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1. 发明申请

WO2011066583A1 AMYLOID BETA AGGREGATES IN CEREBRO SPINAL FLUID AS BIOMARKERS FOR ALZHEIMER'S DISEASE 审中-公开
标题翻译：作为ALZHEIMER病的生物标志物的CEREBRO脊柱液中的AMYLOID BETA聚集
公开(公告)号：WO2011066583A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/058450
申请日：2010-11-30
申请人： NOVARTIS AG , PERETZ, David , ALLAUZEN, Sophie , WANG, Xuemei , GAO, Man (carol) , YAM, Alice , FEDYNYSHYN, Joseph
发明人： PERETZ, David , ALLAUZEN, Sophie , WANG, Xuemei , GAO, Man (carol) , YAM, Alice , FEDYNYSHYN, Joseph
IPC分类号： G01N33/68 , C07K7/00
CPC分类号： G01N33/543 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention provides methods for assessing increased probability of having Alzheimer's disease in a subject under assessment including a step of obtaining a measurement of Aβ40 aggregates in a biological sample from the subject, where the biological sample does not include brain tissue, a fraction of brain tissue, or brain homogenate. In some embodiments, the invention relates to methods of assessing increased probability of early stage Alzheimer's disease. The invention further provides methods of assessing increased probability of not having Alzheimer's disease, methods of monitoring disease progression in a subject with Alzheimer's disease, and methods of assigning disease stage for a subject with Alzheimer's disease, and methods of assessing increased probability of MCI progressing to Alzheimer's disease.
摘要翻译：本发明提供用于评估在评估受试者中具有阿尔茨海默氏病的可能性增加的方法，包括获得来自受试者的生物样品中Aß40聚集体的测量的步骤，其中生物样品不包括脑组织，脑组织的一部分，或脑匀浆。在一些实施方案中，本发明涉及评估早期阿尔茨海默氏病的概率增加的方法。本发明还提供了评估增加阿尔茨海默氏病的可能性的方法，用阿尔茨海默病监测受试者的疾病进展的方法，以及为阿尔茨海默氏病患者分配疾病阶段的方法，以及评估增加的MCI进展概率的方法阿尔茨海默氏病。

2. 发明申请

WO2009134942A1 ASSAY FOR PATHOGENIC CONFORMERS 审中-公开
标题翻译：病原性制剂的测定
公开(公告)号：WO2009134942A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/042185
申请日：2009-04-29
申请人： NOVARTIS AG. , PERETZ, David , WANG, Xuemei , GAO, Man (Carol) , YAM, Alice , LAU, Anthony , WU, Ping
发明人： PERETZ, David , WANG, Xuemei , GAO, Man (Carol) , YAM, Alice , LAU, Anthony , WU, Ping
IPC分类号： A61K38/00 , G01N33/53
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention provides methods for detecting the presence of a non-prion pathogenic conformer in a sample by contacting the sample suspected of containing a non-prion pathogenic conformer with a pathogenic conformer- specific binding reagent under conditions that allow the binding of the reagent to the pathogenic conformer, if present; and detecting the presence the pathogenic conformer, if any, in the sample by its binding to the reagent; where the pathogenic conformer- specific binding reagent is typically derived from a prion protein fragment and interacts preferentially with a pathogenic prion protein. Methods for diagnosis of conformational diseases are also provided.
摘要翻译：本发明提供了通过在怀疑含有非朊病毒致病性构象异构体的样品与致病性构象异构体特异性结合试剂的接触的条件下，将样品中的非朊病毒致病性构象异构体存在的方法，致病性构象异构体，如果存在; 并通过其与试剂的结合来检测样品中致病性构象异构体（如果有的话）的存在; 其中致病性构象异构体特异性结合试剂通常衍生自朊病毒蛋白片段并优先与致病性朊病毒蛋白相互作用。还提供了构象疾病诊断方法。

