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1. 发明授权

EP1230041B1 COATING PROCESS 有权
公开(公告)号：EP1230041B1
公开(公告)日：2004-12-01
申请号：EP00975918.4
申请日：2000-10-25
申请人： Novartis AG , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , Novartis Pharma GmbH
发明人： PASIC, Paul , GRIESSER, Hans, Jörg , KAMBOURIS, Peter , CHABRECEK, Peter
IPC分类号： B05D7/00 , B05D1/18
CPC分类号： B82Y30/00 , A61L27/34 , B05D1/185 , B05D7/00 , B82Y40/00 , C08J7/16 , G02B1/043
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) covalently binding a compound comprising an ethylenically unsaturated double bond to the material surface; (b) polymerizing a monomer comprising a reactive or crosslinkable group on the surface and thereby providing a primary polymer coating comprising reactive or crosslinkable groups; (c) in case of a monomer comprising a reactive group in step (b) reacting the reactive groups of the primary coating with a further compound comprising an ethylenically unsaturated double bond and graft-polymerizing a hydrophilic monomer and optionally a co-monomer having a crosslinkable group onto the primary coating obtained according to step (b) and;(d) in case of crosslinkable groups being present in step (b) or (c) initiating crosslinking of said groups. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

2. 发明授权

EP1315985B1 PROCESS FOR SURFACE MODIFYING SUBSTRATES AND MODIFIED SUBSTRATES RESULTING THEREFROM 有权转让
标题翻译：表面修饰基质和修饰的基质的过程
公开(公告)号：EP1315985B1
公开(公告)日：2017-07-26
申请号：EP01969631.9
申请日：2001-08-22
申请人： NOVARTIS AG , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
发明人： QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin , CHABRECEK, Peter , PASIC, Paul , GRIESSER, Hans, Jörg , KAMBOURIS, Peter
IPC分类号： G02B1/04 , A61L27/34 , C08J7/16
CPC分类号： C08J7/16 , A61L27/34 , G02B1/043 , Y10T428/31511 , Y10T428/31663 , Y10T428/31667 , Y10T428/31909 , Y10T428/31928

3. 发明公开

EP1315985A2 PROCESS FOR SURFACE MODIFYING SUBSTRATES AND MODIFIED SUBSTRATES RESULTING THEREFROM 有权转让
标题翻译： VERFAHREN ZUR MODIFIZIERUNG VON基板在改性基板
公开(公告)号：EP1315985A2
公开(公告)日：2003-06-04
申请号：EP01969631.9
申请日：2001-08-22
申请人： Novartis AG , Novartis Pharma GmbH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
发明人： QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin , CHABRECEK, Peter , PASIC, Paul , GRIESSER, Hans, Jörg , KAMBOURIS, Peter
IPC分类号： G02B1/04
CPC分类号： C08J7/16 , A61L27/34 , G02B1/043 , Y10T428/31511 , Y10T428/31663 , Y10T428/31667 , Y10T428/31909 , Y10T428/31928
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double bond to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：本发明涉及一种涂覆材料表面的方法，包括以下步骤：（a）向材料表面施加包含聚离子材料的粘结层; （b）将包含烯属不饱和双键3 nd的双官能化合物共价结合到连接层上; 和（c）将亲水性单体接枝聚合到包含烯属不饱和双键的化合物上。通过本发明的方法可获得的涂覆制品对于与基材的粘合性，耐久性，亲水性，润湿性，生物相容性和渗透性有所期望的特性，因此可用于制造生物医学制品如眼科装置。

4. 发明公开

EP1230041A2 COATING PROCESS 有权
标题翻译：涂层工艺
公开(公告)号：EP1230041A2
公开(公告)日：2002-08-14
申请号：EP00975918.4
申请日：2000-10-25
申请人： Novartis AG , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
发明人： PASIC, Paul , GRIESSER, Hans, Jörg , KAMBOURIS, Peter , CHABRECEK, Peter
IPC分类号： B05D7/00 , B05D1/18
CPC分类号： B82Y30/00 , A61L27/34 , B05D1/185 , B05D7/00 , B82Y40/00 , C08J7/16 , G02B1/043
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) covalently binding a compound comprising an ethylenically unsaturated double bond to the material surface; (b) polymerizing a monomer comprising a reactive or crosslinkable group on the surface and thereby providing a primary polymer coating comprising reactive or crosslinkable groups; (c) in case of a monomer comprising a reactive group in step (b) reacting the reactive groups of the primary coating with a further compound comprising an ethylenically unsaturated double bond and graft-polymerizing a hydrophilic monomer and optionally a co-monomer having a crosslinkable group onto the primary coating obtained according to step (b) and;(d) in case of crosslinkable groups being present in step (b) or (c) initiating crosslinking of said groups. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：该方法包括以下步骤：（a）将包含烯属不饱和双键的化合物共价结合到材料表面; （b）在表面上聚合包含反应性或可交联基团的单体，从而提供包含反应性或可交联基团的初级聚合物涂层; （c）在步骤（b）中包含反应性基团的单体的情况下，使底涂层的反应性基团与另一种包含烯键式不饱和双键的化合物反应并接枝聚合亲水单体和任选的共聚单体，所述共聚单体具有（b）和（d）在步骤（b）或（c）中存在可交联基团的情况下，引发所述基团的交联。可通过本发明的方法获得的涂覆制品具有关于与基材的粘合性，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此可用于制造生物医学制品如眼科装置。

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