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1. 发明申请

WO2003013541A1 4-AMINO-6-PHENYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES 审中-公开
标题翻译： 4-氨基-6-苯基 - 吡咯并[2,3-D]吡啶衍生物
公开(公告)号：WO2003013541A1
公开(公告)日：2003-02-20
申请号：PCT/EP2002/008780
申请日：2002-08-06
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , BOLD, Guido , CAPRARO, Hans-Georg , CARAVATTI, Giorgio , TRAXLER, Peter
发明人： BOLD, Guido , CAPRARO, Hans-Georg , CARAVATTI, Giorgio , TRAXLER, Peter
IPC分类号： A61K31/519
CPC分类号： C07D487/04
摘要： The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives-alone or in combination with one or more other pharmaceutically active compounds-for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.
摘要翻译：本发明涉及式I的7H-吡咯并[2,3-d]嘧啶衍生物，其中符号和取代基如说明书中所定义，其制备方法，包含该衍生物的药物组合物及其用途衍生物 - 单独或与一种或多种其它药学活性化合物组合 - 用于制备用于治疗特别是增殖性疾病如肿瘤的药物组合物。

2. 发明申请

WO2005054237A1 1H-IMIDAZOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译： 1H-咪唑啉衍生物作为蛋白激酶抑制剂
公开(公告)号：WO2005054237A1
公开(公告)日：2005-06-16
申请号：PCT/EP2004/013178
申请日：2004-11-19
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CAPRARO, Hans-Georg , CARAVATTI, Giorgio , FURET, Pascal , GARCIA-ECHEVERRIA, Carlos , IMBACH, Patricia , STAUFFER, Frédéric
发明人： CAPRARO, Hans-Georg , CARAVATTI, Giorgio , FURET, Pascal , GARCIA-ECHEVERRIA, Carlos , IMBACH, Patricia , STAUFFER, Frédéric
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to imidazoquinolines of formula (I) for use in the treatment of protein kinase dependent diseases; pharmaceutical preparations comprinsing an imidazoquinoline, especially for the treatment of a pretein kinase dependent disease; novel imidazoquinolines; and a process for the preparation of the novel imidazoquinilines.
摘要翻译：本发明涉及用于治疗蛋白激酶依赖性疾病的式（I）的咪唑并喹啉; 包含咪唑并喹啉的药物制剂，特别是用于治疗前蛋白激酶依赖性疾病; 新型咪唑并喹啉; 以及制备新型咪唑并喹啉的方法。

3. 发明申请

WO2008138834A1 SUBSTITUTED IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS 审中-公开
标题翻译：作为PI3K脂质激酶抑制剂的替米沙唑胺
公开(公告)号：WO2008138834A1
公开(公告)日：2008-11-20
申请号：PCT/EP2008/055636
申请日：2008-05-07
申请人： NOVARTIS AG , CAPRARO, Hans-Georg , IMBACH, Patricia , CARAVATTI, Giorgio , FURET, Pascal
发明人： CAPRARO, Hans-Georg , IMBACH, Patricia , CARAVATTI, Giorgio , FURET, Pascal
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00 , A61P29/00
CPC分类号： C07D487/04
摘要： The invention relates to novel compounds of formula (I), as well as other invention embodiments related to these compounds. The compounds are e.g. useful in the treatment of the animal or human body in view of their ability to inhibit protein kinases such as especially PI3 kinase.
摘要翻译：本发明涉及新的式（I）化合物，以及与这些化合物有关的其它发明实施方案。化合物是例如鉴于其抑制蛋白激酶（例如PI3激酶）的能力，可用于动物或人体的治疗。

4. 发明申请

WO2008138889A2 SUBSTITUTED IMIDAZOPYRIDAZINES AND PYRROLOPYRIMIDINES AS LIPID KINASE INHIBITORS 审中-公开
标题翻译：作为脂质激酶抑制剂的取代的咪唑吡啶和吡咯并嘧啶
公开(公告)号：WO2008138889A2
公开(公告)日：2008-11-20
申请号：PCT/EP2008/055751
申请日：2008-05-09
申请人： NOVARTIS AG , CAPRARO, Hans-Georg , CARAVATTI, Giorgio , FURET, Pascal , IMBACH, Patricia , LAN, Jiong , PECCHI, Sabina , SCHOEPFER, Joseph
发明人： CAPRARO, Hans-Georg , CARAVATTI, Giorgio , FURET, Pascal , IMBACH, Patricia , LAN, Jiong , PECCHI, Sabina , SCHOEPFER, Joseph
IPC分类号： A61K31/5025 , A61K31/519 , A61P29/00 , A61P37/00 , A61P35/00 , A61P11/00 , A61P11/06 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds are of the formula I, processes for the preparation thereof, more generally these compounds for use in the treatment of the human or animal body, in the treatment of an inflammatory or obstructive airway disease, disorders commonly occurring in connection with transplantation, or a proliferative disease, which disease responds to an inhibition of kinases of the PI3-kinase-related protein kinase family.
摘要翻译：本发明涉及式I化合物，其制备方法，更一般地，这些用于治疗人或动物体的化合物，用于治疗炎性或阻塞性气道疾病，通常在连接中发生的疾病移植或增殖性疾病，该疾病对PI3激酶相关蛋白激酶家族的激酶的抑制作出反应。

