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1. 发明申请

WO2007128817A3 INSULIN DERIVATIVE 审中-公开
标题翻译：胰岛素衍生物
公开(公告)号：WO2007128817A3
公开(公告)日：2008-03-06
申请号：PCT/EP2007054444
申请日：2007-05-08
申请人： NOVO NORDISK AS , HUBALEK FRANTISEK , HOEG-JENSEN THOMAS , JONASSEN IB , GARIBAY PATRICK WILLIAM , JAKOBSEN PALLE , HAVELUND SVEND , KODRA JANOS TIBOR
发明人： HUBALEK FRANTISEK , HOEG-JENSEN THOMAS , JONASSEN IB , GARIBAY PATRICK WILLIAM , JAKOBSEN PALLE , HAVELUND SVEND , KODRA JANOS TIBOR
IPC分类号： C07K14/62 , A61K38/28
CPC分类号： C07K14/62 , A61K38/00
摘要： The present invention relates to novel human insulin derivatives which are soluble at physiological pH values and have a prolonged profile of action. The invention also relates to methods of providing such derivatives, to pharmaceutical compositions containing them, to methods of treating diabetes and hyperglycaemia using the insulin derivatives of the invention and to the use of such insulin derivatives in the treatment of diabetes and hyperglycaemia.
摘要翻译：本发明涉及新的人胰岛素衍生物，其在生理pH值下是可溶的并具有延长的作用特征。本发明还涉及提供这样的衍生物，含有它们的药物组合物的方法，使用本发明的胰岛素衍生物治疗糖尿病和高血糖的方法以及这种胰岛素衍生物在治疗糖尿病和高血糖中的用途。

2. 发明申请

WO2007074133A3 COMPOSITIONS COMPRISING AN ACYLATED INSULIN AND ZINC AND METHOD OF MAKING THE SAID COMPOSITIONS 审中-公开
标题翻译：包含ACLLATED INSULIN和ZINC的组合物和制备该组合物的方法
公开(公告)号：WO2007074133A3
公开(公告)日：2007-10-11
申请号：PCT/EP2006070104
申请日：2006-12-21
申请人： NOVO NORDISK AS , HAVELUND SVEND , HUBALEK FRANTISEK , OLSEN HELLE BIRK , JONASSEN IB , HOEG-JENSEN THOMAS , PLUM ANNE , RIBEL-MADSEN ULLA
发明人： HAVELUND SVEND , HUBALEK FRANTISEK , OLSEN HELLE BIRK , JONASSEN IB , HOEG-JENSEN THOMAS , PLUM ANNE , RIBEL-MADSEN ULLA
IPC分类号： C07K14/62 , A61K38/28
CPC分类号： A61K47/48015 , A61K38/28 , A61K47/52 , C07K14/62
摘要： The invention is related to insulin compositions with a high content of zinc atoms per six molecules of acylated insulin. The insulin is an acylated insulin and may be mixed with a further insulin analogue such as the rapid acting insulin Asp B28 human insulin.
摘要翻译：本发明涉及每六分子酰化胰岛素具有高锌含量的胰岛素组合物。胰岛素是酰化胰岛素，并且可以与另外的胰岛素类似物例如快速作用的胰岛素Asp B28人胰岛素混合。

3. 发明申请

WO2006079641A3 INSULIN DERIVATIVES CONJUGATED WITH STRUCTURALLY WELL DEFINED BRANCHED POLYMERS 审中-公开
标题翻译：结构分布良好的分离聚合物的胰岛素衍生物
公开(公告)号：WO2006079641A3
公开(公告)日：2007-06-14
申请号：PCT/EP2006050458
申请日：2006-01-26
申请人： NOVO NORDISK AS , BEHRENS CARSTEN , LAU JESPER , KODRA JANOS TIBOR , KOFOD-HANSEN MIKAEL , HOEG-JENSEN THOMAS , MADSEN PETER , HAVELUND SVEND
发明人： BEHRENS CARSTEN , LAU JESPER , KODRA JANOS TIBOR , KOFOD-HANSEN MIKAEL , HOEG-JENSEN THOMAS , MADSEN PETER , HAVELUND SVEND
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/641 , A61K47/6949
摘要： Insulin conjugated with structurally well defined, bifurcated and trifurcated polymers can be use by pulmonary delivery for systemic absorption through the lungs to reduce or eliminate the need for administering other insulins by injection.
摘要翻译：与结构明确定义的分叉和三叉酸聚合物结合的胰岛素可以通过肺部递送用于通过肺的全身吸收，以减少或消除通过注射施用其它胰岛素的需要。

