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1. 发明申请

WO1990002794A1 THERMOPHILIC ALGINATE LYASE FROM BACILLUS STEAROTHERMOPHILUS NRRL B-18394 审中-公开
标题翻译：来自BACILLUS STEAROTHERMOPHILUS NRRL B-18394的热乳酸
公开(公告)号：WO1990002794A1
公开(公告)日：1990-03-22
申请号：PCT/DK1989000214
申请日：1989-09-15
申请人： NOVO-NORDISK A/S , LIU, Chi-Li
发明人： NOVO-NORDISK A/S
IPC分类号： C12N01/20
CPC分类号： C12R1/07 , C02F1/50 , C02F2103/023 , C12N9/88 , Y10S435/832
摘要： A method of producing algal cell wall degrading enzyme by cultivating a thermophilic, bacterial strain of atypical Bacillus stearothermophilus e.g., W36-7-4 (NRRL B-18394) productive of the alginate lyase in an aqueous medium containing sodium alginate and tryptone, then allowing growth to take place to accumulate alginate lyase, and then recovering the enzyme from the fermentation broth. The alginate lyase is useful as a treatment agent for cooling waters.

2. 发明申请

WO1990010645A1 GLYCOSYLATED INSULINS 审中-公开
标题翻译：谷氨酸胰岛素
公开(公告)号：WO1990010645A1
公开(公告)日：1990-09-20
申请号：PCT/DK1990000062
申请日：1990-03-06
申请人： NOVO-NORDISK A/S
发明人： NOVO-NORDISK A/S , HALSTROM, John, Broberg
IPC分类号： C07K07/40
CPC分类号： C07K14/62 , A61K38/00
摘要： Specifically glycosylated insulins and pharmaceutical preparations hereof are provided. The novel insulins will preferably be mono-, di- or triglycosylated and contain a monosaccharide group or an oligosaccharide group with two or three sugar units. The specifically glycosylated insulins will have a high solubility and a more rapid onset of insulin action than for instance human insulin.
摘要翻译：提供了具体的糖基化胰岛素及其药物制剂。新型胰岛素优选是单，二或三糖基化并含有具有两个或三个糖单元的单糖基团或寡糖基团。特异性糖基化的胰岛素将具有比例如人胰岛素更高的溶解度和更快速的胰岛素作用发作。

3. 发明申请

WO1990008182A1 BLEACHING DETERGENT COMPOSITION 审中-公开
标题翻译：漂白剂洗涤剂组合物
公开(公告)号：WO1990008182A1
公开(公告)日：1990-07-26
申请号：PCT/DK1990000022
申请日：1990-01-22
申请人： NOVO-NORDISK A/S , PROCTER & GAMBLE COMPANY , DAMHUS, Ture , KIRK, Ole , HARDY, Frederick, Edward
发明人： NOVO-NORDISK A/S , PROCTER & GAMBLE COMPANY
IPC分类号： C11D03/39
CPC分类号： C11D1/662 , C11D3/3912
摘要： Esters of monosaccharides and their lower alkyl glycosides are effective both as surfactants and as bleach activators (peracid precursors). The compounds are non-toxic and biodegradable. They act as nonionic surfactants and are effective in soil removal from textiles, e.g. of fatty soiling. In the presence of a hydrogen peroxide source, the sugar derivatives are perhydrolyzed during the washing process to form long-chain peracid. This enhances the bleaching effect, especially on hydrophobic stains.

4. 发明申请

WO1990002175A1 A METHOD OF PRODUCING POLYPEPTIDES BY CULTURING EUKARYOTIC CELLS IN THE PRESENCE OF PROTEASE INHIBITORS 审中-公开
标题翻译：通过在蛋白酶抑制剂存在下培养真核细胞产生多肽的方法
公开(公告)号：WO1990002175A1
公开(公告)日：1990-03-08
申请号：PCT/DK1989000194
申请日：1989-08-15
申请人： NOVO-NORDISK A/S , HANSEN, Karen , MIKKELSEN, Jan, Moller
发明人： NOVO-NORDISK A/S
IPC分类号： C12N15/00
CPC分类号： C12P21/02 , C12N5/0037 , C12N2501/70
摘要： In an improved method of producing polypeptides, eukariotic cells, containing a DNA-structure coding for the actual polypeptide, are cultured in a medium in the presence of one or more protease inhibitors, such as a polypeptide having functional groups. Preferably, the medium should be serum free. The method can, in principle, be used for the production of any valuable polypeptide. Examples are the production of Factor VIII:C and subunits of fragments or derivatives of FVIII:C. An improved yield is obtained.
摘要翻译：在生产多肽的改进方法中，含有编码实际多肽的DNA结构的真核细胞在一种或多种蛋白酶抑制剂如具有官能团的多肽的存在下在培养基中培养。优选地，培养基应该是无血清的。该方法原则上可用于生产任何有价值的多肽。实例是产生因子VIII：C和FVIII：C的片段或衍生物的亚基。获得了提高的产率。

