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1. 发明申请

WO9825887A3 FORMULATIONS AND POLYMORPHIC FORMS OF DESFERRIOXAMINE AND THE PREPARATION THEREOF 审中-公开
标题翻译： DESFERRIOXAMINE的制剂和多形态及其制备方法
公开(公告)号：WO9825887A3
公开(公告)日：1998-08-13
申请号：PCT/EP9706849
申请日：1997-12-08
申请人： NOVARTIS AG , MARTI ERWIN , GEOFFROY ANDRE JOSEPH , HIRT HANS , BURKHARD ANDREAS , HASSAN IAN FRANCIS , LOWTHER NICHOLAS , NICKLIN JOANNE , STEWARD ALAN , VAN HOOGEVEST PETER
发明人： MARTI ERWIN , GEOFFROY ANDRE JOSEPH , HIRT HANS , BURKHARD ANDREAS , HASSAN IAN FRANCIS , LOWTHER NICHOLAS , NICKLIN JOANNE , STEWARD ALAN , VAN HOOGEVEST PETER
IPC分类号： A61K31/16 , C07C259/06 , C07C259/00
CPC分类号： A61K31/16 , C07C259/06
摘要： A parenterally injectable composition comprising particles of a desferrioxamine-B salt of an aliphatic sulphonic acid having at least 8 carbon atoms suspended in a parenterally administrable oil. New crystalline modifications of desferrioxamine B decanesulphonic salt are provided, and one crystal form with outstanding stability is disclosed. 00000
摘要翻译：一种肠胃外可注射组合物，其包含悬浮在肠胃外给药的油中的具有至少8个碳原子的脂肪族磺酸的去铁胺B盐的颗粒。提供了去铁胺B癸烷磺酸盐的新的结晶改性，并且公开了一种具有突出稳定性的一种晶体形式。 00000

2. 发明申请

WO2006125591A8 DIRECT DISSOLUTION 审中-公开
标题翻译：直接溶解
公开(公告)号：WO2006125591A8
公开(公告)日：2007-04-19
申请号：PCT/EP2006004842
申请日：2006-05-22
申请人： PHARES PHARM RES NV , LEIGH STEVE , LEIGH MATHEW LOUIS STEVEN , VAN HOOGEVEST PETER
发明人： LEIGH STEVE , LEIGH MATHEW LOUIS STEVEN , VAN HOOGEVEST PETER
IPC分类号： A23K1/16 , A23L1/275 , A23L1/30 , A23L1/302 , C09B61/00
CPC分类号： C09B61/00 , A23K20/158 , A23K20/179 , A23K40/20 , A23K40/25 , A23K50/80 , A23L5/44 , A23L33/105 , A23L33/115 , A23L33/15 , A23L33/155 , A23P10/35 , A23V2002/00 , Y02A40/818 , Y02P20/13 , A23V2250/211 , A23V2200/224 , A23V2250/186 , A23V2250/156
摘要： The present invention describes a method for the continuous dissolution of e.g. crystalline astaxanthin or canthaxanthin suspension in oil, by applying heat for a predetermined period using an in-line or optionally batch wise-process, followed by cooling the heated solution with an oil phase or heat exchanger. The resulting oil solution may be used as such or added directly to feed components which are turned into feed compositions by extrusion, compaction or granulation. Alternatively the oil solution is spray coated or directly loaded to extruded or compacted pellets and granulates. The invention avoids using formulated carotenoids prepared by known multi-step production methods requiring solvents, solvent removal, cooling and emulsification with an aqueous phase or precipitation and recovery steps. Thus the present invention is a more economical, efficient and environmentally friendly method to add nutrients and colorants to feed compositions instead of using colloid dispersed particulate Hydrocolloid compositions.
摘要翻译：本发明描述了用于连续溶解的方法。结晶的虾青素或角黄素悬浮液在油中，通过使用在线或任选的分批方法施加热量预定的时间，然后用油相或热交换器冷却加热的溶液。所得油溶液可以直接使用或直接加入通过挤出，压实或造粒转化成进料组合物的进料组分。或者，油溶液被喷涂或直接装载到挤出或压实的颗粒和颗粒中。本发明避免使用通过已知的多步骤生产方法制备的配制的类胡萝卜素，其需要溶剂，溶剂去除，冷却和乳化用水相或沉淀和回收步骤。因此，本发明是一种更经济，有效和环保的方法，用于向饲料组合物中加入营养物和着色剂，而不是使用胶体分散的颗粒状水胶体组合物。

