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1. 发明申请

WO2005025551A3 PHARMACEUTICAL PRODUCTS COMPRISING BISPHOSPHONATES 审中-公开
标题翻译：包含二磷酸的药物产品
公开(公告)号：WO2005025551A3
公开(公告)日：2006-01-12
申请号：PCT/EP2004010470
申请日：2004-09-17
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , GLAUSCH ALEXANDRA , LOEFFLER ROLF , SIGG JUERGEN
发明人： GLAUSCH ALEXANDRA , LOEFFLER ROLF , SIGG JUERGEN
IPC分类号： A61K9/00 , A61K31/00 , A61K31/66 , A61K47/10 , A61K47/12 , A61K47/26 , A61K31/663
CPC分类号： A61K9/0019 , A61K31/66 , A61K31/663 , A61K47/10 , A61K47/12 , A61K47/26
摘要： A pharmaceutical product comprises a container containing a bisphosphonate solution, in which at least the internal surface of the container comprises a plastic material and in which the container is heat sterilisable, and which is in the form of a ready to use infusion solution, for administration of the bisphosphonate to a patient in need of bisphosphonate treatment.
摘要翻译：药物制品包含含有双膦酸盐溶液的容器，其中容器的至少内表面包括塑料材料，容器是可加热灭菌的，并且其为待使用的输注溶液的形式，用于给药的双膦酸盐治疗需要双膦酸盐治疗的患者。

2. 发明专利

AU2004271731B2 Pharmaceutical products comprising bisphosphonates 未知
公开(公告)号：AU2004271731B2
公开(公告)日：2008-07-24
申请号：AU2004271731
申请日：2004-09-17
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH
发明人： SIGG JUERGEN , GLAUSCH ALEXANDRA , LOFFLER ROLF
IPC分类号： A61K31/66 , A61K9/00 , A61K31/00 , A61K47/10 , A61K47/12 , A61K47/26
摘要： A pharmaceutical product comprises a container containing a bisphosphonate solution, in which at least the internal surface of the container comprises a plastic material and in which the container is heat sterilisable, and which is in the form of a ready to use infusion solution, for administration of the bisphosphonate to a patient in need of bisphosphonate treatment.

3. 发明专利

AU2004271731A1 Pharmaceutical products comprising bisphosphonates 未知
公开(公告)号：AU2004271731A1
公开(公告)日：2005-03-24
申请号：AU2004271731
申请日：2004-09-17
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH
发明人： SIGG JUERGEN , GLAUSCH ALEXANDRA , LOFFLER ROLF
IPC分类号： A61K31/00 , A61K9/00 , A61K31/66 , A61K47/10 , A61K47/12 , A61K47/26
摘要： A pharmaceutical product comprises a container containing a bisphosphonate solution, in which at least the internal surface of the container comprises a plastic material and in which the container is heat sterilisable, and which is in the form of a ready to use infusion solution, for administration of the bisphosphonate to a patient in need of bisphosphonate treatment.

