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1. 发明申请

WO2011092293A3 CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS 审中-公开
标题翻译： CYCLOHEXYL AMIDE衍生物作为CRF受体拮抗剂
公开(公告)号：WO2011092293A3
公开(公告)日：2011-08-04
申请号：PCT/EP2011/051225
申请日：2011-01-28
申请人： NOVARTIS AG , ATKINSON, Benjamin , BEATTIE, David , CULSHAW, Andrew James , DALE, James , DEVEREUX, Nicholas James , MCKENNA, Jeffrey
发明人： ATKINSON, Benjamin , BEATTIE, David , CULSHAW, Andrew James , DALE, James , DEVEREUX, Nicholas James , MCKENNA, Jeffrey
IPC分类号： C07D209/34 , C07D217/24 , C07D401/12 , C07D413/12 , C07D471/04 , C07D471/20 , C07D487/04 , C07D498/04 , A61K31/437 , A61P5/04
摘要： There are described cydohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists.
摘要翻译：描述了用作促肾上腺皮质素释放因子（CRF）受体拮抗剂的环己基酰胺衍生物。

2. 发明申请

WO2012164473A1 3-SPIROCYCLIC PIPERIDINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS 审中-公开
标题翻译：作为GHRELIN受体激动剂的3-螺环哌啶衍生物
公开(公告)号：WO2012164473A1
公开(公告)日：2012-12-06
申请号：PCT/IB2012/052649
申请日：2012-05-25
申请人： NOVARTIS AG , AMBARKHANE, Ameet Vijay , BHALAY, Gurdip , BECKETT, Martin , DALE, James , HAMADI, Ahmed , MAZZACANI, Alessandro , MCKENNA, Jeffrey , THOMSON, Christopher
发明人： AMBARKHANE, Ameet Vijay , BHALAY, Gurdip , BECKETT, Martin , DALE, James , HAMADI, Ahmed , MAZZACANI, Alessandro , MCKENNA, Jeffrey , THOMSON, Christopher
IPC分类号： C07D471/10 , C07D487/10 , A61K31/438 , A61P1/00
CPC分类号： C07D471/10 , A61K31/407 , A61K31/435 , A61K31/55 , A61K45/06 , C07D487/10
摘要： The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.
摘要翻译：本发明涉及式（I）的衍生物，其中取代基如说明书中所定义; 制备此类衍生物的方法; 包含这些衍生物的药物组合物; 这种衍生物作为药物; 用于治疗疾病或由生长素释放肽受体介导的疾病的衍生物。

3. 发明申请

WO2015175796A1 CARBOXAMIDE DERIVATIVES 审中-公开
标题翻译：羧酰胺衍生物
公开(公告)号：WO2015175796A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030817
申请日：2015-05-14
申请人： NOVARTIS AG , D'SOUZA, Anne-Marie , AHMED, Mahbub , PULZ, Robert Alexander , ROONEY, Lisa Ann , SMITH, Nichola , TROXLER, Thomas Josef , BALA, Kamlesh Jagdis , BREARLEY, Andrew , DALE, James , PORTER, David , SANDHAM, David Andrew , SHAW, Duncan , TAYLOR, Jessica Louise , TAYLOR, Roger John , WRIGGLESWORTH, Joe
发明人： D'SOUZA, Anne-Marie , AHMED, Mahbub , PULZ, Robert Alexander , ROONEY, Lisa Ann , SMITH, Nichola , TROXLER, Thomas Josef , BALA, Kamlesh Jagdis , BREARLEY, Andrew , DALE, James , PORTER, David , SANDHAM, David Andrew , SHAW, Duncan , TAYLOR, Jessica Louise , TAYLOR, Roger John , WRIGGLESWORTH, Joe
IPC分类号： C07D413/14 , A61K31/4155 , A61K31/422 , C07D413/12 , A61P11/00 , A61P9/12 , A61P19/02 , A61P19/08
CPC分类号： A61K31/422 , A61K31/4155 , C07D413/12 , C07D413/14 , A61K2300/00
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐; （I）制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

