专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005080593A8 P53 WILD-TYPE AS BIOMARKER FOR THE TREATMENT WITH MTOR INHIBITORS IN COMBINATION WITH A CYTOTOXIC AGENT 审中-公开
标题翻译： P53野生型生物标记用MTV抑制剂与CYTOTOXIC AGENT联合治疗
公开(公告)号：WO2005080593A8
公开(公告)日：2006-10-19
申请号：PCT/EP2005001849
申请日：2005-02-22
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , EDRICH MIESCHER INST FOR BIOME , BEUVINK IWAN , BOULAY ANNE , LANE HEIDI , O'REILLY TERENCE , THOMAS GEORGE
发明人： BEUVINK IWAN , BOULAY ANNE , LANE HEIDI , O'REILLY TERENCE , THOMAS GEORGE
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/5748 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N2800/52
摘要： Provided are biomarkers for determining the sensitivity of proliferative diseases such as cancer to therapeutic agents, in particular mTOR inhibitors in combination with a cytotoxic agent, in particular a cytotoxic agent which damages or affects the integrity of DNA.
摘要翻译：提供了用于确定增殖性疾病如癌症对治疗剂，特别是mTOR抑制剂与细胞毒性剂，特别是损伤或影响DNA完整性的细胞毒性剂的敏感性的生物标志物。

2. 发明申请

WO2005080593A3 P53 WILD-TYPE AS BIOMARKER FOR THE TREATMENT WITH MTOR INHIBITORS IN COMBINATION WITH A CYTOTOXIC AGENT 审中-公开
标题翻译： P53野生型生物标记用MTV抑制剂与CYTOTOXIC AGENT联合治疗
公开(公告)号：WO2005080593A3
公开(公告)日：2005-11-24
申请号：PCT/EP2005001849
申请日：2005-02-22
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , NOVARTIS FORSCHUNGSSTIFTUNG , BEUVINK IWAN , BOULAY ANNE , LANE HEIDI , O'REILLY TERENCE , THOMAS GEORGE
发明人： BEUVINK IWAN , BOULAY ANNE , LANE HEIDI , O'REILLY TERENCE , THOMAS GEORGE
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/5748 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N2800/52
摘要： Provided are biomarkers for determining the sensitivity of proliferative diseases such as cancer to therapeutic agents, in particular mTOR inhibitors in combination with a cytotoxic agent, in particular a cytotoxic agent which damages or affects the integrity of DNA.
摘要翻译：提供了用于确定增殖性疾病如癌症对治疗剂，特别是mTOR抑制剂与细胞毒性剂，特别是损伤或影响DNA完整性的细胞毒性剂的敏感性的生物标志物。

3. 发明申请

WO9803662A3 Drosophila melanogaster p70 s6 kinase 审中-公开
标题翻译：果蝇果蝇p70 s6激酶
公开(公告)号：WO9803662A3
公开(公告)日：1998-03-12
申请号：PCT/EP9703680
申请日：1997-07-11
申请人： NOVARTIS AG , STEWART MARY , KOZMA SARA , THOMAS GEORGE
发明人： STEWART MARY , KOZMA SARA , THOMAS GEORGE
IPC分类号： A01K67/033 , C12N9/12 , C12N15/54 , C07K16/40 , C12Q1/48
CPC分类号： C12N9/1205 , A01K67/0339 , A01K2217/05
摘要： The invention provides Drosophila melanogasterp70S6K, as well as nucleic acids encoding this kinase. The sequence of Drosophila p70S6K and the gene encoding it are represented in SEQ ID NO. 2 and 1 respectively. The invention moreover provides mutated forms of Drosophila p70S6K, including constitutively active and dominant negative forms thereof, which are useful in the study of p70S6K activity. Furthermore, the invention provides expression systems which produce Drosophila p70S6K in Drosophila and other organisms, and in particular systems in which expression of Drosophila p70S6K has been modulated so as to facilitate the study of its activity.