3. 发明申请

WO2011057029A1 POSITIVELY CHARGED SPECIES AS BINDING REAGENTS IN THE SEPARATION OF PROTEIN AGGREGATES FROM MONOMERS 审中-公开
标题翻译：作为联合试剂在单体分离蛋白质聚集体中的积极物种
公开(公告)号：WO2011057029A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/055528
申请日：2010-11-04
申请人： NOVARTIS AG , SALISBURY, Cleo , PERETZ, David , YAM, Alice , WANG, Xuemei , GAO, Man, (carol)
发明人： SALISBURY, Cleo , PERETZ, David , YAM, Alice , WANG, Xuemei , GAO, Man, (carol)
IPC分类号： G01N33/68 , C07K7/00
CPC分类号： G01N33/6896 , A61K38/00 , C07K7/06 , C07K7/08 , G01N33/531 , G01N2800/2821 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods for detecting the presence of an aggregate in a sample by contacting the sample suspected of containing an aggregate with an aggregate-specific binding reagent under conditions that allow the binding of the reagent to the aggregate, if present; and detecting the presence of the aggregate, if any, in the sample by its binding to the reagent; where the aggregate-specific binding reagent typically has a net charge of at least about positive one at the pH at which the sample is contacted with the ASB reagent, is attached to a solid support at a charge density of at least about 60 nmol net charge per square meter, and binds preferentially with aggregates over monomers when attached to the solid support. Methods for detecting the presence of oligomer are also provided. Compositions for use in the methods arc provided.
摘要翻译：本发明提供了在允许试剂与聚集体结合的条件下（如果有的话），将怀疑含有骨料的样品与聚集体特异性结合试剂接触的方式来检测样品中骨料的存在; 并通过与样品的结合来检测样品中聚集体（如果有的话）的存在; 其中聚集体特异性结合试剂通常在样品与ASB试剂接触的pH下通常具有至少约为1的净电荷，以至少约60nmol净电荷的电荷密度附着于固体支持物当连接到固体支持物上时，优先与聚集体相对于单体结合。还提供了检测低聚物存在的方法。提供了用于方法的组合。

4. 发明申请

WO2008124098A1 PRION ASSAY 审中-公开
标题翻译： PRION测试
公开(公告)号：WO2008124098A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/004454
申请日：2008-04-03
申请人： NOVARTIS AG , PERETZ, David , YAM, Alice
发明人： PERETZ, David , YAM, Alice
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2828
摘要： The invention relates to an assay method for detecting the presence of PrP Sc using at least one sequence-specific protease for a substantially complete digestion of the proteins in a sample, leaving the octarepeat region in both PrP Sc and PrP C intact, leaving the protease-resistant core of PrP Sc intact and remain connected to the octarepeat region, while digesting away at least part of the amino acid sequences in PrP C corresponding to the protease-resistant core in PrP Sc . The method further comprises a step of inhibiting further digestion by the protease, a step of denaruration, and a step of detecting the presence of PrP Sc using at least two binding partners, a first binding partner and a second binding partner, wherein the first binding partner specifically binds an epitope in the amino-proximal region, and the second binding partner specifically binds an epitope within a region of the protease-resistant core of PrP Sc that has been cleaved away in PrP C . The invention also relates to a kit comprising reagents that can be used in the assay method.
摘要翻译：本发明涉及使用至少一种用于基本上完全消化样品中的蛋白质的序列特异性蛋白酶来检测PrP 的存在的测定方法，将Octpepeat区域保留在PrP ^{Sc>和PrP 完整，使得PrP Sc蛋白酶抗性核心完整并保持连接到八边形区域，同时消化掉至少部分 PrP 中对应于蛋白酶抗性核心的PrP 中的氨基酸序列。该方法还包括使用至少两个结合配偶体，第一结合配偶体和第二结合配偶体，抑制蛋白酶进一步消化，脱色步骤和检测PrP 的存在的步骤其中所述第一结合配偶体特异性结合所述氨基邻近区域中的表位，并且所述第二结合配偶体特异性结合已经在所述蛋白酶抗性核心的区域中的表位在PrP 中切断。本发明还涉及包含可用于测定方法的试剂的试剂盒。}

