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1. 发明申请

WO1997015192A1 1,3,5-OXADIAZINES AS MOLLUSCICIDES 审中-公开
标题翻译： 1,3,5-OXADIAZINES as MOLLUSCICIDES
公开(公告)号：WO1997015192A1
公开(公告)日：1997-05-01
申请号：PCT/EP1996004534
申请日：1996-10-18
申请人： NOVARTIS AG , SENN, Robert , MAIENFISCH, Peter , LEADBEATER, Andrew
发明人： NOVARTIS AG
IPC分类号： A01N43/88
CPC分类号： A01N51/00 , A01N47/40
摘要： The invention relates to the use of oxadiazine derived compounds of formula (I), in which A is an optionally substituted heterocyclyl group; R is hydrogen, alkyl, phenylalkyl, cycloalkyl, alkenyl or alkynyl; and X is N-NO2 or N-CN; or, if appropriate, tautomers thereof, in each case in free form or in molluscicidally utilisable salt form, for controlling representatives of the phylum Mollusca, to molluscicidal compositions, whose active ingredient is selected from these compounds and tautomers, in each case in free form or in molluscicidally utilisable salt form, to a process for the preparation and to the use of these compositions, to plant propagation material treated with these compositions and to a method of controlling representatives of the phylum Mollusca.
摘要翻译：本发明涉及恶二嗪衍生的式（I）化合物的用途，其中A是任选取代的杂环基; R是氢，烷基，苯基烷基，环烷基，烯基或炔基; X为N-NO 2或N-CN; 或其合适的互变异构体，以游离形式或以软体动物营养的盐形式，用于控制软体动物门的代表，其活性成分选自这些化合物和互变异构体，在每种情况下为游离形式或以软体动物食用的盐形式，用于制备和使用这些组合物，用这些组合物处理的植物繁殖材料的方法和控制门柔毛菌的代表的方法。

