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1. 发明申请

WO0216974A8 PROCESS FOR SURFACE MODIFYING SUBSTRATES AND MODIFIED SUBSTRATES RESULTING THEREFROM 审中-公开
标题翻译：表面修饰基板和改性基板的工艺
公开(公告)号：WO0216974A8
公开(公告)日：2004-04-08
申请号：PCT/EP0109712
申请日：2001-08-22
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , COMMW SCIENT IND RES ORG , QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER
发明人： QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER
IPC分类号： G02C7/04 , A61L27/34 , C08J7/04 , C08J7/16 , G02B1/04 , G02B1/14 , G02B1/10
CPC分类号： C08J7/16 , A61L27/34 , G02B1/043 , Y10T428/31511 , Y10T428/31663 , Y10T428/31667 , Y10T428/31909 , Y10T428/31928
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double bond to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：本发明涉及一种涂覆材料表面的方法，包括以下步骤：（a）向材料表面施加包含聚离子材料的粘结层; （b）将包含烯键式不饱和双键的双官能化合物共价结合到连接层上; 和（c）将亲水性单体接枝聚合到包含烯属不饱和双键的化合物上。通过本发明的方法可获得的涂覆制品具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的所需特性，因此可用于制造生物医学制品如眼科装置。

2. 发明申请

WO0216974A3 PROCESS FOR SURFACE MODIFYING SUBSTRATES AND MODIFIED SUBSTRATES RESULTING THEREFROM 审中-公开
标题翻译：表面修饰基板及其改性基板的工艺
公开(公告)号：WO0216974A3
公开(公告)日：2002-07-18
申请号：PCT/EP0109712
申请日：2001-08-22
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , COMMW SCIENT IND RES ORG , QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER
发明人： QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER
IPC分类号： G02C7/04 , A61L27/34 , C08J7/04 , C08J7/16 , G02B1/04 , G02B1/14 , G02B1/10
CPC分类号： C08J7/16 , A61L27/34 , G02B1/043 , Y10T428/31511 , Y10T428/31663 , Y10T428/31667 , Y10T428/31909 , Y10T428/31928
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double bond to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：本发明涉及一种用于涂覆材料表面的方法，包括以下步骤：（a）向材料表面施加包含聚离子材料的粘结层; （b）将包含烯键式不饱和双键的双官能化合物共价结合到粘结层上; 和（c）将亲水性单体接枝聚合到包含烯属不饱和双键的化合物上。通过本发明的方法可获得的涂覆制品具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的所需特性，因此可用于制造生物医学制品如眼科装置。

3. 发明申请

WO0130512A3 COATING PROCESS 审中-公开
标题翻译：涂层工艺
公开(公告)号：WO0130512A3
公开(公告)日：2001-12-27
申请号：PCT/EP0010529
申请日：2000-10-25
申请人： NOVARTIS AG , COMMW SCIENT IND RES ORG , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER , CHABRECEK PETER
发明人： PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER , CHABRECEK PETER
IPC分类号： G02C7/04 , A61L27/34 , B05D1/18 , B05D7/00 , C08J7/16 , C09D151/06 , G02B1/04 , G02B1/10
CPC分类号： B82Y30/00 , A61L27/34 , B05D1/185 , B05D7/00 , B82Y40/00 , C08J7/16 , G02B1/043
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) covalently binding a compound comprising an ethylenically unsaturated double bond to the material surface; (b) polymerizing a monomer comprising a reactive or crosslinkable group on the surface and thereby providing a primary polymer coating comprising reactive or crosslinkable groups; (c) in case of a monomer comprising a reactive group in step (b) reacting the reactive groups of the primary coating with a further compound comprising an ethylenically unsaturated double bond and graft-polymerizing a hydrophilic monomer and optionally a co-monomer having a crosslinkable group onto the primary coating obtained according to step (b) and;(d) in case of crosslinkable groups being present in step (b) or (c) initiating crosslinking of said groups. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：该方法包括以下步骤：（a）将包含烯属不饱和双键的化合物共价结合到材料表面; （b）在表面上聚合包含反应性或可交联基团的单体，从而提供包含反应性或可交联基团的初级聚合物涂层; （c）在步骤（b）中包含反应性基团的单体的情况下，使底涂层的反应性基团与另一种包含烯键式不饱和双键的化合物反应并接枝聚合亲水单体和任选的共聚单体，所述共聚单体具有（b）和（d）在步骤（b）或（c）中存在可交联基团的情况下，引发所述基团的交联。可通过本发明的方法获得的涂覆制品具有关于与基材的粘合性，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此可用于制造生物医学制品如眼科装置。

4. 发明专利

SK2152003A3 Process for surface modifying substrates and modified substrates resulting therefrom 未知
公开(公告)号：SK2152003A3
公开(公告)日：2003-08-05
申请号：SK2152003
申请日：2001-08-22
申请人： NOVARTIS AG , COMMW SCIENT IND RES ORG
发明人： QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JORG , KAMBOURIS PETER
IPC分类号： G02C7/04 , A61L27/34 , C08J7/04 , C08J7/16 , G02B1/04 , G02B1/14 , G02B1/10
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double b 3 nd to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherences to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

