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1. 发明申请

WO2012016097A2 AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF 审中-公开
标题翻译：聚硅氧烷聚合物预聚物及其用途
公开(公告)号：WO2012016097A2
公开(公告)日：2012-02-02
申请号：PCT/US2011045809
申请日：2011-07-29
申请人： NOVARTIS AG , CHANG FRANK , SCOTT ROBERT , HUANG JINYU , MEDINA ARTURO N , SMITH DAWN A , SANDERS LAURA ANN , PRUITT JOHN DALLAS
发明人： CHANG FRANK , SCOTT ROBERT , HUANG JINYU , MEDINA ARTURO N , SMITH DAWN A , SANDERS LAURA ANN , PRUITT JOHN DALLAS
IPC分类号： G02C7/04 , B29D11/00 , C07F7/10 , G02B1/12
CPC分类号： G02B1/043 , C08F290/068 , C08G77/388 , C08G77/458 , C08G2210/00 , C08L2205/02 , C08L83/04 , C08L51/085 , C08L101/14 , C08F220/56 , C08F220/28
摘要： The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.
摘要翻译：本发明提供一种两亲性聚硅氧烷预聚物，其包含衍生自至少一种亲水乙烯基单体的亲水性单体单元，衍生自至少一种具有至少两个末端烯属不饱和基团的聚硅氧烷交联剂的聚硅氧烷交联单元，悬浮聚硅氧烷链各自被终止具有一个烯键式不饱和基团，以及衍生自除RAFT试剂之外的链转移剂的链转移单元。本发明的预聚物适用于制备水凝胶隐形眼镜。本发明还涉及由本发明的两亲聚硅氧烷预聚物制成的水凝胶隐形眼镜以及制备本发明的两亲性聚硅氧烷预聚物和制备硅酮水凝胶隐形眼镜的方法。

2. 发明公开

EP2598938A4 A SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 审中-实审转让
公开(公告)号：EP2598938A4
公开(公告)日：2018-01-24
申请号：EP11813222
申请日：2011-07-29
申请人： NOVARTIS AG
发明人： QIU YONGXING , SAMUEL NEWTON T , PRUITT JOHN DALLAS , KOLLURU CHANDANA , MEDINA ARTURO N , WINTERTON LYNN COOK , WU DAQING , QIAN XINMING , NELSON JARED
IPC分类号： G02C7/04 , B05D5/06 , B29D11/00 , G02B1/04
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： Hydrated silicone hydrogel contact lens having a layered structural configuration: a low water content silicone hydrogel core (or bulk material) completely covered with a layer of a water-rich (e.g., a water content greater than 80%), hydrogel totally or substantially free of silicone. The hydrated silicone hydrogel contact lens possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

3. 发明公开

EP2598937A4 AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF 失效转让
标题翻译：两亲性聚硅氧烷预聚物及其用途
公开(公告)号：EP2598937A4
公开(公告)日：2014-06-04
申请号：EP11813221
申请日：2011-07-29
申请人： NOVARTIS AG
发明人： CHANG FRANK , SCOTT ROBERT , HUANG JINYU , MEDINA ARTURO N , SMITH DAWN A , SANDERS LAURA ANN , PRUITT JOHN DALLAS
IPC分类号： G02C7/04 , B29D11/00 , C07F7/10 , C08F290/06 , C08L51/08 , G02B1/12
CPC分类号： G02B1/043 , C08F290/068 , C08G77/388 , C08G77/458 , C08G2210/00 , C08L2205/02 , C08L83/04 , C08L51/085 , C08L101/14 , C08F220/56 , C08F220/28

4. 发明专利

DK2598937T3 Amphiphile polylsiloxanpræpolymerer og anvendelser deraf 未知
公开(公告)号：DK2598937T3
公开(公告)日：2016-09-19
申请号：DK11813221
申请日：2011-07-29
申请人： NOVARTIS AG
发明人： CHANG FRANK , SCOTT ROBERT , HUANG JINYU , MEDINA ARTURO N , SMITH DAWN A , SANDERS LAURA ANN , PRUITT JOHN DALLAS
IPC分类号： G02C7/04 , B29D11/00 , C07F7/10 , C08F290/06 , C08L51/08 , G02B1/12