2. 发明申请

WO1997040691A1 PESTICIDAL COMPOSITION 审中-公开
标题翻译：农药组合物
公开(公告)号：WO1997040691A1
公开(公告)日：1997-11-06
申请号：PCT/EP1997001925
申请日：1997-04-17
申请人： NOVARTIS AG , SENN, Robert , MAIENFISCH, Peter , WYSS, Peter
发明人： NOVARTIS AG
IPC分类号： A01N51/00
CPC分类号： A01N47/40 , A01N51/00 , A01N57/16 , A01N57/14 , A01N47/12 , A01N2300/00
摘要： Composition for controlling insects and representatives of the order Acarina, which comprises a combination of variable amounts of one or more compounds of formula (A), in which A is an unsubstituted or, depending on the possibility of substitution on the ring system, mono- to tetrasubstituted, aromatic or non-aromatic monocyclic or bicyclic heterocyclic radical, in which the substituents of A are chosen from the group consisting of C1-C3alkyl, C1-C3alkoxy, halogen, halo-C1-C3alkyl, cyclopropyl, halocyclopropyl, C2-C3alkenyl, C2-C3alkynyl, halo-C2-C3alkenyl, halo-C2-C3alkynyl, halo-C1-C3alkoxy, C1-C3alkylthio, halo-C1-C3alkylthio, allyloxy, propargyloxy, allylthio, propargylthio, haloallyloxy, haloallylthio, cyano and nitro; R is hydrogen, C1-C6alkyl, phenyl-C1-C4alkyl, C3-C6cycloalkyl, C2-C6alkenyl or C2-C6alkynyl; and X is N-NO2 or N-CN, in the free form or in salt form, if appropriate tautomers, in the free form or salt form, and one or more of the compounds: azamethiphos; chlorfenvinphos; cypermethrin, cypermethrin high-cis; cyromazin; diafenthiuron; diazinon; dichlorvos; dicrotophos; dicyclanil; fenoxycarb; fluazuron; furathiocarb; isazofos; jodfenphos; kinoprene; lufenuron; methacriphos; methidathion; monocrotophos; phosphamidon; profenofos; diofenolan; a substance obtainable from a Bacillus thuringiensis strain; pymetrozine; bromopropylate; methoprene; disulfuton; quinalphos; tau-fluvalinate; thiocyclam; or thiometon and at least one auxiliary; a method of controlling pests, a process for the preparation of the composition, its use and plant propagation material treated with it, and the use of the compound of the formula (A) for the preparation of the composition are described.
摘要翻译：用于控制昆虫的组合物和蜱螨纲的代表，其包含可变量的一种或多种式（A）化合物的组合，其中A是未取代的，或者根据在环系上取代的可能性，芳基或非芳族单环或双环杂环基，其中A的取代基选自C 1 -C 3烷基，C 1 -C 3烷氧基，卤素，卤代-C 1 -C 3烷基，环丙基，卤代环丙基，C 2 -C 3烯基 C 1 -C 3烷氧基，C 1 -C 3烷硫基，卤代C 1 -C 3烷硫基，烯丙氧基，炔丙氧基，烯丙硫基，炔丙硫基，卤代烯氧基，卤代烯硫基，氰基和硝基; R是氢，C 1 -C 6烷基，苯基-C 1 -C 4烷基，C 3 -C 6环烷基，C 2 -C 6烯基或C 2 -C 6炔基; 和X为游离形式或盐形式的N-NO 2或N-CN，如果适当的互变异构体，以游离形式或盐形式，以及一种或多种化合物：氮杂螺旋体; 毒虫畏; 氯氰菊酯，氯氰菊酯高顺式; 环丙氨嗪; 丁醚脲; 二嗪磷; 敌敌畏; 百治磷; 昔尼尔; 苯氧威; 啶蜱脲; 呋线威; 氯唑磷; jodfenphos; kinoprene; 虱螨脲; methacriphos; 杀扑磷; 久效磷; 磷胺; 丙溴磷; 苯虫醚; 可从苏云金芽孢杆菌菌株获得的物质; 吡蚜酮; 溴螨酯; 普林; disulfuton; 喹硫磷; 牛头氟胺氰菊酯; 杀虫环; 或硫代醇和至少一种辅助剂; 描述了用于控制害虫的方法，用于制备组合物的方法，其使用和用其处理的植物繁殖材料，以及式（A）化合物用于制备组合物的用途。