3. 发明申请

WO2005110360A3 COMPOSITIONS FOR INJECTION 审中-公开
标题翻译：注射用组合物
公开(公告)号：WO2005110360A3
公开(公告)日：2006-04-06
申请号：PCT/EP2005005365
申请日：2005-05-17
申请人： PHARES PHARM RES NV , LEIGH STEVE , LEIGH MATHEW LOUIS STEVEN , VAN HOOGEVEST PETER
发明人： LEIGH STEVE , LEIGH MATHEW LOUIS STEVEN , VAN HOOGEVEST PETER
IPC分类号： A61K9/00 , A61K9/127 , A61K47/06 , A61K47/24 , A61K47/00
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/1274 , A61K47/06 , A61K47/24
摘要： The present invention relates to a homogeneous pharmaceutical composition for the gradual release of biologically active compounds after intramuscular or subcutaneous administration comprising at least one membrane lipid which is in the liquid crystalline state and a process for the preparation of said composition.
摘要翻译：本发明涉及用于在肌内或皮下给药后逐渐释放生物活性化合物的均匀药物组合物，其包含至少一种处于液晶状态的膜脂质和制备所述组合物的方法。

4. 发明申请

WO2012085171A3 PHARMACEUTICAL COMPOSITIONS OF PYRIDINIUM AND QUINOLINIUM DERIVATIVES 审中-公开
标题翻译：吡啶和喹啉衍生物的药物组合物
公开(公告)号：WO2012085171A3
公开(公告)日：2012-10-11
申请号：PCT/EP2011073722
申请日：2011-12-22
申请人： TRASLATIONAL CANCER DRUGS PHARMA S L , PALACIOS IZQUIERDO BEATRIZ , VAN HOOGEVEST PETER , L S LEIGH MATHEW
发明人： PALACIOS IZQUIERDO BEATRIZ , VAN HOOGEVEST PETER , L S LEIGH MATHEW
IPC分类号： A61K9/127 , A61K31/4425 , A61K31/4706 , A61K47/48 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00
CPC分类号： A61K47/40 , A61K9/0019 , A61K9/08 , A61K9/127 , A61K31/4425 , A61K31/4706 , A61K47/6951 , B82Y5/00 , C07D213/74 , C07D215/44
摘要： The present invention relates to pharmaceutical compositions comprising a compound of formula (I) and a cyclodextrin or a liposome, to the process of preparing said compositions and their use for antitumor, antiviral, antiparasitic and antifungal treatment.
摘要翻译：本发明涉及包含式（I）化合物和环糊精或脂质体的药物组合物，涉及制备所述组合物的方法及其用于抗肿瘤，抗病毒，抗寄生虫和抗真菌治疗。

