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1. 发明申请

WO2003084540A2 METHODS FOR THE TREATMENT OF CHRONIC PAIN AND COMPOSITIONS THEREFOR 审中-公开
标题翻译：治疗慢性疼痛及其组合物的方法
公开(公告)号：WO2003084540A2
公开(公告)日：2003-10-16
申请号：PCT/EP2003/003643
申请日：2003-04-08
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , BUXTON, Francis, Paul , FOX, Alyson , GANJU, Pamposh , GRAY, Andrew, J. , SONG, CHUANZHENG , URBAN, Laszlo
发明人： BUXTON, Francis, Paul , FOX, Alyson , GANJU, Pamposh , GRAY, Andrew, J. , SONG, CHUANZHENG , URBAN, Laszlo
IPC分类号： A61K31/445
CPC分类号： C12N9/6491 , A01K2267/0356 , A61K31/00 , A61K31/445 , A61K31/7088 , C12Q1/37 , G01N33/573 , G01N2333/8146 , G01N2333/96486 , G01N2500/04 , G01N2500/20 , G01N2800/2842
摘要： The invention discloses MMP7 as a suitable target for the development of new therapeutics to treat or ameliorate chronic pain. The invention relates to methods to treat and/or ameliorate chronic pain and pharmaceutical compositions therefor comprising modulators with inhibitory effect on MMP7 enzyme activity and/or MMP7 gene expression. The invention also relates to a method to identify compounds with therapeutic usefulness to treat chronic pain, comprising identifying compounds that can inhibit MMP7 activity and/or gene expression which can also reverse the pathological effects of chronic pain in vivo.
摘要翻译：本发明公开了MMP7作为开发用于治疗或改善慢性疼痛的新疗法的合适靶标。本发明涉及治疗和/或改善慢性疼痛的方法及其药物组合物，其包含对MMP7酶活性和/或MMP7基因表达具有抑制作用的调节剂。本发明还涉及鉴定具有治疗慢性疼痛的治疗有用性的化合物的方法，其包括鉴定能够抑制MMP7活性和/或基因表达的化合物，其也可逆转慢性疼痛在体内的病理作用。

2. 发明申请

WO2004071513A1 USE OF R-10-HYDROXY-10, 11-DIHYDRO-CARBAMAZEPINE IN NEUROPATHIC PAIN 审中-公开
标题翻译： R-10-羟基-10,11-二氢 - 卡巴肼在神经性疼痛中的应用
公开(公告)号：WO2004071513A1
公开(公告)日：2004-08-26
申请号：PCT/EP2004/001451
申请日：2004-02-16
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , FOX, Alyson , BEVAN, Stuart
发明人： FOX, Alyson , BEVAN, Stuart
IPC分类号： A61K31/55
CPC分类号： A61K31/55 , A61K2300/00
摘要： The present invention relates to the use of a mixture of the enantiomers of a compound of Formula (I) or of pharmaceutically acceptable salts of said enantiomers consisting of at least 55% of the R-enantiomer, most preferably of at least 98 % of the R-enantiomer, and not more than 45 % of the S-enantiomer, most preferably not more than 2 % of the Senantiomer, for the manufacture of a pharmaceutical composition for the treatment of neuropathic pain; to a method for the treatment of neuropathic pain; and to a pharmaceutical composition comprising as active agent a mixture of the enantiomers of the compound of formula I or pharmaceutically acceptable salts of said enantiomers consisting of at least 55 % of the R-enantiomer and not more than 45 % of the S-enantiomer.
摘要翻译：本发明涉及式（I）化合物的对映异构体或所述对映异构体的药学上可接受的盐的混合物在至少55％R-对映异构体，最优选至少98％的R- R-对映体和不超过45％的S-对映异构体，最优选不超过2％的对映异构体，用于制备用于治疗神经性疼痛的药物组合物; 涉及治疗神经性疼痛的方法; 以及包含作为活性剂的式I化合物的对映异构体的混合物的药物组合物或由至少55％的R-对映体和不超过45％的S-对映异构体组成的所述对映体的药学上可接受的盐。