3. 发明申请

WO1997040692A1 PESTICIDAL COMPOSITIONS 审中-公开
标题翻译：农药组合物
公开(公告)号：WO1997040692A1
公开(公告)日：1997-11-06
申请号：PCT/EP1997001926
申请日：1997-04-17
申请人： NOVARTIS AG , SENN, Robert , MAIENFISCH, Peter , WYSS, Peter
发明人： NOVARTIS AG
IPC分类号： A01N51/00
CPC分类号： A01N53/00 , A01N43/88 , A01N47/40 , A01N51/00 , A01N43/56 , A01N43/40 , A01N43/30 , A01N2300/00 , A01N57/12
摘要： Composition for controlling insects and representatives of the order Acarina, which comprises a combination of variable amounts of one or more compounds of formula (A), in which A is an unsubstituted or, depending on the possibility of substitution on the ring system, mono- to tetrasubstituted, aromatic or non-aromatic monocyclic or bicyclic heterocyclic radical, in which the substituents of A can be chosen from the group consisting of C1-C3alkyl, C1-C3alkoxy, halogen, halo-C1-C3alkyl, cyclopropyl, halocyclopropyl, C2-C3alkenyl, C2-C3alkynyl, halo-C2-C3alkenyl, halo-C2-C3alkynyl, halo-C1-C3alkoxy, C1-C3alkylthio, halo-C1-C3alkylthio, allyloxy, propargyloxy, allylthio, propargylthio, haloallyloxy, haloallylthio, cyano and nitro; R is hydrogen, C1-C6alkyl, phenyl-C1-C4alkyl, C3-C6cycloalkyl, C2-C6alkenyl or C2-C6alkynyl; and X is N-NO2 or N-CN, in the free form or in the salt form, if appropriate tautomers, in the free form or salt form, and one or more of the compounds (I to CLXXXIV) mentioned according to the invention and at least one auxiliary. A method of controlling pests, a process for the preparation of the composition, its use and plant propagation material treated with it, and the use of the compound of formula (A) for the preparation of the composition, are described.
摘要翻译：用于防治昆虫的组合物和Acarina序列的代表，其包含可变量的一种或多种式（A）化合物的组合，其中A是未取代的，或者根据在环系上取代的可能性，其中A的取代基可以选自C 1 -C 3烷基，C 1 -C 3烷氧基，卤素，卤代-C 1 -C 3烷基，环丙基，卤代环丙基，C 2 -C 3烷氧基， C 3链烯基，C 2 -C 3炔基，卤代-C 2 -C 3烯基，卤代-C 2 -C 3炔基，卤代-C 1 -C 3烷氧基，C 1 -C 3烷硫基，卤代C 1 -C 3烷硫基，烯丙氧基，炔丙氧基，烯丙硫基，炔丙硫基，卤代烯氧基，卤代烯硫基，氰基和硝基。 R是氢，C 1 -C 6烷基，苯基-C 1 -C 4烷基，C 3 -C 6环烷基，C 2 -C 6烯基或C 2 -C 6炔基; 和X是以游离形式或盐形式的N-NO 2或N-CN，如果适当的互变异构体，以游离形式或盐形式，以及根据本发明提及的一种或多种化合物（I至CLXXXIV）和至少一个辅助物。描述了控制害虫的方法，用于制备组合物的方法，其使用和植物繁殖材料的处理方法以及式（A）化合物用于制备组合物的用途。

4. 发明申请

WO1998027074A1 PROCESS FOR THE PREPARATION OF THIAZOLE DERIVATIVES 审中-公开
标题翻译：制备噻唑衍生物的方法
公开(公告)号：WO1998027074A1
公开(公告)日：1998-06-25
申请号：PCT/EP1997007087
申请日：1997-12-17
申请人： NOVARTIS AG , PITTERNA, Thomas , SZCZEPANSKI, Henry , MAIENFISCH, Peter , HÜTER, Ottmar, Franz , RAPOLD, Thomas , SENN, Marcel , GÖBEL, Thomas , O'SULLIVAN, Anthony, Cornelius , SEIFERT, Gottfried
发明人： NOVARTIS AG
IPC分类号： C07D277/32
CPC分类号： C07D277/32 , C07D277/16 , C07D277/36 , C07D417/06
摘要： The invention relates to a process for the preparation of a compound of formula (I), wherein Q, Y, Z, R1, R2, R3, R4 and R5 are as defined in the specification, which comprises a) reacting a compound of formula (II), with a halogenating agent to form a compound of formula (III), or b) converting a compound of formula (II) by means of a halogenating agent into a compound of formula (IV); optionally c) converting the compound of formula (IV) into a compound of formula (III); d) converting a compound of formula (III) by means of a compound of formula (V) into a compound of formula (VI); or e) converting a compound (IV) by means of a compound (V) into a compound (VI); and f) converting a compound (VI) by means of a chlorinating agent into a compound (I); a compound (IV); to a process for the preparation of a compound (III) and to a process for the preparation of a compound (IV).
摘要翻译：本发明涉及制备式（I）化合物的方法，其中Q，Y，Z，R 1，R 2，R 3，R 4和R 5如本说明书中所定义，其包括：a）使式（II）化合物与卤化剂反应形成式（III）化合物，或b）将式（Ⅱ）化合物用卤化剂转化为式（Ⅳ）化合物; 任选地c）将式（IV）的化合物转化成式（III）的化合物; d）通过式（V）化合物将式（III）化合物转化为式（VI）化合物; 或e）通过化合物（V）将化合物（IV）转化为化合物（VI）; 和f）通过氯化剂将化合物（VI）转化为化合物（I）; 化合物（IV）; 涉及制备化合物（III）的方法和制备化合物（IV）的方法。

