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1. 发明专利

AT441712T 未知
公开(公告)号：AT441712T
公开(公告)日：2009-09-15
申请号：AT02724178
申请日：2002-02-21
申请人： NOVARTIS PHARMA GMBH , SCRIPPS RESEARCH INST
发明人： BARBAS CARLOS , DREIER BIRGIT
IPC分类号： C12N15/09 , C12N15/12 , A61K38/00 , A61P43/00 , C07K14/46 , C07K14/47 , C12N15/85

2. 发明专利

AT382691T 未知
公开(公告)号：AT382691T
公开(公告)日：2008-01-15
申请号：AT01951681
申请日：2001-07-16
申请人： NOVARTIS PHARMA GMBH , SCRIPPS RESEARCH INST
发明人： BEERLI ROGER , SCHOPFER ULRICH , BARBAS CARLOS
IPC分类号： C12N15/09 , C12N15/12 , C07K14/47 , C07K14/72 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/62 , C12N15/63

3. 发明专利

JP2003204797A OLIGONUCLEOTIDE 审中-公开
公开(公告)号：JP2003204797A
公开(公告)日：2003-07-22
申请号：JP2002289257
申请日：2002-08-26
申请人： SCRIPPS RESEARCH INST
发明人： KANG ANGRAY , BARBAS CARLOS , LERNER RICHARD A
IPC分类号： C12N15/09 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/40 , C07K19/00 , C12N7/00 , C12N7/01 , C12N15/10 , C12N15/62 , C12N15/70 , C12P21/08 , C40B40/02 , C40B50/06 , G01N33/53 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide an oligonucleotide useful as a primer which induces a mutation induction in the complementarity-determining domain of an immunoglobulin gene. SOLUTION: This oligonucleotide has 3'- and 5'-terminals, and comprises (a) a nucleotide sequence capable of being hybridized with the first frame structure domain of the immunoglobulin gene at the 3'-terminal, (b) a nucleotide sequence capable of being hybridized with the second frame structure domain of the immunoglobulin gene at the 5'-terminal, and (c) a nucleotide sequence of the formula: [NNR] n between the 3'- and 5'-terminals [N is independently one of all nucleotides; R is S, K or an analogue thereof; (n) is 3 to about 24; S is G or C; K is G or T; and the 3'- and 5'-terminated nucleotide sequence has a length of about 6 to 50 nucleotides] and a sequence complementary to the same. COPYRIGHT: (C)2003,JPO

4. 发明公开

EP0580737A4 HETERODIMERIC RECEPTOR LIBRARIES USING PHAGEMIDS 失效
标题翻译：使用PHAGEMIDS的偶氮受体文库
公开(公告)号：EP0580737A4
公开(公告)日：1996-04-24
申请号：EP92910558
申请日：1992-04-10
申请人： SCRIPPS RESEARCH INST
发明人： KANG ANGRAY , BARBAS CARLOS , LERNER RICHARD A
IPC分类号： C12N15/09 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/40 , C07K19/00 , C12N7/00 , C12N7/01 , C12N15/10 , C12N15/62 , C12N15/70 , C12P21/08 , C40B40/02 , C40B50/06 , G01N33/53 , G01N33/68
CPC分类号： C40B40/02 , C07K14/705 , C07K16/00 , C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2319/02 , C12N15/1037 , C12P19/34

5. 发明专利

AT269401T 未知
公开(公告)号：AT269401T
公开(公告)日：2004-07-15
申请号：AT92910558
申请日：1992-04-10
申请人： SCRIPPS RESEARCH INST
发明人： KANG ANGRAY , BARBAS CARLOS , LERNER RICHARD A
IPC分类号： C12N15/09 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/40 , C07K19/00 , C12N7/00 , C12N7/01 , C12N15/10 , C12N15/62 , C12N15/70 , C12P21/08 , C40B40/02 , C40B50/06 , G01N33/53 , G01N33/68
摘要： A filamentous phage (FP) encapsulating a genome encoding a ligand-binding heterodimeric receptor (LBHR) is new. Also new are (1) LBHR consisting of a polypeptide (P1) flanked by an N-terminal prokaryotic secretion signal (SS) domain and a C-terminal FP-membrane-anchor (MA) domain, and a second polypeptode (P2) fused to an N-terminal SS domain; (2) vector for expressing a fusion polypeptide (FPP) comprising connected DNA sequences (one encoding SS and the other MA) operably linked to appropriate expression signals; (3) polypeptide (PP) having a ligand-binding receptor component linked at the N-terminus to an SS domain and at the C-terminus to an MA domain; (4) libraries of FP particles each contg. a vector of (2); (5) oligonucleotides (I) useful as primers for mutangenesis in a comentarity-determining region (CDR) of an Ig gene consisting of 3'- and 5'-terminal sequences able to hybridise with framework regions of the Ig gene and connected by the sequence (NNR)n N = any nucleotide, R = 5 (i.e. G or C) or K (i.e. G or T) or their analogues; n = 3-24; the terminal sequences are 6-50 nucleotides long; and (b) libraries of dicistronic DNA molecules each with 2 citrons expressing polypeptides of a heterodimeric receptor on the surface of FP.

