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1. 发明申请

WO2010139793A1 MIXING DEVICE WITH PISTON COUPLING ARRANGEMENT 审中-公开
标题翻译：具有活塞连接装置的混合装置
公开(公告)号：WO2010139793A1
公开(公告)日：2010-12-09
申请号：PCT/EP2010/057849
申请日：2010-06-04
申请人： NOVO NORDISK A/S , BENDIX, Klaus , REISENHUS, Michael, Bech , LJUNGGREEN, Henrik
发明人： BENDIX, Klaus , REISENHUS, Michael, Bech , LJUNGGREEN, Henrik
IPC分类号： A61M5/28 , A61M5/315
CPC分类号： A61M5/2448 , A61M5/3148 , A61M5/31511 , A61M5/31513 , A61M5/31515 , A61M2005/3123 , A61M2005/3132 , Y10T29/49826
摘要： A device (1) for mixing substances to obtain an injectable medical product, the device (1) comprising a cartridge (50), a front piston (5), a front chamber (17) containing a liquid or a powder, a rear piston (6), a rear chamber (18) containing a liquid, a piston rod (7), and a bypass channel (19). The piston rod (7) is adapted to advance the rear piston (6) to collapse the rear chamber (18), whereby the liquid in the rear chamber (18) is forced to move to the front chamber (17) via the bypass channel (19). The piston rod (7) has a projection (10) which is adapted to mate with a recess (12) in the front piston (5) to provide an interlocking between the two components.
摘要翻译：一种用于混合物质以获得可注射医疗产品的装置（1），所述装置（1）包括盒（50），前活塞（5），容纳液体或粉末的前室（17），后活塞（6），容纳液体的后室（18），活塞杆（7）和旁通通道（19）。活塞杆（7）适于使后活塞（6）前进以使后室（18）倒塌，由此后室（18）中的液体被迫通过旁路通道移动到前室（17）（19）。活塞杆（7）具有突起（10），该突起适于与前活塞（5）中的凹部（12）配合，以提供两个部件之间的互锁。

2. 发明申请

WO2013030224A1 ARRANGEMENT FOR SEQUENTIAL DELIVERY OF FLUID VOLUMES 审中-公开
标题翻译：顺序输送流体体积的安排
公开(公告)号：WO2013030224A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/066755
申请日：2012-08-29
申请人： NOVO NORDISK A/S , BENDIX, Klaus , LINDBLAD, Thomas , SMARTT, Nick
发明人： BENDIX, Klaus , LINDBLAD, Thomas , SMARTT, Nick
IPC分类号： A61M5/32 , A61M5/315
CPC分类号： A61M5/31561 , A61M5/31525 , A61M5/3155 , A61M5/31551 , A61M5/31555 , A61M5/31585 , A61M5/31596 , A61M5/3291 , A61M5/3294 , A61M2005/1787
摘要： The present invention relates to a reservoir unit (40, 140, 240) for a drug delivery arrangement (1, 100, 200), the reservoir unit (40, 140, 240) comprising: a housing (41, 141, 241) adapted to accommodate a fluid substance and comprising a displaceable wall (43, 143, 243), a fluid transport member (50, 150, 250) comprising a fluid outlet (52, 152, 252), first fluid communication means (53, 153, 253) for providing fluid communication with an interior of another reservoir, and second fluid communication means (54, 154, 254) for providing fluid communication with an interior (44, 144, 244) of the housing (41, 141, 241), and coupling means (45, 145, 245) adapted for connection with mating coupling means associated with the other reservoir. The invention further relates to a drug delivery arrangement (1, 100, 200) employing the reservoir unit (40, 140, 240). The fluid transport member being a needle (50) fixedly retained by the outlet portion (42) and having a side hole (54) in the needle body (51) just proximally of the outlet portion (42).
摘要翻译：本发明涉及一种用于药物输送装置（1,100,200）的储存器单元（40,140,240），所述储存器单元（40,140,240）包括：适于以容纳流体物质并且包括可移动壁（43,43,243），包括流体出口（52,152,252）的流体输送构件（50,150,250），第一流体连通装置（53,153，用于提供与另一容器的内部的流体连通的第二流体连通装置（54,154,254），用于提供与壳体（41,141,241）的内部（44,144,244）的流体连通，以及适于与与另一储存器相关联的配合联接装置连接的联接装置（45,145,245）。本发明还涉及采用储存器单元（40,140,240）的药物输送装置（1,100,200）。所述流体输送构件是由所述出口部分（42）固定地保持并且在所述针体（51）中的靠近所述出口部分（42）的近侧具有侧孔（54）的针（50）。