5. 发明申请

WO1997020829A1 PROCESS FOR PREPARING 2-CHLOROTHIAZOLE COMPOUNDS 审中-公开
标题翻译：制备2-氯代噻唑化合物的方法
公开(公告)号：WO1997020829A1
公开(公告)日：1997-06-12
申请号：PCT/IB1996001329
申请日：1996-12-02
申请人： NOVARTIS AG , SZCZEPANSKI, Henry , GÖBEL, Thomas , HÜTER, Ottmar, Franz , O'SULLIVAN, Anthony, Cornelius , SENN, Marcel , RAPOLD, Thomas , MAIENFISCH, Peter , PITTERNA, Thomas
发明人： NOVARTIS AG
IPC分类号： C07D277/32
CPC分类号： C07D277/32 , C07D277/36 , C07D417/06
摘要： The invention relates to a process for preparing a compound of formula (I), in which X is CH or N, Y is NO2 or CN, Z is CHR3, O, NR3 or S, R1 and R2 are either each, independently of the other, hydrogen or unsubstituted or R4-substituted alkyl or together a two- or three-membered alkylene bridge or a two- or three-membered alkylene bridge in which one member is replaced by a hetero member selected from the group, consisting of NR5, O and S, R3 is H or unsubstituted or R4-substituted alkyl, R4 is an unsubstituted or substituted aryl or heteroaryl group, and R5 is H or alkyl, which comprises a) reacting a compound of formula (II) with a chlorinating agent or b1) initially reacting a compound of formula (IV) with a compound of formula (V) and b2) further reacting the compound of formula (II) obtainable thereby, with or without intermediate isolation, with a chlorinating agent, to intermediates used in this process, to the use of these intermediates and to a process for the preparation of these intermediates.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中X是CH或N，Y是NO 2或CN，Z是CHR 3，O，NR 3或S，R 1和R 2各自独立地是另一个，氢或未取代的或R4取代的烷基或二元或三元亚烷基桥或二元或三元亚烷基桥，其中一个成员被选自NR5， O和S，R 3是H或未取代的或R 4取代的烷基，R 4是未取代或取代的芳基或杂芳基，R 5是H或烷基，其包括a）使式（II）化合物与氯化剂或 b1）最初使式（Ⅳ）化合物与式（Ⅴ）化合物反应，和b2）使可得到的式（Ⅳ）化合物与氯化剂进行中间分离或不用中间分离进一步使其与本文所用的中间体反应过程，使用这些中间体和制备过程这些中间体。

