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1. 发明申请

WO2013149111A2 ANTI-TLR4 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗TLR4抗体及其用途
公开(公告)号：WO2013149111A2
公开(公告)日：2013-10-03
申请号：PCT/US2013/034543
申请日：2013-03-29
申请人： NOVIMMUNE S.A. , ROUSSEAU, Francois , LOYAU, Jérémy , FISCHER, Nicolas , ELSON, Greg , KOSCO-VILBOIS, Marie
发明人： ROUSSEAU, Francois , LOYAU, Jérémy , FISCHER, Nicolas , ELSON, Greg , KOSCO-VILBOIS, Marie
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , C07K16/2866 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： Disclosed are antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and diagnostic agents.
摘要翻译：公开了特异性结合Toll样受体4（TLR-4）的抗体，以及使用抗TLR4抗体作为治疗剂和诊断剂的方法。

2. 发明申请

WO2005118635A2 ANTI-CD3 ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗CD3抗体及其使用方法
公开(公告)号：WO2005118635A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/019922
申请日：2005-06-03
申请人： NOVIMMUNE S.A. , MACH, Bernard , DEAN, Yann , KOSCO-VILBOIS, Marie , ELSON, Greg, Christopher, Andrew , FISCHER, Nicolas , LEGER, Olivier
发明人： MACH, Bernard , DEAN, Yann , KOSCO-VILBOIS, Marie , ELSON, Greg, Christopher, Andrew , FISCHER, Nicolas , LEGER, Olivier
IPC分类号： C07K14/47
CPC分类号： C07K16/2809 , A61K39/3955 , A61K45/06 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/74
摘要： The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR’s), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译：本发明涉及针对抗原CD3的抗体和这种抗体的用途。特别地，本发明提供了完全针对CD3的人单克隆抗体。编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是包含重链和轻链免疫球蛋白分子的序列，特别是对应于跨越框架区和/或互补决定区的连续重链和轻链序列的序列（CDR ），特别是FR1至FR4或CDR1至CDR3。还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

3. 发明申请

WO2011084255A2 SYNTHETIC POLYPEPTIDE LIBRARIES AND METHODS FOR GENERATING NATURALLY DIVERSIFIED POLYPEPTIDE VARIANTS 审中-公开
标题翻译：合成多肽图书馆和产生自然多样性多肽变体的方法
公开(公告)号：WO2011084255A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/057780
申请日：2010-11-23
申请人： NOVIMMUNE S.A. , FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
发明人： FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
IPC分类号： C12N15/13 , C12N15/70 , C07K16/18
CPC分类号： C12N15/70 , C07K16/005 , C07K16/249 , C07K16/42 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N15/1034
摘要： The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence.
摘要翻译：本发明提供了用于产生编码同源多肽的DNA序列文库的组合物和方法，以及文库鉴定天然多样化多肽变体的用途。本发明还提供用于产生合成抗体片段的组合物的组合物和方法，其中一个或几个互补决定区域（CDR）由从天然来源捕获的相应CDR的集合代替。本发明还提供了通过插入合成或天然来源的多样化序列来多样化多肽的组合物和方法，而不需要修饰原始多肽编码序列。

4. 发明申请

WO2009054873A2 ANTI-RANTES ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗RANTES抗体及其使用方法
公开(公告)号：WO2009054873A2
公开(公告)日：2009-04-30
申请号：PCT/US2008/009382
申请日：2008-08-04
申请人： NOVIMMUNE S.A. , FISCHER, Nicolas , KOSCO-VILBOIS, Marie , MACH, Francois
发明人： FISCHER, Nicolas , KOSCO-VILBOIS, Marie , MACH, Francois
IPC分类号： C07K2/00 , C07H21/00 , C07K16/18 , A61K39/395
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RANTES and one of more of its receptors, such as, e.g., CCR1, CCR3, CCR4 and CCR5, and/or modulating the biological activities of RANTES. The invention also relates to the use of these or any anti-RANTES antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder.
摘要翻译：本发明涉及完全人单克隆抗体及其片段，其结合活化时调节的趋化因子，表达正常T细胞和分泌型（RANTES，CCL5），从而调节RANTES与其多个受体之一的相互作用，例如CCR1，CCR3，CCR4和CCR5，和/或调节RANTES的生物学活性。本发明还涉及这些或任何抗RANTES抗体在预防或治疗免疫相关疾病以及改善与免疫相关病症相关的一种或多种症状中的用途。