4. 发明申请

WO9818935A3 P70-S6K or related kinase with constitutive activity 审中-公开
标题翻译： P70-S6K或具有组成型活性的相关激酶
公开(公告)号：WO9818935A3
公开(公告)日：1998-07-30
申请号：PCT/EP9705979
申请日：1997-10-29
申请人： NOVARTIS AG , THOMAS GEORGE , KOZMA SARA
发明人： THOMAS GEORGE , KOZMA SARA
IPC分类号： C12N9/12 , C12N15/54 , G01N33/573
CPC分类号： C12N9/1205
摘要： A protein kinase having a structure related to that of a kinase enzyme of the p70S6K signalling pathway is described, wherein a serine or threonine residue homologous to T¿389? in p70?S6K¿ is replaced with an acidic amino acid residue in order to confer constitutive activity.

5. 发明专利

AT346940T 未知
公开(公告)号：AT346940T
公开(公告)日：2006-12-15
申请号：AT97938818
申请日：1997-07-11
申请人： NOVARTIS PHARMA GMBH
发明人： STEWART MARY , KOZMA SARA , THOMAS GEORGE
IPC分类号： A01K67/033 , C12N9/12 , C12N15/54 , C07K16/40 , C12Q1/48

6. 发明申请

WO0109169A3 CYSTEINE PROTEASE INHIBITORS 审中-公开
标题翻译：半胱氨酸蛋白酶抑制剂
公开(公告)号：WO0109169A3
公开(公告)日：2001-09-13
申请号：PCT/GB0002830
申请日：2000-07-21
申请人： NAEJA PHARMACEUTICAL INC , SINGH RAJESHWAR , ZHOU NIAN , REDDY ANDHE V N , THOMAS GEORGE , DING QIZHU , KALETA JADWIGA , MICETICH RONALD GEORGE , WHITTAKER MARK
发明人： SINGH RAJESHWAR , ZHOU NIAN , REDDY ANDHE V N , THOMAS GEORGE , DING QIZHU , KALETA JADWIGA , MICETICH RONALD GEORGE , WHITTAKER MARK
IPC分类号： A61K38/00 , A61P9/00 , A61P19/00 , A61P25/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07D207/14 , C07D295/125 , C07D333/38 , C07K5/06 , C07K5/065 , C07K5/062 , A61K31/381 , A61K31/5375 , A61K38/05 , C07D295/12
CPC分类号： C07D295/125 , A61K38/00 , C07D207/14 , C07D333/38 , C07K5/06043 , C07K5/06078
摘要： This invention relates to derivatives of alpha-amino acid amides, to pharmaceutical compositions containing such compounds, and to their use in medicine as inhibitors of cysteine proteases, particularly the cathepsins. A compound of formula (I) is described or a pharmaceutically acceptable salt, hydrate or solvate thereof. Pharmaceutically acceptable salts of the compounds of this invention include the sodium, potassium, magnesium, calcium, hydrogen chloride, tartaric acid, succinic acid, fumaric acid and p-toluenesulfonic acid salts.
摘要翻译：本发明涉及α-氨基酸酰胺的衍生物，含有这些化合物的药物组合物，以及它们在药物中作为半胱氨酸蛋白酶，特别是组织蛋白酶的抑制剂的用途。描述了式（I）化合物或其药学上可接受的盐，水合物或溶剂合物。本发明化合物的药学上可接受的盐包括钠盐，钾盐，镁盐，钙盐，氯化氢盐，酒石酸盐，琥珀酸盐，富马酸盐和对甲苯磺酸盐。