5. 发明申请

WO2006076687A2 ELISA ASSAYS USING PRION-SPECIFIC PEPTIDE REAGENTS 审中-公开
标题翻译：使用特异性肽试剂进行ELISA测定
公开(公告)号：WO2006076687A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/001437
申请日：2006-01-13
申请人： CHIRON CORPORATION , PERETZ, David , MICHELITSCH, Melissa , HU, Celine , WANG, Xuemei , GAO, Man , CONNOLLY, Michael , HORN, Thomas , ZUCKERMANN, Ronald , CHIEN, David
发明人： PERETZ, David , MICHELITSCH, Melissa , HU, Celine , WANG, Xuemei , GAO, Man , CONNOLLY, Michael , HORN, Thomas , ZUCKERMANN, Ronald , CHIEN, David
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： B82Y30/00 , G01N33/6896 , G01N2800/2828
摘要： Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described for use in detecting PrPsc in biological samples. In particular, ELISA assays are described.
摘要翻译：描述了与PrPsc形式的朊病毒蛋白优先相互作用的肽试剂，用于检测生物样品中的PrPsc。特别地，描述了ELISA测定。

6. 发明申请

WO2006076497A2 OSPLATION OF PATHOGENIC PRIONS 审中-公开
标题翻译：致病性的影响
公开(公告)号：WO2006076497A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/001090
申请日：2006-01-13
申请人： CHIRON CORPORATION , PERETZ, David , MICHELITSCH, Melissa , HU, Celine , CHIEN, David , HALL, John , WANG, Xuemei , GAO, Man
发明人： PERETZ, David , MICHELITSCH, Melissa , HU, Celine , CHIEN, David , HALL, John , WANG, Xuemei , GAO, Man
IPC分类号： C12Q1/70
CPC分类号： C07K14/47
摘要： Peptide reagents that interact preferentially with the PrP sc form of the prion protein are described. Methods of using the reagents for isolation and purification of the PrP sc isoform are described.
摘要翻译：描述了与Prion蛋白质的PrPßsc形式优先相互作用的肽试剂。描述了使用用于分离和纯化PrP标准同种型的试剂的方法。

7. 发明申请

WO2007030804A1 PRION-SPECIFIC PEPTOID REAGENTS 审中-公开
标题翻译：特异性PEPTOID试剂
公开(公告)号：WO2007030804A1
公开(公告)日：2007-03-15
申请号：PCT/US2006/035226
申请日：2006-09-08
申请人： NOVARTIS AG , PERETZ, David , CONNOLLY, Michael, D. , ZUCKERMANN, Ronald , GAO, Man , SHIMIZU, Robert, M. , TIMOTEO, Gulliver
发明人： PERETZ, David , CONNOLLY, Michael, D. , ZUCKERMANN, Ronald , GAO, Man , SHIMIZU, Robert, M. , TIMOTEO, Gulliver
IPC分类号： C07K5/00 , C07K7/00 , A61K38/08 , A61K38/10 , A61K31/16
CPC分类号： C07K14/001 , A61K38/00 , C07K14/47 , Y02P20/55
摘要： The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.
摘要翻译：本发明涉及与构象疾病蛋白质的非致病形式相比优先与构象疾病蛋白质的致病形式相互作用的拟肽试剂，其中拟肽试剂包含氨基末端区域，羧基末端区域和至少一个氨基末端区域和羧基末端区域之间的拟肽区域，其中拟肽区域包含3至约30个N-取代的甘氨酸，以及任选的一个或多个氨基酸。本发明还涉及使用拟肽来检测和分离朊病毒以及治疗和预防朊病毒相关疾病的方法。