4. 发明申请

WO2005012347A3 NOVEL INSULIN DERIVATIVES 审中-公开
标题翻译：新型胰岛素衍生物
公开(公告)号：WO2005012347A3
公开(公告)日：2005-04-14
申请号：PCT/DK2004000511
申请日：2004-07-22
申请人： NOVO NORDISK AS , JONASSEN IB , HOEG-JENSEN THOMAS , HAVELUND SVEND , RIBEL-MADSEN ULLA , TAGMOSE TINA MOELLER , MADSEN PETER
发明人： JONASSEN IB , HOEG-JENSEN THOMAS , HAVELUND SVEND , RIBEL-MADSEN ULLA , TAGMOSE TINA MOELLER , MADSEN PETER
IPC分类号： A61K38/28 , A61P5/50 , C07K14/62
CPC分类号： C07K14/62 , A61K38/28 , A61K47/542
摘要： The present invention relates to insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the a-amino group of the N-terminal amino acid residue of the B chain or to the e-amino group of a Lys residue present in the B chain of the parent insulin, the side chain being of the general formula: -W-X-Y-Z wherein W, X, Y and Z are as defined in the disclosure.
摘要翻译：本发明涉及胰岛素衍生物，其是天然存在的胰岛素或其类似物，其具有连接到B链的N端氨基酸残基的α-氨基或Lys的e-氨基上的侧链残基存在于母体胰岛素的B链中，侧链具有以下通式：-WXYZ其中W，X，Y和Z如本文所定义。

5. 发明申请

WO2006125765A2 ACYLATED INSULIN WITH HIGH PURITY 审中-公开
标题翻译：高纯度的精制胰岛素
公开(公告)号：WO2006125765A2
公开(公告)日：2006-11-30
申请号：PCT/EP2006062495
申请日：2006-05-22
申请人： NOVO NORDISK AS , MARKUSSEN JAN , HAVELUND SVEND , JACOBSEN JES KRISTIAN , HVASS AAGE , JONASSEN IB , JENSEN GEORG WILHELM
发明人： MARKUSSEN JAN , HAVELUND SVEND , JACOBSEN JES KRISTIAN , HVASS AAGE , JONASSEN IB , JENSEN GEORG WILHELM
IPC分类号： A61K38/28
CPC分类号： A61K38/28 , C07K14/62
摘要： The present invention is related to a highly purified pharmaceutical preparation comprising an acylated insulin where the acyl group is attached via a linker molecule to the e- amino group of the B29Lys residue of the parent insulin moiety. The insulin pharmaceutical formulation comprises less than about 3% weight/weight of an isomer of the acylated insulin.
摘要翻译：本发明涉及包含酰化胰岛素的高度纯化的药物制剂，其中酰基经由连接分子连接到母体胰岛素部分的B29Lys残基的e-氨基。胰岛素药物制剂包含小于约3重量％的酰化胰岛素的异构体。