3. 发明申请

WO2017114921A1 MECHANISM FOR SEQUENTIAL DOSE DELIVERY 审中-公开
标题翻译：连续剂量递送的机制
公开(公告)号：WO2017114921A1
公开(公告)日：2017-07-06
申请号：PCT/EP2016/082875
申请日：2016-12-29
申请人： NOVO NORDISK A/S
发明人： BENDIX, Klaus
IPC分类号： A61M5/19 , A61M5/20 , A61M5/24 , A61M5/315 , A61M5/32
CPC分类号： A61M5/19 , A61M5/2053 , A61M5/2066 , A61M5/2448 , A61M5/31596 , A61M5/3294
摘要： The present invention provides a drug delivery device (2, 3; 102) for sequential administration of substances, comprising a first variable volume reservoir (40a; 140a) holding a first substance and comprising a first outlet (41 a, 141 a) and a first displaceable wall (43a; 143a), a second variable volume reservoir (40b; 140b) holding a second substance and comprising a second outlet (41 b; 141 b) and a second displaceable wall (43b; 143b), a first wall actuation structure (65a, 70a, 75a, 77a; 177a) activatable to move the first displaceable wall (43a; 143a) and thereby expel a dose of the first substance through the first outlet (41 a; 141 a), a second wall actuation structure (65b, 70b, 75b, 77b; 177b) activatable to move the second displaceable wall (43b; 143b) and thereby expel a dose of the second substance through the second outlet (41 b; 141 b), and a drive structure (90; 190) for activating the first wall actuation structure (65a, 70a, 75a, 77a; 177a) and the second wall actuation structure (65b, 70b, 75b, 77b; 177b). The drive structure (90; 190) performs a predetermined movement during one sequential administration of the first substance and the second substance, the prede- termined movement comprising a first part movement followed by a second part movement, and is configured to activate the first wall actuation structure (65a, 70a, 75a, 77a; 177a) during the first part movement and to activate the second wall actuation structure (65b, 70b, 75b, 77b; 177b) during the second part movement.
摘要翻译：本发明提供了用于物质的顺序给药的药物递送装置（2,3; 102），其包括容纳第一物质并且包括第一出口（40a; 140a）的第一可变容积储存器（40a; 140a）（41a，141a）和第一可移动壁（43a; 143a）;第二可变容积储存器（40b; 140b），其容纳第二物质并且包括第二出口（41b; 141b）;和第二可移动壁（43b ;第一壁致动结构（65a，70a，75a，77a; 177a），所述第一壁致动结构可激活以移动所述第一可移动壁（43a; 143a）并由此将一定剂量的所述第一物质通过所述第一出口（41a; 141 a）;第二壁致动结构（65b，70b，75b，77b; 177b），其可致动以移动所述第二可移动壁（43b; 143b）并且由此通过所述第二出口（41b; 141b）排出一定剂量的所述第二物质）以及用于激活第一壁致动结构（65a，70a，75a，77a; 177a）和驱动结构（90; 190）的驱动结构 d壁致动结构（65b，70b，75b，77b; 177B）。所述驱动结构（90; 190）在所述第一物质和所述第二物质的一次连续施用期间执行预定的移动，所述预定移动包括随后是第二部分移动的第一部分移动，并且被配置为激活所述第一壁（65a，70a，75a，77a; 177a），并且在所述第二部件移动期间激活所述第二壁致动结构（65b，70b，75b，77b; 177b）。

