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1. 发明申请

WO2005058587A2 METHOD FOR PRODUCING TINTED CONTACT LENSES 审中-公开
标题翻译：生产接触式镜片的方法
公开(公告)号：WO2005058587A2
公开(公告)日：2005-06-30
申请号：PCT/EP2004/014427
申请日：2004-12-17
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , WINTERTON, Lynn, Cook , LALLY, John, Martin , VOGT, Jürgen
发明人： WINTERTON, Lynn, Cook , LALLY, John, Martin , VOGT, Jürgen
IPC分类号： B29D11/00
CPC分类号： B29D11/00317
摘要： The invention provides a method of producing a full-body tinted contact lens. The method of the invention comprises the steps of: preconditioning particles of a pigments; dispersing the preconditioned pigment particles in a polymerizable fluid composition to obtain a pigment-containing polymerizable dispersion; introducing an amount of the pigment-containing polymerizable dispersion in a mold for making a contact lens; polymerizing the polymerizable dispersion in the mold to form a full-body tinted contact lens with the particles of the pigment entrapped and distributed therein. In addition, the invention provides a method for preparing preconditioned pigment particles and full-body tinted contact lenses produced according the method of the invention.
摘要翻译：本发明提供一种制造全身有色隐形眼镜的方法。本发明的方法包括以下步骤：预处理颜料颗粒; 将预处理的颜料颗粒分散在可聚合流体组合物中以获得含颜料的可聚合分散体; 将一定量的含颜料的可聚合分散体引入用于制造隐形眼镜的模具中; 将可聚合分散体聚合在模具中以形成全身有色隐形眼镜，其中包含并分布在其中的颜料颗粒。此外，本发明提供了一种根据本发明的方法制备预处理的颜料颗粒和全身有色隐形眼镜的方法。

2. 发明申请

WO2007020010A1 METHOD FOR MAKING CONTACT LENSES 审中-公开
标题翻译：制造接触镜的方法
公开(公告)号：WO2007020010A1
公开(公告)日：2007-02-22
申请号：PCT/EP2006/007924
申请日：2006-08-10
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , WANG, Guigui , SMITH, Dawn , VOGT, Jürgen , LALLY, John, Martin , DEVLIN, Brian, Gerrard
发明人： WANG, Guigui , SMITH, Dawn , VOGT, Jürgen , LALLY, John, Martin , DEVLIN, Brian, Gerrard
IPC分类号： G02B1/04
CPC分类号： B29C33/60 , B29C33/62 , B29D11/00134 , B29D11/00192 , G02B1/043
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a non-crosslinkable hydrophilic polymer into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the non-crosslinkable hydrophilic polymer and to provide a disparity of about 10 N or less in mold separation force. The non-crosslinkable hydrophilic polymer has a limited miscibility with the lens-forming material low enough to successfully and timely form an intact interfacial film with a sufficient thickness at an interface between the mold and the fluid composition therein, and has a structure that minimizes entanglement of the non-crosslinkable hydrophilic polymer in the interfacial film with the polymer matrix of the formed lens.
摘要翻译：本发明涉及一种用于制造具有改善的镜片质量和增加的产品产量的隐形眼镜的方法和流体组合物。本发明的方法包括将不可交联的亲水性聚合物添加到包含透镜形成材料的流体组合物中，该透镜形成材料的量足以将平均的模具分离力减小至少约40％，与不使用不可交联的亲水性并且在模具分离力中提供约10N或更小的差异。不可交联的亲水性聚合物与透镜形成材料的混溶性有限，足够低以在模具和其中的流体组合物之间的界面处成功地及时地形成具有足够厚度的完整界面膜，并且具有最小化缠结的结构的界面膜中的不可交联的亲水聚合物与形成的透镜的聚合物基体。

3. 发明申请

WO2009055082A3 METHOD FOR IMPARTING HYDROGEL CONTACT LENSES WITH DESIRED PROPERTIES 审中-公开
公开(公告)号：WO2009055082A3
公开(公告)日：2009-04-30
申请号：PCT/US2008/054641
申请日：2008-02-22
申请人： NOVARTIS AG , QIU, Yongxing , VOGT, Jürgen , LALLY, John Martin
发明人： QIU, Yongxing , VOGT, Jürgen , LALLY, John Martin
IPC分类号： G02B1/04 , B29D11/00
摘要： A cost-effective method for making hydrogel contact lenses with desired properties, such as antimicrobial property and/or increased surface hydrophilicity. The method comprises a step of contacting a dry or unhydrated hydrogel contact lens with an aqueous solution (or hydrating solution) containing silver nanoparticles and/or a lubricant or wetting agent. By using a method of the invention, resultant hydrogel contact lenses can have antimicrobial capability and/or enhanced lens wearer's comfort.

