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1. 发明申请

WO03027246A3 ANTAGONISTS 审中-公开
标题翻译：拮抗剂
公开(公告)号：WO03027246A3
公开(公告)日：2003-07-31
申请号：PCT/US0230412
申请日：2002-09-24
申请人： NOVO NORDISK AS , DGI BIOTECHNOLOGIES , PILLUTLA RENUKA , DEDOVA OLGA , BLUME ARTHUR J , GOLDSTEIN NEIL I , BRISSETTE RENEE , WANG PINGER , LIU HAO , HSIAO KU-CHUAN , LENNICK MICHAEL , FLETCHER PAUL
发明人： PILLUTLA RENUKA , DEDOVA OLGA , BLUME ARTHUR J , GOLDSTEIN NEIL I , BRISSETTE RENEE , WANG PINGER , LIU HAO , HSIAO KU-CHUAN , LENNICK MICHAEL , FLETCHER PAUL
IPC分类号： G01N33/50 , A61K38/00 , A61K48/00 , A61P3/10 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/62 , C07K14/65 , C12N5/06 , C12N15/09 , G01N33/15 , A61K38/08 , G01N33/567
CPC分类号： C07K14/65 , C07K14/62
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.
摘要翻译：公开了能够以激动剂或拮抗剂活性结合胰岛素和/或胰岛素样生长因子受体并由各种肽文库鉴定的肽序列。本发明还鉴定存在于胰岛素和胰岛素样生长因子受体上并且选择性结合本发明的肽的至少两个不同的结合位点。作为激动剂，本发明的肽可用于开发作为补充或代替内源肽激素的治疗剂。拮抗剂肽也可以作为治疗剂开发。

2. 发明公开

EP1432433A4 ANTAGONISTS 审中-公开
标题翻译：拮抗剂
公开(公告)号：EP1432433A4
公开(公告)日：2006-08-30
申请号：EP02775987
申请日：2002-09-24
申请人： NOVO NORDISK AS , DGI BIOTECHNOLOGIES INC
发明人： PILLUTLA RENUKA , DEDOVA OLGA , BLUME ARTHUR J , GOLDSTEIN NEIL I , BRISSETTE RENEE , WANG PINGER , LIU HAO , HSIAO KU-CHUAN , LENNICK MICHAEL , FLETCHER PAUL
IPC分类号： A61K38/28 , G01N33/50 , A61K38/00 , A61K48/00 , A61P3/10 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/62 , C07K14/65 , C12N5/06 , C12N15/09 , G01N33/15
CPC分类号： C07K14/65 , C07K14/62
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.

3. 发明专利

AU2002341834A1 Antagonists 未知
公开(公告)号：AU2002341834A1
公开(公告)日：2003-04-07
申请号：AU2002341834
申请日：2002-09-24
申请人： NOVO NORDISK AS , DGI BIOTECHNOLOGIES
发明人： BLUME ARTHUR J , WANG PINGER , DEDOVA OLGA , BRISSETTE RENEE , LENNICK MICHAEL , HSIAO KU-CHUAN , PILLUTLA RENUKA , FLETCHER PAUL , GOLDSTEIN NEIL I , LIU HAO
IPC分类号： G01N33/50 , A61K38/00 , A61K48/00 , A61P3/10 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/62 , C07K14/65 , C12N5/06 , C12N15/09 , G01N33/15 , A61K38/08 , G01N33/567

4. 发明专利

CA2459999A1 ANTAGONISTS 未知
公开(公告)号：CA2459999A1
公开(公告)日：2003-04-03
申请号：CA2459999
申请日：2002-09-24
申请人： NOVO NORDISK AS , DGI BIOTECHNOLOGIES
发明人： PILLUTLA RENUKA , DEDOVA OLGA , BRISSETTE RENEE , GOLDSTEIN NEIL I , FLETCHER PAUL , WANG PINGER , BLUME ARTHUR J , LENNICK MICHAEL , HSIAO KU-CHUAN , LIU HAO
IPC分类号： G01N33/50 , A61K38/00 , A61K48/00 , A61P3/10 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/62 , C07K14/65 , C12N5/06 , C12N15/09 , G01N33/15 , A61K38/04 , A61K38/08 , A61K38/28 , A61K38/30 , C07K7/00 , G01N33/566 , G01N33/567
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insul in- like growth factor receptors, and which selectively bind the peptides of thi s invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.