5. 发明专利

BR112013002154A2 pré-polímeros anfifílicos de polissiloxano e seus usos 未知
公开(公告)号：BR112013002154A2
公开(公告)日：2016-05-31
申请号：BR112013002154
申请日：2011-07-29
申请人： NOVARTIS AG
发明人： MEDINA ARTURO N , SMITH DAWN A , CHANG FRANK , HUANG JINYU , PRUITT JOHN DALLAS , SANDERS LAURA ANN , SCOTT ROBERT
IPC分类号： C08F26/02 , C08F226/00
摘要： pré-polímeros anfifílicos de polissiloxano e seus usos. a presente invenção refere-se a um pré-polímero anfifílico de polissloxano que inclui unidades monoméricas hidrofílicas derivadas de pelo menos um monômero vinílico hidrofílico, unidades de reticulação de polissiloxano derivadas de pelo menos um reticulador de polissiloxano tendo pelo menos dois grupos eilenicamente insaturados terminais em um grupo etilenicamente insaturados terminais, cadeias etilenicamente insaturado, e unidades de transferência de cadeia derivadas de um agente de transferência de cadeia diferente de um agente raft. um pré-polímero da invenção é adequado para fabricar lentes de contato de hidrogel. a presente invenção também se refere a lentes de contato de hidrogel feitas a partir de um pré-polímero anfifílico de polissiloxano da invenção e a processos para preparar um pré-polímero anfifílico de polissiloxano da invenção e para fabricar lentes de contato de silicone-hidrogel.

6. 发明专利

HK1207689A1 A SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 未知
公开(公告)号：HK1207689A1
公开(公告)日：2016-02-05
申请号：HK15108427
申请日：2015-08-31
申请人： NOVARTIS AG
发明人： QIU YONGXING , SAMUEL NEWTON T , PRUITT JOHN DALLAS , KOLLURU CHANDANA , MEDINA ARTURO N , WINTERTON LYNN COOK , WU DAQING , QIAN XINMING , NELSON JARED
IPC分类号： G02C20060101 , G02B20060101
摘要： Hydrated silicone hydrogel contact lens having a layered structural configuration: a low water content silicone hydrogel core (or bulk material) completely covered with a layer of a water-rich (e.g., a water content greater than 80%), hydrogel totally or substantially free of silicone. The hydrated silicone hydrogel contact lens possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

7. 发明专利

CA2802337C A SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 未知
公开(公告)号：CA2802337C
公开(公告)日：2014-11-18
申请号：CA2802337
申请日：2011-07-29
申请人： NOVARTIS AG
发明人： QIU YONGXING , SAMUEL NEWTON T , PRUITT JOHN DALLAS , KOLLURU CHANDANA , MEDINA ARTURO N , WINTERTON LYNN COOK , WU DAQING , QIAN XINMING , NELSON JARED
IPC分类号： C08L79/02 , A61L12/04 , B29D11/00 , C08J3/24 , C08L77/00 , C08L101/02 , G02B1/04 , G02C7/04
摘要： A cost-effective method for making a silicone hydrogel contact lens has a crosslinked hydrophilic coating applied thereon. The method involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally- crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, and at a temperature from 40 Centigrade to 140 Centigrade for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

8. 发明专利

AU2013203441A1 A silicone hydrogel lens with a crosslinked hydrophilic coating 未知
公开(公告)号：AU2013203441A1
公开(公告)日：2013-05-02
申请号：AU2013203441
申请日：2013-04-10
申请人： NOVARTIS AG
发明人： QIU YONGXING , SAMUEL NEWTON T , PRUITT JOHN DALLAS , KOLLURU CHANDANA , MEDINA ARTURO N , WINTERTON LYNN COOK , WU DAQING , QIAN XINMING , NELSON JARED
IPC分类号： G02C7/04 , B05D5/06 , B29D11/00
摘要： H:\daInterovei\NRPotbDCDAR\OS60181_LDOC-9D4/2013 A cost-effective method for making a silicone hydrogel contact lens has a crosslinked hydrophilic coating applied thereon. The method involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, and at a temperature from 40 Centigrade to 140 Centigrade for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