5. 发明公开

EP2052045A4 POLYMERIC COATINGS AND METHODS FOR FORMING THEM 审中-公开
标题翻译：聚合物涂层及其制造方法
公开(公告)号：EP2052045A4
公开(公告)日：2012-09-12
申请号：EP07784811
申请日：2007-08-17
申请人： COMMW SCIENT IND RES ORG
发明人： MEAGHER LAURENCE , THISSEN HELMUT , PASIC PAUL , EVANS RICHARD ALEXANDER , JOHNSON GRAHAM
IPC分类号： C09D201/02 , C08L101/02 , C09D5/16
CPC分类号： C08J7/123

6. 发明专利

CZ2003523A3 Surface modification process of substrates and modified substrates obtained in such a manner 未知
公开(公告)号：CZ2003523A3
公开(公告)日：2003-05-14
申请号：CZ2003523
申请日：2001-08-22
申请人： NOVARTIS AG , COMMW SCIENT IND RES ORG
发明人： QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JORG , KAMBOURIS PETER
IPC分类号： G02C7/04 , A61L27/34 , C08J7/04 , C08J7/16 , G02B1/04 , G02B1/14 , G02B1/10
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double b 3 nd to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherences to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

7. 发明专利

DE60016449D1 未知
公开(公告)号：DE60016449D1
公开(公告)日：2005-01-05
申请号：DE60016449
申请日：2000-10-25
申请人： NOVARTIS AG , COMMW SCIENT IND RES ORG
发明人： PASIC PAUL , GRIESSER JOERG , KAMBOURIS PETER , CHABRECEK PETER
IPC分类号： G02C7/04 , A61L27/34 , B05D1/18 , B05D7/00 , C08J7/16 , C09D151/06 , G02B1/04 , G02B1/10
摘要： The invention relates to a process for coating a material surface, comprising the steps of:(a) covalently binding a compound comprising an ethylenically unsaturated double bond to the material surface;(b) polymerizing a monomer comprising a reactive or crosslinkable group on the surface and thereby providing a primary polymer coating comprising reactive or crosslinkable groups,(c) in case of a monomer comprising a reactive group in step (b) reacting the reactive groups of the primary coating with a further compound comprising an ethylenically unsaturated double bond and graft-polymerizing a hydrophilic monomer and optionally a co-monomer having a crosslinkable group onto the primary coating obtained according to step (b) and(d) in case of crosslinkable groups being present in step (b) or (c) initiating crosslinking of said groups. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

8. 发明专利

AU1387401A Coating process 未知
公开(公告)号：AU1387401A
公开(公告)日：2001-05-08
申请号：AU1387401
申请日：2000-10-25
申请人： NOVARTIS AG , COMMW SCIENT IND RES ORG
发明人： PASIC PAUL , GRIESSER HANS JORG , KAMBOURIS PETER , CHABRECEK PETER
IPC分类号： G02C7/04 , A61L27/34 , B05D1/18 , B05D7/00 , C08J7/16 , C09D151/06 , G02B1/04 , G02B1/10
摘要： The invention relates to a process for coating a material surface, comprising the steps of:(a) covalently binding a compound comprising an ethylenically unsaturated double bond to the material surface;(b) polymerizing a monomer comprising a reactive or crosslinkable group on the surface and thereby providing a primary polymer coating comprising reactive or crosslinkable groups,(c) in case of a monomer comprising a reactive group in step (b) reacting the reactive groups of the primary coating with a further compound comprising an ethylenically unsaturated double bond and graft-polymerizing a hydrophilic monomer and optionally a co-monomer having a crosslinkable group onto the primary coating obtained according to step (b) and(d) in case of crosslinkable groups being present in step (b) or (c) initiating crosslinking of said groups. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

9. 发明专利

DE60016449T2 未知
公开(公告)号：DE60016449T2
公开(公告)日：2005-12-08
申请号：DE60016449
申请日：2000-10-25
申请人： NOVARTIS AG , COMMW SCIENT IND RES ORG
发明人： PASIC PAUL , GRIESSER JOERG , KAMBOURIS PETER , CHABRECEK PETER
IPC分类号： G02C7/04 , A61L27/34 , B05D1/18 , B05D7/00 , C08J7/16 , C09D151/06 , G02B1/04 , G02B1/10
摘要： The invention relates to a process for coating a material surface, comprising the steps of:(a) covalently binding a compound comprising an ethylenically unsaturated double bond to the material surface;(b) polymerizing a monomer comprising a reactive or crosslinkable group on the surface and thereby providing a primary polymer coating comprising reactive or crosslinkable groups,(c) in case of a monomer comprising a reactive group in step (b) reacting the reactive groups of the primary coating with a further compound comprising an ethylenically unsaturated double bond and graft-polymerizing a hydrophilic monomer and optionally a co-monomer having a crosslinkable group onto the primary coating obtained according to step (b) and(d) in case of crosslinkable groups being present in step (b) or (c) initiating crosslinking of said groups. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

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