6. 发明申请

WO2012049307A2 NOVEL N-TERMINALLY MODIFIED INSULIN DERIVATIVES 审中-公开
标题翻译：新型N-末端改性胰岛素衍生物
公开(公告)号：WO2012049307A2
公开(公告)日：2012-04-19
申请号：PCT/EP2011068019
申请日：2011-10-14
申请人： NOVO NORDISK AS , MADSEN PETER , BALSCHMIDT PER , HAVELUND SVEND , HOEG-JENSEN THOMAS , KJELDSEN THOMAS BOERGLUM , FYNBO CHARLOTTE HARKJAER
发明人： MADSEN PETER , BALSCHMIDT PER , HAVELUND SVEND , HOEG-JENSEN THOMAS , KJELDSEN THOMAS BOERGLUM , FYNBO CHARLOTTE HARKJAER
IPC分类号： C07K14/62
CPC分类号： C07K14/62
摘要： The invention is related to novel N-terminally modified insulin derivatives, pharmaceutical compositions comprising such and methods of making such.
摘要翻译：本发明涉及新的N末端修饰的胰岛素衍生物，包含这种衍生物的药物组合物以及制备该组合物的方法。

7. 发明申请

WO2004056347A3 PHARMACEUTICAL COMPOSITIONS COMPRISING INSULIN AND LEGENDS OF INSULIN HEXAMER 审中-公开
标题翻译：含有胰岛素和胰岛素六聚体的药物组合物
公开(公告)号：WO2004056347A3
公开(公告)日：2004-08-12
申请号：PCT/DK0300931
申请日：2003-12-22
申请人： NOVO NORDISK AS , KAARSHOLM NIELS CHRISTIAN , MADSEN PETER , SCHLEIN MORTEN , OLSEN HELLE BIRK , HAVELUND SVEND , STEENSGAARD DORTE BJERRE , LUDVIGSEN SVEND , JAKOBSEN PALLE , PETERSEN ANDERS KLARSKOV , SCHLUCKEBIER GERD
发明人： KAARSHOLM NIELS CHRISTIAN , MADSEN PETER , SCHLEIN MORTEN , OLSEN HELLE BIRK , HAVELUND SVEND , STEENSGAARD DORTE BJERRE , LUDVIGSEN SVEND , JAKOBSEN PALLE , PETERSEN ANDERS KLARSKOV , SCHLUCKEBIER GERD
IPC分类号： A61K31/416 , A61K31/4192 , A61K38/00 , A61K38/28 , C07D249/06 , C07D249/18 , C07D277/34 , C07D403/04 , C07D413/12 , C07D417/12 , C07K14/62 , C07D413/02 , C07D417/02 , C07K5/00 , C07K7/00
CPC分类号： C07D403/04 , A61K31/416 , A61K31/4192 , A61K38/28 , C07D249/06 , C07D249/18 , C07D277/34 , C07D413/12 , C07D417/12 , C07K14/62 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions comprising insulin and novel ligands for the His Zn sites of the R-state insulin hexamer. The resulting preparations have improved physical and chemical stability.
摘要翻译：本发明提供了包含胰岛素和用于R-状态胰岛素六聚体的His B10 Zn 2+位点的新配体的药物组合物。所得制剂具有改善的物理和化学稳定性。

8. 发明申请

WO2008132224A3 METHOD FOR DRYING A PROTEIN COMPOSITION, A DRIED PROTEIN COMPOSITION AND A PHARMACEUTICAL COMPOSITION COMPRISING THE DRIED PROTEIN 审中-公开
标题翻译：干燥蛋白质组合物，干燥蛋白质组合物的方法和包含干燥蛋白质的药物组合物
公开(公告)号：WO2008132224A3
公开(公告)日：2009-03-19
申请号：PCT/EP2008055306
申请日：2008-04-30
申请人： NOVO NORDISK AS , HAVELUND SVEND , JENSEN SIMON BJERREGAARD
发明人： HAVELUND SVEND , JENSEN SIMON BJERREGAARD
IPC分类号： A61K9/16 , A61K38/28
CPC分类号： A61K9/1688 , A61K38/26 , A61K38/28
摘要： The present invention relates to a method for spray-drying of protein solutions and the spray-dried protein product. The invention also relates to pharmaceutical compositions containing such spray-dried protein, to methods of treating diabetes and hyperglycaemia using the spray-dried protein of the invention and to the use of such spray-dried protein in the treatment of diabetes and hyperglycaemia.
摘要翻译：本发明涉及一种用于喷雾干燥蛋白质溶液和喷雾干燥蛋白质产物的方法。本发明还涉及含有这种喷雾干燥蛋白质的药物组合物，使用本发明的喷雾干燥蛋白质治疗糖尿病和高血糖的方法以及使用这种喷雾干燥的蛋白质治疗糖尿病和高血糖。

