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1. 发明申请

WO1998008077A1 OPTICAL DETECTOR 审中-公开
标题翻译：光学探测装置
公开(公告)号：WO1998008077A1
公开(公告)日：1998-02-26
申请号：PCT/EP1997004317
申请日：1997-08-08
申请人： NOVARTIS AG , DUVENECK, Gert, Ludwig , GULDEN, Karlheinz , KUNZ, Rino, Ernst , SÖCHTIG, Jürgen
发明人： NOVARTIS AG
IPC分类号： G01N21/55
CPC分类号： G01N21/648 , B01J2219/00707 , G01N21/7703
摘要： An optical detector for carrying out chemical analyses has at least one light source, at least one electric detection unit and at least one measurement cell. One or several optical paths coupled to the measurement cell(s) are formed between the light source(s) and the photoelectric detection unit(s). Separate edge-emitting semiconductor lasers applied on a substrate have been used in the prior art when miniaturising such detection devices arranged in arrays to simultaneously detect a plurality of analytes. The invention provides instead the use of surface-emitting semiconductor lasers as light sources, which have the advantage of being relatively easy to produce and of occupying considerably less space. The process hitherto required to separate the laser from the mother substrate and to glue it on a foreign substrate can be dispensed with in the disclosed detector.
摘要翻译：本发明涉及一种光学检测装置用于化学与至少一个光源，至少一个电检测单元和至少一个测量单元，其中，所述一个或多个光源和一个或多个光电检测单元，之间的一个或多个光路被形成，其耦合到所述至少一个测量单元分析是。在阵列，例如检测装置为多个分析物技术的同时检测的小型化的过程中已经被根据所述状态分离，在基板施加边缘发射半导体激光器。本发明提供了代替作为光源的表面发射半导体激光器，其具有相对简单的生产的优点和显著空间需求减少来使用。切割从母基板和在异质衬底上的粘合剂粘结的激光器的先前必要过程是在新颖检测装置删去。

2. 发明申请

WO1998009156A1 OPTICAL CHEMICAL / BIOCHEMICAL SENSOR 审中-公开
标题翻译：光学化学/生化传感器
公开(公告)号：WO1998009156A1
公开(公告)日：1998-03-05
申请号：PCT/EP1997004678
申请日：1997-08-27
申请人： NOVARTIS AG , DUVENECK, Gert, Ludwig , DÜBENDORFER, Jürg , KUNZ, Rino, Ernst , KRAUS, Gerolf
发明人： NOVARTIS AG
IPC分类号： G01N21/77
CPC分类号： G01N21/7743
摘要： The invention relates to a planar ATR and evanescently exited luminescence optical sensor platform, consisting of a transducer and a recognition layer, wherein changes in the effective refractive index of the recognition layer are converted into a measurable variable in accordance with the integrated-optical light pointer principle. The invention relates also to the use of the method and to the method itself using the sensor platform, for example in label-free biosensory analysis.
摘要翻译：本发明涉及由换能器和识别层组成的平面ATR和消逝的发光光学传感器平台，其中识别层的有效折射率的变化根据集成光学光指示器被转换成可测量的变量原理。本发明还涉及使用该方法和方法本身使用传感器平台，例如在无标签的生物传感分析中。

3. 发明申请

WO1997037211A1 INTEGRATED OPTICAL LUMINESCENCE SENSOR 审中-公开
标题翻译：集成的光致发光
公开(公告)号：WO1997037211A1
公开(公告)日：1997-10-09
申请号：PCT/EP1997001468
申请日：1997-03-22
申请人： NOVARTIS AG , DANIELZIK, Burkhard , NEUSCHÄFER, Dieter , PAWLAK, Michael , DUVENECK, Gert, Ludwig
发明人： NOVARTIS AG
IPC分类号： G01N21/77
CPC分类号： G01N21/648 , G01N21/7703
摘要： An integrated optical luminescence sensor with an exciting light beam with a first optical axis (Kein), a planar waveguide (1), a sample interacting with its evanescent field and a detection beam path running from the waveguide with a second optical axis and/or a decoupling grid (7) to decouple the part of the luminescent light conducted in the waveguide, in which the luminescence light to be detected is spatially separated from the exciting light.
摘要翻译：具有第一光轴的激发光光束的集成光学发光传感器（否），与平面波导（1），（与渐逝场样品和出射波导检测光束路径与第二光轴的交互和/或与输出耦合光栅 7），用于耦合出在发光光的波导部分的导波的，其特征在于，要被检测的发光光在空间上与激发光分开。

