专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007149798A2 BIOMARKERS FOR THE PROGRESSION OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：生物标志物对阿尔茨海默病的进展
公开(公告)号：WO2007149798A2
公开(公告)日：2007-12-27
申请号：PCT/US2007071421
申请日：2007-06-18
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , HE YUNSHENG , GOMEZ-MANCILLA BALTAZAR , MEYER JOANNE , ROVELLI GIORGIO , KUHN RAINER R , BILBE GRAEME
发明人： HE YUNSHENG , GOMEZ-MANCILLA BALTAZAR , MEYER JOANNE , ROVELLI GIORGIO , KUHN RAINER R , BILBE GRAEME
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The genetic polymorphism LRRK2 (leucine-rich repeat kinase 2)-T1602S is significantly associated with conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD), with the patients with TT genotype being at greater risk to progress to Alzheimer's disease. The LRRK2-T2352 also showed a trend for conversion to Alzheimer's disease, with the patients with CC genotype tending to progress to Alzheimer's disease. Similar to the APOE-E4 allele, in the presence of a BuChE-K variant, LRRK2-T1602S and LRRK2-T2352 showed a greater association with the rate of conversion from mild cognitive impairment to Alzheimer's disease. In another study with placebo-treated Alzheimer's disease patients, LRRK2-T1602S and LRRK2-T2352 showed a same trend of association. The Alzheimer's disease patients with TT genotype of LRRK2-T1602S or CC genotype of LRRK2-T2352 tended to decline faster on cognitive performance over 6 months, especially in the presence of a BuChE-K variant. The association between the two common LRRK2 polymorphisms and Alzheimer's disease progression shows that LRRK2 may play a role in Alzheimer's disease pathogenesis, especially disease progression, and that polymorphisms of LRRK2 can be used as biomrkers of this progression.
摘要翻译：遗传多态性LRRK2（富含亮氨酸的重复激酶2）-T1602S与轻度认知障碍（MCI）与阿尔茨海默病（AD）的转化显着相关，TT基因型患者进入阿尔茨海默氏病的风险更大。 LRRK2-T2352也显示出转化为阿尔茨海默病的趋势，CC基因型患者往往进展为阿尔茨海默氏病。与APOE-E4等位基因相似，在BuChE-K变体存在下，LRRK2-T1602S和LRRK2-T2352显示与从轻度认知障碍转变为阿尔茨海默氏病的速率更大的关联。在安慰剂治疗的阿尔茨海默病患者的另一项研究中，LRRK2-T1602S和LRRK2-T2352显示出相同的关联趋势。具有LRRK2-T1602S的TT基因型或LRRK2-T2352的CC基因型的阿尔茨海默氏病患者在6个月以上的认知功能上往往更快下降，特别是在存在BuChE-K变体的情况下。两种常见的LRRK2多态性与阿尔茨海默病进展的关系表明，LRRK2可能在阿尔茨海默氏病发病机制中发挥重要作用，特别是疾病进展，LRRK2的多态性可作为这一进展的生物学家。

2. 发明专利

CA2657980A1 BIOMARKERS FOR THE PROGRESSION OF ALZHEIMER'S DISEASE 未知
公开(公告)号：CA2657980A1
公开(公告)日：2007-12-27
申请号：CA2657980
申请日：2007-06-18
申请人： NOVARTIS AG
发明人： MEYER JOANNE , GOMEZ-MANCILLA BALTAZAR , ROVELLI GIORGIO , KUHN RAINER R , BILBE GRAEME , HE YUNSHENG
IPC分类号： C12Q1/68
摘要： The genetic polymorphism LRRK2 (leucine-rich repeat kinase 2)-T1602S is s ignificantly associated with conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD), with the patients with TT genotype being at gr eater risk to progress to Alzheimer's disease. The LRRK2-T2352 also showed a trend for conversion to Alzheimer's disease, with the patients with CC geno type tending to progress to Alzheimer's disease. Similar to the APOE-E4 alle le, in the presence of a BuChE-K variant, LRRK2-T1602S and LRRK2-T2352 showe d a greater association with the rate of conversion from mild cognitive impa irment to Alzheimer's disease. In another study with placebo-treated Alzheim er's disease patients, LRRK2-T1602S and LRRK2-T2352 showed a same trend of a ssociation. The Alzheimer's disease patients with TT genotype of LRRK2-T1602 S or CC genotype of LRRK2-T2352 tended to decline faster on cognitive perfor mance over 6 months, especially in the presence of a BuChE-K variant. The as sociation between the two common LRRK2 polymorphisms and Alzheimer's disease progression shows that LRRK2 may play a role in Alzheimer's disease pathoge nesis, especially disease progression, and that polymorphisms of LRRK2 can b e used as biomrkers of this progression.