4. 发明申请

WO2020260576A1 DRUG DELIVERY DEVICE WITH PLUNGER ROD HAVING NONUNIFORM STOPPER INTERFACE 审中-公开
公开(公告)号：WO2020260576A1
公开(公告)日：2020-12-30
申请号：PCT/EP2020/068013
申请日：2020-06-26
申请人： NOVO NORDISK A/S
发明人： BENDIX, Klaus , TRUE, Daniel, Patrick, Godskesen , SØRENSEN, Dan, Nørtoft
IPC分类号： A61M5/315 , A61M5/31
摘要： The present invention provides a drug delivery device (1) comprising: a drug reservoir (20) comprising a reservoir body (21) extending along a reference axis and an elastomeric stopper (30) arranged in the reservoir body (21), the elastomeric stopper (30) comprising a stopper body (31) extending between a front stopper end (32) and a rear stopper end (34) and having a plurality of axially spaced apart circumferential ribs (33) for sealing interaction with an interior wall (22) of the reservoir body (21), and a plunger rod structure (10) for displacing the elastomeric stopper (30) relative to the interior wall (22), the plunger rod structure (10) extending along the reference axis and comprising a distal end face (12, 14) adapted to interface with the rear stopper end (34). The distal end face (12, 14) comprises a first force transferring portion (14) and a second force transferring portion (12), the first force transferring portion (14) axially leading the second force transferring portion (12) and being adapted to interact with a peripheral portion of the rear stopper end (34).

5. 发明申请

WO2016075254A1 A METHOD OF MANUFACTURING ONE OF A RANGE OF AUTOINJECTORS 审中-公开
标题翻译：制造自动曝光范围之一的方法
公开(公告)号：WO2016075254A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/076466
申请日：2015-11-12
申请人： NOVO NORDISK A/S
发明人： SCHENSTRØM, Mads , HANSEN, Søren, Kjellerup , BENDIX, Klaus
IPC分类号： A61M5/20 , A61M5/24 , A61M5/32 , A61M5/315 , A61M5/50
CPC分类号： A61M5/2033 , A61M5/24 , A61M5/31541 , A61M5/31585 , A61M5/32 , A61M5/3234 , A61M5/3243 , A61M5/3245 , A61M5/50 , A61M2005/2013 , A61M2005/2073 , A61M2005/2407 , A61M2005/247 , A61M2005/3247 , A61M2005/3267 , A61M2205/581 , A61M2205/6081 , A61M2207/00
摘要： A method of manufacturing one of a range of autoinjectors having cartridges (600, 600', 600") with different preset fill volumes, the method comprising the steps of: a) providing a front body assembly (100b, 100c, 100c', 100c"), b) providing a cartridge (600, 600', 600") of given fill volume, c) providing a rear body assembly (100a) comprising a spring-driven drive ram assembly (310, 320) configured to drive the piston of a held cartridge (600, 600', 600"), d) providing a ram spacer member (400, 400', 400"), the ram spacer member defining a spacing geometry of length dimension (Χ1', X1", X1'", XS', XS", XS"',XR', XR", XR'") selected according to the fill volume of the cartridge (600, 600', 600"), and e) assembling a front body assembly (100b, 100c, 100c', 100c"), the cartridge (600, 600', 600"), the ram spacer member (400, 400', 400") and the rear body assembly (100a) so that the ram spacer member (400, 400', 400") is arranged axially between the drive ram assembly (310, 320) of the rear body assembly (100a) and the piston of a held cartridge (600, 600', 600").
摘要翻译：一种制造具有不同预设填充体积的盒（600,600'，600“）的一系列自动注射器之一的方法，所述方法包括以下步骤：a）提供前体组件（100b，100c，100c'，100c “），b）提供给定填充体积的盒（600,600'，600”），c）提供包括弹簧驱动的驱动柱塞组件（310,320）的后体组件（100a），其构造成驱动活塞（600,600'，600“），d）提供柱塞间隔件（400,400'，400”），所述柱塞间隔件限定长度尺寸（X1'，X1“，X1 根据盒（600,600'，600“）的填充体积选择的”XS“，XS”，XS“'，XR'，XR”，XR“），以及e）组装前体组件（100b，100c，100c'，100c“），盒（600,600'，600”），柱塞间隔件（400,400'，400“）和后主体组件（100a）构件（400,400'，400“）轴向布置在r的驱动柱塞组件（310,320）之间耳体组件（100a）和被保持的盒（600,600'，600“）的活塞。