6. 发明专利

FI120309B 未知
公开(公告)号：FI120309B
公开(公告)日：2009-09-15
申请号：FI934422
申请日：1993-10-08
申请人： SCRIPPS RESEARCH INST
发明人： KANG ANGRAY , BARBAS CARLOS , LERNER RICHARD A
IPC分类号： C12N7/01 , C12N15/09 , C07H21/04 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/40 , C07K19/00 , C12N7/00 , C12N15/10 , C12N15/34 , C12N15/62 , C12N15/70 , C12P21/08 , C40B40/02 , C40B50/06 , G01N33/53 , G01N33/569 , G01N33/68
摘要： A filamentous phage (FP) encapsulating a genome encoding a ligand-binding heterodimeric receptor (LBHR) is new. Also new are (1) LBHR consisting of a polypeptide (P1) flanked by an N-terminal prokaryotic secretion signal (SS) domain and a C-terminal FP-membrane-anchor (MA) domain, and a second polypeptode (P2) fused to an N-terminal SS domain; (2) vector for expressing a fusion polypeptide (FPP) comprising connected DNA sequences (one encoding SS and the other MA) operably linked to appropriate expression signals; (3) polypeptide (PP) having a ligand-binding receptor component linked at the N-terminus to an SS domain and at the C-terminus to an MA domain; (4) libraries of FP particles each contg. a vector of (2); (5) oligonucleotides (I) useful as primers for mutangenesis in a comentarity-determining region (CDR) of an Ig gene consisting of 3'- and 5'-terminal sequences able to hybridise with framework regions of the Ig gene and connected by the sequence (NNR)n N = any nucleotide, R = 5 (i.e. G or C) or K (i.e. G or T) or their analogues; n = 3-24; the terminal sequences are 6-50 nucleotides long; and (b) libraries of dicistronic DNA molecules each with 2 citrons expressing polypeptides of a heterodimeric receptor on the surface of FP.

7. 发明专利

ES2315612T3 GENOTECAS DE RECEPTORES HETERODIMERICOS USANDO FAGEMIDOS. 未知
公开(公告)号：ES2315612T3
公开(公告)日：2009-04-01
申请号：ES04076718
申请日：1992-04-10
申请人： SCRIPPS RESEARCH INST
发明人： KANG ANGRAY , BARBAS CARLOS , LERNER RICHARD A
IPC分类号： C12N15/09 , C12N15/10 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/40 , C07K19/00 , C12N7/00 , C12N7/01 , C12N15/62 , C12N15/70 , C12P21/08 , C40B40/02 , C40B50/06 , G01N33/53 , G01N33/68
摘要： Un fago filamentoso que encapsula un genoma codificante de un primer y un segundo polipéptido capaces de formar un receptor heterodimérico de unión a un ligando, en el que el primer polipéptido está flanqueado por un dominio de señal de secreción procariota amino-terminal y un dominio de anclaje a la membrana de fago filamentoso carboxi-terminal, y el segundo polipéptido está fusionado a un dominio de señal de secreción procariota amino-terminal, y en el que dicho primer polipéptido tiene una secuencia de residuos de aminoácido representada por la fórmula, mostrada en el sentido del terminal amino al terminal carboxilo: NH2 - O - (U)m - V - (X)n - Z - COOH, en la que O representa una secuencia de residuos de aminoácido que define un dominio de señal de secreción procariota amino-terminal; U representa un primer polipéptido espaciador; V representa una secuencia de residuos de aminoácido que define el dominio de unión a un ligando de una cadena de un polipéptido receptor heterodimérico; X representa un segundo espaciador; y Z representa una secuencia de residuos de aminoácido que define un dominio de anclaje a la membrana de una cubierta proteínica de fago filamentoso, con la condición de que m sea el número entero 0 ó 1, tal que cuando m sea 0, U no esté presente, y cuando m sea 1, U esté presente; y n sea 0 ó 1, tal que cuando n sea 0, X no esté presente y cuando n sea 1, X esté presente, y en la que los espaciadores polipeptídicos U y X, cuando están presentes, pueden tener cada uno cualquier secuencia de residuos de aminoácido de una longitud de 1 a 6 residuos de aminoácido.