3. 发明专利

BRPI0713738A2 未知
公开(公告)号：BRPI0713738A2
公开(公告)日：2014-06-24
申请号：BRPI0713738
申请日：2007-06-18
申请人： NOVARTIS AG
发明人： HE YUNSHENG , GOMEZ-MANCILLA BALTAZAR , MEYER JOANNE , ROVELLI GIORGIO , KUHN RAINER R , BILBE GRAEME
IPC分类号： C13K1/02 , C12P19/02

4. 发明专利

MX2008016524A BIOMARCADORES PARA LA PROGRESION DE LA ENFERMEDAD DE ALZHEIMER. 未知
公开(公告)号：MX2008016524A
公开(公告)日：2009-03-09
申请号：MX2008016524
申请日：2007-06-18
申请人： NOVARTIS AG
发明人： BILBE GRAEME , HE YUNSHENG , MEYER JOANNE , GOMEZ-MANCILLA BALTAZAR , ROVELLI GIORGIO , KUHN RAINER R
IPC分类号： C12Q1/00
摘要： Se describe el polimorfismo genético de LRRK2 (cinasa 2 repetitiva rica en leucina)-T1602S se asocia significativamente a la conversión del deterioro cognoscitivo moderado (MCI) a la enfermedad de Alzheimer (AD), en los pacientes con el genotipo TT que están en mayor riesgo de progresar a la enfermedad de Alzheimer. El LRRK2-T2352 también mostró una tendencia a la conversión a la enfermedad de Alzheimer, en los pacientes con el genotipo CC que tienden a progresar a la enfermedad de Alzheimer. Similar al alelo APOE-E4, en presencia de una variante de BuChE-K, un LRRK2-T1602S y un LRRK2-T2352 mostraron una mayor asociación al índice de conversión del deterioro cognoscitivo moderado a la enfermedad de Alzheimer. En otro estudio en los pacientes de la enfermedad de Alzheimer tratados con placebo, LRRK2-T1602S y LRRK2-T2352 mostraron una misma tendencia de asociación. Los pacientes con enfermedad de Alzheimer con el genotipo TT de LRRK2-T1602S o con el genotipo CC de LRRK2-T2352 tendieron a disminuir más rápidamente el funcionamiento cognoscitivo durante 6 meses, especialmente en presencia de una variante de BuChE-K. La asociación entre los dos polimorfismos de LRRK2 y el progreso de la enfermedad de Alzheimer mostró que LRRK2 puede desempeñar una función en la patogénesis de la enfermedad de Alzheimer, especialmente en el progreso de la enfermedad, y que los polimorfismos de LRRK2 se pueden utilizar como marcadores biológicos de este progreso.

5. 发明专利

AU2007261095A1 Biomarkers for the progression of Alzheimer's disease 未知
公开(公告)号：AU2007261095A1
公开(公告)日：2007-12-27
申请号：AU2007261095
申请日：2007-06-18
申请人： NOVARTIS AG
发明人： ROVELLI GIORGIO , MEYER JOANNE , BILBE GRAEME , KUHN RAINER R , HE YUNSHENG , GOMEZ-MANCILLA BALTAZAR
IPC分类号： C12Q1/68

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式