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1. 发明申请

WO2006087309A1 3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID 5-AMINOPYRIDIN-2-YL ESTERS 审中-公开
标题翻译： 3,4-二氢-1H-异喹啉-2-羧酸5-氨基吡啶-2-酮
公开(公告)号：WO2006087309A1
公开(公告)日：2006-08-24
申请号：PCT/EP2006/050882
申请日：2006-02-13
申请人： NOVO NORDISK A/S , DE JONG, Johannes Cornelis , JACOBSEN, Poul
发明人： DE JONG, Johannes Cornelis , JACOBSEN, Poul
IPC分类号： C07D401/14 , C07D417/14 , A61K31/4725 , A61P3/04
CPC分类号： C07D401/14 , C07D417/14
摘要： Novel compounds of formula (I), pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which modulation of the activity of hormone sensitive lipase is beneficial.
摘要翻译：新颖的式（I）化合物，包含它们的药物组合物及其用于治疗和/或预防与激素敏感性脂肪酶相关的疾病和病症的用途。更具体地，这些化合物可用于治疗和/或预防激素敏感性脂肪酶的活性调节有益的疾病和病症。

2. 发明申请

WO2004111006A1 PARA-SUBTITUTED PHENYL CARBAMATES AS INHIBITORS OF HORMONE SENSITIVE LIPASE 审中-公开
标题翻译：作为丙烯酸敏感性脂质体的抑制剂的PARA受体的苯基碳酸酯
公开(公告)号：WO2004111006A1
公开(公告)日：2004-12-23
申请号：PCT/DK2004/000401
申请日：2004-06-10
申请人： NOVO NORDISK A/S , VEDSØ, Per , EBDRUP, Søren , JACOBSEN, Poul
发明人： VEDSØ, Per , EBDRUP, Søren , JACOBSEN, Poul
IPC分类号： C07D213/68
CPC分类号： C07D213/30 , C07D213/68 , C07D233/84
摘要： Novel para-substituted phenyl carbamates, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which modulation of the activity of hormone sensitive lipase is beneficial.
摘要翻译：新型对位取代的苯基氨基甲酸酯，包含它们的药物组合物及其用于治疗和/或预防与激素敏感性脂肪酶相关的疾病和病症的用途。更具体地，这些化合物可用于治疗和/或预防激素敏感性脂肪酶的活性调节有益的疾病和病症。

3. 发明申请

WO1998018776A1 NOVEL CIS-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES 审中-公开
公开(公告)号：WO1998018776A1
公开(公告)日：1998-05-07
申请号：PCT/DK1997000483
申请日：1997-10-28
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , JACOBSEN, Poul , TREPPENDAHL, Svend , STANLEY BURY, Paul , KANSTRUP, Anders , BROWN CHRISTIANSEN, Lise
IPC分类号： C07D311/74
CPC分类号： C07D413/04 , C07D311/58
摘要： The present invention relates to therapeutically active compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.

4. 发明申请

WO1994026746A1 [1,2,4]TRIAZOLO[4,3-a]QUINOXALINE COMPOUNDS, THEIR PREPARATION AND USE 审中-公开
标题翻译： [1,2,4]三唑[4,3-a]喹啉化合物，其制备和使用
公开(公告)号：WO1994026746A1
公开(公告)日：1994-11-24
申请号：PCT/DK1994000170
申请日：1994-04-28
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , JACOBSEN, Poul , NIELSEN, Flemming, Elmelund , JEPPESEN, Lone
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： [1,2,4]triazolo[4,3-a]quinoxaline derivatives of general formula (I) wherein one of R and R is a 5- or 6-membered N-containing heterocyclic ring optionally substituted, or a fused ring system comprising a 5- or 6-membered N-containing heterocyclic ring optionally substituted; and the other of R and R is H, alkyl, alkoxy, halogen, NO2, NH2, CN, CF3, COC1-6-alkyl or SO2NR'R", wherein R' and R" are independently H or alkyl and X is O or S; and pharmaceutically acceptable salts thereof have affinity for the AMPA receptors and are antagonists in connection with this type of receptors which makes them useful in the treatment of CNS ailments, especially in the treatment of any of the numerous indications caused by hyperactivity of excitatory amino acids.
摘要翻译： [1,2,4]通式（I）的三唑并[4,3-a]喹喔啉衍生物，其中R 1和R 2之一是任选取代的5-或6-元含N杂环或包含任选取代的5或6元含氮杂环的稠环体系; R 1和R 2中的另一个为H，烷基，烷氧基，卤素，NO 2，NH 2，CN，CF 3，COC 1-6 - 烷基或SO 2 NR'R“，其中R'和R”独立地为H 或烷基，X是O或S; 和其药学上可接受的盐对AMPA受体具有亲和力，并且是与这种类型的受体有关的拮抗剂，这使得它们可用于治疗CNS疾病，特别是治疗由兴奋性氨基酸的多动症引起的许多适应症中的任何一种。

5. 发明申请

WO1998018777A1 NOVEL CIS-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES 审中-公开
公开(公告)号：WO1998018777A1
公开(公告)日：1998-05-07
申请号：PCT/DK1997000484
申请日：1997-10-28
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , JACOBSEN, Poul , TREPPENDAHL, Svend , BURY, Paul, Stanley , KANSTRUP, Anders , CHRISTIANSEN, Lise, Brown
IPC分类号： C07D311/74
CPC分类号： C07D311/58
摘要： The present invention relates to therapeutically active compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.