8. 发明专利

DK0580737T3 未知
公开(公告)号：DK0580737T3
公开(公告)日：2004-11-01
申请号：DK92910558
申请日：1992-04-10
申请人： SCRIPPS RESEARCH INST
发明人： KANG ANGRAY , BARBAS CARLOS , LERNER RICHARD A
IPC分类号： C12N15/09 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/40 , C07K19/00 , C12N7/00 , C12N7/01 , C12N15/10 , C12N15/62 , C12N15/70 , C12P21/08 , C40B40/02 , C40B50/06 , G01N33/53 , G01N33/68
摘要： A filamentous phage (FP) encapsulating a genome encoding a ligand-binding heterodimeric receptor (LBHR) is new. Also new are (1) LBHR consisting of a polypeptide (P1) flanked by an N-terminal prokaryotic secretion signal (SS) domain and a C-terminal FP-membrane-anchor (MA) domain, and a second polypeptode (P2) fused to an N-terminal SS domain; (2) vector for expressing a fusion polypeptide (FPP) comprising connected DNA sequences (one encoding SS and the other MA) operably linked to appropriate expression signals; (3) polypeptide (PP) having a ligand-binding receptor component linked at the N-terminus to an SS domain and at the C-terminus to an MA domain; (4) libraries of FP particles each contg. a vector of (2); (5) oligonucleotides (I) useful as primers for mutangenesis in a comentarity-determining region (CDR) of an Ig gene consisting of 3'- and 5'-terminal sequences able to hybridise with framework regions of the Ig gene and connected by the sequence (NNR)n N = any nucleotide, R = 5 (i.e. G or C) or K (i.e. G or T) or their analogues; n = 3-24; the terminal sequences are 6-50 nucleotides long; and (b) libraries of dicistronic DNA molecules each with 2 citrons expressing polypeptides of a heterodimeric receptor on the surface of FP.

9. 发明专利

FI934422A 未知
公开(公告)号：FI934422A
公开(公告)日：1993-12-08
申请号：FI934422
申请日：1993-10-08
申请人： SCRIPPS RESEARCH INST
发明人： KANG ANGRAY , BARBAS CARLOS , LERNER RICHARD A
IPC分类号： C12N15/09 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/40 , C07K19/00 , C12N7/00 , C12N7/01 , C12N15/10 , C12N15/62 , C12N15/70 , C12P21/08 , C40B40/02 , C40B50/06 , G01N33/53 , G01N33/68
摘要： A filamentous phage (FP) encapsulating a genome encoding a ligand-binding heterodimeric receptor (LBHR) is new. Also new are (1) LBHR consisting of a polypeptide (P1) flanked by an N-terminal prokaryotic secretion signal (SS) domain and a C-terminal FP-membrane-anchor (MA) domain, and a second polypeptode (P2) fused to an N-terminal SS domain; (2) vector for expressing a fusion polypeptide (FPP) comprising connected DNA sequences (one encoding SS and the other MA) operably linked to appropriate expression signals; (3) polypeptide (PP) having a ligand-binding receptor component linked at the N-terminus to an SS domain and at the C-terminus to an MA domain; (4) libraries of FP particles each contg. a vector of (2); (5) oligonucleotides (I) useful as primers for mutangenesis in a comentarity-determining region (CDR) of an Ig gene consisting of 3'- and 5'-terminal sequences able to hybridise with framework regions of the Ig gene and connected by the sequence (NNR)n N = any nucleotide, R = 5 (i.e. G or C) or K (i.e. G or T) or their analogues; n = 3-24; the terminal sequences are 6-50 nucleotides long; and (b) libraries of dicistronic DNA molecules each with 2 citrons expressing polypeptides of a heterodimeric receptor on the surface of FP.

10. 发明专利

NO933610D0 未知
公开(公告)号：NO933610D0
公开(公告)日：1993-10-08
申请号：NO933610
申请日：1993-10-08
申请人： SCRIPPS RESEARCH INST
发明人： KANG ANGRAY , BARBAS CARLOS , LERNER RICHARD A
IPC分类号： C12N15/09 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/40 , C07K19/00 , C12N7/00 , C12N7/01 , C12N15/10 , C12N15/62 , C12N15/70 , C12P21/08 , C40B40/02 , C40B50/06 , G01N33/53 , G01N33/68
摘要： A filamentous phage (FP) encapsulating a genome encoding a ligand-binding heterodimeric receptor (LBHR) is new. Also new are (1) LBHR consisting of a polypeptide (P1) flanked by an N-terminal prokaryotic secretion signal (SS) domain and a C-terminal FP-membrane-anchor (MA) domain, and a second polypeptode (P2) fused to an N-terminal SS domain; (2) vector for expressing a fusion polypeptide (FPP) comprising connected DNA sequences (one encoding SS and the other MA) operably linked to appropriate expression signals; (3) polypeptide (PP) having a ligand-binding receptor component linked at the N-terminus to an SS domain and at the C-terminus to an MA domain; (4) libraries of FP particles each contg. a vector of (2); (5) oligonucleotides (I) useful as primers for mutangenesis in a comentarity-determining region (CDR) of an Ig gene consisting of 3'- and 5'-terminal sequences able to hybridise with framework regions of the Ig gene and connected by the sequence (NNR)n N = any nucleotide, R = 5 (i.e. G or C) or K (i.e. G or T) or their analogues; n = 3-24; the terminal sequences are 6-50 nucleotides long; and (b) libraries of dicistronic DNA molecules each with 2 citrons expressing polypeptides of a heterodimeric receptor on the surface of FP.

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