5. 发明申请

WO2010135558A1 SYSTHETIC POLYPEPTIDE LIBRARIES AND METHODS FOR GENERATING NATURALLY DIVERSIFIED POLYPEPTIDE VARIANTS 审中-公开
公开(公告)号：WO2010135558A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035619
申请日：2010-05-20
申请人： NOVIMMUNE S.A. , FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
发明人： FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
IPC分类号： C12N15/10
CPC分类号： C12N15/1037 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C12N15/66 , C40B40/08 , C40B50/06
摘要： The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence.
摘要翻译：本发明提供用于产生编码同源多肽的DNA序列文库的组合物和方法，以及文库用于鉴定天然多样化多肽变体的用途。本发明还提供用于产生合成抗体片段的组合物的组合物和方法，其中一个或几个互补决定区域（CDR）被从天然来源捕获的相应CDR的集合代替。本发明还提供了通过插入合成或天然来源的多样化序列多样化多肽的组合物和方法，而不需要修饰原始多肽编码序列。

6. 发明申请

WO2006109191A2 ANTI-INTERFERON GAMMA ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗干扰素抗体及其使用方法
公开(公告)号：WO2006109191A2
公开(公告)日：2006-10-19
申请号：PCT/IB2006/001514
申请日：2006-01-27
申请人： NOVIMMUNE S.A. , FERLIN, Walter , FISCHER, Nicolas , ELSON, Greg , LEGER, Olivier
发明人： FERLIN, Walter , FISCHER, Nicolas , ELSON, Greg , LEGER, Olivier
CPC分类号： C07K16/249 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The invention relates to fully human antibodies, and fragments thereof, that bind to human interferon gamma (hlFNγ), thereby modulating the interaction between IFNγ and its receptor, IFNγ-R, and/or modulating the biological activities of IFNγ. The invention also relates to the use of such anti-IFNγ antibodies in the prevention or treatment of immune- related disorders and in the amelioration of a symptom associated with an immune-related disorder.
摘要翻译：本发明涉及与人类干扰素γ（hIFN1β）结合的完全人抗体及其片段，从而调节IFNα 和其受体IFNγ-R，和/或调节IFNα的生物学活性。本发明还涉及使用这种抗-IFN？抗体在预防或治疗免疫相关疾病和改善与免疫相关病症相关的症状中。

7. 发明申请

WO2013088259A2 METHODS OF PURIFYING ANTIBODIES 审中-公开
标题翻译：纯化抗体的方法
公开(公告)号：WO2013088259A2
公开(公告)日：2013-06-20
申请号：PCT/IB2012/003028
申请日：2012-10-19
申请人： NOVIMMUNE S.A. , ELSON, Greg , FOUQUE, Nicolas , DEPOISIER, Jean-François , FISCHER, Nicolas , MAGISTRELLI, Giovanni
发明人： ELSON, Greg , FOUQUE, Nicolas , DEPOISIER, Jean-François , FISCHER, Nicolas , MAGISTRELLI, Giovanni
IPC分类号： A61K39/00
CPC分类号： C07K16/00 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K16/468 , C07K2317/32 , C07K2317/52
摘要： The invention provides methods of purifying antibodies using various antibody- specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains.
摘要翻译：本发明提供使用各种抗体特异性纯化介质纯化抗体的方法，以快速且有效地分离抗体，抗体片段和/或抗体组分的混合物，以从混合物中分离所需的抗体产物。本发明涉及对免疫球蛋白分子的每个结合位点具有不同特异性的双特异性单克隆抗体的纯化，例如由单个重链和两个不同轻链组成的抗体，一个含有κ恒定结构域，另一个包含λ恒定结构域，包括具有共同重链的不同特异性的抗体。本发明还提供了通过将完整抗体与包括游离轻链在内的不完整抗体分离来有效纯化完整抗体的方法。