6. 发明申请

WO2016110580A1 NEEDLE UNIT WITH A LOCKABLE NEEDLE SHIELD AND AN INJECTION DEVICE COMPRISING SUCH A NEEDLE UNIT 审中-公开
标题翻译：具有可锁定针头的针单元和包括这样的单元的注射装置
公开(公告)号：WO2016110580A1
公开(公告)日：2016-07-14
申请号：PCT/EP2016/050302
申请日：2016-01-08
申请人： NOVO NORDISK A/S
发明人： BENDIX, Klaus , KJELLERUP HANSEN, Søren , GAARDSVIG KJELDSEN, Bastian , SCHENSTRØM STEFANSEN, Mads
IPC分类号： A61M5/32 , A61M5/00 , A61M5/24 , A61M5/20
CPC分类号： A61M5/002 , A61M5/2033 , A61M5/2466 , A61M5/3202 , A61M5/326 , A61M5/3293 , A61M2005/247 , A61M2005/3247 , A61M2005/3254 , A61M2005/3267 , A61M2207/00
摘要： A needle unit (20) comprising: a needle hub (21) comprising a needle (23) and a needle shield (22), wherein the needle hub (21) and the needle shield (22) are arranged to form a needle unit (20) where the needle hub is arranged displaceably inside the needle shield such that the needle hub is displaceable along an axis which is parallel with the longitudinal axis of the needle (23) between a shielded position and an exposed position. The needle hub (21) further comprises a first hub locking element (24) and a second hub locking element (26) and the needle shield (22) further comprises a first shield locking element (25) and a second shield locking element (27), said first hub locking element (24) and said first shield locking element (25) engaging each other in the shielded position to establish a first releasable locking mechanism (24, 25) between the needle hub (21) and the needle shield (22), said second hub locking element (26) and said second shield locking element (27) engaging each other in the shielded position to establish a second locking mechanism (26, 27) between the needle hub (21) and the needle shield (22), both the first and second locking mechanisms (24, 25, 26, 27) being arranged as shock proof locks, and where the first releasable lock mechanism (24, 25) is arranged to engage with the lock release element (31) of the injection device (1) when the needle unit (20) is coupled to the injection device, said engagement allowing the first releasable lock mechanism (24, 25) to be unlocked. The invention further provides an injection device comprising the needle unit and a method of assembling an injection device with the needle unit.
摘要翻译：一种针单元（20），包括：针座（21），包括针（23）和针护罩（22），其中针座（21）和针护罩（22）布置成形成针单元 20），其中所述针毂在所述针护罩内可移动地布置，使得所述针座可沿着与所述针（23）的纵向轴线平行的轴线在屏蔽位置和暴露位置之间移位。针座（21）还包括第一轮毂锁定元件（24）和第二轮毂锁定元件（26），并且所述针罩（22）还包括第一屏蔽锁定元件（25）和第二屏蔽锁定元件），所述第一毂锁定元件（24）和所述第一屏蔽锁定元件（25）在屏蔽位置彼此接合，以在针座（21）和针护罩（21）之间建立第一可释放锁定机构（24,25） 22），所述第二轮毂锁定元件（26）和所述第二屏蔽锁定元件（27）在所述屏蔽位置彼此接合以在所述针座（21）和所述针罩（21）之间建立第二锁定机构（26,27）第一和第二锁定机构（24,25,26,27）被布置为防震锁，并且其中第一可释放锁定机构（24,25）被布置成与锁定释放元件（31）接合，当所述针单元（20）联接到所述注射装置时，所述注射装置（1） e，所述接合允许第一可释放锁定机构（24,25）被解锁。本发明还提供了一种注射装置，其包括针单元和将注射装置与针单元组装的方法。

7. 发明申请

WO2019180214A1 DRUG DELIVERY DEVICE WITH DOSE COUNTING MECHANISM 审中-公开
公开(公告)号：WO2019180214A1
公开(公告)日：2019-09-26
申请号：PCT/EP2019/057261
申请日：2019-03-22
申请人： NOVO NORDISK A/S
发明人： JENSEN, Nicolai, Michael , BENDIX, Klaus
IPC分类号： A61M5/20 , A61M5/315
摘要： The present invention provides a drug delivery device with a dose counting mechanism and an end-of-content identification.