5. 发明专利

CA3000106A1 HORIZONTAL TRI-ELECTRODE SINGLE FLOW ZINC-AIR BATTERY WITH A FLOATING CATHODE 未知
公开(公告)号：CA3000106A1
公开(公告)日：2017-03-30
申请号：CA3000106
申请日：2016-09-23
申请人： CHEN ZHONGWEI , LIU HAO
发明人： CHEN ZHONGWEI , LIU HAO
IPC分类号： H01M8/18 , H01M12/06
摘要： A rechargeable horizontally configured tri-electrode single flow zinc-air battery with a floating cathode, which is theoretically capable of providing unlimited cycle life is provided. The tri-electrode configuration consists of one anode and two cathodes, one for charging and one for discharging. The charge cathode may comprise a water permeable alkaline resisting metal/mesh foam, which avoids carbon corrosion. The floating discharge cathode comprises an air permeable and water permeable catalytic oxygen reduction electrode, which eliminates or reduces the blockage of air tunnels. The anode comprises an inert, conductive electrode allowing for zinc deposition during battery charging and zinc dissolving during battery discharging. The flowing electrolyte removes zinc ions from the anode preventing or minimizing the formation of zinc oxides during discharging and cleans the anode after each full discharge. The horizontal configuration further eliminates or reduces electrolyte leakage.

6. 发明申请

WO2007127012B1 ANTIFUNGAL AGENTS 审中-公开
标题翻译：反真菌药
公开(公告)号：WO2007127012B1
公开(公告)日：2008-02-21
申请号：PCT/US2007007856
申请日：2007-03-29
申请人： MERCK & CO INC , SCYNEXIS INC , BALKOVEC JAMES M , BOUFFARD FRANCES AILEEN , TSE BRUNO , DROPINSKI JAMES , MENG DONGFANG , GREENLEE MARK L , PEEL MICHAEL , FAN WEIMING , MAMAI AHMED , LIU HAO , LI KEQAING
发明人： BALKOVEC JAMES M , BOUFFARD FRANCES AILEEN , TSE BRUNO , DROPINSKI JAMES , MENG DONGFANG , GREENLEE MARK L , PEEL MICHAEL , FAN WEIMING , MAMAI AHMED , LIU HAO , LI KEQAING
IPC分类号： A61K31/58 , A61P31/10 , C07J71/00
CPC分类号： C07J71/0005
摘要： The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (l,3)-ß-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
摘要翻译：本发明涉及式I的新型烯虫腈衍生物及其药学上可接受的盐，其合成及其作为（1,3）-β-D-葡聚糖合酶抑制剂的用途。本发明化合物及其药学上可接受的盐，以及包含本发明化合物及其药学上可接受的盐的药物组合物可用于治疗或预防抗真菌感染和相关疾病和病症。

7. 发明申请

WO2012020310A3 METHOD OF TRANSMITTING FEEDBACK INFORMATION IN A MIMO COMMUNICATION SYSTEM AND DEVICE THEREOF 审中-公开
标题翻译：在MIMO通信系统中传送反馈信息的方法及其装置
公开(公告)号：WO2012020310A3
公开(公告)日：2012-04-05
申请号：PCT/IB2011002065
申请日：2011-07-27
申请人： ALCATEL LUCENT , LIU HAO
发明人： LIU HAO
IPC分类号： H04B7/04 , H04B7/06
CPC分类号： H04B7/0478 , H04B7/0417 , H04B7/0641 , H04B7/065
摘要： The present invention provides a method of providing feedback information in a user equipment of a communication system based on MIMO, comprising: determining a first latest measured long-term covariance matrix according to a downlink channel matrix model; transmitting the quantization of a first latest estimated long-term covariance matrix corresponding to the first latest measured long-term covariance matrix to the base station; determining a second latest measured long-term covariance matrix according to a downlink channel matrix model; determining the variation information of a second latest estimated long-term covariance matrix with respect to an estimated long-term covariance matrix of the last-time reset point; and transmitting the quantization of the variation information to the base station. With such a solution, overhead during the feedback of long-term covariance matrix is greatly reduced in MIMO scenario.
摘要翻译：本发明提供了一种在基于MIMO的通信系统的用户设备中提供反馈信息的方法，包括：根据下行信道矩阵模型确定第一最新测量的长期协方差矩阵; 将对应于所述第一最近测量的长期协方差矩阵的第一最新估计的长期协方差矩阵的量化发送到所述基站; 根据下行链路信道矩阵模型确定第二最新测量的长期协方差矩阵; 确定第二最新估计的长期协方差矩阵相对于最后一次重置点的估计的长期协方差矩阵的变化信息; 并且将变化信息的量化发送到基站。采用这种解决方案，在MIMO情况下，长期协方差矩阵反馈期间的开销大大降低。

