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1. 发明申请

WO2016014222A1 OPHTHALMIC SURGICAL MICROSCOPE WITH ADAPTIVE OPTICS FOR OPTICAL WAVEFRONT COMPENSATION 审中-公开
标题翻译：具有光学波形补偿的自适应光学的眼科手术显微镜
公开(公告)号：WO2016014222A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/038618
申请日：2015-06-30
申请人： NOVARTIS AG , ARTSYUKHOVICH, Alexander N.
发明人： ARTSYUKHOVICH, Alexander N.
IPC分类号： A61B3/15 , G01N21/49
CPC分类号： A61B3/13 , A61B3/0025 , A61B3/1015 , A61B3/12 , A61F9/007 , A61F2009/00848 , G02B21/0012 , G02B21/365 , G02B26/0825 , G02B27/0068
摘要： An ophthalmic surgical microscope can include a first light source configured to project a first light beam at an observer's eye. The microscope can include a first wavefront sensor. The first wavefront sensor can be configured to determine aberrations in the first reflection wavefront of a reflection of the first light beam. The microscope can include adaptive optical element(s). The adaptive optical element(s) can be controlled to modify the phase of incident light. The microscope can include a computing device in communication with the first wavefront sensor and the adaptive optical element(s). The computing device can be configured to generate the control signal to compensate for the aberrations and to provide the control signal to the adaptive optical element(s). A second light source and second wavefront sensor can be provided to compensate for aberrations of a subject's eye.
摘要翻译：眼科手术显微镜可以包括被配置为在观察者眼睛处投射第一光束的第一光源。显微镜可以包括第一波前传感器。第一波前传感器可以被配置为确定第一光束的反射的第一反射波前的像差。显微镜可以包括自适应光学元件。可以控制自适应光学元件以修改入射光的相位。显微镜可以包括与第一波前传感器和自适应光学元件通信的计算设备。计算设备可以被配置为产生控制信号以补偿像差并向自适应光学元件提供控制信号。可以提供第二光源和第二波前传感器来补偿被检者的眼睛的像差。

2. 发明申请

WO2015026414A1 SYSTEMS AND METHODS FOR INTRA-OPERATIVE EYE BIOMETRY OR REFRACTIVE MEASUREMENT 审中-公开
标题翻译：用于手术眼睛生物测定或折射测量的系统和方法
公开(公告)号：WO2015026414A1
公开(公告)日：2015-02-26
申请号：PCT/US2014/039579
申请日：2014-05-27
申请人： NOVARTIS AG , ARTSYUKHOVICH, Alexander N. , ASLAN, Aras , YU, Lingfeng
发明人： ARTSYUKHOVICH, Alexander N. , ASLAN, Aras , YU, Lingfeng
IPC分类号： A61F9/007
CPC分类号： A61B3/16 , A61B3/103 , A61F9/00736 , A61F9/00781
摘要： Systems and methods for capturing intraoperative biometry and/or refractive measurements include a sensor or valve associated with the eye and configured to detect a pressure of the eye. The system also includes an intra-op diagnostics device including a control unit arranged to actuate the intra-op diagnostics device to capture the intraoperative biometry and/or refractive measurements when the sensor or valve detects pressure within a predetermined pressure range.
摘要翻译：用于捕获术中生物测定和/或折射测量的系统和方法包括与眼睛相关联并被配置为检测眼睛压力的传感器或瓣膜。该系统还包括操作内诊断装置，其包括控制单元，该控制单元被布置成当传感器或阀检测到预定压力范围内的压力时致动操作内诊断装置以捕获术中生物测定和/或折射测量。