5. 发明申请

WO2004071494A3 LIPOPHILIC COMPOSITIONS 审中-公开
标题翻译：脂质组合物
公开(公告)号：WO2004071494A3
公开(公告)日：2004-12-16
申请号：PCT/EP2004001355
申请日：2004-02-13
申请人： PHARES PHARM RES NV , LEIGH MATHEW LOUIS STEVEN , VAN HOOGEVEST PETER , QUINTON JACQUES , LEIGH STEVE
发明人： LEIGH MATHEW LOUIS STEVEN , VAN HOOGEVEST PETER , QUINTON JACQUES , LEIGH STEVE
IPC分类号： A61K9/14 , A61K9/16 , A61K9/48
CPC分类号： A61K9/1652 , A61K9/146 , A61K9/4866
摘要： There is described dry compositions comprising lipophilic compounds associated with low viscosity grades of water insoluble polymer and optionally hydrophilic agent/ s associated either as monomolecular or amorphous complexes. There is also described a method of preparing said lipophilic polymer complexes from a solution or homogeneous dispersion employing either water miscible or immiscible organic solvents. The lipophilic polymer complex is precipitated from the solution comprising a water miscible solvent by dilution with water, separating out the precipitated complex, washing, drying and conversion to oral and topical dosage forms. The lipophilic polymer complex may also be prepared by solvent removal involving spray drying or vacuum drying under elevated temperatures using either water miscible or water immiscible solvents. The compositions are characterised by improved dissolution and solubility of the associated compound in aqueous medium.
摘要翻译：描述了干组合物，其包含与低粘度等级的水不溶性聚合物结合的亲脂性化合物和任选地作为单分子或无定形复合物缔合的亲水性试剂。还描述了从使用水可混溶或不可混溶的有机溶剂的溶液或均匀分散体制备所述亲脂性聚合物复合物的方法。亲水性聚合物复合物通过用水稀释而从包含水混溶性溶剂的溶液中沉淀出来，分离出沉淀的复合物，洗涤，干燥并转化为口服和局部剂型。亲脂性聚合物复合物也可以通过溶剂去除来制备，包括喷雾干燥或在升高的温度下使用水混溶性或水不混溶性溶剂进行真空干燥。该组合物的特征在于相关化合物在水性介质中的溶解度和溶解度提高。

6. 发明申请

WO03023394A8 KIT FOR SCREENING COMPOUNDS WITH LOW WATER SOLUBILITY 审中-公开
标题翻译：用于筛选具有低水溶性的化合物的试剂盒
公开(公告)号：WO03023394A8
公开(公告)日：2003-10-30
申请号：PCT/EP0210241
申请日：2002-09-12
申请人： PHARES PHARM RES NV , LEIGH STEVE , LEIGH MATHEW LOUIS STEVEN , VAN HOOGEVEST PETER , TIEMESSEN HENRICUS
发明人： LEIGH STEVE , LEIGH MATHEW LOUIS STEVEN , VAN HOOGEVEST PETER , TIEMESSEN HENRICUS
IPC分类号： G01N33/15 , G01N33/92
CPC分类号： G01N33/92

7. 发明申请

WO03010330A2 TEST SYSTEM AND METHOD SUITABLE FOR SELECTING TEST MATERIALS AND FORMULATIONS 审中-公开
标题翻译：适用于选择测试材料和配方的测试系统和方法
公开(公告)号：WO03010330A2
公开(公告)日：2003-02-06
申请号：PCT/EP0208215
申请日：2002-07-23
申请人： PHARES PHARM RES NV , LEIGH STEVE , LEIGH MATHEW LOUIS STEVEN , VAN HOOGEVEST PETER , TIEMESSEN HENRICUS
发明人： LEIGH STEVE , LEIGH MATHEW LOUIS STEVEN , VAN HOOGEVEST PETER , TIEMESSEN HENRICUS
IPC分类号： G01N33/50 , G01N33/543 , G01N33/92 , C12Q1/00
CPC分类号： G01N33/92 , G01N33/5432 , G01N2500/20
摘要： The present invention provides a test system and a method for screening lipophilic and amphipathic materials with low water solubility. It generally relates to membrane lipid suspensions or dispersions employed as a test system for obtaining desired physico-chemical and biological information relating to the interaction of materials with membrane lipids in early screens in discovery. It serves as a selection method for derivatives of a test material for optimal membrane affinity and membrane permeation and thereby predict the potential for absorption in vivo. Furthermore, it may be used in later screening in formulation development, to select a carrier for a test material or derivative to enable the highest drug load. The data obtained by using the invention in primary screening provide key information on physico-chemical properties early on which may affect drug absorption and may be more predictive than log-octanol determinations. Compared to other screening methods which utilise cell models such as liposomes and cell lines, Transmembrane Screen (TS) is a versatile miniature tool that requires minimal amounts of test substances. It is adaptable, practical, cost effective and may be used routinely in high throughput screening.
摘要翻译：本发明提供了用于筛选具有低水溶性的亲脂和两亲物质的测试系统和方法。它通常涉及膜脂悬浮液或分散体，其用作用于在发现的早期筛选中获得与材料与膜脂质的相互作用相关的期望的物理化学和生物学信息的测试系统。它用作测试材料衍生物的选择方法，以获得最佳膜亲和力和膜渗透性，从而预测体内吸收的可能性。此外，它可用于配方开发的后期筛选，以选择用于测试材料或衍生物的载体以实现最高药物负载。通过在初步筛选中使用本发明获得的数据提供了关于早期物理化学性质的关键信息，其可能影响药物吸收并且可能比对 - 辛醇测定更具预测性。与利用细胞模型（如脂质体和细胞系）的其他筛选方法相比，跨膜筛选（TS）是一种多功能的微型工具，只需要最少量的测试物质。它具有适应性，实用性和成本效益，可以在高通量筛选中常规使用。