8. 发明申请

WO2012023053A2 METHODS FOR THE GENERATION OF MULTISPECIFIC AND MULTIVALENT ANTIBODIES 审中-公开
标题翻译：产生多种特异性和多种抗体的方法
公开(公告)号：WO2012023053A2
公开(公告)日：2012-02-23
申请号：PCT/IB2011/002664
申请日：2011-08-16
申请人： NOVIMMUNE S.A. , FISCHER, Nicolas , MAGISTRELLI, Giovanni , GUENEAU, Franck , RAVN, Ulla , ELSON, Greg
发明人： FISCHER, Nicolas , MAGISTRELLI, Giovanni , GUENEAU, Franck , RAVN, Ulla , ELSON, Greg
CPC分类号： C07K16/468 , C07K16/005 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K2317/31 , C07K2317/32 , C07K2317/622 , C07K2317/92 , C12N15/1037 , C12N15/1075
摘要： The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody.
摘要翻译：本发明提供了对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体，以及生产对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体的方法。抗体由单一重链和两条不同轻链组成，一条轻链包含κ恒定结构域和另一个λ恒定结构域。本发明提供了用于分离不同特异性但共享共同重链的抗体的方法。本发明还提供了用于受控共表达两条轻链和单条重链的方法，导致组装单特异性和双特异性抗体。本发明提供了产生完全人源双特异性和二价抗体的平均值，其序列未改变，并且不涉及使用接头或其他非人序列，以及两种单特异性抗体和一种双特异性抗体的抗体混合物。本发明还提供了有效纯化双特异性抗体的方法。

9. 发明申请

WO2013136186A2 READILY ISOLATED BISPECIFIC ANTIBODIES WITH NATIVE IMMUNOGLOBULIN FORMAT 审中-公开
标题翻译：具有本身免疫球蛋白格式的自述分离的双歧杆菌抗体
公开(公告)号：WO2013136186A2
公开(公告)日：2013-09-19
申请号：PCT/IB2013/000902
申请日：2013-03-13
申请人： NOVIMMUNE S.A. , FISCHER, Nicolas , MAGISTRELLI, Giovanni , ROUSSEAU, Francois , MASTERNAK, Krzysztof , MALINGE, Pauline
发明人： FISCHER, Nicolas , MAGISTRELLI, Giovanni , ROUSSEAU, Francois , MASTERNAK, Krzysztof , MALINGE, Pauline
CPC分类号： C07K16/468 , C07K16/244 , C07K16/2809 , C07K2317/31
摘要： The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e ., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).
摘要翻译：本发明涉及抗原结合蛋白或具有重链异源二聚体的抗体，即两条免疫球蛋白重链之间的差异，所述两条免疫球蛋白重链基于差异亲和力允许分离抗原结合蛋白的至少一个或两个氨基酸的免疫球蛋白重链和修饰/突变的免疫球蛋白重链朝向亲和试剂。本发明还涉及包含双特异性抗体的抗原结合蛋白，其具有相对于亲和试剂具有不同亲和力的IgG CH1区域，其允许通过IgG区域与亲和试剂的差异结合快速分离。

10. 发明申请

WO2008106200A2 ANTI-IP-10 ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗IP-10抗体及其使用方法
公开(公告)号：WO2008106200A2
公开(公告)日：2008-09-04
申请号：PCT/US2008/002650
申请日：2008-02-28
申请人： NOVIMMUNE SA , FISCHER, Nicolas , KOSCO-VILBOIS, Marie , LEGER, Olivier
发明人： FISCHER, Nicolas , KOSCO-VILBOIS, Marie , LEGER, Olivier
IPC分类号： C07K16/24 , A61P37/06
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to fully human antibodies, and fragments thereof, that bind to interferon-inducible-protein-10 (IP-IO, CXCLlO), thereby modulating the interaction between IP-IO and its receptor, CXCR3, and/or modulating the biological activities of IP-IO. The invention also relates to the use of such anti-IP- 10 antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder.
摘要翻译：本发明涉及与干扰素诱导蛋白-10（IP-10，CXCL10）结合从而调节IP-10与其受体之间的相互作用的完全人抗体及其片段， CXCR3，和/或调节IP-10的生物学活性。本发明还涉及这种抗IP-10抗体在预防或治疗免疫相关病症和改善与免疫相关病症相关的一种或多种症状中的用途。

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