：PCT/US1995013728
申请日：1995-10-23
申请人： NOVOSTE CORPORATION
发明人： NOVOSTE CORPORATION , WAKSMAN, Ron , WELDON, Thomas, D. , HILLSTEAD, Richard, A. , ROSEN, Jonathan, J. , LARSON, Charles, E. , CROCKER, Ian, R. , MELOUL, Raphael, F.
IPC分类号： A61N05/00
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： This invention is an apparatus and method for delivering a treating element (22), such as a radiation source, through a catheter (60) to a desired site in a vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongate flexible catheter tube (20) having proximal and distal portions, with a lumen (202) extending therebetween, and a diameter sufficiently small for insertion into the patient's vascular system. One or more treating elements (22), such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of a liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.
摘要翻译：本发明是一种用于将诸如辐射源的处理元件（22）通过导管（60）输送到患者（例如冠状动脉）的血管系统中用于抑制形成的患者的期望部位的装置和方法的瘢痕组织，例如可能发生在球囊血管成形术后再狭窄。该装置包括具有近端部分和远端部分的细长的柔性导管（20），其中在其间延伸的腔（202）以及足够小以插入患者的血管系统的直径。一个或多个处理元件（22），例如包含放射性物质的胶囊或丸粒可定位在内腔中，并且可在液体流过内腔的力的作用下在近端部分和远端部分之间移动。公开了一种使用这种装置的方法，包括与球囊血管成形术程序同时使用这种装置的方法。

2. 发明申请

WO1997035141A1 AUTOMATIC FLUID CONTROL VALVE 审中-公开
标题翻译：自动流体控制阀
公开(公告)号：WO1997035141A1
公开(公告)日：1997-09-25
申请号：PCT/US1996003692
申请日：1996-03-18
申请人： NOVOSTE CORPORATION
发明人： NOVOSTE CORPORATION , MELOUL, Raphael, F. , ROSEN, Jonathan, J.
IPC分类号： F16L29/02
CPC分类号： F16L29/02
摘要： An automatic fluid control having a first (14) and second (18) tube member and a slidable valve element (20) capable of moving from a sealed closed position to an open position permitting fluid passage therethrough. In a preferred first embodiment, the elastomeric valve element is slidingly received with a passageway (28) in the first tube. The valve element has a flange portion containing a plurality of slits (82) in the first tube. The valve element has a flange portion containing a plurality of slits (82) that, when inverted and stretched, permit fluid to pass therethrough, but when closed, are in contact with the inner wall of the first tube and prevents fluid from passing therethrough. The valve element also can have a rigid plug (90) attached within an opening in the top surface to present a preferably non-deformable contact point for a male luer tip (112) which, when pressed downward on the valve element, breaks a seal between the valve element and the first tube inner wall.
摘要翻译：具有第一管（14）和第二管（18）的自动流体控制和能够从密封的关闭位置移动到允许流体通过其中的打开位置的可滑动的阀元件（20）。在优选的第一实施例中，弹性阀元件以第一管中的通道（28）滑动地容纳。阀元件具有在第一管中包含多个狭缝（82）的凸缘部分。阀元件具有凸缘部分，该凸缘部分包含多个狭缝（82），当反向和拉伸时允许流体通过，但是当关闭时，它们与第一管的内壁接触并防止流体通过。阀元件还可以具有附接在顶表面中的开口内的刚性塞子（90），以呈现用于阳性鲁尔末梢（112）的优选不可变形的接触点，当阳性鲁棒末端（112）向下压在阀元件上时，破坏密封件在阀元件和第一管内壁之间。

3. 发明申请

WO1997037715A1 RADIATION TREATMENT OF THE VASCULAR SYSTEM 审中-公开
标题翻译：血管系统的放射治疗
公开(公告)号：WO1997037715A1
公开(公告)日：1997-10-16
申请号：PCT/US1997005538
申请日：1997-04-04
申请人： NOVOSTE CORPORATION , EMORY UNIVERSITY
发明人： NOVOSTE CORPORATION , EMORY UNIVERSITY , WAKSMAN, Ron , WELDON, Thomas, D. , MELOUL, Raphael, F. , HILLSTEAD, Richard, A. , ROSEN, Jonathan, J. , BONNOITT, George, K. , HALPERN, David, S. , LARSEN, Charles, E. , CROCKER, Ian, R.
IPC分类号： A61M29/00
CPC分类号： A61M37/0069 , A61M25/0029 , A61M25/1002 , A61M25/1006 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61N5/1002 , A61N5/1007 , A61N2005/1003 , A61N2005/1005 , A61N2005/1008 , A61N2005/1023
摘要： Apparatus for delivery of a treatment element (22) such as a radiation source, through a catheter (92) to a desired site in the interluminal passageways of a patient, such as the coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. One or more treatment elements (22), such as a capsule or pellet containing radioactive material, is positionable within the lumen (144) and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. Balloon membrane (256) can be used for angioplasty.
摘要翻译：用于将诸如辐射源的治疗元件（22）（例如辐射源）递送到诸如冠状动脉的患者的椎间通道中的期望部位的用于抑制诸如可能的瘢痕组织的形成的装置发生在球囊血管成形术后再狭窄。一个或多个治疗元件（例如包含放射性物质的胶囊或丸粒）可定位在内腔（144）内，并可在液体流过内腔的液体力的作用下在近端部分和远端部分之间移动。球囊膜（256）可用于血管成形术。