6. 发明申请

WO1998018775A1 NOVEL (+)-ENANTIOMERS OF CIS-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES 审中-公开
标题翻译：新的（+） - CIS-3,4-CHROMAN衍生物的有效成分用于预防或治疗雌激素相关疾病或综合征
公开(公告)号：WO1998018775A1
公开(公告)日：1998-05-07
申请号：PCT/DK1997000482
申请日：1997-10-28
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , JACOBSEN, Poul , TREPPENDAHL, Svend , STANLEY BURY, Paul , KANSTRUP, Anders , BROWN CHRISTIANSEN, Lise
IPC分类号： C07D311/74
CPC分类号： C07D263/52 , C07D265/28 , C07D311/74 , C07D405/12
摘要： The present invention relates to therapeutically active compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.
摘要翻译：本发明涉及治疗活性的式（I）化合物，其制备方法和包含该化合物的药物组合物。新型化合物可用于预防或治疗雌激素相关疾病或综合征。

7. 发明申请

WO1998018774A1 NOVEL TRANS-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES 审中-公开
标题翻译：用于预防或治疗雌激素相关疾病或综合症的新型转3,4-CHROMAN衍生物
公开(公告)号：WO1998018774A1
公开(公告)日：1998-05-07
申请号：PCT/DK1997000481
申请日：1997-10-28
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , JACOBSEN, Poul , TREPPENDAHL, Svend , BURY, Paul, Stanley , KANSTRUP, Anders , BROWN CHRISTIANSEN, Lise
IPC分类号： C07D311/74
CPC分类号： C07D413/04 , C07D311/58
摘要： The present invention relates to therapeutically active compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.
摘要翻译：本发明涉及治疗活性的式（I）化合物，其制备方法和包含该化合物的药物组合物。新型化合物可用于预防或治疗雌激素相关疾病或综合征。

8. 发明申请

WO1998018772A1 NOVEL cis-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES 审中-公开
标题翻译：用于预防或治疗雌激素相关疾病或综合症的新型顺式-3,4-色胺衍生物
公开(公告)号：WO1998018772A1
公开(公告)日：1998-05-07
申请号：PCT/DK1997000479
申请日：1997-10-28
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , JACOBSEN, Poul , TREPPENDAHL, Svend , BURY, Paul, Stanley , KANSTRUP, Anders , CHRISTIANSEN, Lise, Brown
IPC分类号： C07D311/74
CPC分类号： C07D311/58
摘要： The present invention relates to therapeutically active compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.
摘要翻译：本发明涉及治疗活性的式（I）化合物，其制备方法和包含该化合物的药物组合物。新型化合物可用于预防或治疗雌激素相关疾病或综合征。

9. 发明申请

WO2006087308A1 METHYLPHENYLCARBAMIC ACID 5-(4-ISOBUTYL-2,6,-DIOXOPIPERAZIN-l-YL) PYRIDINYL-2-YL ESTER ANS SALTS AS HORMONE SENSITIVE LIPASE INHIBITORS 审中-公开
标题翻译：甲基苯甲酸5-（4-异丁基-2,6-二氧代哌嗪-1-基）吡啶-2-基酯盐酸盐作为HORMONE敏感性脂质体抑制剂
公开(公告)号：WO2006087308A1
公开(公告)日：2006-08-24
申请号：PCT/EP2006/050881
申请日：2006-02-13
申请人： NOVO NORDISK A/S , DE JONG, Johannes Cornelis , JACOBSEN, Poul
发明人： DE JONG, Johannes Cornelis , JACOBSEN, Poul
IPC分类号： C07D401/04 , A61K31/496
CPC分类号： C07D401/04
摘要： Novel methylphenylcarbamic acids, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which modulation of the activity of hormone sensitive lipase is beneficial.
摘要翻译：新型甲基苯基氨基甲酸，包含它们的药物组合物及其用于治疗和/或预防与激素敏感性脂肪酶相关的疾病和病症的用途。更具体地，这些化合物可用于治疗和/或预防激素敏感性脂肪酶的活性调节有益的疾病和病症。

10. 发明申请

WO2004111004A1 SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE 审中-公开
标题翻译：取代的哌嗪碳酸氢盐用作HORMONE敏感性脂质体的抑制剂
公开(公告)号：WO2004111004A1
公开(公告)日：2004-12-23
申请号：PCT/DK2004/000397
申请日：2004-06-10
申请人： NOVO NORDISK A/S , HANSEN, Holger, Claus , CORNELIS DE JONG, Johannes , VEDSØ, Per , JACOBSEN, Poul , EBDRUP, Søren
发明人： HANSEN, Holger, Claus , CORNELIS DE JONG, Johannes , VEDSØ, Per , JACOBSEN, Poul , EBDRUP, Søren
IPC分类号： C07D213/38
CPC分类号： C07D401/14 , C07D213/42 , C07D213/643 , C07D213/75 , C07D401/12
摘要： Novel substituted piperazine carbamates of formula (I), pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which modulation of the activity of hormone sensitive lipase is beneficial.
摘要翻译：式（I）的新型取代哌嗪氨基甲酸酯，包含它们的药物组合物及其用于治疗和/或预防与激素敏感性脂肪酶相关的疾病和病症的用途。更具体地，这些化合物可用于治疗和/或预防激素敏感性脂肪酶的活性调节有益的疾病和病症。

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