3. 发明申请

WO2015042305A1 INTEGRATED OCT-REFRACTOMETER SYSTEM FOR OCULAR BIOMETRY 审中-公开
标题翻译：用于眼科生物测定的集成OCT-压力计系统
公开(公告)号：WO2015042305A1
公开(公告)日：2015-03-26
申请号：PCT/US2014/056381
申请日：2014-09-18
申请人： NOVARTIS AG , ARTSYUKHOVICH, Alexander N. , ASLAN, Z. Aras , YU, Lingfeng , BOUKHNY, Mikhail
发明人： ARTSYUKHOVICH, Alexander N. , ASLAN, Z. Aras , YU, Lingfeng , BOUKHNY, Mikhail
IPC分类号： A61B3/14
CPC分类号： A61B3/0025 , A61B3/0041 , A61B3/1015 , A61B3/102 , A61B3/103 , A61B3/135 , A61F2009/00851 , A61F2009/00887 , A61F2240/002
摘要： A Slit-lamp-or-Microscope-Integrated-OCT-Refractometer system includes an eye-visualization system, configured to provide a visual image of an imaged region in an eye; an Optical Coherence Tomographic (OCT) imaging system, configured to generate an OCT image of the imaged region; a refractometer, configured to generate a refractive mapping of the imaged region; and an analyzer, configured to determine refractive characteristics of the eye based on the OCT image and the refractive mapping, wherein the refractometer and the OCT imaging system are integrated into the eye visualization system.
摘要翻译：狭缝灯或显微镜集成OCT折射仪系统包括眼睛可视化系统，其被配置为提供眼睛中的成像区域的视觉图像; 光学相干断层扫描（OCT）成像系统，被配置为产生所述成像区域的OCT图像; 折射计，被配置为产生所述成像区域的折射映射; 以及分析器，被配置为基于所述OCT图像和所述折射映射来确定所述眼睛的折射特性，其中所述折射计和所述OCT成像系统被集成到所述眼睛可视化系统中。

4. 发明申请

WO2011078963A1 LIGHT COLLECTOR FOR A WHITE LIGHT LED ILLUMINATOR 审中-公开
标题翻译：用于白光LED照明器的集光器
公开(公告)号：WO2011078963A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/059264
申请日：2010-12-07
申请人： ALCON RESEARCH, LTD. , ARTSYUKHOVICH, Alexander N. , BOUKHNY, Mikhail , SMITH, Ronald T. , HORVATH, Christopher
发明人： ARTSYUKHOVICH, Alexander N. , BOUKHNY, Mikhail , SMITH, Ronald T. , HORVATH, Christopher
IPC分类号： F21V7/04
CPC分类号： G02B19/0028 , G02B19/0061 , H01L33/58
摘要： A white light source includes a light-emitting diode (LED) configured to emit white light in an angular distribution. The white light source further includes a light guide and a light collector configured to collect light across the angular distribution. The light collected by the light collector contributes to a total luminous flux of the white light coupled into the light guide.
摘要翻译：白光源包括被配置为以角度分布发射白光的发光二极管（LED）。白光源还包括导光体和被配置为收集角度分布上的光的集光器。由光收集器收集的光有助于耦合到光导中的白光的总光通量。

5. 发明申请

WO2006053273A2 OPTICAL FIBER DETECTION METHOD AND SYSTEM 审中-公开
标题翻译：光纤检测方法与系统
公开(公告)号：WO2006053273A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/041097
申请日：2005-11-14
申请人： ALCON, INC. , ARTSYUKHOVICH, Alexander N. , LASSALAS, Bruno X. , ROWE, Scott T. , NGUYEN, Peter
发明人： ARTSYUKHOVICH, Alexander N. , LASSALAS, Bruno X. , ROWE, Scott T. , NGUYEN, Peter
IPC分类号： G02B6/42
CPC分类号： A61F9/007 , A61B2017/00477 , A61B2090/306 , G02B6/02 , G02B6/102 , G02B6/4201 , G02B6/4215 , G02B6/428 , G02B6/4284 , G02B6/4285 , G02B6/4286
摘要： An optical fiber detector, and a method and system for optical fiber detection are disclosed. One embodiment of the optical fiber detector of this invention comprises: a receptacle, to receive and position an optical fiber connector; an infra-red ("IR") source for providing an incident IR beam onto a cross-sectional face of an optical fiber and a cross-sectional face of the optical fiber connector; and an IR detector for receiving a reflected IR beam from the face of the optical fiber and the face of the optical fiber connector and generating a detector signal representative of the intensity of the reflected IR beam, wherein the intensity of the reflected IR beam is representative of the presence and type of the optical fiber. This embodiment of the optical fiber can further comprise an IR filter for filtering non-IR wavelengths from the reflected IR beam before the IR beam is received at the IR detector and signal processing and control means, for receiving and processing the detector signal to provide display, control or monitoring functions. The receptacle can be part of an illuminator system enclosure housing a light source, wherein the receptacle is further operable to position the connector such that the optical fiber is optically coupled to the light source. The infra-red source can comprise an IR light emitting diode ("LED") and the IR detector can comprise a photodiode operable to detect IR wavelengths. The intensity of the reflected IR beam can vary, and is inversely proportional to the ratio of the area of cross-sectional face of the optical fiber reflecting the incident IR beam to the area of cross-sectional optical fiber connector reflecting the incident IR beam. Embodiments of this invention can be implemented within any fiber-optic illuminator machine or system for use in ophthalmic or other surgery. Further, it is contemplated that the optical fiber detector of this invention can be implemented or incorporated in any machine or system requiring connection of an optical fiber to a light source. Other uses for an optical fiber detection method and system designed in accordance with the teachings of this invention will be apparent to those familiar with the art.
摘要翻译：公开了一种光纤检测器，以及用于光纤检测的方法和系统。本发明的光纤检测器的一个实施例包括：接收器，用于接收和定位光纤连接器; 用于将入射IR光束提供到光纤的横截面和光纤连接器的横截面上的红外（“IR”）源; 以及IR检测器，用于从光纤的表面和光纤连接器的表面接收反射的IR光束，并产生表示反射的IR光束的强度的检测器信号，其中反射的IR光束的强度是代表性的的光纤的存在和类型。该光纤的该实施例还可以包括IR滤波器，用于在红外线检测器和信号处理和控制装置接收IR波束之前从反射的IR波束滤除非IR波长，用于接收和处理检测器信号以提供显示，控制或监控功能。容器可以是容纳光源的照明器系统外壳的一部分，其中容器还可操作以定位连接器，使得光纤光学耦合到光源。红外源可以包括IR发光二极管（“LED”），并且IR检测器可以包括可操作以检测IR波长的光电二极管。反射的IR光束的强度可以变化，并且与反射入射的IR光束的光纤的横截面面积与反射入射的IR光束的横截面光纤连接器的面积的比率成反比。本发明的实施例可以在用于眼科或其他手术的任何光纤照明器机器或系统中实现。此外，可以想到，本发明的光纤检测器可以实现或并入需要将光纤连接到光源的任何机器或系统中。根据本发明的教导设计的用于光纤检测方法和系统的其它用途对于本领域技术人员将是显而易见的。