4. 发明申请

WO2007098040A1 METHOD FOR STERILIZATION OF HYDROGEL CONTACT LENSES 审中-公开
标题翻译：水凝胶接触镜的灭菌方法
公开(公告)号：WO2007098040A1
公开(公告)日：2007-08-30
申请号：PCT/US2007/004155
申请日：2007-02-15
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , VOGT, Jürgen , MOWREY-MCKEE, Mary Flowers , SMITH, Dawn
发明人： VOGT, Jürgen , MOWREY-MCKEE, Mary Flowers , SMITH, Dawn
IPC分类号： A61L12/14 , A61L12/08 , A61L12/04 , A61L101/36 , A61L101/16
CPC分类号： A61L12/04 , A61L12/08 , A61L12/14 , C11D1/722 , C11D3/0078 , C11D7/10 , C11D7/263 , C11D7/265 , C11D7/3218 , C11D7/34 , C11D7/36
摘要： The present invention provides an aqueous solution for sterilizing and storing ophthalmic devices, preferably a contact lens, made of a hydrogel material, preferably a poly(oxyalkylene)-containing hydrogel material. The solution comprises one or more organic buffer agents, such as a Good buffer or a bis-aminopolyols; an organic tonicity-adjusting agent with multiple hydroxyl groups in an amount sufficient to provide an osmolarity of from about 200 to about 450 mosm/l, wherein the aqueous solution has a pH of from about 5.5 to about 8.5, provided that the aqueous solution include phosphate buffer at a concentration of about 15 mM or less and about 5000 ppm sodium chloride. The present invention also provides a method for sterilizing and storing an ophthalmic device using an aqueous solution of the invention.
摘要翻译：本发明提供一种水溶液，用于消毒和储存由水凝胶材料，优选含有（含氧化烯）的水凝胶材料制成的眼科装置，优选隐形眼镜。溶液包含一种或多种有机缓冲剂，例如Good缓冲液或双 - 氨基多元醇; 具有多个羟基的有机张力调节剂，其量足以提供约200至约450 mosm / l的渗透压，其中所述水溶液的pH为约5.5至约8.5，条件是所述水溶液包括浓度为约15mM或更低和约5000ppm氯化钠的磷酸盐缓冲液。本发明还提供了使用本发明的水溶液对眼科装置进行消毒和储存的方法。

5. 发明申请

WO2010071691A1 METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：制造硅胶水凝胶接触透镜的方法
公开(公告)号：WO2010071691A1
公开(公告)日：2010-06-24
申请号：PCT/US2009/047428
申请日：2009-06-16
申请人： NOVARTIS AG , CHANG, Frank , VOGT, Jürgen , PRUITT, John, Dallas , QIAN, Xinming , SMITH, Dawn, A. , DOMSCHKE, Angelika, Maria , HOLLAND, Troy, Vernon , TUREK, Richard, Charles , WU, Daqing
发明人： CHANG, Frank , VOGT, Jürgen , PRUITT, John, Dallas , QIAN, Xinming , SMITH, Dawn, A. , DOMSCHKE, Angelika, Maria , HOLLAND, Troy, Vernon
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , C08F283/124 , C08L83/04 , C08L51/085
摘要： A method for producing silicone hydrogel contact lenses and silicon hydrogel contact lens thereof. The method comprising the steps of: providing a mold for making a soft contact lens, wherein the mold has a first mold half with a first molding surface defining the anterior surface of a contact lens and a second mold half with a second molding surface defining the posterior surface of the contact lens, wherein said first and second mold halves are configured to receive each other such that a cavity is formed between said first and second molding surfaces; introduce a monomer mixture of lens-forming materials into the cavity, wherein the monomer mixture comprises at least one hydrophilic amide-type vinylic monomer, at least one siloxane-containing (meth)acrylamide monomer, at least one polysiloxane vinylic monomer or macromer, and from about 0.05 % to about 1.5 % by weight of a photoinitiator, wherein the lens forming material is characterized by having an ability to be cured by a UV light having an UV-intensity of about 4.1 mW/cm 2 within about 100 seconds; and irradiating, under a spatial limitation of actinic radiation, the lens-forming material in the mold for a time period of about 120 seconds or less, so as to crosslink the lens-forming material to form the silicone hydrogel contact lens, wherein the produced contact lens comprises an anterior surface defined by the first molding surface, an opposite posterior surface defined by the second molding surface, and a lens edge defined by the spatial limitation of actinic radiation.
摘要翻译：硅酮水凝胶隐形眼镜及其硅水凝胶隐形眼镜的制造方法。该方法包括以下步骤：提供用于制造软性隐形眼镜的模具，其中所述模具具有第一半模，其具有限定隐形眼镜的前表面的第一模制表面和具有限定所述隐形眼镜的第二模制表面的第二半模接触透镜的后表面，其中所述第一和第二半模被配置为彼此接收，使得在所述第一和第二模制表面之间形成空腔; 将透镜形成材料的单体混合物引入空腔中，其中单体混合物包含至少一种亲水性酰胺型乙烯基单体，至少一种含硅氧烷的（甲基）丙烯酰胺单体，至少一种聚硅氧烷乙烯基单体或大分子单体，以及约0.05重量％至约1.5重量％的光引发剂，其中所述透镜形成材料的特征在于具有在约100秒内具有约4.1mW / cm 2的UV强度的UV光固化的能力; 并且在光化辐射的空间限制下将模具中的透镜形成材料照射大约120秒或更短的时间，以使透镜形成材料交联以形成硅氧水凝胶隐形眼镜，其中所产生的隐形眼镜包括由第一成型表面限定的前表面，由第二成型表面限定的相对的后表面和由光化辐射的空间限制限定的透镜边缘。