8. 发明申请

WO9939694A2 COMPOSITIONS CONTAINING ORGANIC COMPOUNDS 审中-公开
标题翻译：含有机化合物的组合物
公开(公告)号：WO9939694A2
公开(公告)日：1999-08-12
申请号：PCT/EP9900702
申请日：1999-02-03
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , HOOGEVEST PETER VAN
发明人： VAN HOOGEVEST PETER
IPC分类号： C07D493/04 , A61K20060101 , A61K9/00 , A61K9/08 , A61K9/19 , A61K31/335 , A61K31/365 , A61K31/425 , A61K31/427 , A61K31/724 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/26 , A61K47/40 , A61P35/00 , C07D20060101
CPC分类号： A61K31/427 , A61K9/0019 , A61K9/19 , A61K31/724 , A61K47/10 , A61K47/26 , A61K47/40
摘要： Pharmaceutical formulations comprising en epothilone in the form of an infusion concentrate or a lyophilised composition, and methods of administration of an epothilone in suitable form for parenteral administration.
摘要翻译：包含输注浓缩物或冻干组合物形式的enepothilone的药物制剂，以及适合非肠道给药的埃坡霉素给药方法。

9. 发明专利

SK287487B6 Lyophilised formulation and reconstituted lyophilised formulation 未知
公开(公告)号：SK287487B6
公开(公告)日：2010-11-08
申请号：SK50202009
申请日：1999-02-03
申请人： NOVARTIS AG
发明人： VAN HOOGEVEST PETER
IPC分类号： A61K9/08 , C07D493/04 , A61K20060101 , A61K9/00 , A61K9/19 , A61K31/335 , A61K31/365 , A61K31/425 , A61K31/427 , A61K31/724 , A61K47/10 , A61K47/16 , A61K47/18 , A61K47/22 , A61K47/26 , A61K47/40 , A61P35/00 , C07D20060101
摘要： Described is a lyophilised formulation comprising an epothilone and mannitol or cyclodextrin and a reconstituted lyophilised formulation comprising the lyophilised formulation in a pharmaceutically acceptable solvent.

10. 发明专利

PL201329B1 Preparat farmaceutyczny w postaci koncentratu infuzyjnego 未知
公开(公告)号：PL201329B1
公开(公告)日：2009-03-31
申请号：PL34262999
申请日：1999-02-03
申请人： NOVARTIS AG
发明人： VAN HOOGEVEST PETER
IPC分类号： A61K9/08 , C07D493/04 , A61K20060101 , A61K9/00 , A61K9/19 , A61K31/335 , A61K31/365 , A61K31/425 , A61K31/427 , A61K31/724 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/26 , A61K47/40 , A61P35/00 , C07D20060101

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