5. 发明申请

WO1990000600A1 A TISSUE PLASMINOGEN ACTIVATOR ANALOGUE 审中-公开
标题翻译：一个组织的PLASMINOGEN ACTIVATOR ANALOGUE
公开(公告)号：WO1990000600A1
公开(公告)日：1990-01-25
申请号：PCT/DK1989000171
申请日：1989-07-07
申请人： NOVO-NORDISK A/S , PETERSEN, Lars, Christian , BOEL, Esper
发明人： NOVO-NORDISK A/S
IPC分类号： C12N09/50
CPC分类号： C12N9/6459 , A61K38/00 , C12Y304/21069
摘要： A tissue plasminogen activator (t-PA) analogue in substantially inactivated one-chain form capble of being converted to the active two-chain form is modified in the region from position 414 to position 433. In particular, the t-PA analogue is one in which a positively charged amino acid residue in position 419 and optionally also in position 420 has been replaced by a negatively charged or uncharged amino acid residue to inhibit interaction with the amino acid residue in position 480.

6. 发明申请

WO1990000157A1 PROCESS FOR DECOMPOSITION OF METAL-CYANO COMPLEXES USING MICROBIAL ENZYMES 审中-公开
标题翻译：使用微生物酶分解金属 - 氰基复合物的方法
公开(公告)号：WO1990000157A1
公开(公告)日：1990-01-11
申请号：PCT/DK1989000164
申请日：1989-06-30
申请人： NOVO-NORDISK A/S , INGVORSEN, Kjeld
发明人： NOVO-NORDISK A/S
IPC分类号： C02F03/00
CPC分类号： C02F9/005 , C02F3/1231 , C02F3/342 , C12N9/00 , C12N9/78 , C22B3/18 , Y02P10/234 , Y02W10/15
摘要： An enzymatic process for specific decomposition of metal-cyano complexes in waste waters and process streams wherein microbial enzymes which are not oxygenases and which do not require the regeneration of coenzymes or prostetic groups are brought into contact with said waste water or process stream for a period sufficient to decompose said metal-cyano complexes to a desired concentration.

7. 发明申请

WO1990010687A1 FAT HYDROLYSIS PROCESS 审中-公开
标题翻译： FAT水解过程
公开(公告)号：WO1990010687A1
公开(公告)日：1990-09-20
申请号：PCT/DK1990000064
申请日：1990-03-08
申请人： NOVO-NORDISK A/S , HANSEN, Tomas, T. , NORMAN, Barrie, E.
发明人： NOVO-NORDISK A/S
IPC分类号： C11C01/04
CPC分类号： C12P7/6418 , C11C1/045
摘要： In an industrial process for lipase-catalyzed hydrolysis of fat, addition of a minor amount of cyclodextrin improves the degree of fat hydrolysis. beta -cyclodextrin and derivatives such as methyl- beta -cyclodextrin are preferred.
摘要翻译：在用于脂肪酶催化水解脂肪的工业过程中，加入少量环糊精可提高脂肪水解度。 β-环糊精和诸如甲基-β-环糊精的衍生物是优选的。