6. 发明申请

WO2012130956A1 COMPOSITION FOR FORMING A CONTACT LENS 审中-公开
标题翻译：用于形成接触镜的组合物
公开(公告)号：WO2012130956A1
公开(公告)日：2012-10-04
申请号：PCT/EP2012/055661
申请日：2012-03-29
申请人： NOVARTIS AG , SEIFERLING, Bernhard , SCHMIDT, Thomas , VOGT, Jürgen
发明人： SEIFERLING, Bernhard , SCHMIDT, Thomas , VOGT, Jürgen
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , C08F20/56 , C08L101/14 , C08L33/26 , C08L33/10 , C08L83/04
摘要： There is described a composition for forming an contact lens, in particular for forming a silicone hydrogel contact lens, comprising at least one first vinylic monomer or macromer having one first ethylenically unsaturated group and at least one second vinylic monomer or macromer having one second ethylenically unsaturated group, wherein the first and second ethylenically unsaturated groups are different from each other and wherein the composition further comprises a crosslinker with at least two ethylenically unsaturated (polymerizable) groups with a selected kinetic copolymerization parameter η of less than 1.0 relative to one of the first and second ethylenically unsaturated (polymerizable) groups as defined above.
摘要翻译：描述了用于形成隐形眼镜的组合物，特别是用于形成硅氧水凝胶隐形眼镜的组合物，其包含至少一种具有一个第一烯属不饱和基团的第一乙烯基单体或大分子单体和至少一种具有一个第二烯属不饱和基团的第二乙烯基单体或大分子单体基团，其中第一和第二烯键式不饱和基团彼此不同，并且其中所述组合物还包含具有至少两个具有选定的动力学共聚参数的烯属不饱和（可聚合）基团的交联剂，相对于如上所述的第一和第二烯属不饱和（可聚合）基团之一小于1.0。

7. 发明授权

EP1988936B1 OPHTALMIC PRODUCT AND METHOD FOR STERILIZATION 有权转让
标题翻译：眼科产品和方法进行消毒
公开(公告)号：EP1988936B1
公开(公告)日：2014-08-06
申请号：EP07750954.5
申请日：2007-02-15
申请人： Novartis AG , Novartis Pharma GmbH
发明人： VOGT, Jürgen , MOWREY-MCKEE, Mary Flowers , SMITH, Dawn
IPC分类号： A61L12/14 , A61L12/08 , A61L12/04 , A61L101/36 , A61L101/16
CPC分类号： A61L12/04 , A61L12/08 , A61L12/14 , C11D1/722 , C11D3/0078 , C11D7/10 , C11D7/263 , C11D7/265 , C11D7/3218 , C11D7/34 , C11D7/36

8. 发明公开

EP1988936A1 METHOD FOR STERILIZATION OF HYDROGEL CONTACT LENSES 有权转让
标题翻译：眼科产品和方法进行消毒
公开(公告)号：EP1988936A1
公开(公告)日：2008-11-12
申请号：EP07750954.5
申请日：2007-02-15
申请人： NOVARTIS AG , NOVARTIS-PHARMA GMBH
发明人： VOGT, Jürgen , MOWREY-MCKEE, Mary Flowers , SMITH, Dawn
IPC分类号： A61L12/14 , A61L12/08 , A61L12/04 , A61L101/36 , A61L101/16
CPC分类号： A61L12/04 , A61L12/08 , A61L12/14 , C11D1/722 , C11D3/0078 , C11D7/10 , C11D7/263 , C11D7/265 , C11D7/3218 , C11D7/34 , C11D7/36
摘要： The present invention provides an aqueous solution for sterilizing and storing ophthalmic devices, preferably a contact lens, made of a hydrogel material, preferably a poly(oxyalkylene)-containing hydrogel material. The solution comprises one or more organic buffer agents, such as a Good buffer or a bis-aminopolyols; an organic tonicity-adjusting agent with multiple hydroxyl groups in an amount sufficient to provide an osmolarity of from about 200 to about 450 mosm/l, wherein the aqueous solution has a pH of from about 5.5 to about 8.5, provided that the aqueous solution include phosphate buffer at a concentration of about 15 mM or less and about 5000 ppm sodium chloride. The present invention also provides a method for sterilizing and storing an ophthalmic device using an aqueous solution of the invention.