6. 发明申请

WO1998027075A1 PREPARATION OF THIAZOLES 审中-公开
标题翻译：制备THIAZOLES
公开(公告)号：WO1998027075A1
公开(公告)日：1998-06-25
申请号：PCT/EP1997007088
申请日：1997-12-17
申请人： NOVARTIS AG , PITTERNA, Thomas , SZCZEPANSKI, Henry , MAIENFISCH, Peter , HÜTER, Ottmar, Franz , RAPOLD, Thomas , SENN, Marcel , GÖBEL, Thomas , O'SULLIVAN, Anthony, Cornelius
发明人： NOVARTIS AG
IPC分类号： C07D277/32
CPC分类号： C07D277/32 , C07D277/16 , C07D277/36 , C07D277/70 , C07D277/74
摘要： Described is a process for the preparation of a compound of formula (I) wherein R is unsubstituted or substituted C1-C12alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, aryl or heteroaryl, or -SR1; R1 is unsubstituted or substituted C1-C12alkyl, C2-C4alkenyl, C2-C4alkynyl, cycloalkyl, aryl or heteroaryl; and X is a leaving group; which comprises: a) reacting a compound of formula (II) wherein R is as defined for formula (I), with a water-removing reagent; or b) for the preparation of a compound of formula (I) wherein X is halogen or a sulfonate, reacting a compound of the formula (III) wherein R is as defined for formula (I), with a halogenating or a sulfonylating agent; or c) for the preparation of a compound of formula (I) wherein X is halogen, reacting a compound of formula (IV) wherein R is as defined for formula (I); and wherein R2 and R3 are for example H, C1-C6alkyl, C3-C6cycloalkyl, phenyl or benzyl; with a compound of the formula halogen-C(=O)-O-C1-C8alkyl, halogen-C(=O)-O-aryl or halogen-C(=O)-O-benzyl. Intermediates for the preparation of the synthesis of compounds (II) to (IV) and method of the preparation thereof.
摘要翻译：描述了制备式（I）化合物的方法，其中R是未取代的或取代的C 1 -C 12烷基，C 2 -C 4烯基，C 2 -C 4炔基，C 3 -C 6环烷基，芳基或杂芳基或-SR 1; R1是未取代的或取代的C1-C12烷基，C2-C4链烯基，C2-C4炔基，环烷基，芳基或杂芳基; X为离去群; 其包括：a）使其中R如式（I）所定义的式（II）化合物与除水试剂反应; 或者b）用于制备其中X为卤素或磺酸盐的式（I）化合物，其中R为式（I）所定义的式（III）化合物与卤化剂或磺酰化剂反应; 或c）用于制备其中X为卤素的式（I）化合物，其中R为式（I）所定义的式（IV）化合物; 并且其中R 2和R 3是例如H，C 1 -C 6烷基，C 3 -C 6环烷基，苯基或苄基; 与卤素-C（= O）-O-C 1 -C 8烷基，卤素-C（= O）-O-芳基或卤素-C（= O）-O-苄基的化合物反应。用于制备化合物（II）至（IV）的合成的中间体及其制备方法。

7. 发明申请

WO1998006710A1 SUBSTITUTED 4-NITROIMINO-PERHYDRO-1,3,5-OXADIAZINE DERIVATIVES, THEIR USE AS PESTICIDES AND INTERMEDIATES FOR THEIR PREPARATION 审中-公开
标题翻译：取代的4-硝基 - 间苯二酚-1,3,5-氧杂吖啶衍生物，它们作为杀虫剂及其制备用途的中间体
公开(公告)号：WO1998006710A1
公开(公告)日：1998-02-19
申请号：PCT/EP1997004137
申请日：1997-07-30
申请人： NOVARTIS AG , MAIENFISCH, Peter , GSELL, Laurenz
发明人： NOVARTIS AG
IPC分类号： C07D273/04
CPC分类号： C07D413/06 , A01N51/00 , C07D273/04 , C07D413/14 , C07D417/06 , C07D417/14
摘要： Compounds of formula (I), in which A is a substituted or unsubstituted heterocyclyl group; -E-R is -C(=O)-R, -C(=O)O-R, -C(=O)N(R1)-R, -C(=O)C(=O)-R, -C(=O)C(=O)O-R, -C(=O)C(=O)N(R1)-R or -C(=S)N(R1)-R; R is hydrogen or a substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heteroaryl group; and R1 is hydrogen or a substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloakyl, aryl or heteroaryl group, and, where appropriate, tautomers thereof, in each case in free form or in salt form, can be used as agrochemical active ingredients and can be prepared in a manner known per se.
摘要翻译：式（I）化合物，其中A是取代或未取代的杂环基; -ER是-C（= O）-R，-C（= O）OR，-C（= O）N（R1）-R，-C（= O）C（= O） = O）C（= O）OR，-C（= O）C（= O）N（R 1）-R或-C（= S）N（R 1） R是氢或取代或未取代的烷基，烯基，炔基，环烷基，芳基或杂芳基; 并且R 1是氢或取代或未取代的烷基，烯基，炔基，环烷基，芳基或杂芳基，并且在适当的情况下，互变异构体在每种情况下以游离形式或盐形式可用作农业化学活性成分，并且可以以本身已知的方式进行准备。