8. 发明申请

WO2012020309A3 METHOD AND APPARATUS FOR DECREASING MULTI-CELL FEEDBACK OVERHEAD 审中-公开
标题翻译：减少多重反应的方法和装置
公开(公告)号：WO2012020309A3
公开(公告)日：2012-04-26
申请号：PCT/IB2011002064
申请日：2011-07-27
申请人： ALCATEL LUCENT , LIU HAO
发明人： LIU HAO
IPC分类号： H04B7/02 , H04L1/06
CPC分类号： H04W24/02 , H04B7/024 , H04B7/0417 , H04B7/0641 , H04B7/065
摘要： Method and apparatus for decreasing multi-cell feedback overhead is provided in the present invention. Wherein a user equipment utilizes a first period to feedback short-term channel direction information of a serving base station, utilizes a second period to feedback long-term channel direction information of neighboring base stations, further, the user equipment utilizes a third period to feedback long-term relative amplitude information, utilizes a fourth period to feedback short-term relative phase information, wherein the first period is shorter than the second period, and the third period is longer than the fourth period.
摘要翻译：在本发明中提供了用于减少多小区反馈开销的方法和装置。其中，用户设备利用第一周期来反馈服务基站的短期信道方向信息，利用第二周期来反馈相邻基站的长期信道方向信息，此外，用户设备利用第三周期来反馈长期相对幅度信息，利用第四周期反馈短期相对相位信息，其中第一周期短于第二周期，第三周期长于第四周期。

9. 发明申请

WO2011056498A2 TRIPOD HEAD WITH FOLDING HANDLE 审中-公开
标题翻译：三折头与折叠手柄
公开(公告)号：WO2011056498A2
公开(公告)日：2011-05-12
申请号：PCT/US2010053926
申请日：2010-10-25
申请人： MAMIYA AMERICA CORP , LIU HAO , ROSE ROBERT M
发明人： LIU HAO , ROSE ROBERT M
IPC分类号： F16M11/18 , F16M11/06 , F16M11/14 , G03B17/56
CPC分类号： G03B17/563 , F16M11/08 , F16M11/18 , F16M11/2071
摘要： A tripod head comprises a mount and an angle adjustment mechanism for adjusting and locking the angle of the mount with respect to a tripod. The mechanism comprises an elongated handle. The handle is adapted to rotate around its longitudinal axis to lock the angle of the mechanism when rotated in one direction and unlock the angle of the mechanism when rotated in the other direction. The handle comprises a proximal portion and a distal portion. The distal portion is attached at a pivot point whereby the distal portion can pivot between an operative position in line with the proximal portion and a storage position generally perpendicular to the proximal portion. The handle further comprises a locking device for releasably locking the distal portion in the operative position.
摘要翻译：三脚架头包括安装件和角度调节机构，用于调节和锁定安装座相对于三脚架的角度。该机构包括细长手柄。手柄适于围绕其纵向轴线旋转以锁定机构在一个方向上旋转时的角度，并且在沿另一方向旋转时解锁机构的角度。手柄包括近端部分和远端部分。远端部分附接在枢转点处，由此远侧部分可以在与近端部分成直线的操作位置和大致垂直于近端部分的存储位置之间枢转。手柄还包括用于将远端部分可释放地锁定在操作位置的锁定装置。

10. 发明申请

WO2011005753A3 MULTI-AXIS PHOTOGRAPHIC TRIPOD HEADS 审中-公开
标题翻译：多轴摄影三脚架头
公开(公告)号：WO2011005753A3
公开(公告)日：2011-04-28
申请号：PCT/US2010041057
申请日：2010-07-06
申请人： MAC GROUP , LIU HAO , ROSE ROBERT M
发明人： LIU HAO , ROSE ROBERT M
IPC分类号： G03B17/56 , F16M11/02 , F16M11/06
CPC分类号： F16M11/2035 , F16M11/041 , F16M11/08
摘要： A tripod head comprises a tripod mounting component, an angle adjusting component, and a camera mounting component. The angle adjusting component is configured to allow adjustment and locking of the angle between the tripod mounting component and the camera mounting component about first and second perpendicular axes. The camera mounting component is rotatably mounted to the angle adjusting component to allow the camera mounting component to be rotated and locked with respect to the angle adjusting component about a third axis.
摘要翻译：三脚架头包括三脚架安装部件，角度调节部件和相机安装部件。角度调节部件构造成允许围绕第一和第二垂直轴线调节和锁定三角架安装部件和摄像机安装部件之间的角度。相机安装部件可旋转地安装到角度调节部件，以允许相机安装部件相对于角度调节部件围绕第三轴旋转和锁定。

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