8. 发明申请

WO1990010075A1 YEAST PROCESSING SYSTEM COMPRISING A NEGATIVELY CHARGED AMINO ACID ADJACENT TO THE PROCESSING SITE 审中-公开
标题翻译：包含负责加工场地的负责任氨基酸的YEAST处理系统
公开(公告)号：WO1990010075A1
公开(公告)日：1990-09-07
申请号：PCT/DK1990000058
申请日：1990-03-01
申请人： NOVO-NORDISK A/S
发明人： NOVO-NORDISK A/S , BJORN, Soren , NORRIS, Kjeld , NORRIS, Fanny
IPC分类号： C12N15/81
CPC分类号： C12N15/625 , C07K14/62 , C07K14/8117 , C07K2319/033 , C07K2319/036 , C07K2319/04 , C07K2319/61 , C07K2319/75
摘要： A polypeptide for production in yeast comprises a fusion of a signal peptide, a leader peptide and a heterologous protein or polypeptide. The polypeptide is modified in its amino acid sequence adjacent to a yeast processing site positioned between the C-terminal end of the leader peptide and the N-terminal end of the heterologous protein so as to provide a presentation of the processing site which makes it accessible to proteolytic cleavage. Such a presentation is provided by adding one or more amino acids (at least one of which is negatively charged) to either the C-terminal end of the leader or the N-terminal end of the protein, or both. The heterologous protein may, for instance, be aprotinin or insulin precursor or an analogue thereof.
摘要翻译：用于在酵母中生产的多肽包括信号肽，前导肽和异源蛋白质或多肽的融合物。该多肽在与位于前导肽的C-末端和异源蛋白质的N-末端之间的酵母加工位点相邻的氨基酸序列中被修饰，从而提供使得其可接近的处理位点的呈现蛋白水解切割。通过将一个或多个氨基酸（其中至少一个带负电荷）添加到前导序列的C-末端或蛋白质的N-末端或二者之间来提供这种呈递。异源蛋白质可以是例如抑肽酶或胰岛素前体或其类似物。

9. 发明申请

WO1990008158A1 METHOD OF RECOVERING PURIFIED EPI PROTEIN FROM A SOLUTION ESPECIALLY A FERMENTATION SOLUTION 审中-公开
标题翻译：从溶液中回收纯化的EPI蛋白的方法特别是发酵溶液
公开(公告)号：WO1990008158A1
公开(公告)日：1990-07-26
申请号：PCT/DK1990000016
申请日：1990-01-18
申请人： NOVO-NORDISK A/S , NORDFANG, Ole , CARLSEN, Soren
发明人： NOVO-NORDISK A/S
IPC分类号： C07K03/18
CPC分类号： C12Q1/56 , C07K5/0821 , C07K14/745 , C12Q2337/12 , G01N2333/96461
摘要： The EPI protein is isolated and purified from a fermentation solution, using chromatographic technique, wherein the solution containing the EPI protein is applied to a matrix coupled with heparin, preferably heparin-Sepharose.
摘要翻译：使用色谱技术从发酵溶液中分离和纯化EPI蛋白质，其中将含有EPI蛋白质的溶液施用于与肝素（优选肝素 - 琼脂糖）偶联的基质。

10. 发明申请

WO1990005462A1 METHOD FOR UPGRADING OF MRM (MECHANICALLY RECOVERED MEAT) 审中-公开
标题翻译： MRM（机械恢复肉）升级方法
公开(公告)号：WO1990005462A1
公开(公告)日：1990-05-31
申请号：PCT/DK1989000272
申请日：1989-11-17
申请人： NOVO-NORDISK A/S , RASMUSSEN, Peter, Boyen , RANCKE-MADSEN, Anders
发明人： NOVO-NORDISK A/S
IPC分类号： A23L01/317
CPC分类号： A23L13/48
摘要： In the method for upgrading of MRM (mechanically recovered meat), wherein MRM is treated with an endoprotease with a pH-activity optimum above neutrality with a proteolytic activity related to a weight unit of dry protein which will generate a maximum viscosity increase in relation to the initial viscosity of at least 50 %, for a period of time corresponding to a resulting viscosity of the MRM which is between 100 and 75 % of the maximum viscosity generated by the enzyme treatment, whereafter the enzymatic activity is destroyed by means of any method which does not harm the functionality of the meat. The method does not involve any dilution with relatively large amounts of non-meat proteins, it gives rise to satisfactory organoleptic and functional properties, and it is relatively cheap.
摘要翻译：在用于升级MRM（机械回收肉）的方法中，其中MRM用具有优于中性的pH活性的内切蛋白酶处理，具有与干蛋白重量单位相关的蛋白水解活性，其将相对于初始粘度至少为50％，一段时间对应于由酶处理产生的最大粘度的100-75％之间的MRM的所得粘度，然后通过任何方法破坏酶活性这不会损害肉的功能。该方法不涉及相对大量非肉蛋白的任何稀释，它产生令人满意的感官和功能特性，并且相对便宜。

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