7. 发明申请

WO2009073568A3 TECHNIQUES TO MANAGE A RADIO BASED ON LOCATION INFORMATION 审中-公开
标题翻译：基于位置信息管理无线电的技术
公开(公告)号：WO2009073568A3
公开(公告)日：2009-07-23
申请号：PCT/US2008085063
申请日：2008-11-28
申请人： PALM INC , TU JEROME C , SHI JIANXIONG , PAULSON JANELL L , THOMAS GEORGE , FONG THOMAS , RAMASWAMY GURUNATH
发明人： TU JEROME C , SHI JIANXIONG , PAULSON JANELL L , THOMAS GEORGE , FONG THOMAS , RAMASWAMY GURUNATH
IPC分类号： H04W72/04 , H04W8/08 , H04W28/18 , H04W64/00
CPC分类号： H04W8/18 , G01S5/0252 , H04W4/02 , H04W36/08 , H04W48/16
摘要： Techniques to manage a radio based on location information are described. A mobile computing device may include a radio module, a location detector operative to determine a location for the mobile computing device, and a processor to couple to the radio module and the resource database. The processor may be operative to execute a resource management module to access a resource profile having resource information for one or more cellular radiotelephone network resources accessible from the location, and control operations for a radio module based on the resource profile. Other embodiments are described and claimed.
摘要翻译：描述了基于位置信息来管理无线电的技术。移动计算设备可以包括无线电模块，用于确定移动计算设备的位置的位置检测器，以及耦合到无线电模块和资源数据库的处理器。处理器可操作以执行资源管理模块以访问具有可从该位置访问的一个或多个蜂窝无线电话网络资源的资源信息的资源简档，以及基于资源简档的无线电模块的控制操作。描述和要求保护其他实施例。

8. 发明申请

WO2008002731A3 METHOD AND SYSTEM FOR RAPIDLY DEVELOPING SENS0R-ENABLED SOFTWARE APPLICATIONS 审中-公开
标题翻译：用于快速开发SENSOR启动软件应用的方法和系统
公开(公告)号：WO2008002731A3
公开(公告)日：2008-11-13
申请号：PCT/US2007069246
申请日：2007-05-18
申请人： AUGUSTA SYSTEMS INC , HARVEY CLINT , MOODY JOHN , WILLIAMS II JACKIE , ESPOSITO II PATRICK , THOMAS GEORGE , REED JARED , KESECKER II BIRAN , ESPOSITO PATRICK
发明人： HARVEY CLINT , MOODY JOHN , WILLIAMS II JACKIE , ESPOSITO II PATRICK , THOMAS GEORGE , REED JARED , KESECKER II BIRAN , ESPOSITO PATRICK
IPC分类号： G06F9/44
CPC分类号： G06F8/36
摘要： The teachings herein disclose methods and apparatus that provide software components (objects) as building blocks for rapidly developing sensor-enabled software applications. In at least one embodiment, a component-based software toolset provides data source components (30) for obtaining sensor data, data series components (32) for automatically collecting sensor data incoming from data source components, data field components (42) for controlling that collection, and data destination components (34) for automatically receiving data from the data series components. By providing methods and properties within these and other components in the toolset, the programmer builds sophisticated, hierarchical data flow processing with little or no manual programming. The toolset may further include group components for merging data from multiple data series components, and for linking different data series components, and the data source/destination component definitions may include network socket-enabled components for LAN, WAN data collection, for example.
摘要翻译：本文的教导公开了将软件组件（对象）作为构建块提供的方法和装置，用于快速开发具有传感器功能的软件应用程序。在至少一个实施例中，基于组件的软件工具集提供用于获取传感器数据的数据源组件（30），用于自动收集从数据源组件传入的传感器数据的数据系列组件（32），用于控制该数据源组件收集和数据目的地组件（34），用于从数据系列组件自动接收数据。通过在工具集中的这些和其他组件中提供方法和属性，程序员可以很少或没有手动编程来构建复杂的分层数据流处理。工具集还可以包括用于合并来自多个数据系列组件的数据的组组件，以及用于链接不同数据系列组件的数据源/目标组件定义可以包括例如用于LAN，WAN数据采集的网络套接字使能组件。