5. 发明申请

WO2005054238A1 1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES 审中-公开
标题翻译： 1H-IMIDAZO [4,5-C]喹啉衍生物治疗蛋白激酶依赖性疾病
公开(公告)号：WO2005054238A1
公开(公告)日：2005-06-16
申请号：PCT/EP2004/013179
申请日：2004-11-19
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CAPRARO, Hans-Georg , FURET, Pascal , GARCIA-ECHEVERRIA, Carlos , STAUFFER, Frédéric
发明人： CAPRARO, Hans-Georg , FURET, Pascal , GARCIA-ECHEVERRIA, Carlos , STAUFFER, Frédéric
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/41
摘要： The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.
摘要翻译：本发明涉及咪唑并喹啉及其盐在治疗蛋白激酶疾病中的用途以及制备用于治疗所述疾病的药物制剂，用于治疗蛋白激酶依赖性疾病的咪唑并喹啉，治疗所述疾病，包括向温血动物，特别是包含咪唑并喹啉的药物制剂，特别是用于治疗蛋白激酶依赖性疾病，新型咪唑并喹啉和其制备新型咪唑并喹啉的方法施用咪唑并喹啉。

6. 发明申请

WO2004043962A1 4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES 审中-公开
标题翻译： 4-氨基-5-苯基-7-环己基 - 吡咯并[2,3-d]吡啶衍生物
公开(公告)号：WO2004043962A1
公开(公告)日：2004-05-27
申请号：PCT/EP2003/012594
申请日：2003-11-11
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CAPRARO, Hans-Georg , FURET, Pascal , GARCIA-ECHEVERRIA, Carlos
发明人： CAPRARO, Hans-Georg , FURET, Pascal , GARCIA-ECHEVERRIA, Carlos
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to new 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d] pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment of a disease, especially a proliferative disease, such as a tumour disease, a method for the treatment of such diseases in mammals, especially in humans, and the use of such a compound - alone or in combination with one or more other pharmaceutically active compounds - for the preparation of a pharmaceutical composition (medicament) for the treatment especially of a proliferative disease, such as a tumour.
摘要翻译：本发明涉及新的4-氨基-5-苯基-7-环己基 - 吡咯并[2,3-d]嘧啶衍生物，其制备方法，其在治疗人或动物体的方法中的应用，其用途 - 单独或与一种或多种其它药学活性化合物组合用于治疗疾病，特别是增殖性疾病，例如肿瘤疾病，用于治疗哺乳动物，特别是人类中的这些疾病的方法，以及这种化合物 - 单独或与一种或多种其它药学活性化合物组合用于制备用于特别是增殖性疾病如肿瘤的药物组合物（药物）的用途。

7. 发明申请

WO2003097641A3 1H-IMIDAZO[4,5-C] QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES 审中-公开
公开(公告)号：WO2003097641A3
公开(公告)日：2003-11-27
申请号：PCT/EP2003/005291
申请日：2003-05-20
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , GARCIA-ECHEVERRIA, Carlos , CAPRARO, Hans-Georg , FURET, Pascal
发明人： GARCIA-ECHEVERRIA, Carlos , CAPRARO, Hans-Georg , FURET, Pascal
IPC分类号： A61K31/47
摘要： The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoloquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.