6. 发明申请

WO2012030505A1 LED ILLUMINATOR 审中-公开
标题翻译： LED照明器
公开(公告)号：WO2012030505A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/047603
申请日：2011-08-12
申请人： ALCON RESEARCH, LTD. , ARTSYUKHOVICH, Alexander N. , PAPAC, Michael J. , SMITH, Ronald T.
发明人： ARTSYUKHOVICH, Alexander N. , PAPAC, Michael J. , SMITH, Ronald T.
IPC分类号： A61B1/06
CPC分类号： A61B90/30 , A61B2090/309 , A61F9/007
摘要： Disclosed is an exemplary illumination device for enhancing the brightness and chromaticity of a light pump employing light emitting diodes (LED). The illumination device may include a first light source configured to emit light at a first wavelength range. A first dichroic optical element associated with the first light source may be configured to optically block less than the entire wavelength range of the light emitted from the first light source. The illumination device may also include a second light source configured to emit light at second wavelength range substantially corresponding to the wavelength range optically blocked by the first dichroic optical element.
摘要翻译：公开了一种用于增强采用发光二极管（LED）的光泵的亮度和色度的示例性照明装置。照明装置可以包括被配置为发射第一波长范围的光的第一光源。与第一光源相关联的第一分色光学元件可以被配置为光学阻挡小于从第一光源发射的光的整个波长范围。照明装置还可以包括被配置为发射基本上对应于由第一分色光学元件光学阻挡的波长范围的第二波长范围的光的第二光源。

7. 发明申请

WO2012030595A2 OPTICAL SENSING SYSTEM INCLUDING ELECTRONICALLY SWITCHED OPTICAL MAGNIFICATION 审中-公开
标题翻译：光电传感系统，包括电子切换光学放大
公开(公告)号：WO2012030595A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/048923
申请日：2011-08-24
申请人： ALCON RESEARCH, LTD. , ARTSYUKHOVICH, Alexander N.
发明人： ARTSYUKHOVICH, Alexander N.
IPC分类号： G01L11/02
CPC分类号： G01D5/34 , G01L9/0077 , G02B15/00 , G02B21/0004
摘要： Disclosed is an exemplary optical sensing system including at least one light source for emitting light in a first wavelength range and light in a second wavelength. An image sensor is provided for detecting light emitted from the at least one light source. The optical sensing system also includes a first optical filter disposed in a first optical path extending between the light source and the image sensor, the first optical filter configured to pass light emitted in the first wavelength range, and to substantially block light emitted in the second wavelength range. A second optical filter is disposed in a second optical path extending between the light source and the image sensor, the second optical filter configured to pass light emitted from the at least one light source in the second wavelength range, and to substantially block light emitted in the first wavelength range.
摘要翻译：公开了一种示例性光学感测系统，其包括用于发射第一波长范围的光和第二波长的光的至少一个光源。提供一种用于检测从至少一个光源发出的光的图像传感器。光学传感系统还包括设置在光源和图像传感器之间延伸的第一光路中的第一滤光器，第一滤光器被配置为使在第一波长范围内发射的光通过，并且基本上阻挡在第二光源波长范围。第二滤光器设置在在光源和图像传感器之间延伸的第二光路中，第二滤光器被配置为将来自至少一个光源的光在第二波长范围内通过，并基本上阻挡在第一波长范围。