4. 发明申请

WO1998022799A2 MEASUREMENT DEVICE AND ITS USE 审中-公开
标题翻译：测量设备及其用途
公开(公告)号：WO1998022799A2
公开(公告)日：1998-05-28
申请号：PCT/EP1997006443
申请日：1997-11-18
申请人： NOVARTIS AG , KRAUS, Gerolf , PAWLAK, Michael , DUVENECK, Gert, Ludwig , OROSZLAN, Peter , HELG, Andreas , BRUNO, Alfredo, Emilio
发明人： NOVARTIS AG
IPC分类号： G01N21/00
CPC分类号： G01N21/648 , G01N21/05 , G01N21/7703 , G01N2021/0346
摘要： A device has a planar optical waveguide which consists of a transparent support (40) and of a waveguide layer (41). The waveguide has at least one diffractive element (42) for inputting an exciting radiation into the waveguide layer. An additional hermetically closing layer (43) located on the waveguide layer is made of a material which at least at the support surface is transparent both to the exciting radiation and to the evanescently excited radiation at least to the depth of penetration of the evanescent field. The device has at least in one partial area of the guided exciting radiation a recess (45) open at the top or a recess (6) closed at the top and connected to a feed channel (2) and outflow channel (3) for receiving a sample to be analysed. The depth of the recess corresponds to at least the depth of penetration of the evanescent field. The diffractive element (42) is completely covered by the material of the layer (43) at least in the input area of the exciting radiation.
摘要翻译：装置由包括一个透明的载体（40）和波导层（41），其中所述波导具有至少用于耦合激发辐射到波导层的衍射元件（42）的一个平面光波导和所述层上的波导更紧密的密封层（43）中被引导激发辐射的部分区域至少由可至少在所述支承表面的至少内的渐逝场两者的对激发辐射的穿透深度和所述倏逝激发辐射透明的材料制成，并且通过向上开口的凹部（45），或经由流入管道（2）和连接到所述向上闭合狭槽（6），用于分析样品，其深度至少至渐逝场的穿透深度，以及其中，所述衍射元件出口通道（3）（42 ）所述Schich的材料吨（43）被完全至少在激发辐射的耦合覆盖。

5. 发明申请

WO1998021571A1 USE OF BIOSENSORS TO DIAGNOSE PLANT DISEASES 审中-公开
标题翻译：使用生物传感器诊断植物病害
公开(公告)号：WO1998021571A1
公开(公告)日：1998-05-22
申请号：PCT/EP1997006202
申请日：1997-11-07
申请人： NOVARTIS AG , ETIENNE, Laurent , SHÜRMANN, Evelyn , OROSZLAN, Peter , EHRAT, Markus , DUVENECK, Gert, Ludwig , BINDER, Andres
发明人： NOVARTIS AG
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , G01N33/5438
摘要： The invention relates to a biosensor for the diagnosis of plant diseases, which is suitable for recognising plant diseases, as well as its use in the course of this process, as well as a sensor platform as a component of a biosensor for the diagnosis of plant diseases, whereby the biosensor as an analytical measuring unit consists of the sensor platform according to the invention, which may be modified and on which immobilised biochemical recognition elements are immobilised, whilst in close contact with an appropriate transducer arrangement. The said biochemical recognition elements are structures which are specific for the plant pathogens to be evaluated, and therefore allow individual detection of these plant pathogens to be carried out in the course of the diagnostic process according to the invention.
摘要翻译：本发明涉及用于诊断植物病害的生物传感器，其适用于识别植物病害，以及其在该过程中的使用，以及作为用于诊断植物的生物传感器的组件的传感器平台疾病，由此作为分析测量单元的生物传感器由根据本发明的传感器平台组成，其可以被修改，并且在固定化的生物化学识别元件被固定的同时与适当的换能器装置紧密接触。所述生物化学识别元件是对待评估的植物病原体特异的结构，因此允许在根据本发明的诊断过程中进行这些植物病原体的个体检测。

6. 发明公开

EP1689702A1 ORGANIC COMPOUNDS 有权
标题翻译：有机化合物
公开(公告)号：EP1689702A1
公开(公告)日：2006-08-16
申请号：EP04819222.3
申请日：2004-11-25
申请人： NOVARTIS-PHARMA GMBH , Novartis AG
发明人： NOVARTIS AG , BAESCHLIN, Daniel, Kaspar , MAIBAUM, Jürgen, Klaus , SELLNER, Holger
IPC分类号： C07C237/20 , C07D295/02 , C07C237/24 , C07C271/24 , C07C323/29 , C07C255/50 , C07D319/18 , C07D313/08 , C07D307/79 , C07D207/09 , C07D333/08 , A61P9/12 , A61K31/165 , A61K31/325 , A61K31/44
CPC分类号： C07C237/20 , C07C237/24 , C07C255/60 , C07C271/22 , C07C271/24 , C07C323/41 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07D207/09 , C07D295/027 , C07D307/79 , C07D313/08 , C07D319/18 , C07D333/08
摘要： Disclosed are δ-amino-Ϝ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.
摘要翻译：公开了具有肾素抑制性质的式（I）的δ-氨基-β-羟基-ω-芳基 - 链烷酸酰胺化合物及其盐。还公开了包含这些化合物的药物组合物和施用它们以治疗高血压，动脉粥样硬化，不稳定冠状动脉综合征，充血性心力衰竭，心脏肥大，心脏纤维化，心肌梗塞后梗塞，不稳定冠状动脉综合征，舒张功能障碍，慢性肾病，肝纤维化，由糖尿病引起的并发症如肾病，血管病和神经病，冠状血管疾病，血管成形术后再狭窄，眼内压升高，青光眼，血管生长异常，醛固酮增多症，认知障碍，阿尔茨海默病，痴呆，焦虑状态和认知障碍。