4. 发明公开

EP0836502A1 RADIATION TREATMENT OF THE VASCULAR SYSTEM 失效
标题翻译：对于BlutgefäE中的放射线治疗装置
公开(公告)号：EP0836502A1
公开(公告)日：1998-04-22
申请号：EP97922288.0
申请日：1997-04-04
申请人： NOVOSTE CORPORATION , EMORY UNIVERSITY
发明人： WAKSMAN, Ron , WELDON, Thomas, D. , MELOUL, Raphael, F. , HILLSTEAD, Richard, A. , ROSEN, Jonathan, J. , BONNOITT, George, K. , HALPERN, David, S. , LARSEN, Charles, E. , CROCKER, Ian, R.
IPC分类号： A61N5 , A61F2 , A61M29 , A61M36 , A61M25
CPC分类号： A61M37/0069 , A61M25/0029 , A61M25/1002 , A61M25/1006 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61N5/1002 , A61N5/1007 , A61N2005/1003 , A61N2005/1005 , A61N2005/1008 , A61N2005/1023
摘要： Apparatus for delivery of a treatment element (22) such as a radiation source, through a catheter (92) to a desired site in the interluminal passageways of a patient, such as the coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. One or more treatment elements (22), such as a capsule or pellet containing radioactive material, is positionable within the lumen (144) and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. Balloon membrane (256) can be used for angioplasty.

5. 发明公开

EP0790844A1 VASCULAR SYSTEM TREATING METHOD AND APPARATUS 失效
标题翻译： DEVICE FOR血管的治疗
公开(公告)号：EP0790844A1
公开(公告)日：1997-08-27
申请号：EP95937621.0
申请日：1995-10-23
申请人： NOVOSTE CORPORATION
发明人： WAKSMAN, Ron , WELDON, Thomas, D. , HILLSTEAD, Richard, A. , ROSEN, Jonathan, J. , LARSON, Charles, E. , CROCKER, Ian, R. , MELOUL, Raphael, F.
IPC分类号： A61B , A61M , A61N , A61M36 , A61F2 , A61M3 , A61M25 , A61M29 , A61M31 , A61N5 , G21F5
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： This invention is an apparatus and method for delivering a treating element (22), such as a radiation source, through a catheter (60) to a desired site in a vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongate flexible catheter tube (20) having proximal and distal portions, with a lumen (202) extending therebetween, and a diameter sufficiently small for insertion into the patient's vascular system. One or more treating elements (22), such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of a liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.

6. 发明授权

EP0836502B1 Radiation treatment device for the vascular system 失效
标题翻译：对于BlutgefäE中的放射线治疗装置
公开(公告)号：EP0836502B1
公开(公告)日：2006-02-15
申请号：EP97922288.2
申请日：1997-04-04
申请人： NOVOSTE CORPORATION , EMORY UNIVERSITY
发明人： WAKSMAN, Ron , WELDON, Thomas, D. , MELOUL, Raphael, F. , HILLSTEAD, Richard, A. , ROSEN, Jonathan, J. , BONNOITT, George, K. , HALPERN, David, S. , LARSEN, Charles, E. , CROCKER, Ian, R.
IPC分类号： A61M29/00 , A61N5/10
CPC分类号： A61M37/0069 , A61M25/0029 , A61M25/1002 , A61M25/1006 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61N5/1002 , A61N5/1007 , A61N2005/1003 , A61N2005/1005 , A61N2005/1008 , A61N2005/1023
摘要： Apparatus for delivery of a treatment element (22) such as a radiation source, through a catheter (92) to a desired site in the interluminal passageways of a patient, such as the coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. One or more treatment elements (22), such as a capsule or pellet containing radioactive material, is positionable within the lumen (144) and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. Balloon membrane (256) can be used for angioplasty.

7. 发明授权

EP0790844B1 VASCULAR SYSTEM TREATING APPARATUS 失效
标题翻译： DEVICE FOR血管的治疗
公开(公告)号：EP0790844B1
公开(公告)日：2005-04-20
申请号：EP95937621.1
申请日：1995-10-23
申请人： NOVOSTE CORPORATION
发明人： WAKSMAN, Ron , WELDON, Thomas, D. , HILLSTEAD, Richard, A. , ROSEN, Jonathan, J. , LARSON, Charles, E. , CROCKER, Ian, R. , MELOUL, Raphael, F.
IPC分类号： A61N5/00
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： This invention is an apparatus and method for delivering a treating element (22), such as a radiation source, through a catheter (60) to a desired site in a vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongate flexible catheter tube (20) having proximal and distal portions, with a lumen (202) extending therebetween, and a diameter sufficiently small for insertion into the patient's vascular system. One or more treating elements (22), such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of a liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.

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