9. 发明申请

WO2008002730A2 METHOD AND SYSTEM FOR RAPIDLY DEVELOPING AND DEPLOYING SENS0R-ENABLED SOFTWARE APPLICATIONS 审中-公开
标题翻译：方法和系统，用于快速开发和部署SENSOR启用的软件应用程序
公开(公告)号：WO2008002730A2
公开(公告)日：2008-01-03
申请号：PCT/US2007069230
申请日：2007-05-18
申请人： AUGUSTA SYSTEMS INC , HARVEY CLINT , MOODY JOHN , WILLIAMS II JACKIE , ESPOSITO II PATRICK , THOMAS GEORGE , REED JARED , KESECKER II BIRAN , ESPOSITO PATRICK
发明人： HARVEY CLINT , MOODY JOHN , WILLIAMS II JACKIE , ESPOSITO II PATRICK , THOMAS GEORGE , REED JARED , KESECKER II BIRAN , ESPOSITO PATRICK
IPC分类号： G06F15/177
CPC分类号： G06F8/61
摘要： A system for deploying component-based software systems for the implementation of desired sensor data process flows makes use of a toolset of software components specially tailored for building sensor data process flows. In one or more embodiments, the system comprises a front-end application operative to generate system specifications from user input, each system specification defining a desired component-based software system of one or more sensor components and their corresponding configurations in accordance with sensor component class definitions (e.g., the toolset) for a predefined set of sensor components tailored for building desired sensor data process flows. The system further includes a back-end application operative to store the sensor component class definitions for use in instantiating sensor components as needed, receive system specifications, and dynamically build and run the corresponding desired component-based software systems within a run-time environment provided by the back-end application.
摘要翻译：用于部署基于组件的软件系统以实现期望的传感器数据处理流程的系统使用专门为构建传感器数据处理流程而定制的软件组件的工具集。在一个或多个实施例中，该系统包括可操作以从用户输入生成系统规范的前端应用程序，每个系统规范根据传感器组件类定义一个或多个传感器组件的期望的基于组件的软件系统及其对应配置定义（例如，工具集）用于预定义的传感器组件集，适用于构建所需的传感器数据处理流程。该系统进一步包括后端应用程序，用于存储传感器组件类定义，用于根据需要实例化传感器组件，接收系统规范，并在提供的运行时环境内动态构建和运行相应的所需基于组件的软件系统通过后端应用程序。

10. 发明申请

WO2012058131A3 COMPOSITE FILM FOR BOARD LEVEL EMI SHIELDING 审中-公开
标题翻译：用于板级EMI屏蔽的复合膜
公开(公告)号：WO2012058131A3
公开(公告)日：2012-06-28
申请号：PCT/US2011057418
申请日：2011-10-24
申请人： HENKEL CORP , CHENG CHIH-MIN , XIA BO , THOMAS GEORGE
发明人： CHENG CHIH-MIN , XIA BO , THOMAS GEORGE
IPC分类号： H05K9/00 , H05K3/28
CPC分类号： G21F1/00 , H05K9/0088
摘要： An EMI shielding composite film for use in printed circuit boards has at least two layers, a top layer electrically conductive in all directions (isotropic), and a bottom layer electrically conductive only in the Z (thickness) direction (anisotropic) after thermo-compression. The bottom layer is in contact with the grounding pads of the circuitry of the electronic device to be shielded. The conductive top layer functions similarly to metallic boxes to prevent the electromagnetic radiation from both entering the boxes and escaping into the environment. The bottom layer interconnects the top conductive layer to the grounding pads on the PCB after thermo-compression so that electromagnetic waves collected by the top layer are directed and released to PCB grounding pads through the bottom layer.
摘要翻译：用于印刷电路板的EMI屏蔽复合膜具有至少两层，在所有方向上导电的顶层（各向同性）和仅在热压缩后的Z（厚度）方向（各向异性）上导电的底层。底层与要屏蔽的电子设备的电路的接地焊盘接触。导电顶层的作用类似于金属盒，以防止电磁辐射进入箱体并逃逸到环境中。底层在热压缩之后将顶部导电层与PCB上的接地焊盘相互连接，使得由顶层收集的电磁波通过底层引导并释放到PCB接地焊盘。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式