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1. 发明申请

WO2005014035A3 USE OF GALACTOSE OXIDASE FOR SELECTIVE CHEMICAL CONJUGATION OF PROTRACTOR MOLECULES TO PROTEINS OF THERAPEUTIC INTEREST 审中-公开
标题翻译：胶体氧化酶用于选择性化学结合引导剂分子到治疗感染蛋白质的用途
公开(公告)号：WO2005014035A3
公开(公告)日：2005-07-28
申请号：PCT/DK2004000530
申请日：2004-08-09
申请人： NOVO NORDISK HEALTHCARE AG , BEHRENS CARSTEN , GARIBAY PATRICK WILLIAM , ZUNDEL MAGALI , KLAUSEN NIELS KRISTIAN , BJOERN SOEREN E
发明人： BEHRENS CARSTEN , GARIBAY PATRICK WILLIAM , ZUNDEL MAGALI , KLAUSEN NIELS KRISTIAN , BJOERN SOEREN E
IPC分类号： A61K38/44 , A61K38/36
CPC分类号： A61K38/26 , A61K38/4846 , A61K47/60 , C12Y304/21021
摘要： This invention relates to novel compounds, methods for selective chemical conjugation of protractor molecules and the use thereof for diagnostic and/or therapeutic purposes.
摘要翻译：本发明涉及新化合物，量角器分子的选择性化学共轭的方法及其用于诊断和/或治疗目的的用途。

2. 发明申请

WO2004064870A3 RADIOLABELLED TISSUE FACTOR BINDING AGENT AND THE USE THEREOF 审中-公开
标题翻译：放射性组织因子结合剂及其用途
公开(公告)号：WO2004064870A3
公开(公告)日：2005-04-28
申请号：PCT/DK2004000041
申请日：2004-01-22
申请人： NOVO NORDISK AS , H S RIGSHOSPITALET , HESSE BIRGER , KJAER ANDREAS , STENNICKE HENNING RALF , BJOERN SOEREN E , PETERSEN LARS CHRISTIAN
发明人： HESSE BIRGER , KJAER ANDREAS , STENNICKE HENNING RALF , BJOERN SOEREN E , PETERSEN LARS CHRISTIAN
IPC分类号： A61K51/08 , C12N9/64 , A61K51/10
CPC分类号： A61K51/088 , C12N9/6437 , C12Y304/21021
摘要： This invention relates to novel compounds, which bind to tissue factor and the use thereof for diagnostic markers. The invention also relates to pharmaceutical compositions comprising the novel compounds as well as their use in the diagnosing, prophylaxis or treatment of diseases or disorders relates to pathobiology involving tissue factor (TF) including bleedings, cancer, inflammation, atherosclerosis and ischemia/reperfusion. Radiolabelled TF agonists may be valuable for diagnostic imaging with a gamma camera, a PET camera or a PET/CT camera, in particular for the evaluation of TF expression of tumor cells, for grading the malignancy of tumor cells known to express TF receptors, for the monitoring of tumors with TF expression during conventional chemotherapy or radiation therapy. Also TF agonists and/or TF antagonists labelled with alpha or beta-emitting isotopes could be used for therapy, possibly with bi-specific binding to compounds with chemotherapeutic action, which may be related tp the presence of TF receptors.
摘要翻译：本发明涉及结合组织因子的新化合物及其用于诊断标记物的用途。本发明还涉及包含新化合物的药物组合物及其在诊断，预防或治疗疾病或病症中涉及包括渗血，癌症，炎症，动脉粥样硬化和缺血/再灌注的组织因子（TF）的病理生物学的用途。放射性标记的TF激动剂对于使用γ照相机，PET照相机或PET / CT照相机的诊断成像可能是有价值的，特别是用于评估肿瘤细胞的TF表达，用于分级已知表达TF受体的肿瘤细胞的恶性肿瘤，用于在常规化学疗法或放射治疗期间监测具有TF表达的肿瘤。也可以用α或β发射同位素标记的TF激动剂和/或TF拮抗剂用于治疗，可能与化学治疗作用的化合物双特异性结合，这可能与TF受体的存在相关。

3. 发明申请

WO2005024006A2 COAGULATION FACTOR VII POLYPEPTIDES 审中-公开
标题翻译：凝血因子VII多肽
公开(公告)号：WO2005024006A2
公开(公告)日：2005-03-17
申请号：PCT/DK2004000594
申请日：2004-09-09
申请人： NOVO NORDISK AS , OESTERGAARD HENRIK , BJOERN SOEREN E , PERSSON EGON
发明人： OESTERGAARD HENRIK , BJOERN SOEREN E , PERSSON EGON
IPC分类号： C12N9/64 , C12N9/00
CPC分类号： C12N9/6437 , C12N9/647 , C12Y304/21021
摘要： The present invention relates to novel coagulation Factor VII polypeptides, polynucleotide constructs encoding such polypeptides, as well as vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.
摘要翻译：本发明涉及新的凝血因子VII多肽，编码此类多肽的多核苷酸构建体，以及包含和表达所述多核苷酸，药物组合物，用途和治疗方法的载体和宿主细胞。

4. 发明申请

WO2004064870A8 RADIOLABELLED TISSUE FACTOR BINDING AGENT AND THE USE THEREOF 审中-公开
标题翻译：放射性组织因子结合剂及其用途
公开(公告)号：WO2004064870A8
公开(公告)日：2004-11-04
申请号：PCT/DK2004000041
申请日：2004-01-22
申请人： NOVO NORDISK AS , H S RIGSHOSPITALET , HESSE BIRGER , KJAER ANDREAS , STENNICKE HENNING RALF , BJOERN SOEREN E , PETERSEN LARS CHRISTIAN
发明人： HESSE BIRGER , KJAER ANDREAS , STENNICKE HENNING RALF , BJOERN SOEREN E , PETERSEN LARS CHRISTIAN
IPC分类号： A61K51/08 , C12N9/64
CPC分类号： A61K51/088 , C12N9/6437 , C12Y304/21021
摘要： This invention relates to novel compounds, which bind to tissue factor and the use thereof for diagnostic markers. The invention also relates to pharmaceutical compositions comprising the novel compounds as well as their use in the diagnosing, prophylaxis or treatment of diseases or disorders relates to pathobiology involving tissue factor (TF) including bleedings, cancer, inflammation, atherosclerosis and ischemia/reperfusion. Radiolabelled TF agonists may be valuable for diagnostic imaging with a gamma camera, a PET camera or a PET/CT camera, in particular for the evaluation of TF expression of tumor cells, for grading the malignancy of tumor cells known to express TF receptors, for the monitoring of tumors with TF expression during conventional chemotherapy or radiation therapy. Also TF agonists and/or TF antagonists labelled with alpha or beta-emitting isotopes could be used for therapy, possibly with bi-specific binding to compounds with chemotherapeutic action, which may be related tp the presence of TF receptors.

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