8. 发明公开

EP1689702A1 ORGANIC COMPOUNDS 有权
标题翻译：有机化合物
公开(公告)号：EP1689702A1
公开(公告)日：2006-08-16
申请号：EP04819222.3
申请日：2004-11-25
申请人： NOVARTIS-PHARMA GMBH , Novartis AG
发明人： NOVARTIS AG , BAESCHLIN, Daniel, Kaspar , MAIBAUM, Jürgen, Klaus , SELLNER, Holger
IPC分类号： C07C237/20 , C07D295/02 , C07C237/24 , C07C271/24 , C07C323/29 , C07C255/50 , C07D319/18 , C07D313/08 , C07D307/79 , C07D207/09 , C07D333/08 , A61P9/12 , A61K31/165 , A61K31/325 , A61K31/44
CPC分类号： C07C237/20 , C07C237/24 , C07C255/60 , C07C271/22 , C07C271/24 , C07C323/41 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07D207/09 , C07D295/027 , C07D307/79 , C07D313/08 , C07D319/18 , C07D333/08
摘要： Disclosed are δ-amino-Ϝ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.
摘要翻译：公开了具有肾素抑制性质的式（I）的δ-氨基-β-羟基-ω-芳基 - 链烷酸酰胺化合物及其盐。还公开了包含这些化合物的药物组合物和施用它们以治疗高血压，动脉粥样硬化，不稳定冠状动脉综合征，充血性心力衰竭，心脏肥大，心脏纤维化，心肌梗塞后梗塞，不稳定冠状动脉综合征，舒张功能障碍，慢性肾病，肝纤维化，由糖尿病引起的并发症如肾病，血管病和神经病，冠状血管疾病，血管成形术后再狭窄，眼内压升高，青光眼，血管生长异常，醛固酮增多症，认知障碍，阿尔茨海默病，痴呆，焦虑状态和认知障碍。

9. 发明专利

AR069938A1 METODO Y COMPOSICION PARA PREPARAR LENTES DE CONTACTO 未知
公开(公告)号：AR069938A1
公开(公告)日：2010-03-03
申请号：ARP080105672
申请日：2008-12-22
申请人： NOVARTIS AG
发明人： NOVARTIS AG
IPC分类号： G02B1/04 , B29D11/00
摘要： La presente pertenece a un método y a una composicion fluida para producir lentes de contacto con calidad de lentes mejorada y con un aumento del rendimiento del producto. El método de la solicitud involucra agregar un fosfolípido a una composicion fluida incluyendo un material formador de lentes en una cantidad que es suficiente para reducir una fuerza de separacion de molde promediada de por lo menos aproximadamente 40% en comparacion con la que es sin los fosfolípidos.

10. 发明专利

BR112012004453A8 composto inibidor de proteína quinase, sua composição farmacêutica e seu uso 未知
公开(公告)号：BR112012004453A8
公开(公告)日：2021-06-08
申请号：BR112012004453
申请日：2010-08-27
申请人： IRC LLC , NOVARTIS AG
发明人： DANIEL POON , JOHN E TELLEW , NOVARTIS AG , SHENLIN HUANG , XIANMIG JIN , XING WANG , YONGPING XIE , YONGQIN WAN , ZUOSHENG LIU
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00 , C07D403/04
摘要： composto inibidor de proteína quinase, sua composição farmacêutica e seu uso. a presente invenção refere-se a uma nova classe de com-postos de fórmula 1 , composições farmacêuticas compreendendo tais compostos e méto-dos de utili2ação de tais compostos para tratar ou prevenir doenças ou distúrbios associados com atividade de quinase anormal ou desregu - lada' particularmente doenças ou distúrbios que envolvem a ativação anormal de b-raf.

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