9. 发明专利

CA2802337A1 A SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 未知
公开(公告)号：CA2802337A1
公开(公告)日：2012-02-02
申请号：CA2802337
申请日：2011-07-29
申请人： NOVARTIS AG
发明人： QIU YONGXING , SAMUEL NEWTON T , PRUITT JOHN DALLAS , KOLLURU CHANDANA , MEDINA ARTURO N , WINTERTON LYNN COOK , WU DAQING , QIAN XINMING , NELSON JARED
IPC分类号： G02C7/04 , B05D5/06 , B29D11/00
摘要： A cost-effective method for making a silicone hydrogel contact lens has a crosslinked hydrophilic coating applied thereon. The method involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally- crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, and at a temperature from 40 Centigrade to 140 Centigrade for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

10. 发明专利

RU2675109C1 СИЛИКОНОВЫЕ ГИДРОГЕЛЕВЫЕ ЛИНЗЫ СО СШИТЫМ ГИДРОФИЛЬНЫМ ПОКРЫТИЕМ 未知
公开(公告)号：RU2675109C1
公开(公告)日：2018-12-17
申请号：RU2018103054
申请日：2018-01-26
申请人： NOVARTIS AG
发明人： TSYU YUNSIN , SAMYUEL NYUTON T , PRUITT DZHON DALLAS , KOLLURU CHANDANA , MEDINA ARTURO N , VINTERTON LIN KUK , VU DATSIN , TSYAN SINMIN , NELSON DZHARED
IPC分类号： A61L12/00 , A61L12/08 , G02B1/04
摘要： Изобретениеотноситсяк легкимв использованиисиликоновымгидрогелевымконтактнымлинзам, аименнок упаковочномурастворудляконтактныхлинз, которыйпредставляетсобойводныйраствор, содержащийпоменьшеймереодинбуферныйагентв количестве, достаточномдляподдержаниязначения pH, равногоот 6,0 до 8,5 иот 0,01 % до 2 мас.% растворимогов водеи термическисшивающегосягидрофильногополимерногоматериала; гдерастворимыйв водеи термическисшивающийсягидрофильныйполимерныйматериалсодержит (i) от 20% до 95 мас.% первыхполимерныхцепей, образованныхизфункционализированногоэпихлоргидриномполиаминаилиполиамидоамина,(ii) от 5% до 80 мас.% гидрофильныхфрагментовиливторыхполимерныхцепей, образованныхпоменьшеймереизодногоувеличивающегогидрофильностьагента, содержащегопоменьшеймереоднуреакционно-способнуюфункциональнуюгруппу, выбраннуюизгруппы, включающейаминогруппу, карбоксигруппу, тиогруппуи ихкомбинацию, и (iii) положительнозаряженныеазетидиниевыегруппы, которыеявляютсячастямипервыхполимерныхцепейилибоковыхиликонцевыхгрупп, ковалентносвязанныхс первымиполимернымицепями, гдегидрофильныефрагментыиливторыеполимерныецепиковалентносвязаныс первымиполимернымицепямис помощьюоднойилибольшегоколичестваковалентныхсвязей, каждаяизкоторыхобразованамеждуоднойазетидиниевойгруппойфункционализированногоэпихлоргидриномполиаминаилиполиамидоаминаи однойаминогруппой, карбоксигруппойилитиогруппойувеличивающегогидрофильностьагента. Изобретениеобеспечиваетполучениеофтальмологическибезопасногоупаковочногораствора, причемупаковочныйрастворобладаеттоничностью, составляющейот 200 до 450 миллиосмол (мОсм), ивязкостью, равнойот 1 сПдопримерно 20 сП, при 25°C. 39 з.п. ф-лы, 10 табл., 24 пр.

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