专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007107304A2 AN EFFICIENT METHOD FOR LOADING AMPHOTERIC LIPOSOMES WITH NUCLEIC ACID ACTIVE SUBSTANCES 审中-公开
标题翻译：一种用核酸活性物质装载AMPHTERIC脂质体的有效方法
公开(公告)号：WO2007107304A2
公开(公告)日：2007-09-27
申请号：PCT/EP2007002349
申请日：2007-03-16
申请人： NOVOSOM AG , PANZNER STEFFEN , ENDERT GEROLD , RAUCHHAUS UNA , HERZOG NATALIE , MULLER NATALIE
发明人： PANZNER STEFFEN , ENDERT GEROLD , RAUCHHAUS UNA , HERZOG NATALIE , MULLER NATALIE
IPC分类号： A61K9/127
CPC分类号： A61K48/00 , A61K9/1272 , A61K9/1277 , C07H21/00 , C12N15/88 , Y02P20/582
摘要： A method for preparing amphoteric liposomes loaded with a polyanionic active agent as cargo, characterised by admixing an aqueous solution of said polyanionic active agent and an alcoholic solution of one or more amphiphiles and buffering said admixture to an acidic pH, said one or more amphiphiles being susceptible of forming amphoteric liposomes at said acidic pH, thereby to form such amphoteric liposomes in suspension encapsulating said active agent under conditions such that said liposomes form aggregates, and thereafter treating said suspension to dissociate said aggregates. Also disclosed are nucleic acid loaded amphoteric liposomes produced in accordance with the method, wherein said nucleic acids are oligonucleotides and said liposomes are multilamellar.
摘要翻译：一种制备负载聚阴离子活性剂作为货物的两性脂质体的方法，其特征在于将所述聚阴离子活性剂的水溶液和一种或多种两亲物的醇溶液混合并将所述混合物缓冲至酸性pH，所述一个或多个两亲物为易于在所述酸性pH下形成两性脂质体，从而在使所述脂质体形成聚集体的条件下形成包封所述活性剂的悬浮液中的这种两性脂质体，然后处理所述悬浮液以解离所述聚集体。还公开了根据该方法生产的核酸负载的两性脂质体，其中所述核酸是寡核苷酸，所述脂质体是多层的。

2. 发明申请

WO2007031333A3 IMPROVEMENTS IN OR RELATING TO AMPHOTERIC LIPOSOMES 审中-公开
标题翻译：改善或与两性脂质体有关
公开(公告)号：WO2007031333A3
公开(公告)日：2007-07-19
申请号：PCT/EP2006009013
申请日：2006-09-15
申请人： NOVOSOM AG , PANZNER STEFFEN , KERWITZ YVONNE , RAUCHHAUS UNA , LUTZ SILKE , ENDERT GEROLD
发明人： PANZNER STEFFEN , KERWITZ YVONNE , RAUCHHAUS UNA , LUTZ SILKE , ENDERT GEROLD
IPC分类号： A61K9/127 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/16 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P37/06
CPC分类号： A61K9/1271 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K31/713 , A61K48/00 , C12N15/1138 , C12N15/88 , C12N2310/11 , C12N2320/32
摘要： A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.
摘要翻译：能够包封活性剂以形成脂质体的血清稳定的脂质混合物，所述混合物包含比例范围为约0.5至约8的磷脂酰胆碱和磷脂酰乙醇胺。混合物还可以包括pH敏感的阴离子和阳离子两亲物，例如该混合物是两性的，在pH7.4带负电或中性，在pH4带正电。包含这种混合物的两性脂质体可用于包封核酸治疗剂，如寡核苷酸和DNA质粒。可以调整药物/脂质比率以将脂质体靶向至身体中的特定器官或其他部位。

3. 发明申请

WO2004047792A2 LIPOSOMAL GLUCOCORTICOIDS 审中-公开
标题翻译：脂质体糖皮质激素
公开(公告)号：WO2004047792A2
公开(公告)日：2004-06-10
申请号：PCT/DE0303893
申请日：2003-11-24
申请人： NOVOSOM AG , PANZNER STEFFEN , BRAEUER ROLF , KINNE RAIMUND W , RAUCHHAUS UNA
发明人： PANZNER STEFFEN , BRAEUER ROLF , KINNE RAIMUND W , RAUCHHAUS UNA
IPC分类号： A61K9/127 , A61K9/00
CPC分类号： A61K9/1272 , A61K9/127 , A61K9/1271
摘要： The invention relates to a liposomal formulation comprising water-soluble glucocorticoids, the use of said formulation for treating inflammatory diseases, and a kit containing the liposomal formulation, e.g. as a pharmaceutical agent.
摘要翻译：本发明涉及一种脂质体制剂，其包括水溶性的糖皮质激素，使用该制剂的炎症性疾病的治疗，并且包括脂质体制剂作为药物试剂的试剂盒，例如。

4. 发明专利

AU2003294635A2 Liposomal glucocorticoids 未知
公开(公告)号：AU2003294635A2
公开(公告)日：2004-06-18
申请号：AU2003294635
申请日：2003-11-24
申请人： NOVOSOM AG
发明人： PANZER STEFFEN , BRAUER ROLF , KINNE RAIMUND W , RAUCHHAUS UNA
IPC分类号： A61K9/127 , A61K9/00