8. 发明申请

WO2007071393A2 SULPHONAMIDOANILINE DERIVATIVES BEING JANUS KINASES INHIBITORS 审中-公开
标题翻译：磺酰胺衍生物是JANUS KINASES抑制剂
公开(公告)号：WO2007071393A2
公开(公告)日：2007-06-28
申请号：PCT/EP2006/012311
申请日：2006-12-20
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CAPRARO, Hans-Georg , COUPEZ, Bernard , FURET, Pascal , MANLEY, Paul, W. , PISSOT SOLDERMANN, Carole
发明人： CAPRARO, Hans-Georg , COUPEZ, Bernard , FURET, Pascal , MANLEY, Paul, W. , PISSOT SOLDERMANN, Carole
IPC分类号： C07D473/16 , C07D473/18 , C07D487/04 , C07D519/00 , A61K31/5377
CPC分类号： C07D473/16 , C07D473/18 , C07D487/04 , C07D519/00
摘要： The invention relates to sulphonamidoanilines of formula (I) wherein A is N or CH, W, X, Y and Z are N or CH under the proviso that at least one of the three symbols W, X and Y represent CH, R 1 represents NR 4 R 5 or OR 4 , wherein R 4 represents optionally substituted alkyl, optionally substituted cycloalkyl optionally comprising one or two nitrogen or oxygen atoms, or substituted aryl, and R 5 represents hydrogen or unsubstituted or substituted alkyl, or R 4 and R 5 together with the nitrogen to which they are attached represent an optionally substituted five- or six-membered nitrogen containing monocyclic ring, an optionally substituted nitrogen containing fully saturated bicyclic ring, or an spirocyclic fully saturated ring system containing one or two nitrogen atoms, R 2 is hydrogen, lower alkenyl or alkyl, R 3 is alkyl which is unsubstituted or mono-, di- or trisubstituted by halogen; alkenyl or aryl, and their salts; processes for their preparation, their application in the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment of diseases, a method for the treatment of such a disease and the use of such a compound - alone or in combination with one or more other pharmaceutically active compounds - for the manufacture of a pharmaceutical preparation for the treatment of a proliferative disease.
摘要翻译：
本发明涉及式（I）其中A是N或CH，W，X，Y和Z的sulphonamidoanilines是N或CH，条件下，所述三个符号W，X中的至少一个 Y代表CH，R 1代表NR 4 R 5或OR 4，其中R 4 表示任选取代的烷基，任选包含一个或两个氮或氧原子的任选取代的环烷基或取代的芳基，并且R5表示氢或未取代或取代的烷基，或R 4 R 5和它们所连接的氮一起代表任选取代的五元或六元含氮单环，任选取代的含氮完全饱和双环或含有一个或两个氮原子的螺环全饱和环体系，R 2是氢，低级链烯基或烷基，R 3是未取代的或者单 - ，二 - 或三 - trisubstit 被卤素所阻挡; 烯基或芳基，及其盐; 它们的制备方法，它们在人体或动物体的治疗中的应用，单独或与一种或多种其它药物活性化合物组合用于治疗疾病的方法，治疗这种疾病的方法和单独或与一种或多种其它药物活性化合物组合使用这样的化合物用于制备用于治疗增殖性疾病的药物制剂。

9. 发明申请

WO2003097641A2 1H-IMIDAZO[4,5-c]QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES 审中-公开
标题翻译： 1H-IMIDAZO [4,5-c]喹啉衍生物治疗蛋白激酶依赖性疾病
公开(公告)号：WO2003097641A2
公开(公告)日：2003-11-27
申请号：PCT/EP2003/005291
申请日：2003-05-20
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , GARCIA-ECHEVERRIA, Carlos , CAPRARO, Hans-Georg , FURET, Pascal
发明人： GARCIA-ECHEVERRIA, Carlos , CAPRARO, Hans-Georg , FURET, Pascal
IPC分类号： C07D471/00
CPC分类号： C07D471/04
摘要： The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoloquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.
摘要翻译：本发明涉及咪唑并喹啉及其盐在治疗蛋白激酶依赖性疾病中的用途，以及用于制备用于治疗所述疾病的药物制剂，用于治疗蛋白激酶依赖性疾病的咪唑并喹啉，所述疾病包括将咪唑并喹啉给予包含咪唑并喹啉的温血动物，特别是用于治疗蛋白激酶依赖性疾病的新型咪唑并喹啉的药物制剂，以及制备新的咪唑并喹啉的方法。

10. 发明申请

WO2009023978A1 PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE 审中-公开
标题翻译：吡咯并[3,4-D]吡嗪化合物及其作为蛋白激酶调节剂的用途
公开(公告)号：WO2009023978A1
公开(公告)日：2009-02-26
申请号：PCT/CH2008/000348
申请日：2008-08-14
申请人： ONCALIS AG , LÜTHI, Urs , BERSET, Catherine , SCHMID, Gerhard , CAPRARO, Hans-Georg , TRAXLER, Peter Martin
发明人： LÜTHI, Urs , BERSET, Catherine , SCHMID, Gerhard , CAPRARO, Hans-Georg , TRAXLER, Peter Martin
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention relates to pyrazolo[3,4-d]pyrimidine compounds of formula (I) and its salts wherein the substitents are as defined in the specification, their use for the treatment of protein kinase modulation responsive diseases or in the manufacture of pharmaceutical preparations useful in the treatment of said diseases, pharmaceutical preparations, especially useful against said diseases, comprising said compounds and a pharmaceutically acceptable carrier, said compounds for use in the treatment of the animal or human body, especially against said diseases, methods of treatment of the animal or human body comprising administering said compounds to an animal or human, and processes for the manufacture of said compounds.
摘要翻译：本发明涉及式（I）的吡唑并[3,4-d]嘧啶化合物及其盐，其中取代基如本说明书中所定义，其用于治疗蛋白激酶调节反应性疾病或用于制备药物制剂可用于治疗所述疾病，特别可用于所述疾病的药物制剂，其包含所述化合物和药学上可接受的载体，所述化合物用于治疗动物或人体，特别是针对所述疾病，治疗所述疾病的方法动物或人体，包括向动物或人施用所述化合物，以及制备所述化合物的方法。

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