4. 发明专利

JP2006312651A Suspension comprising oxcarbazepine 审中-公开
标题翻译：包含奥沙利珠的悬浮液
公开(公告)号：JP2006312651A
公开(公告)日：2006-11-16
申请号：JP2006221159
申请日：2006-08-14
申请人： Novartis Ag , ノバルティスアクチエンゲゼルシャフト
发明人： SIGG JUERGEN , BILLINGTON MICHAEL
IPC分类号： A61K9/10 , A61K31/55 , A61J3/00 , A61K9/00 , A61K47/22 , A61K47/38 , A61P25/06 , A61P25/08
CPC分类号： A61K9/0095 , A61K31/55 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To provide an oral suspension of oxcarbazepine having improved physical-chemical properties such that a patient can very easily use. SOLUTION: The stable and easily injectable pharmaceutical composition in the form of a suspension, comprising oxcarbazepine, and having a viscosity in the range of 5-52 mPa s, e.g., 10-40 mPa s or 10-30 mPa s, e.g., 10-25 mPa s when shaken, is provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供具有改善的物理化学性质的奥卡西平的口服悬浮液，使得患者可以非常容易地使用。解决方案：稳定和容易注射的悬浮液形式的药物组合物，包含奥卡西平，粘度范围为5-52mPa·s，例如10-40mPa·s或10-30mPa·s，例如，当摇动时为10-25mPa·s。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2014087678A Syringe 有权
标题翻译：注射器
公开(公告)号：JP2014087678A
公开(公告)日：2014-05-15
申请号：JP2013266737
申请日：2013-12-25
申请人： Novartis Ag , ノバルティスアーゲー
发明人： SIGG JUERGEN , ROYER CHRISTOPHE , ANDREW MARK BRYANT , BUETTGEN HEINRICH MARTIN , PICCI MARIE
IPC分类号： A61L31/00 , A61J1/06 , A61J1/14 , A61K38/00 , A61K39/395 , A61P9/00 , A61P9/10 , A61P27/02 , A61P35/00 , A61P43/00 , C07K16/24
CPC分类号： A61F9/0008 , A61K9/0019 , A61K9/0048 , A61K38/179 , A61M5/002 , A61M5/178 , A61M5/28 , A61M5/31 , A61M5/315 , A61M5/31505 , A61M5/31513 , A61M2005/3104 , A61M2005/3139
摘要： PROBLEM TO BE SOLVED: To provide a syringe which is easy to use and has a new structure sealing the contents reliably.SOLUTION: A filled syringe 1 includes a body part 2, a stopper, or stopping part, 10 and a plunger 4, and the body part has an outlet 12 in an outlet end part 14. The stopper 10 is arranged in such a way that the front surface 16 and the body part determine the boundary of a volume variable inner chamber, and a liquid can be discharged from the volume variable inner chamber through the outlet. The plunger includes a plunger contact surface of a first end part 24 and a rod 26 extending between the plunger contact surface and the rear part of the plunger. The plunger contact surface 22 is arranged in such a way as to come into contact with the stopper and thereby push the stopper in the direction toward the outlet end part of the body part and reduce the volume of the volume variable inner chamber. The liquid contains a solution for ophthalmology.
摘要翻译：要解决的问题：提供一种易于使用并且具有可靠地密封内容物的新型结构的注射器。解决方案：填充注射器1包括主体部分2，止动件或止动部件10和柱塞4，以及主体部分在出口端部分14具有出口12.止动件10以这样的方式设置，使得前表面16和主体部分确定体积可变内腔的边界，并且液体可以从体积可变内腔通过出口。柱塞包括第一端部24的柱塞接触表面和在柱塞接触表面和柱塞的后部之间延伸的杆26。柱塞接触表面22以与止动件接触的方式布置，从而沿着朝向主体部分的出口端部分的方向推动止动件，并减小体积可变内腔的体积。该液体含有用于眼科的溶液。

6. 发明专利

JP2014028114A Syringe 有权
标题翻译：注射器
公开(公告)号：JP2014028114A
公开(公告)日：2014-02-13
申请号：JP2013012497
申请日：2013-01-25
申请人： Novartis Ag , ノバルティスアーゲー
发明人： SIGG JUERGEN , ROYER CHRISTOPHE , ANDREW MARK BRYANT , BUETTGEN HEINRICH MARTIN , PICCI MARIE
IPC分类号： A61M5/315 , A61F9/007 , A61K9/08 , A61K38/00 , A61K39/395 , A61M5/28 , A61M5/31 , A61P27/02 , A61P43/00
CPC分类号： A61F9/0008 , A61K9/0019 , A61K9/0048 , A61K38/179 , A61M5/002 , A61M5/178 , A61M5/28 , A61M5/31 , A61M5/315 , A61M5/31505 , A61M5/31513 , A61M2005/3104 , A61M2005/3139
摘要： PROBLEM TO BE SOLVED: To provide a novel syringe suitable especially for ophthalmic injections, keeping convenience in use while contents are well sealed.SOLUTION: A syringe 1 is suitable for use in ophthalmic injections. The syringe 1 includes a trunk 2, a stopper 10 and a plunger 4. The syringe 1 is extended along a first axis A. The trunk 2 has an outlet 12 at an outlet end part 14, and the stopper 10 is disposed in the trunk 2 so that a front 16 of the stopper 10 and the trunk 2 determine a boundary of a capacity variable inner chamber 18. The capacity variable inner chamber 18 contains an injection medicament 20 containing a solution for ophthalmology containing VEGF antagonist such as Ranibizumab. The injection liquid 20 can be discharged through the outlet 12 by the movement toward an outlet end part 14 of the stopper 10, so that the capacity of the capacity variable inner chamber 18 decreases. The plunger 4 includes a plunger contact surface 22 at a first end part 24 and a rod 26 extended between the plunger contact surface 22 and a rear part 25.
摘要翻译：要解决的问题：提供一种特别适用于眼科注射的新型注射器，保持使用方便，同时内容物密封良好。解决方案：注射器1适用于眼科注射。注射器1包括躯干2，止动件10和柱塞4.注射器1沿着第一轴线A延伸。躯干2在出口端部14处具有出口12，止动件10设置在躯干 2，使得止动件10的前部16和躯干2确定容量可变内腔18的边界。容量可变内腔18包含含有含有VEGF拮抗剂如兰尼珠单抗的眼科溶液的注射药剂20。注射液20可以通过朝向止动件10的出口端部14的移动而通过出口12排出，使得容量可变内腔18的容量减小。柱塞4包括在第一端部24处的柱塞接触表面22和延伸在柱塞接触表面22和后部25之间的杆26。