8. 发明申请

WO2020245295A1 DUAL CHAMBER DRUG RESERVOIR AND STOPPER THEREFOR 审中-公开
公开(公告)号：WO2020245295A1
公开(公告)日：2020-12-10
申请号：PCT/EP2020/065524
申请日：2020-06-04
申请人： NOVO NORDISK A/S
发明人： WINTHER, Knud, Skifter , MARSTRAND, Anders, Binderup , BENDIX, Klaus
IPC分类号： A61M5/19 , A61M5/20 , A61M5/178 , A61M5/315
摘要： The present invention concerns an elastomeric stopper (18, 28, 38) for a drug reservoir, comprising: a stopper body (18.1, 28.1, 38.1) extending along a reference axis between a leading end surface (18.2, 28.2, 38.2) and a trailing end surface (18.3, 28.3, 38.3) and having a generally cylindrical sidewall with an outer body diameter, a circumferential convex rib (18.6, 28.6, 38.6) extending radially outwardly from the sidewall, a non-convex trim edge portion (18.7, 28.7, 38.7) at the trailing end surface (18.3, 28.3, 38.3), the non-convex trim edge portion (18.7, 28.7, 38.7) having an outer trim edge diameter which is greater than the outer body diameter and being axially spaced apart from the circumferential convex rib (18.6, 28.6, 38.6), providing an annular recess (18.9, 28.9, 38.9) therebetween. The elastomeric stopper (18, 28, 38) further comprises a channel structure (18.10, 28.10, 38.10) enabling fluid flow from the trailing end surface (18.3, 28.3, 38.3) to the annular recess (18.9, 28.9, 38.9) through the non-convex trim edge portion (18.7, 28.7, 38.7).

9. 发明申请

WO2020084109A1 ZERO-POINT ADJUSTMENT OF PREFILLED DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：WO2020084109A1
公开(公告)日：2020-04-30
申请号：PCT/EP2019/079155
申请日：2019-10-25
申请人： NOVO NORDISK A/S
发明人： JENSEN, Nicolai, Michael , BENDIX, Klaus
IPC分类号： A61M5/19 , A61M5/20 , A61M5/31 , A61M5/315
摘要： The present invention provides a solution for zero-point adjustment of drug delivery devices, including twin chamber drug delivery devices with a single dose engine.

10. 发明公开

EP2750741A1 ARRANGEMENT FOR SEQUENTIAL DELIVERY OF FLUID VOLUMES 审中-公开
标题翻译：安排的流体体积依次递送
公开(公告)号：EP2750741A1
公开(公告)日：2014-07-09
申请号：EP12751082.4
申请日：2012-08-29
申请人： Novo Nordisk A/S
发明人： BENDIX, Klaus , LINDBLAD, Thomas , SMARTT, Nick
IPC分类号： A61M5/32 , A61M5/315
CPC分类号： A61M5/31561 , A61M5/31525 , A61M5/3155 , A61M5/31551 , A61M5/31555 , A61M5/31585 , A61M5/31596 , A61M5/3291 , A61M5/3294 , A61M2005/1787
摘要： The present invention relates to a reservoir unit (40, 140, 240) for a drug delivery arrangement (1, 100, 200), the reservoir unit (40, 140, 240) comprising: a housing (41, 141, 241) adapted to accommodate a fluid substance and comprising a displaceable wall (43, 143, 243), a fluid transport member (50, 150, 250) comprising a fluid outlet (52, 152, 252), first fluid communication means (53, 153, 253) for providing fluid communication with an interior of another reservoir, and second fluid communication means (54, 154, 254) for providing fluid communication with an interior (44, 144, 244) of the housing (41, 141, 241), and coupling means (45, 145, 245) adapted for connection with mating coupling means associated with the other reservoir. The invention further relates to a drug delivery arrangement (1, 100, 200) employing the reservoir unit (40, 140, 240). The fluid transport member being a needle (50) fixedly retained by the outlet portion (42) and having a side hole (54) in the needle body (51) just proximally of the outlet portion (42).

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