3. 发明申请

WO2005039593A1 COMBINATIONS COMPRISING AMPA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROPATHIC PAIN 审中-公开
标题翻译：包含用于治疗神经痛疼痛的AMPA受体拮抗剂的组合
公开(公告)号：WO2005039593A1
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011870
申请日：2004-10-20
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , KAROLCHYK, Mary, Ann , LINGENHÖHL, Kurt , OFNER, Silvio , FOX, Alyson
发明人： KAROLCHYK, Mary, Ann , LINGENHÖHL, Kurt , OFNER, Silvio , FOX, Alyson
IPC分类号： A61K31/675
CPC分类号： A61K45/06 , A61K31/675 , A61K2300/00
摘要： The present invention relates to combinations suitable for the treatment of pain, especially neuropathic pain. The combinations comprise at least one AMPA receptor antagonist and at least one combination partner selected from the group consisting of cyclooxygenase inhibitors, vanilloid receptor antagonists, opioids, tricyclic antidepressants, anticonvulsants, cathepsin S inhibitors and GABA B receptor agonists.
摘要翻译：本发明涉及适用于治疗疼痛，特别是神经性疼痛的组合。所述组合包含至少一种AMPA受体拮抗剂和至少一种选自环氧合酶抑制剂，香草素受体拮抗剂，阿片样物质，三环抗抑郁药，抗惊厥药，组织蛋白酶S抑制剂和GABA B受体激动剂的组合搭配物。

4. 发明申请

WO2003092701A3 SUBSTITUTED AMINOALKANEPHOSPHONIC ACIDS FOR THE TREATMENT OF NEUROPATHIC PAIN, AFFECTIVE AND ATTENTION DISORDERS, SCHIZOPHRENIA, TINNITUS, MYOPIA AND OTHER OCULAR DISORDERS 审中-公开
公开(公告)号：WO2003092701A3
公开(公告)日：2003-11-13
申请号：PCT/EP2003/004466
申请日：2003-04-29
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , LINGENHÖHL, Kurt , AUBERSON, Yves , FOX, Alyson , NEIJT, Hans, Ch. , KALKMAN, Hans, O.
发明人： LINGENHÖHL, Kurt , AUBERSON, Yves , FOX, Alyson , NEIJT, Hans, Ch. , KALKMAN, Hans, O.
IPC分类号： A61K31/675
摘要： The present invention relates the use of substituted aminoalkanephosphonic acids in treating neuropathic pain, affective and attention disorders, schizophrenia, tinnitus, myopia and other ocular disorders.

5. 发明申请

WO2005123694A3 QUINAZOLINONE COMPOUNDS FOR THE TREATMENT OF COUGH 审中-公开
公开(公告)号：WO2005123694A3
公开(公告)日：2005-12-29
申请号：PCT/EP2005/006494
申请日：2005-06-16
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CHARMAN, Christine , FOX, Alyson
发明人： CHARMAN, Christine , FOX, Alyson
IPC分类号： A61K31/517
摘要： The use of a compound of formula (I), in free base or acid addition salt form for the preparation of a medicament for the treatment of cough, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 have the meanings as indicated in the specification.

6. 发明申请

WO2003092701A2 NEW USES OF SUBSTITUTED AMINOALKANEPHOSPHONIC ACIDS 审中-公开
标题翻译：取代的氨基嘌呤磷酸的新用途
公开(公告)号：WO2003092701A2
公开(公告)日：2003-11-13
申请号：PCT/EP2003/004466
申请日：2003-04-29
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , LINGENHÖHL, Kurt , AUBERSON, Yves , FOX, Alyson , NEIJT, Hans, Ch. , KALKMAN, Hans, O.
发明人： LINGENHÖHL, Kurt , AUBERSON, Yves , FOX, Alyson , NEIJT, Hans, Ch. , KALKMAN, Hans, O.
IPC分类号： A61K31/675
CPC分类号： A61K31/675
摘要： The present invention relates the use of substituted aminoalkanephosphonic acids in treating neuropathic pain, affective and attention disorders, schizophrenia, tinnitus, myopia and other ocular disorders.
摘要翻译：本发明涉及取代的氨基烷基膦酸在治疗神经性疼痛，情感和注意障碍，精神分裂症，耳鸣，近视和其他眼部疾病中的用途。