7. 发明专利

AT239555T 未知
公开(公告)号：AT239555T
公开(公告)日：2003-05-15
申请号：AT97935538
申请日：1997-07-23
申请人： NOVARTIS PHARMA GMBH
发明人： SIGG JUERGEN
IPC分类号： A61M5/315 , A61M11/00 , B05B11/00 , G01F11/02

8. 发明专利

AT269694T 未知
公开(公告)号：AT269694T
公开(公告)日：2004-07-15
申请号：AT00988803
申请日：2000-12-19
申请人： NOVARTIS PHARMA GMBH
发明人： SIGG JUERGEN , BILLINGTON MICHAEL
IPC分类号： A61K9/10 , A61K9/00 , A61K31/55 , A61K47/22 , A61K47/38 , A61P25/08
摘要： A pharmaceutical composition in the form of a suspension comprises oxcarbazepine and a mixture (1.25 - 1.95 %(g/ml)) of carboxymethylcellulose and microcrystalline cellulose. The composition has, when shaken, a viscosity of 5 - 52 mPa.s. Independent claims are included for the following: (A) a container having a fill volume of 50 - 300 ml comprising the composition and a dosing syringe adapted to fit the container; and (B) prevention or treatment of primary generalized tonic-clonic seizures and partial seizures, with or without secondary generalization, by administering the composition. ACTIVITY : Anticonvulsant. MECHANISM OF ACTION : None given.

9. 发明申请

WO0145671A3 SUSPENSION COMPRISING OXCARBAZEPINE 审中-公开
标题翻译：包含奥沙利珠的悬浮液
公开(公告)号：WO0145671A3
公开(公告)日：2002-02-21
申请号：PCT/EP0012968
申请日：2000-12-19
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , SIGG JUERGEN , BILLINGTON MICHAEL
发明人： SIGG JUERGEN , BILLINGTON MICHAEL
IPC分类号： A61K9/10 , A61K9/00 , A61K31/55 , A61K47/22 , A61K47/38 , A61P25/08
CPC分类号： A61K9/0095 , A61K31/55 , A61K47/38
摘要： This invention provides a pharmaceutical composition in the form of a suspension comprising oxcarbazepine
摘要翻译：本发明提供了包含奥卡西平的悬浮液形式的药物组合物

10. 发明申请

WO2010081838A3 ENCASING A STERILE PREFILLED CONTAINER 审中-公开
标题翻译：创建一个纯粹的预充集装箱
公开(公告)号：WO2010081838A3
公开(公告)日：2010-09-23
申请号：PCT/EP2010050365
申请日：2010-01-13
申请人： NOVARTIS AG , BAZILE DIDIER , TIMBAL OLIVIER , SIGG JUERGEN , SCHOCH CHRISTIAN
发明人： BAZILE DIDIER , TIMBAL OLIVIER , SIGG JUERGEN , SCHOCH CHRISTIAN
IPC分类号： B65B55/04 , A61M5/00
CPC分类号： B65B55/04 , A61M5/002 , A61M5/008 , A61M2205/585 , A61M2205/6063 , A61M2205/6072 , A61M2207/00 , B65B3/003
摘要： Described herein is an assembly (100) for encasing a sterile prefilled container (102) and methods of preparing same. The assembly (100) is ideally suited for end use involving intravitreal injection. The methods described herein provide a prefilled container (102) with sterile exterior surfaces to an end user, even in the absence of terminal sterilization. This is particularly beneficial when the drug product contained in the prefilled container is otherwise sensitive to classical means of terminal sterilization.
摘要翻译：这里描述的是用于封装无菌预填充容器（102）的组件（100）及其制备方法。组件（100）非常适用于涉及玻璃体内注射的最终用途。本文所述的方法即使在没有末端灭菌的情况下，也向最终用户提供具有无菌外表面的预填充容器（102）。当包装在预装容器中的药物产品对经典的终端灭菌手段是敏感的时，这是特别有益的。

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