9. 发明申请

WO2009021956A3 RAPID ACTING INSULIN ANALOGUES 审中-公开
标题翻译：快速行动胰岛素类似物
公开(公告)号：WO2009021956A3
公开(公告)日：2009-04-30
申请号：PCT/EP2008060597
申请日：2008-08-12
申请人： NOVO NORDISK AS , OLSEN HELLE BIRK , KJELDSEN THOMAS BOERGLUM , BALSCHMIDT PER , GLENDORF TINE , HAVELUND SVEND
发明人： OLSEN HELLE BIRK , KJELDSEN THOMAS BOERGLUM , BALSCHMIDT PER , GLENDORF TINE , HAVELUND SVEND
IPC分类号： C07K14/62
CPC分类号： C07K14/62
摘要： The invention is related to fast acting insulin analogues which can form soluble mixtures (pre-mixed or self-mixed) with long acting insulin analogues. The fast action is achieved through monomerizing substitutions/deletions in the C-terminus of the B-chain of human insulin and the mixability with long acting insulin analogues is achieved through a substitution of the Zn-binding H is in position B10 of human insulin with lie, VaI, Ala or Phe. In one embodiment the invention is related to fast acting insulin analogues in which at least one of the natural amino acid residues in position B22-B30 in the human B-chain has been substituted with another amino acid residue having the effect of promoting formation of the monomeric form of insulin, the H is amino acid residue in position 10 in the B-chain is substituted with lie, VaI, Ala or Phe and wherein further one or more of the amino acid residues in position B22-B30 optionally have been deleted.
摘要翻译：本发明涉及可与长效胰岛素类似物形成可溶性混合物（预混合或自混合）的快速作用胰岛素类似物。通过在人胰岛素的B链的C末端单体化取代/缺失实现快速作用，并且通过用人胰岛素B10位置上的Zn结合H取代与长效胰岛素类似物的混合性来实现，，Val，Ala或Phe。在一个实施方案中，本发明涉及快速作用的胰岛素类似物，其中人B链中位置B22-B30中的至少一个天然氨基酸残基已经被另一个氨基酸残基取代，其具有促进形成单体形式的胰岛素，H是B链中位置10的氨基酸残基被取代为，Val，Ala或Phe，并且其中一个或多个位置B22-B30的氨基酸残基任选地被缺失。

10. 发明申请

WO2008132229A3 HIGHLY CONCENTRATED INSULIN SOLUTIONS AND COMPOSITIONS 审中-公开
标题翻译：高浓度胰岛素溶液和组合物
公开(公告)号：WO2008132229A3
公开(公告)日：2009-03-12
申请号：PCT/EP2008055341
申请日：2008-04-30
申请人： NOVO NORDISK AS , BALSCHMIDT PER , WAHLUND PER-OLUF , HAVELUND SVEND , BJERREGAARD JENSEN SIMON
发明人： BALSCHMIDT PER , WAHLUND PER-OLUF , HAVELUND SVEND , BJERREGAARD JENSEN SIMON
IPC分类号： A61K9/16 , A61K38/28
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/0095 , A61K9/1075 , A61K9/19 , A61K47/34
摘要： Highly concentrated insulin solutions and pharmaceutical compositions are described as are methods of their preparation and uses thereof.
摘要翻译：高度浓缩的胰岛素溶液和药物组合物被描述为它们的制备方法和用途。

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