7. 发明申请

WO2009010529A1 SYNERGISTIC COMBINATIONS OF VR-1 ANTAGONISTS AND COX-2 INHIBITORS 审中-公开
标题翻译： VR-1拮抗剂和COX-2抑制剂的协同组合
公开(公告)号：WO2009010529A1
公开(公告)日：2009-01-22
申请号：PCT/EP2008/059296
申请日：2008-07-16
申请人： NOVARTIS AG , FOX, Alyson , NASH, Mark , SOHAL, Bindi , LILLEY, Elliot
发明人： FOX, Alyson , NASH, Mark , SOHAL, Bindi , LILLEY, Elliot
IPC分类号： A61K45/06 , A61P29/00 , A61K31/4418 , A61K31/517
CPC分类号： A61K45/06 , A61K31/4418 , A61K31/517 , G11B33/0427
摘要： A synergistic combination of a vanilloid receptor VR-1 antagonist and an NSAID or a pharmaceutically acceptable salt or solvate of either or both compounds thereof.
摘要翻译：香草酸受体VR-1拮抗剂与其一种或两种化合物的NSAID或其药学上可接受的盐或溶剂化物的协同组合。

8. 发明公开

EP1496901A2 COMPOSITIONS COMPRISING MMP7 MODULATORS FOR THE TREATMENT OF CHRONIC PAIN 审中-公开
标题翻译：组合物MMP7调节剂治疗慢性疼痛
公开(公告)号：EP1496901A2
公开(公告)日：2005-01-19
申请号：EP03720437.7
申请日：2003-04-08
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BUXTON, Francis, Paul , FOX, Alyson , GANJU, Pamposh , GRAY, Andrew, J. , SONG, CHUANZHENG , URBAN, Laszlo,Novartis Inst. BioMedical Rs. Inc.
IPC分类号： A61K31/445 , A61K39/395 , A61K31/7088 , A61P25/02 , C12Q1/37
CPC分类号： C12N9/6491 , A01K2267/0356 , A61K31/00 , A61K31/445 , A61K31/7088 , C12Q1/37 , G01N33/573 , G01N2333/8146 , G01N2333/96486 , G01N2500/04 , G01N2500/20 , G01N2800/2842
摘要： The invention discloses MMP7 as a suitable target for the development of new therapeutics to treat or ameliorate chronic pain. The invention relates to methods to treat and/or ameliorate chronic pain and pharmaceutical compositions therefor comprising modulators with inhibitory effect on MMP7 enzyme activity and/or MMP7 gene expression. The invention also relates to a method to identify compounds with therapeutic usefulness to treat chronic pain, comprising identifying compounds that can inhibit MMP7 activity and/or gene expression which can also reverse the pathological effects of chronic pain in vivo.

9. 发明公开

EP2178562A1 SYNERGISTIC COMBINATIONS OF VR-1 ANTAGONISTS AND COX-2 INHIBITORS 有权
标题翻译： Synergistische Kombinationen aus VR-1 Antagonisten und COX-2 Inhibitoren
公开(公告)号：EP2178562A1
公开(公告)日：2010-04-28
申请号：EP08775119.4
申请日：2008-07-16
申请人： Novartis AG
发明人： FOX, Alyson , NASH, Mark , SOHAL, Bindi , LILLEY, Elliot
IPC分类号： A61K45/06 , A61P29/00 , A61K31/4418 , A61K31/517
CPC分类号： A61K45/06 , A61K31/4418 , A61K31/517 , G11B33/0427
摘要： A synergistic combination of a vanilloid receptor VR-1 antagonist and an NSAID or a pharmaceutically acceptable salt or solvate of either or both compounds thereof.
摘要翻译：香草酸受体VR-1拮抗剂与其一种或两种化合物的NSAID或其药学上可接受的盐或溶剂化物的协同组合。

10. 发明授权

EP2178562B1 Synergistic combinations of vr-1 antagonists and cox-2 inhibitors 有权
标题翻译： vr-1拮抗剂和cox-2抑制剂的协同组合
公开(公告)号：EP2178562B1
公开(公告)日：2017-08-23
申请号：EP08775119.4
申请日：2008-07-16
申请人： Novartis AG
发明人： FOX, Alyson , NASH, Mark , SOHAL, Bindi , LILLEY, Elliot
IPC分类号： A61K45/06 , A61P29/00 , A61K31/4418 , A61K31/517
CPC分类号： A61K45/06 , A61K31/4418 , A61K31/517 , G11B33/0427

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