7. 发明专利

AR069938A1 METODO Y COMPOSICION PARA PREPARAR LENTES DE CONTACTO 未知
公开(公告)号：AR069938A1
公开(公告)日：2010-03-03
申请号：ARP080105672
申请日：2008-12-22
申请人： NOVARTIS AG
发明人： NOVARTIS AG
IPC分类号： G02B1/04 , B29D11/00
摘要： La presente pertenece a un método y a una composicion fluida para producir lentes de contacto con calidad de lentes mejorada y con un aumento del rendimiento del producto. El método de la solicitud involucra agregar un fosfolípido a una composicion fluida incluyendo un material formador de lentes en una cantidad que es suficiente para reducir una fuerza de separacion de molde promediada de por lo menos aproximadamente 40% en comparacion con la que es sin los fosfolípidos.

8. 发明专利

BR112012004453A8 composto inibidor de proteína quinase, sua composição farmacêutica e seu uso 未知
公开(公告)号：BR112012004453A8
公开(公告)日：2021-06-08
申请号：BR112012004453
申请日：2010-08-27
申请人： IRC LLC , NOVARTIS AG
发明人： DANIEL POON , JOHN E TELLEW , NOVARTIS AG , SHENLIN HUANG , XIANMIG JIN , XING WANG , YONGPING XIE , YONGQIN WAN , ZUOSHENG LIU
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00 , C07D403/04
摘要： composto inibidor de proteína quinase, sua composição farmacêutica e seu uso. a presente invenção refere-se a uma nova classe de com-postos de fórmula 1 , composições farmacêuticas compreendendo tais compostos e méto-dos de utili2ação de tais compostos para tratar ou prevenir doenças ou distúrbios associados com atividade de quinase anormal ou desregu - lada' particularmente doenças ou distúrbios que envolvem a ativação anormal de b-raf.

9. 发明专利

GEP20217244B LIPOSOMAL FORMULATION FOR USE IN THE TREATMENT OF CANCER 未知
公开(公告)号：GEP20217244B
公开(公告)日：2021-04-26
申请号：GEAP2017015047
申请日：2017-10-27
申请人： NOVARTIS AG , SERVIER LAB
发明人： NOVARTIS AG , LES LABORATOIRES SERVIER
IPC分类号： A61K9/127 , A61K31/519 , A61P35/00
摘要： Composition comprises 2-{[5-{3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-6-(4-fluorophenyl)thieno [2,3-d]pyrimidin-4-yl]oxy}-3-(2-{[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}phenyl) propanoic acid, negatively charged or polar phospholipid, and antigel stabilizers. s

10. 发明申请

WO1998031704A2 TACHYKININ ANTAGONISTS 审中-公开
公开(公告)号：WO1998031704A2
公开(公告)日：1998-07-23
申请号：PCT/EP1997007307
申请日：1997-12-29
申请人： NOVARTIS AG , NOVARTIS PHARMACEUTICALS UK LIMITED , WALPOLE, Christopher, Simon, John , PRASHAD, Mahavir , HAR, Denis
发明人： NOVARTIS AG , NOVARTIS PHARMACEUTICALS UK LIMITED
IPC分类号： C07K05/00
CPC分类号： C07K5/06165 , A61K38/00 , C07K7/22
摘要： Compounds of formula (I) wherein X is -CH2-, -CO- or direct linkage, Y is -O-, -S- or -NH-, R1 is phenyl, R2=H or phenyl and R3 is H or -CH - and their pharmaceutically acceptable salts have tachykinin antagonist activity and are useful as pharmaceuticals e.g. for the treatment of pain and migraine.
摘要翻译：其中X为-CH 2 - ， - CO-或直接键合的式（I）化合物，Y为-O - ， - S-或-NH-，R1为苯基，R2 = H或苯基，R3为H或-CH 其药学上可接受的盐具有速激肽拮抗剂活性，并且可用作药物例如用于治疗痛苦和偏头痛。

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