9. 发明申请

WO2013050163A1 VORGESPANNTE GLASROLLE 审中-公开
标题翻译： LOADED玻璃辊
公开(公告)号：WO2013050163A1
公开(公告)日：2013-04-11
申请号：PCT/EP2012/004169
申请日：2012-10-05
申请人： SCHOTT AG , ULLMANN, Angelika , SPARSCHUH, Georg , KÜBART, Gregor , WEGENER, Holger , VOGT, Jürgen , SCHWERTFEGER, Rainer , WIEGEL, Thomas
发明人： ULLMANN, Angelika , SPARSCHUH, Georg , KÜBART, Gregor , WEGENER, Holger , VOGT, Jürgen , SCHWERTFEGER, Rainer , WIEGEL, Thomas
IPC分类号： B32B17/06
CPC分类号： B32B7/06 , B32B3/263 , B32B3/28 , B32B3/30 , B32B7/02 , B32B17/065 , B32B17/066 , B32B2266/025 , Y10T428/24355 , Y10T428/24612 , Y10T428/24628 , Y10T428/24752 , Y10T428/24769
摘要： Glasrolle umfassend zumindest eine Glasfolie und ein Zwischenmaterial, welche übereinanderliegend in wenigstens jeweils zwei Lagen auf einen Wickelkern aufgewickelt sind, wobei die Glasfolienlagen durch die Zwischenmateriallagen in der Glasrolle fixiert sind. Die Glasrolle wird mit einem Verfahren hergestellt, das folgende Schritte umfasst: Bereitstellen einer Glasfolie, eines Wickelkerns und eines komprimierbaren Zwischenmaterials, Aufwickeln von zumindest einer inneren Lage des Zwischenmaterials auf den Wickelkern, Aufwickeln der Glasfolie und des Zwischenmaterials auf den Wickelkern derart, dass die Glasfolie lagenweise im Wechsel mit dem Zwischenmaterial auf dem Wickelkern abgelegt wird, wobei das Zwischenmaterial und/oder die Glasfolie mit einer Zugspannung aufgewickelt wird die geeignet ist, das Zwischenmaterial zu komprimieren, Fixierung des Glasfolienendes auf der Glasrolle.
摘要翻译：玻璃辊包括至少一个玻璃板和中间材料，其被叠加在伤口至少两层上的卷绕芯，其中，所述玻璃膜的层通过材料在玻璃辊上的中间层固定。提供玻璃膜，卷绕芯和可压缩的中间材料，在卷芯的中间材料的至少一个内层的绕组，绕组玻璃板和中间材料的卷绕芯，使得所述玻璃板：玻璃部分是通过包括以下步骤的方法制备其中，中间材料和/或玻璃板在张力是适于压缩所述中间材料卷绕，在玻璃辊上的玻璃板端的固定存储在与层上的卷绕芯的中间材料的交替。

10. 发明申请

WO2012052880A3 ANXIETY MONITORING 审中-公开
公开(公告)号：WO2012052880A3
公开(公告)日：2012-04-26
申请号：PCT/IB2011/054496
申请日：2011-10-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN ELSWIJK, Gijs, Antonius, Franciscus , DESSAUD, Nathalie, Magali, Danielle , TIJS, Tim, Johannes, Willem , GILLIES, Murray, Fulton , VOGT, Jürgen
发明人： VAN ELSWIJK, Gijs, Antonius, Franciscus , DESSAUD, Nathalie, Magali, Danielle , TIJS, Tim, Johannes, Willem , GILLIES, Murray, Fulton , VOGT, Jürgen
IPC分类号： A61B5/16 , G06F19/00
摘要： A patient monitoring system comprises a probe module (10) to acquire data of a patient to be monitored. An evaluation module (20) to determines a patient's state of anxiety on the basis of the acquired data. An indicator module (30) to feedback the determined state of anxiety to attending staff. Thus, the staff is enabled on the basis of the feedback from the patient monitoring system to re-assure patients where that is needed and beneficiary.

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