4. 发明申请

WO2007095588A1 PI-3 KINASE INHIBITORS AND METHODS OF THEIR USE 审中-公开
标题翻译： PI-3激酶抑制剂及其使用方法
公开(公告)号：WO2007095588A1
公开(公告)日：2007-08-23
申请号：PCT/US2007/062157
申请日：2007-02-14
申请人： NOVARTIS AG , NI, Zhi-jie , PECCHI, Sabina , BURGER, Matthew , HAN, Wooseok , SMITH, Aaron , ATALLAH, Gordana , BARTULIS, Sarah , FRAZIER, Kelly , VERHAGEN, Joelle , ZHANG, Yanchen , IWANOWICZ, Ed , HENDRICKSON, Tom , KNAPP, Mark , MERRITT, Hanne , VOLIVA, Charles , WIESMANN, Marion , LEGRAND, Darren Mark , BRUCE, Ian , DALE, James , LAN, Jiong , LEVINE, Barry , COSTALES, Abran , LIU, Jie , PICK, Teresa , MENEZES, Daniel
发明人： NI, Zhi-jie , PECCHI, Sabina , BURGER, Matthew , HAN, Wooseok , SMITH, Aaron , ATALLAH, Gordana , BARTULIS, Sarah , FRAZIER, Kelly , VERHAGEN, Joelle , ZHANG, Yanchen , IWANOWICZ, Ed , HENDRICKSON, Tom , KNAPP, Mark , MERRITT, Hanne , VOLIVA, Charles , WIESMANN, Marion , LEGRAND, Darren Mark , BRUCE, Ian , DALE, James , LAN, Jiong , LEVINE, Barry , COSTALES, Abran , LIU, Jie , PICK, Teresa , MENEZES, Daniel
IPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/437 , A61K31/5025 , A61K31/428 , A61P35/00
CPC分类号： C07D487/04 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.
摘要翻译：磷脂酰肌醇（PI）3激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂联合使用的新化合物在预防或治疗以生长因子，蛋白丝氨酸/苏氨酸激酶，磷脂激酶，G蛋白偶联的异常活性为特征的增殖性疾病中的用途受体和磷酸酶。

5. 发明申请

WO2009010530A1 BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS KINASE INHIBITORS 审中-公开
标题翻译：双相异构体化合物及其作为激酶抑制剂的用途
公开(公告)号：WO2009010530A1
公开(公告)日：2009-01-22
申请号：PCT/EP2008/059298
申请日：2008-07-16
申请人： NOVARTIS AG , LEGRAND, Darren, Mark , BRUCE, Ian , DALE, James , HUNT, Thomas, Anthony
发明人： BRUCE, Ian , DALE, James , HUNT, Thomas, Anthony
IPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/4436 , A61K31/437 , A61K31/5025 , A61P35/00
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

6. 发明公开

EP0548071A1 ENCODING SYSTEM 失效
标题翻译：编码系统。
公开(公告)号：EP0548071A1
公开(公告)日：1993-06-30
申请号：EP90913450.0
申请日：1990-09-14
申请人： DALE, James , GROSS, Gary
发明人： DALE, James , GROSS, Gary
IPC分类号： G11B20 , G11B27 , H04H20 , G06F1
CPC分类号： H04H20/31 , G06F2211/007 , G11B20/00086 , G11B20/00123 , G11B20/00884 , G11B27/3027
摘要： Procédé de codage d'un signal enregistré donné composé d'une multitude de fréquences différentes, qui comprend la modification du signal enregistré pour faire varier sélectivement et de façon connue, une partie du signal enregistré pour produire un code de départ reconnaissable par une machine mais généralement imperceptible aux humains quand le signal enregistré est reproduit de façon adéquate. Le signal est analysé et un code d'identification est généré immédiatement après le code de départ, en se basant sur les caractéristiques particulières du signal qui sont collectivement uniques au signal enregistré et au moyen desquelles on peut identifier le signal enregistré. Un signal enregistré qui a été codé en fonction dudit procédé, possède un code de départ qui peut être reconnu par une machine pendant son passage. Ce code de départ reconnu localise une partie du signal utilisée pour identifier ledit signal. L'invention décrit également un dispositif servant à mettre en application ledit procédé, à la fois pour le codage du signal enregistré et pour l'analyse des signaux qui ont été codés. Ladite invention est particulièrement efficace pour la surveillance des signaux de radiodiffusion comprenant des matériaux couverts par des droits d'auteur.