5. 发明专利

DE102006054192A1 Method for loading nucleic acid active substances within amphoteric liposomes, comprises: mixing lipid mixture solution and aqueous solution of nucleic acid active substances; and sterile filtrating the liposomes containing the substances 未知
公开(公告)号：DE102006054192A1
公开(公告)日：2007-09-20
申请号：DE102006054192
申请日：2006-11-10
申请人： NOVOSOM AG
发明人： PANZNER STEFFEN , ENDERT GEROLD , RAUCHHAUS UNA , HERZOG NATALIE , MUELLER CLAUDIA
IPC分类号： A61K48/00 , A61K9/127
摘要： Method for loading of nucleic acid active substances within amphoteric liposomes, comprises: (a) providing a lipid mixture solution; (b) providing an aqueous solution of the nucleic acid active substance; (c) mixing the two solutions by injecting the alcoholic solution of the lipid mixture into the nucleic acid solutions or vice versa; (f) separating the non-included active substance, saturation of the liposome suspension, exchange of the aqueous medium and/or separation of the water-miscible solvent, and (g) optionally sterile filtrating the liposomes containing the active substance. Method for loading of nucleic acid active substances within amphoteric liposomes, comprises: (a) providing a solution of a lipid mixture in a water-miscible solvent, preferably an alcohol that can be optionally acidified; (b) providing an aqueous solution of the nucleic acid active substance to be included that can be optionally acidified, where at least one of the two solutions in (a) and (b) has to be set to a pH value with the help of acids and/or buffer substances; (c) mixing the two solutions by injecting the alcoholic solution of the lipid mixture into the aqueous solution of the nucleic acids or vice versa or by combination of two partial flows of the provided lipid solution and nucleic acid solutions, optionally in one or more mixers; (d) optionally diluting the mixed solutions; (e) breaking up of the interactive forces between the amphoteric liposomes and the nucleic acids through an increase of the pH value to more than 7 or by an increase of the ionic strength and subsequent increase of the pH value to more than 7; (f) separating the non-included active substance and/or saturation of the liposome suspension and/or exchange of the aqueous medium and/or separation of the water-miscible solvent, where each of these steps is independently optional; and (g) optionally sterile filtrating the liposomes containing the active substance, where between the steps (c) and (d) and/or between (d) and (e) and/or between (e) and (f) and/or between (f) and (g), an extruding step can take place and/or between the steps (e) and (f) and/or between (f) and (g), one or more freezing/thawing cycle(s) can take place and/or after step (e), (f) or (g), one or more freezing/thawing cycle(s) and/or a lyophilization of the liposomes containing the active substance can take place. An independent claim is included for the amphoteric liposomes comprising the nucleic acids obtained by the above method. ACTIVITY : None given. MECHANISM OF ACTION : Gene therapy.

6. 发明专利

CA2622584C IMPROVEMENTS IN OR RELATING TO AMPHOTERIC LIPOSOMES 未知
公开(公告)号：CA2622584C
公开(公告)日：2015-08-11
申请号：CA2622584
申请日：2006-09-15
申请人： NOVOSOM AG
发明人： PANZNER STEFFEN , KERWITZ YVONNE , RAUCHHAUS UNA , LUTZ SILKE , ENDERT GEROLD
IPC分类号： A61K9/127 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/16 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P37/06
摘要： A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.

7. 发明专利

DE102004054731A1 New pharmaceutical composition comprising an oligonucleotide that is adapted to target nucleic acids encoding CD40, useful for preventing or treating an inflammatory, immune or autoimmune disorder 未知
公开(公告)号：DE102004054731A1
公开(公告)日：2006-11-23
申请号：DE102004054731
申请日：2004-11-05
申请人： NOVOSOM AG
发明人： PANZNER STEFFEN , ENDERT GEROLD , RAUCHHAUS UNA
IPC分类号： A61K48/00 , A61K9/127 , A61K31/7088 , A61K31/7125 , A61K31/713
摘要： A pharmaceutical composition comprising an oligonucleotide that is adapted to target nucleic acids encoding CD40, thus modulating the expression of CD40 mammalian cells, and an amphoteric liposome as an excipient, is new. ACTIVITY : Immunosuppressive; Dermatological; Antiinflammatory; Antiarthritic; Anti-thyroid; Gastrointestinal. No biological data given. MECHANISM OF ACTION : Immunotherapy.

8. 发明专利

DE10255106A1 未知
公开(公告)号：DE10255106A1
公开(公告)日：2004-06-09
申请号：DE10255106
申请日：2002-11-24
申请人： NOVOSOM AG
发明人： PANZNER STEFFEN , BRAEUER ROLF , KINNE RAIMUND W , RAUCHHAUS UNA
IPC分类号： A61K9/127 , A61K31/57

9. 发明专利

AT445389T 未知
公开(公告)号：AT445389T
公开(公告)日：2009-10-15
申请号：AT03785534
申请日：2003-11-24
申请人： NOVOSOM AG
发明人： PANZNER STEFFEN , BRAEUER ROLF , KINNE RAIMUND , RAUCHHAUS UNA
IPC分类号： A61K9/127

10. 发明专利

CA2622584A1 IMPROVEMENTS IN OR RELATING TO AMPHOTERIC LIPOSOMES 未知
公开(公告)号：CA2622584A1
公开(公告)日：2007-03-22
申请号：CA2622584
申请日：2006-09-15
申请人： NOVOSOM AG
发明人： PANZNER STEFFEN , KERWITZ YVONNE , ENDERT GEROLD , LUTZ SILKE , RAUCHHAUS UNA
IPC分类号： A61K9/127 , A61P1/00 , A61P1/04 , A61P3/10 , A61P5/16 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P37/06
摘要： A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. Th e mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7. 4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixtu re may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式