8. 发明申请

WO2010085414A1 OPHTHALMIC ENDOILLUMINATION USING FIBER GENERATED LIGHT 审中-公开
标题翻译：使用光纤产生的眼睛透视内窥镜
公开(公告)号：WO2010085414A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021001
申请日：2010-01-14
申请人： ALCON RESEARCH, LTD. , ARTSYUKHOVICH, Alexander N. , BUCZEK, Mark , DACQUAY, Bruno , YADLOWSKY, Michael J.
发明人： ARTSYUKHOVICH, Alexander N. , BUCZEK, Mark , DACQUAY, Bruno , YADLOWSKY, Michael J.
IPC分类号： A61B19/00
CPC分类号： A61B1/0661 , A61B3/0008 , A61B90/30 , A61B2090/306
摘要： In one aspect of the invention, an ophthalmic endoilluminator includes at least one pump light source and a scintillator fiber optically coupled to the pump light source. The scintillator fiber receives an output of the pump light source and produces light in a different wavelength range than the output of the pump light source. An optical coupling element couples the light to an optical fiber, which conducts the light into an eye.
摘要翻译：在本发明的一个方面，一种眼科内窥镜包括至少一个泵浦光源和与泵浦光源光学耦合的闪烁体光纤。闪烁体光纤接收泵浦光源的输出并产生与泵浦光源的输出不同的波长范围内的光。光学耦合元件将光耦合到光纤，其将光导入眼睛。

9. 发明申请

WO2018134770A1 METHOD AND APPARATUS FOR OPTICAL COHERENCE TOMOGRAPHY SCANNING 审中-公开
公开(公告)号：WO2018134770A1
公开(公告)日：2018-07-26
申请号：PCT/IB2018/050327
申请日：2018-01-18
申请人： NOVARTIS AG
发明人： ARTSYUKHOVICH, Alexander N. , ASLAN, Z. Aras , REN, Hugang , ZHOU, Chengxin , YU, Lingfeng
IPC分类号： A61B3/10
摘要： An optical coherence tomography system (150, 150') includes a light source (152, 152'), an interferometric system (160, 160'), a processor (182) and a memory (184). The interferometric system (160) is optically coupled with the light source (152) and includes at least one movable scanning mirror (170, 170', 170"). The processor (182) and memory (184) are coupled with the interferometric system (160, 160'). The processor (182) executes instructions stored in the memory (184) to cause the movable scanning mirror (170, 170', 170") to scan a plurality of points in a sample in at least one pattern (250, 250', 252, 254, 256). The at least one pattern is based on at least one of at least one Lissajous curve (250, 250', 252, 254) and at least one Spirograph curve (256).

10. 发明公开

EP2983630A1 SYSTEMS AND METHODS FOR INTRA-OPERATIVE EYE BIOMETRY OR REFRACTIVE MEASUREMENT 有权转让
标题翻译：系统和方法，用于眼科手术中的眼部生物测量或者折射测量
公开(公告)号：EP2983630A1
公开(公告)日：2016-02-17
申请号：EP14837724.5
申请日：2014-05-27
申请人： Novartis AG
发明人： ARTSYUKHOVICH, Alexander N. , ASLAN, Aras , YU, Lingfeng
IPC分类号： A61F9/007
摘要： Systems and methods for capturing intraoperative biometry and/or refractive measurements include a sensor or valve associated with the eye and configured to detect a pressure of the eye. The system also includes an intra-op diagnostics device including a control unit arranged to actuate the intra-op diagnostics device to capture the intraoperative biometry and/or refractive measurements when the sensor or valve detects pressure within a predetermined pressure range.
摘要翻译：用于捕获术中生物测量学和/或屈光度测量的系统和方法包括与眼睛相关联的传感器或瓣膜，并被配置为检测眼睛的压力。该系统还包括操作内诊断装置，该装置包括控制单元，该控制单元被布置为当传感器或阀检测到预定压力范围内的压力时启动操作内诊断装置以捕捉术中生物测量和/或折射测量。

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