7. 发明公开

EP1133260A1 BIOPSY SYSTEM 审中-公开
标题翻译：活检系统
公开(公告)号：EP1133260A1
公开(公告)日：2001-09-19
申请号：EP99961789.7
申请日：1999-11-24
申请人： United States Surgical Corporation , Viola, Frank , Rethy, Csaba L. , Ivanko, David , Martinelli, Scott , Jankowski, Bruce , Lehn, Randolph , Dale, James , Stickney, Arthur , Ehrenfels, Karl
发明人： VIOLA, Frank , RETHY, Csaba, L. , IVANKO, David , MARTINELLI, Scott , JANKOWSKI, Bruce , LEHN, Randolph , DALE, James , STICKNEY, Arthur , EHRENFELS, Karl
IPC分类号： A61B10/00
CPC分类号： A61B10/0275 , A61B10/0283 , A61B2010/0225
摘要： A biopsy system is provided including a housing, a biopsy instrument operatively associated with the housing (12), configured and dimensioned to remove a tissue sample from a patient. A firing module (16) is included that is detachably engageable with the housing (12), and operatively associated with the biopsy instrument to facilitate selective rapid advancement of at least a portion of the biopsy instrument toward a targeted location with the patient. The biopsy instrument includes a tissue receiving portion (80). The system may include an indexing assembly disposed within the housing, and configured to cooperate with the biopsy instrument to selectively orient the tissue receiving portion. The indexing assembly (588) may include a manual gearing assembly (563) configured for selective orientation of the tissue receiving portion. The system may include a linear advancement control assembly (570) disposed within the housing and configured to effect linear actuation of a tubular knife (548) member.

8. 发明申请

WO2014145216A1 RAPID AND INEXPENSIVE ASSAY FOR EVALUATION OF ANTIBODY EFFICACY WITH CUSTOM-DESIGNED FLOURESCENT NANOPARTICLES 审中-公开
标题翻译：用自定义设计的植物纳米颗粒评估抗体效力的快速和独立测定
公开(公告)号：WO2014145216A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/029938
申请日：2014-03-15
申请人： SOUTH DAKOTA BOARD OF REGENTS , HUBER, Victor , SEREDA, Grigoriy , DALE, James
发明人： HUBER, Victor , SEREDA, Grigoriy , DALE, James
IPC分类号： G01N33/53 , G01N33/567 , G01N33/551
CPC分类号： G01N33/56972 , G01N33/6857
摘要： A method for determining the efficacy of a vaccine comprising: providing serum from an animal inoculated with a vaccine; providing a plurality of antigen-linked nanoparticles; contacting the serum with the plurality of antigen linked nanoparticles; contacting the serum and the plurality of antigen linked nanoparticles with a plurality of Fc receptor-expressing cells; measuring amount antigen-linked nanoparticle uptake by of the Fc receptor-expressing cells; determining efficacy of the vaccine by comparing the level of antigen-linked nanoparticle uptake to a baseline level of uptake wherein a greater nanoparticle uptake compared to the baseline level of uptake is indicative of greater vaccine efficacy.
摘要翻译：一种用于确定疫苗功效的方法，包括：从接种疫苗的动物提供血清; 提供多个抗原连接的纳米颗粒; 使血清与多个抗原连接的纳米颗粒接触; 使血清和多个抗原连接的纳米颗粒与多个表达Fc受体的细胞接触; 通过表达Fc受体的细胞测量抗原连接的纳米颗粒的摄取量; 通过将抗原连接的纳米颗粒摄取水平与基线吸收水平进行比较来确定疫苗的功效，其中与基线吸收水平相比，更大的纳米颗粒吸收指示更大的疫苗功效。

9. 发明公开

EP2714690A1 3-SPIROCYCLIC PIPERIDINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS 审中-公开
标题翻译： 3-螺环哌啶ALS生长素释放肽受体激动剂
公开(公告)号：EP2714690A1
公开(公告)日：2014-04-09
申请号：EP12727947.9
申请日：2012-05-25
申请人： Novartis AG
发明人： AMBARKHANE, Ameet Vijay , BHALAY, Gurdip , BECKETT, Martin , DALE, James , HAMADI, Ahmed , MAZZACANI, Alessandro , MCKENNA, Jeffrey , THOMSON, Christopher
IPC分类号： C07D471/10 , C07D487/10 , A61K31/438 , A61P1/00
CPC分类号： C07D471/10 , A61K31/407 , A61K31/435 , A61K31/55 , A61K45/06 , C07D487/10
摘要： The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.

10. 发明公开

EP2178868A1 BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS KINASE INHIBITORS 审中-公开
标题翻译：双环杂芳及其作为激酶抑制剂
公开(公告)号：EP2178868A1
公开(公告)日：2010-04-28
申请号：EP08775120.2
申请日：2008-07-16
申请人： Novartis AG
发明人： BRUCE, Ian , DALE, James , HUNT, Thomas, Anthony , LEGRAND, Darren, Mark
IPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/4436 , A61K31/437 , A61K31/5025 , A61P35/00
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

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