8. 发明申请

WO2008124100A1 PRION ELISA 审中-公开
公开(公告)号：WO2008124100A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/004457
申请日：2008-04-04
申请人： NOVARTIS AG , PERETZ, David
发明人： PERETZ, David
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2828
摘要： Assays for detecting PrP Sc in a sample are described. In particular, pathogenic prion ELISAs are described. The assays utilize pathogenic prion-specific reagents to capture the PrP Sc and digestion with a site-specific protease, for example trypsin or SV-8 protease, to reduce the amount of interference from non-pathogenic prion proteins that are occasionally present in the samples.
摘要翻译：描述了用于检测样品中PrP Sc 的测定。特别地，描述了病原性朊病毒ELISA。该测定法利用致病性朊病毒特异性试剂捕获PrP 并用位点特异性蛋白酶例如胰蛋白酶或SV-8蛋白酶消化，以减少来自非致病性朊病毒蛋白的干扰量偶尔会出现在样品中。

9. 发明申请

WO2002087502A2 ANTIBODIES ABOLISH PRION PROPAGATION AND PROMOTE CLEARANCE OF INFECTIVITY 审中-公开
标题翻译：抗体抗体传播和促进感染的清除
公开(公告)号：WO2002087502A2
公开(公告)日：2002-11-07
申请号：PCT/US2002/013346
申请日：2002-04-25
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PRUSINER, Stanley, B. , PERETZ, David , WILLIAMSON, R., Anthony , BURTON, Dennis, R.
发明人： PRUSINER, Stanley, B. , PERETZ, David , WILLIAMSON, R., Anthony , BURTON, Dennis, R.
IPC分类号： A61K
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/55
摘要： Methods are disclosed whereby formulations of molecules are administered rendering cells resistant to infection with infectious proteins such as prions. The formulation preferably comprises a plurality of Fab fragments which (1) recognize and selectively bind to a range of epitopes on the protein of interest, (e.g. epitopes on PrP C ) and (2) bind to epitopes which interrupt the chain of events resulting in a change of the protein's conformation to an infectious disease conformation of the protein. The molecules and formulation are also useful in clearing infectious proteins from cells.
摘要翻译：公开了方法，其中给予分子的制剂，使细胞对感染性蛋白如朊病毒感染具有抗性。制剂优选包含多个Fab片段，其（1）识别并选择性结合目的蛋白质上的一系列表位（例如PrP C上的表位）和（2）结合中断事件链的表位导致蛋白质构象改变为蛋白质的感染性疾病构象。分子和制剂也可用于从细胞中清除感染性蛋白质。

10. 发明申请

WO2012036835A1 GRANULAR MATERIAL VENDING APPARATUS AND METHOD 审中-公开
标题翻译：颗粒材料采购装置和方法
公开(公告)号：WO2012036835A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/048100
申请日：2011-08-17
申请人： PERETZ, David
发明人： PERETZ, David
IPC分类号： G07F13/06 , B67D7/06
CPC分类号： G07F13/02 , G07F11/54
摘要： One embodiment of the present invention relates to a semi-automated apparatus for vending granular materials in a container comprising a cabinet with a carousel capable of rotating and housing at least one dispensing container. Each dispensing container is adapted to hold granular material and in one embodiment includes a pressure actuated valve. A pneumatic system is coupled to each of the dispensing containers. A motor is coupled to the carousel. The apparatus further comprises a loading station adapted to hold the container, a control system and a user control panel having at least one user interface for controlling operation of the vending machine. The control system, coupled to the motor, the pneumatic system and the user control panel, engages the motor, causing the carousel to rotate, and the pneumatic system, pressurizing the selected dispensing container causing a predetermined amount of granular material to dispense into the vending container.
摘要翻译：本发明的一个实施例涉及一种用于在容器中销售颗粒材料的半自动化设备，其包括具有能够旋转并容纳至少一个分配容器的转盘的机柜。每个分配容器适于保持颗粒材料，并且在一个实施例中包括压力致动阀。气动系统联接到每个分配容器。电机与转盘相连。该装置还包括适于容纳容器的装载站，具有用于控制自动售货机的操作的至少一个用户界面的控制系统和用户控制面板。耦合到电动机，气动系统和用户控制面板的控制系统接合电动机，使得转盘旋转，并且气动系统对所选择的分配容器加压，从而使预定量的颗粒材料分配到销售容器。

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